Van Den Eeden, Stephen K.
Research interests include etiologic and outcomes studies in cancer.
Precision Prostate Cancer Screening with Genetically Adjusted Prostate-Specific Antigen Levels
This is a project more comprehensively determine the genetic factors associated with PSA levels, and to develop and apply prediction…
Precision Prostate Cancer Screening with Genetically Adjusted Prostate-Specific Antigen Levels – DUPLICATED DO NOT ACTIVATE
An effort to more comprehensively determine the genetic factors associated with prostate-specific antigen (PSA) levels, and to develop and apply…
Lubrication Practices and Receptive Anal Sex: Implications for STI Transmission and Prevention
Implications of lubricant use in men having sex with men (MSM) are poorly characterized, particularly associations with sexual behavior and…
Why Do Epidemiologic Studies Find an Inverse Association Between Intraprostatic Inflammation and Prostate Cancer: A Possible Role for Colliding Bias?
Inflammation is an emerging risk factor for prostate cancer based largely on evidence from animal models and histopathologic observations. However,…
Implementation of a Multidisciplinary Expert Testicular Cancer Tumor Board Across a Large Integrated Healthcare Delivery System Via Early Case Ascertainment
In 2016, Kaiser Permanente Northern California began regionalizing testicular cancer care using population-based tumor board review. This mixed methods evaluation…
Long-term follow-up of a racially and ethnically diverse population of men with localized prostate cancer who did not undergo initial active treatment
There is limited research on the racial/ethnic differences in long-term outcomes for men with untreated, localized prostate cancer. Men diagnosed…
Association of Childhood Psychosocial Environment With 30-Year Cardiovascular Disease Incidence and Mortality in Middle Age
Background Childhood adversity and trauma have been shown to be associated with poorer cardiovascular disease (CVD) outcomes in adulthood. However,…
Parental Risk Factors for Fever in their Children 7-10 Days After the First Dose of Measles-Containing Vaccines
We evaluated whether parental clinical conditions were associated with fever after a first dose of measles-containing vaccine (MCV) in the…
A Genome-wide Association Study of Prostate Cancer in Latinos
Latinos represent
Characterizing the Human Immunodeficiency Virus Care Continuum Among Transgender Women and Cisgender Women and Men in Clinical Care: A Retrospective Time-series Analysis
Prior studies suggest that transgender women (TW) with human immunodeficiency virus (HIV) are less likely to be virally suppressed than…
The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies
Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers.…
Haloperidol and Prostate Cancer Prevention: More Epidemiologic Research Needed
The antipsychotic drug haloperidol has antiproliferative and growth-inhibiting properties on prostate cancer cell lines in vitro by binding the sigma…
Selecting Active Surveillance: Decision-Making Factors for Men with a Low-Risk Prostate Cancer
Background. Men with a low-risk prostate cancer (PCa) should consider observation, particularly active surveillance (AS), a monitoring strategy that avoids…
Trichomonas vaginalis infection and prostate-specific antigen concentration: Insights into prostate involvement and prostate disease risk.
BACKGROUND: The protist Trichomonas vaginalis causes a common, sexually transmitted infection and has been proposed to contribute to the development…
Effects of seafood consumption and toenail mercury and selenium levels on cognitive function among American adults: 25 y of follow up
The aim of this study was to examine the longitudinal association between seafood and intake of long-chain ω-3 polyunsaturated fatty…
Sexual Orientation Disparities in Physical Activity: Results From Insured Adults in California
The majority of adults in the United States fail to meet the Centers for Disease Control and Prevention (CDC) physical…
Bisphenol A Exposure and Sperm ACHE Hydroxymethylation in Men
Exposure to bisphenol A (BPA) has been shown to impact human sperm quality. The epigenetic mechanisms underlying the effect remain…
Diet-related inflammation and risk of prostate cancer in the California Men’s Health Study
The purpose of the study was to examine the relationship between proinflammatory diet and prostate cancer risk. Energy-adjusted Dietary Inflammatory…
Genetic variation in the SIM1 locus is associated with erectile dysfunction
Erectile dysfunction affects millions of men worldwide. Twin studies support the role of genetic risk factors underlying erectile dysfunction, but…
The use of 5-alpha reductase inhibitors to manage benign prostatic hyperplasia and the risk of all-cause mortality
To compare the risk of mortality among men treated for benign prostatic hyperplasia (BPH) with 5 alpha-reductase inhibitors (5ARI) to…
Association of Bisphenol A Exposure with LINE-1 Hydroxymethylation in Human Semen
Bisphenol A (BPA), an exogenous endocrine-disrupting chemical, has been shown to alter DNA methylation. However, little information is available about…
Risk of diabetes complications among those with diabetes receiving androgen deprivation therapy for localized prostate cancer
Androgen deprivation therapy (ADT), used increasingly in the treatment of localized prostate cancer, is associated with substantial long-term adverse consequences,…
Sustained influence of infections on prostate-specific antigen concentration: An analysis of changes over 10 years of follow-up.
