Nguyen-Huynh, Mai N.
Research interests include stroke and transient ischemic attack epidemiology
Long-term medical imaging use in children with central nervous system tumors
Children with central nervous system (CNS) tumors undergo frequent imaging for diagnosis and follow-up, but few studies have characterized longitudinal…
The Colonic Microbiome Preceding Parkinson’s Disease: A Pilot Study
Gut changes, including evidence of alpha synuclein and the microbiome, appear to differ between people with and without Parkinson's disease.…
Bipolar Disease and Parkinson’s Disease
This study, along with a parallel effort at the University of California, San Francisco, will focus on the relationship between…
Identifying and Prioritizing Chemicals with Uncertain Burden of Exposure: Opportunities for Biomonitoring and Health-Related Research
The National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) initiative aims to understand the impact of environmental…
Prenatal Opioid Exposure: Neurodevelopmental Consequences and Future Research Priorities
Neonatal opioid withdrawal syndrome (NOWS) has risen in prevalence from 1.2 per 1000 births in 2000 to 5.8 per 1000…
Long-term effectiveness of zoster vaccine live for postherpetic neuralgia prevention
Postherpetic neuralgia (PHN) occurs in 5-30% of individuals with herpes zoster (HZ) and is characterized by long-lasting pain. Zoster vaccine…
Conducting a pilot randomized controlled trial of community-based mindfulness-based stress reduction versus usual care for moderate-to-severe migraine: protocol for the Mindfulness and Migraine Study (M&M)
Migraine is one of the most common neurological disorders in clinical practice and is a substantial cause of disability worldwide.…
ICLIC-MS for Enhancing Outcomes Research and Clinical Care in Multiple Sclerosis
The goal of this project is 1) to collect longitudinal measures of cognitive function, quality of life, and physical disability…
Early Identification and Prognosis in Neurodegenerative Parkinsonism
The goals of this study are to develop an efficient method for identification of people destined to develop a neurodegenerative…
Remote assessment of verbal memory in MS patients using the California Verbal Learning Test
We used the California Verbal Learning Test, Second Edition (CVLT-II), one component of the Brief International Cognitive Assessment for Multiple…
Associations of plasma clusterin and Alzheimer’s disease-related MRI markers in adults at mid-life: The CARDIA Brain MRI sub-study
Clinical and epidemiological studies of older persons have implicated clusterin in Alzheimer's disease (AD) pathogenesis. In the context of identifying…
The interaction between smoking and HLA genes in multiple sclerosis: replication and refinement
Interactions between environment and genetics may contribute to multiple sclerosis (MS) development. We investigated whether the previously observed interaction between…
Sex hormones and brain volumes in a longitudinal study of middle-aged men in the CARDIA study
Several findings suggest that testosterone (T) is neuroprotective and that declining T levels during aging are associated with cognitive and…
Intake of niacin, folate, vitamin B-6, and vitamin B-12 through young adulthood and cognitive function in midlife: the Coronary Artery Risk Development in Young Adults (CARDIA) study
Background: Epidemiologic evidence regarding niacin, folate, vitamin B-6, and vitamin B-12 intake in relation to cognitive function is limited, especially…
Association Between Birth in a High Stroke Mortality State, Race, and Risk of Dementia
Birth in a group of predominantly southern US states is robustly linked to increased stroke risk. Given the role of…
Cardiovascular health in young adulthood and structural brain MRI in midlife: The CARDIA study
To examine the association between the American Heart Association (AHA) Life's Simple 7 (LS7) metric and brain structure. We determined…
Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS
To utilize Mendelian randomization to estimate the causal association between low serum vitamin D concentrations, increased body mass index (BMI),…
Cognitive Function and Physical Disability in White, Black and Hispanic MS Patients
Cognitive impairment, physical disability and progressive disease are common but understudied clinical outcomes that substantially impact quality of life for…
Risk of NTD among Live Births Exposed to Maternal Rx Opioids during Early Pregnancy
The objectives of this study are: 1) To measure the association between in utero exposure to prescription opioids during early…
Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACT TBI)
Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) establishes a public-private partnership of experienced TBI investigators, and philanthropic…
Longitudinal Assessment of Disease Progression and Cognitive Status in Multiple Sclerosis: A Comprehensive Web-Based Approach for Clinical Research
Large, clinically well-characterized, longitudinally followed and population-representative patient cohorts are needed to advance the understanding of MS disease progression/disability and…
Novel Strategies to Identify G x E Contributions to MS Pathogensis
The goal of the study is to examine potential gene X environment interactions in relation to risk and progression of…
Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk
We sought to estimate the causal effect of low serum 25(OH)D on multiple sclerosis (MS) susceptibility that is not confounded…
Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies
We investigated the association between 52 risk variants identified through genome-wide association studies and disease severity in multiple sclerosis (MS).…
Neonatal seizures triple the risk of a remote seizure after perinatal ischemic stroke
To determine incidence rates and risk factors of remote seizure after perinatal arterial ischemic stroke. We retrospectively identified a population-based…
Association Between Lifetime Marijuana Use and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Marijuana use is increasingly common in the United States. It is unclear whether it has long-term effects on memory and…
First translational ‘Think Tank’ on cerebrovascular disease, cognitive impairment and dementia
As the human population continues to age, an increasing number of people will exhibit significant deficits in cognitive function and…
Blood Pressure Reactivity to Psychological Stress in Young Adults and Cognition in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
The classic view of blood pressure (BP) reactivity to psychological stress in relation to cardiovascular risks assumes that excess reactivity…
Feasibility study for remote assessment of cognitive function in multiple sclerosis
Cognitive impairment is common in multiple sclerosis (MS), and affects employment and quality of life. Large studies are needed to…
Is migraine a risk factor for pediatric stroke?
