Silverberg, Michael J.
Research interests include HIV and cardiovascular complications.
Risk of Hepatocellular Carcinoma with Hepatitis B Viremia among HIV/Hepatitis B Virus-Coinfected Persons in North America
Chronic HBV is the predominant cause of HCC worldwide. Although HBV coinfection is common in HIV, the determinants of HCC…
Prevalence and Medication Treatment of Opioid Use Disorder Among Primary Care Patients with Hepatitis C and HIV
Hepatitis C and HIV are associated with opioid use disorders (OUD) and injection drug use. Medications for OUD can prevent…
Alcohol-Related Care and HCV Treatment among Patients with Problematic Alcohol Use and HCV
This study will examine substance use treatment among patients with hepatitis C who have unhealthy alcohol use and how well…
Prevalence of Spontaneous Clearance of Hepatitis C Virus Infection Doubled From 1998 to 2017
Strategic planning for hepatitis C virus (HCV) screening and treatment requires up-to-date information on the prevalence of HCV spontaneous clearance.…
LIFE EXPECTANCY DISPARITIES AMONG ADULTS WITH HIV IN THE UNITED STATES AND CANADA: THE IMPACT OF A REDUCTION IN DRUG- AND ALCOHOL-RELATED DEATHS USING THE LIVES SAVED SIMULATION (LISSO) MODEL
Improvements in life expectancy among people living with human immunodeficiency virus (PLWH) receiving antiretroviral treatment in the United States and…
Uptake and safety of hepatitis A vaccination during pregnancy: A Vaccine Safety Datalink study
Infection with hepatitis A virus (HAV) during pregnancy, although uncommon, is associated with gestational complications and pre-term labor. Hepatitis A…
Determinants of Liver Complications Among HIV/Hepatitis B Virus-Coinfected Patients
Hepatitis B virus (HBV) infection is a leading cause of end-stage liver disease (ESLD) and hepatocellular carcinoma (HCC) in HIV.…
Validation of the Hepatocellular Carcinoma Early detection Screening (HES) algorithm in a Cohort of Veterans with Cirrhosis
Early detection of hepatocellular carcinoma (HCC) through surveillance reduces mortality associated with this cancer. Guidelines recommend HCC surveillance every 6…
Hepatitis C treatment uptake and response among human immunodeficiency virus/hepatitis C virus-coinfected patients in a large integrated healthcare system.
U.S. guidelines recommend that patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) be prioritized for HCV…
Impact of an electronic medical record reminder on hepatitis B vaccine initiation and completion rates among insured adults with diabetes mellitus
The Advisory Committee on Immunization Practices recommends Hepatitis B (HepB) vaccine for previously unvaccinated adults
Immunogenicity and safety following primary and booster vaccination with a hexavalent diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated poliovirus and Haemophilus influenzae type b vaccine: a randomized trial in the United States
Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliomyelitis and Haemophilus influenzae type b vaccine (DTaP-HBV-IPV/Hib) can further reduce the number of injections…
Immunogenicity and safety of the Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine co-administered with human rotavirus, hepatitis A and 13-valent pneumococcal conjugate vaccines: results from a phase III, randomized, multicenter study in infants
This phase III, open-label, randomized study (NCT01978093) evaluated the immunogenicity and safety of co-administered Haemophilus influenzae type b-Neisseria meningitidis serogroups…
Uptake and safety of Hepatitis B vaccination during pregnancy: A Vaccine Safety Datalink study
Hepatitis B virus (HBV) infection acquired during pregnancy can pose a risk to the infant at birth that can lead…
Safety of Direct-Acting Antiviral Medications for Hepatitis C – DUPLICATED DO NOT ACTIVATE
This project will identify all patients who have a laboratory-confirmed diagnosis of Hepatitis C. The intervention group will be those…
Safety of Direct Acting Antiviral Medications for Hepatitis C
This project will identify all patients who have a laboratory-confirmed diagnosis of Hepatitis C. The intervention group will be those…
Disparities in Initiation of Direct-Acting Antiviral Agents for Hepatitis C Virus Infection in an Insured Population
The cost of direct-acting antiviral agents (DAAs) for hepatitis C virus (HCV) infection may contribute to treatment disparities. However, few…
Safety of Direct-Acting Antiviral Medications for Hepatitis C
This study will investigate the safety of direct-acting antiviral medications in patients who have a laboratory-confirmed diagnosis of hepatitis C.…
Effectiveness and safety of interferon-free treatment for hepatitis C virus (HCV) infection in a clinical practice setting
This a cohort study of KPNC patients initiating interferon-free treatment for HCV infection, with the following specific aims: 1) Determine…
A New Lab-Based Algorithm for HCC Surveillance in Patients with Cirrhosis