BACKGROUND: To extend our previous observation of a short-term rise in prostate-specific antigen (PSA) concentration, a marker of prostate inflammation…
Association between paternal alcohol consumption before conception and anogenital distance of offspring
There are limited studies on the effects of paternal alcohol consumption, before conception, on the reproductive development of offspring. Anogenital…
Predictors of Follow-Up Visits Post Radical Prostatectomy.
Long-term follow-up care among prostate cancer patients is important as biochemical recurrence can occur many years after diagnosis, with 20%-30%…
Physicians’ perspectives on the informational needs of low-risk prostate cancer patients
Despite the evidence indicating that decision aids (DA) improve informed treatment decision making for prostate cancer (PCa), physicians do not…
Association of Testosterone Replacement With Cardiovascular Outcomes Among Men With Androgen Deficiency
Controversy exists regarding the safety of testosterone replacement therapy (TRT) following recent reports of an increased risk of adverse cardiovascular…
Television viewing and hostile personality trait increase the risk of injuries
Individuals with high levels of hostility may be more susceptible to the influence of television on violence and risk taking…
Susceptibility Genes for Erectile Dysfunction
This Multi-PI grant (H. Wessells, UW & S. Van Den Eeden KPNC) will 1) develop phenotyping algorithms, 2) examine genetic…
Sociodemographic and clinical predictors of switching to active treatment among a large ethnically diverse cohort of men with low-risk prostate cancer on observational management
We determined the clinical and sociodemographic predictors of beginning active treatment in an ethnically diverse population of men with low…
Treatment Preferences for Active Surveillance vs. Active Treatment Among Men with Low-Risk Prostate Cancer
Due to the concerns about the overtreatment of low-risk prostate cancer, active surveillance (AS) is now a recommended alternative to…
Infectious mononucleosis, other infections and prostate-specific antigen concentration as a marker of prostate involvement during infection.
Although Epstein-Barr virus has been detected in prostate tissue, no associations have been observed with prostate cancer in the few…
Physical Activity and Risk of Male Breast Cancer
The association between leisure-time physical activity (LTPA) and male breast cancer risk is unclear. In the Male Breast Cancer Pooling…
Relationship between self-reported residential indoor remodeling and semen quality: a case-control study
The present study examined the association between residential indoor remodeling and poor semen quality. Sperm donors aged 18-45 years old…
Prediagnostic Sex Steroid Hormones in Relation to Male Breast Cancer Risk
Although previous studies have implicated a variety of hormone-related risk factors in the etiology of male breast cancers, no previous…
Risk of Diabetes among Patients Receiving Primary Androgen Deprivation Therapy for Clinically Localized Prostate Cancer
Androgen deprivation therapy may increase diabetes risk. As the benefits of primary androgen deprivation therapy for localized prostate cancer are…
Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium
The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures…
Exposure to bisphenol-A and reproductive hormones among male adults
Bisphenol A (BPA) is a suspected human endocrine disruptor which is widely used. In order to determine whether urine BPA…
Association Between Cannabis Use and the Risk of Bladder Cancer: Results From the California Men’s Health Study
To investigate the association of cannabis use and tobacco smoking on the incidence of bladder cancer within the California Men's…
Longitudinal study of body mass index in Asian men who immigrate to the US
Cross-sectional studies indicate that adaptation to Western norms, especially at a younger age, might explain the higher average body mass…
Progression and treatment of incident lower urinary tract symptoms among men in the California Men’s Health Study
To characterise the progression and treatment of lower urinary tract symptoms (LUTS) among men aged 45-69 years in the California…
Association of body mass index and prostate cancer mortality
Inconsistent evidence exists on whether obesity is associated with an increased risk of prostate cancer death post-radical prostatectomy. We examined…
Effectiveness of Primary Androgen-Deprivation Therapy for Clinically Localized Prostate Cancer
Primary androgen-deprivation therapy (PADT) is often used to treat clinically localized prostate cancer, but its effects on cause-specific and overall…
Anthropometric and Hormonal Risk Factors for Male Breast Cancer: Male Breast Cancer Pooling Project Results
The etiology of male breast cancer is poorly understood, partly because of its relative rarity. Although genetic factors are involved,…
Effects of physical activity and sedentary time on the risk of heart failure
Although the benefits of physical activity for risk of coronary heart disease are well established, less is known about its…
LINE-1 hypomethylation in spermatozoa is associated with Bisphenol A exposure
Bisphenol A (BPA) is an endocrine disruptor with potentially harmful effects on humans. However, epigenetic mechanisms that modulate the effects…
Relation of serum magnesium levels and postdischarge outcomes in patients hospitalized for heart failure (from the EVEREST Trial).