The objective of this study is to optimize and test the predictive value of a model in predicting the occurrence…
Risk of Acute Liver Injury With Antiretroviral Therapy by Viral Hepatitis Status
The risk of hepatotoxicity with antiretroviral therapy (ART) remains unknown. We determined the comparative risk of acute liver injury (ALI)…
Monocyte activation by interferon-alpha is associated with failure to achieve a sustained virologic response after treatment for hepatitis C virus infection
Interferon ? (IFN-?) and ribavirin can induce a sustained virologic response (SVR) in some but not all hepatitis C virus…
Differences in Response to Antiretroviral Therapy by Sex and Hepatitis C Infection Status
Hepatitis C virus (HCV) co-infection and biological sex may each affect response to antiretroviral therapy (ART), yet no studies have…
Effectiveness of Telaprevir and Boceprevir Triple Therapy for Patients with Hepatitis C Virus Infection in a Large Integrated Care Setting
In 2011, the FDA approved telaprevir (TVR) and boceprevir (BOC) for use with pegylated interferon and ribavirin to treat hepatitis…
Prevention of Vertical Transmission of Hepatitis B: An Observational Study
For mothers with chronic hepatitis B virus (HBV) infection, the Centers for Disease Control and Prevention recommends immunoprophylaxis to decrease…
Telaprevir or boceprevir triple therapy in patients with chronic hepatitis C and varying severity of cirrhosis
Risks and benefits of protease inhibitor (PI) (telaprevir or boceprevir) triple therapy in hepatitis C virus (HCV)-infected patients with mildly…
The effect of hepatitis C treatment response on medical costs: a longitudinal analysis in an integrated care setting
Studies suggest that chronic hepatitis C patients who achieve sustained virologic response (SVR) have lower risks of liver-related morbidity and…
Physical, Social, and Psychological Consequences of Treatment for Hepatitis C : A Community-Based Evaluation of Patient-Reported Outcomes
BACKGROUND: Hepatitis C virus (HCV) antiviral therapy entails a long treatment course, as well as significant side effects that can…
Distribution of hepatitis C virus genotypes in a diverse US integrated health care population
Hepatitis C virus (HCV) genotypes influence response to therapy, and recently approved direct-acting antivirals are genotype-specific. Genotype distribution information can…
The impact of lifetime alcohol use on hepatitis C treatment outcomes in privately insured members of an integrated health care plan
Treatment of chronic hepatitis C infection (HCV(+) ) has historically been shown to be less effective in patients with a…
Enhanced Liver Fibrosis (ELF) test accurately identifies liver fibrosis in patients with chronic hepatitis C
Assessment of liver fibrosis is important in determining prognosis and evaluating interventions. Due to limitations of accuracy and patient hazard…
Prevalence and predictors of hepatic steatosis in adults with newly diagnosed chronic liver disease due to hepatitis C
Obesity appears to be a risk factor for hepatic steatosis, which has been implicated in the development of hepatic fibrosis…
The epidemiology of newly diagnosed chronic liver disease in gastroenterology practices in the United States: results from population-based surveillance
OBJECTIVES: Chronic liver disease (CLD) is an important cause of morbidity and mortality, but the epidemiology is not well described.…
Limitations of conventionally derived chronic liver disease mortality rates: Results of a comprehensive assessment
Standard death certificate-based methods for ascertaining deaths due to chronic liver disease (CLD), such as the U.S. vital statistics approach,…
Hepatic effects of lovastatin exposure in patients with liver disease: a retrospective cohort study
BACKGROUND: Little is known about the potential adverse hepatic effects of HMG-CoA reductase inhibitors ('statins') in patients with existing liver…
Incidence of hepatocellular carcinoma among individuals with hepatitis B virus infection identified using an automated data algorithm
The purpose of this study was to develop an algorithm for identifying patients with chronic hepatitis B virus (HBV) using…
Incidence of non-Hodgkin’s lymphoma among individuals with chronic hepatitis B virus infection
Although hepatitis C virus (HCV) infection has been shown to be associated with development of non-Hodgkin's lymphoma (NHL), few studies…
Global transcriptional response to interferon is a determinant of HCV treatment outcome and is modified by race
Interferon (IFN)-alpha-based therapy for chronic hepatitis C is effective in fewer than 50% of all treated patients, with a substantially…
Sexual behavior, human papillomavirus type 16 (HPV 16) infection, and HPV 16 seropositivity
BACKGROUND: Sexual behaviors have been linked to seropositivity for human papillomavirus (HPV) but not with the magnitude of the seroreactivity.…