Serum magnesium levels may be impacted by neurohormonal activation, renal function, and diuretics. The clinical profile and prognostic significance of…
Leadership and Job Readiness: Addressing Social Determinants of Health Among Ruralafrican American Men
There is increased recognition that the inequitable distribution of social determinants acts as a stressor that influences health outcomes. Men…
Immunohistochemical Expression of ERG in the Molecular Epidemiology of Fatal Prostate Cancer Study
BACKGROUND: Gene fusions between the ERG transcription factor and the androgen-regulated gene TMPRSS2 occur in a subset of prostate cancers…
Impact of type 2 diabetes on lower urinary tract symptoms in men: a cohort study
BACKGROUND: Studies of the impact of type 2 diabetes on the prevalence and incidence of lower urinary tract symptoms (LUTS)…
Clinical effectiveness of pneumococcal polysaccharide vaccine in men: California Men’s Health Study
OBJECTIVE: To examine the effectiveness of pneumococcal polysaccharide vaccine (PPV) among approximately 40,000 community-dwelling men aged 45 years and older…
Population-based study of erectile dysfunction and polypharmacy
Study Type - Symptom prevalence (population cohort). Level of Evidence 1b. What's known on the subject? and What does the…
Validation of FRC, a Fracture Risk Assessment Tool, in a Cohort of Older Men: The Osteoporotic Fractures in Men Study
We evaluated the performance of the Fracture Risk Calculator (FRC) in 5893 men who participated in the baseline visit (March…
Complementary and Alternative Medicine Use, Patient-reported Outcomes, and Treatment Satisfaction Among Men With Localized Prostate Cancer
OBJECTIVE: To evaluate the association between complementary and alternative medicine (CAM) use, satisfaction with treatment, and patient-reported outcomes after treatment.…
Telomerase, telomere length, and coronary artery calcium in black and white men in the CARDIA study
OBJECTIVE: To evaluate whether telomerase activity, measured in circulating blood leukocytes, might be associated with prevalent atherosclerosis, or predict future…
Evaluating Racial/Ethnic Disparities in Lower Urinary Tract Symptoms in Men
PURPOSE: We examined whether there are racial/ethnic disparities in lower urinary tract symptoms in men. MATERIALS AND METHODS: Racial/ethnic disparities…
Preventive care and health behaviors among overweight/obese men in HMOs
OBJECTIVES: To examine potential weight-related disparities in receipt of preventive screening exams and to compare several quality indicators and health…
Effect of Sexually Transmitted Infections, Lifetime Sexual Partner Count, and Recreational Drug Use on Lower Urinary Tract Symptoms in Men Who Have Sex With Men
OBJECTIVE: To investigate the relationship of lower urinary tract symptoms (LUTS) to urinary tract infection, prostatitis, sexually transmitted infection, lifetime…
A comparison of lifestyle and behavioral cardiovascular disease risk factors between Asian Indian and White non-Hispanic men
OBJECTIVE: We compared lifestyle CVD risk factors between Asian Indian and White non-Hispanic men within categories of BMI. DESIGN/SETTING/PARTICIPANTS: Participants…
Performance of the American Urological Association Symptom Index with and without an additional urge incontinence item
OBJECTIVE: To examine the value of adding an urge incontinence question to the American Urological Association Symptom Index (AUASI) among…
What do I tell patients about saw palmetto for benign prostatic hyperplasia?
Saw palmetto is widely used to treat lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH). Although there…
Regular nonsteroidal anti-inflammatory drug use and erectile dysfunction
PURPOSE: Previous data suggest a potential relationship between inflammation and erectile dysfunction. If it is causal, nonsteroidal anti-inflammatory drug use…
A syndemic model of substance abuse, intimate partner violence, HIV infection, and mental health among Hispanics.
Hispanics are disproportionately affected by substance abuse, HIV infection, intimate partner violence, and mental health conditions. To address health disparities…
Urine bisphenol-A (BPA) level in relation to semen quality
OBJECTIVE: To determine whether urine bisphenol-A (BPA) levels are associated with lower semen quality. DESIGN: Cohort study. SETTING: Four regions…
Relationship between urine bisphenol-A level and declining male sexual function
The adverse effect of bisphenol-A (BPA) on the male reproductive system observed in animal studies has not been well examined…
Pneumococcal vaccination and risk of acute myocardial infarction and stroke in men
CONTEXT: Multiple studies have shown that preventing influenza by vaccination reduces the risk of vascular events. However, the effect of…
Increased risk of high-grade prostate cancer among infertile men
BACKGROUND: It has been reported that fatherhood status may be a risk factor for prostate cancer. In the current study,…
Prostatitis, sexually transmitted diseases, and prostate cancer: the California Men’s Health Study
BACKGROUND: Prostatitis and sexually transmitted diseases (STDs) have been positively associated with prostate cancer in previous case-control studies. However, results…
Medical history, body size, and cigarette smoking in relation to fatal prostate cancer
OBJECTIVES: Prostate cancer has few known risk factors. As part of a population-based case-control study conducted in four health maintenance…
Red wine consumption and risk of prostate cancer: the California men’s health study
Red wine contains polyphenol antioxidants that inhibit prostate cancer development in animal studies. We investigated the effect of red wine…
Exposure to magnetic fields and the risk of poor sperm quality
We conducted a population-based case-control study among healthy sperm donors to study exposure to magnetic fields (MFs) and poor sperm…
Racial disparities in erectile dysfunction among participants in the California Men’s Health Study
INTRODUCTION: The burden of erectile dysfunction (ED) among different racial and ethnic groups is unclear, in part, because prior studies…
Correlates of prostate-specific antigen testing in a large multiethnic cohort
OBJECTIVE: To examine factors associated with prostate-specific antigen (PSA) testing in the multiethnic California Men's Health Study. STUDY DESIGN: Cross-Sectional…
Access to information sources and treatment considerations among men with local stage prostate cancer
OBJECTIVES: To determine the role of information sources in the treatment decision-making process of men diagnosed with local stage prostate…
Statin use and risk of colorectal cancer in a cohort of middle-aged men in the US: a prospective cohort study
BACKGROUND: Numerous modifiable factors have been associated with a reduced risk of colorectal cancer, including the chronic use of NSAIDs.…
Effect of intensive glycemic control and diabetes complications on lower urinary tract symptoms in men with type 1 diabetes: Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study
OBJECTIVE: Although diabetes is known to result in lower urinary tract symptoms (LUTS) in men, it remains unclear if glycemic…
Generational status and duration of residence predict diabetes prevalence among Latinos: the California Men’s Health Study
BACKGROUND: Diabetes disproportionately affects Latinos. However, examining Latinos as one group obscures important intra-group differences. This study examined how generational…
Alcoholic beverage intake and risk of lung cancer: the California Men’s Health Study
We investigated the effect of alcoholic beverage consumption on the risk of lung cancer using the California Men's Health Study.…
Association of Preexisting Symptoms with Treatment Decisions among Newly Diagnosed Prostate Cancer Patients
BACKGROUND: The choice between surgical versus non-surgical treatment options is a fundamental decision for men with local stage prostate cancer…
Racial differences in treatment of early-stage prostate cancer
OBJECTIVES: To determine whether differences existed in prostate cancer treatment received by white and African American men at a health…
A detailed safety assessment of a saw palmetto extract
BACKGROUND: Saw palmetto is commonly used by men for lower-urinary tract symptoms. Despite its widespread use, very little is known…
Glycemic status and risk of prostate cancer
BACKGROUND: To examine the risk of prostate cancer and glucose tolerance in a large, racially diverse cohort. METHODS: We conducted…
Statin use and risk of prostate cancer in the California Men’s Health Study cohort
Statins have known anticarcinogenic effects, however, evidence for long-term statin use as effective chemoprevention for prostate cancer is inconsistent. We…
Saw palmetto and lower urinary tract symptoms: what is the latest evidence?
The use of dietary supplements for treating a wide range of health conditions has grown rapidly in the United States.…
Saw palmetto for benign prostatic hyperplasia
BACKGROUND: Saw palmetto is used by over 2 million men in the United States for the treatment of benign prostatic…
California Men’s Health Study (CMHS): a multiethnic cohort in a managed care setting
BACKGROUND: We established a male, multiethnic cohort primarily to study prostate cancer etiology and secondarily to study the etiologies of…
Screening by prostate-specific antigen and digital rectal examination in relation to prostate cancer mortality: a case-control study
BACKGROUND: The potential role of prostate cancer screening in reducing mortality is uncertain. To examine whether screening with the prostate-specific…
Management of cryptorchism and risk of testicular cancer
Cryptorchism is an established risk factor for testicular cancer, but the role of age at surgical correction is unclear. The…
Training, quality assurance, and assessment of medical record abstraction in a multisite study
Clinical studies using medical record review should include careful training and quality assurance methods to enhance the reliability and validity…
Body mass index and colon cancer: an evaluation of the modifying effects of estrogen (United States)
OBJECTIVE: The association between body mass index (BMI) and colon cancer has been reported to be different for men and…
Initial treatment for prostate carcinoma in relation to comorbidity and symptoms
BACKGROUND: Evidence suggests the type of treatment received for prostate carcinoma is associated with comorbidity, but little information is available…
Cause of death in men diagnosed with prostate carcinoma
BACKGROUND: Prostate carcinoma is one of the leading causes of death in men. Although the mortality rate is high, it…