Our understanding of risk factors for childhood stroke is incomplete. In adults, migraine with aura is associated with a two-fold…
Intima-Media Thickness and Cognitive Function in Stroke-Free Middle-Aged Adults: Findings From the Coronary Artery Risk Development in Young Adults Study
The relationship between carotid artery intima-media thickness (IMT) and cognitive function in midlife remains relatively unexplored. We examined the association…
Cardiorespiratory fitness and brain volume and white matter integrity: The CARDIA Study
We hypothesized that greater cardiorespiratory fitness is associated with lower odds of having unfavorable brain MRI findings. We studied 565…
Evaluation of genetic risk loci for intracranial aneurysms in sporadic arteriovenous malformations of the brain
In genome-wide association studies (GWAS) five putative risk loci are associated with intracranial aneurysm. As brain arteriovenous malformations (AVM) and…
Multi-Ethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI
The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk of stroke, dementia, and death. WMH…
Community-Based Case-Control Study of Childhood Stroke Risk Associated With Congenital Heart Disease
A better understanding of the stroke risk factors in children with congenital heart disease (CHD) could inform stroke prevention strategies.…
Vascular Factors and Multiple Measures of Early Brain Health: CARDIA Brain MRI Study
To identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF). Cross-sectional brain Magnetic…
Lack of improved outcomes with increased use of targeted temperature management following out-of-hospital cardiac arrest: A multicenter retrospective cohort study
To assess whether increased use of targeted temperature management (TTM) within an integrated healthcare delivery system resulted in improved rates…
Timing and number of minor infections as risk factors for childhood arterial ischemic stroke
In a population-based case-control study, we examined whether the timing and number of minor infections increased risk of childhood arterial…
Higher Levels of Cystatin C Are Associated with Worse Cognitive Function in Older Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort Cognitive Study
To determine the association between cognition and levels of cystatin C in persons with chronic kidney disease (CKD). Prospective observational…
Early adult to midlife cardiovascular risk factors and cognitive function
Studies have linked midlife and late-life cardiovascular risk factors (CVRFs) to cognitive function, yet little is known about CVRF exposure…
Cardiorespiratory fitness and cognitive function in middle age: The CARDIA Study
To investigate whether greater cardiorespiratory fitness (CRF) is associated with better cognitive function 25 years later. We studied 2,747 participants…
Long-term survival after ischemic stroke in patients with atrial fibrillation
While the short-term impact of atrial fibrillation-related stroke has been well studied, surprisingly little is known about its long-term effect…
Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions
Type 2 diabetes is associated with dementia, and also with more slight cognitive decrements. In this Review we discuss trajectories…
Subclinical atherosclerotic calcification and cognitive functioning in middle-aged adults: The CARDIA study
Cardiovascular risk factors in middle-age are associated with cognitive impairment and dementia in older age. Less is known about the…
Role of trauma and infection in childhood hemorrhagic stroke due to vascular lesions
OBJECTIVE: Trauma and infection have been postulated as 'triggers' for hemorrhage from underlying brain vascular lesions (arteriovenous malformations, cavernous malformations,…
Acute seizures predict epilepsy after childhood stroke
To determine incidence rates and predictors of epilepsy after childhood stroke and compare these to published estimates of 3 to…
Association between the initiation of anti-tumor necrosis factor therapy and the risk of herpes zoster
IMPORTANCE: Herpes zoster reactivation disproportionately affects patients with rheumatoid arthritis (RA). It is unclear whether anti-tumor necrosis factor (anti-TNF) therapy…
Retinopathy and Cognitive Impairment in Adults With CKD
BACKGROUND: Retinal microvascular abnormalities have been associated with cognitive impairment, possibly serving as a marker of cerebral small-vessel disease. This…
Cardiovascular health through young adulthood and cognitive functioning in midlife
OBJECTIVE: A study was undertaken to examine the association between overall cardiovascular health as recently defined by the American Heart…
A genome-wide investigation of copy number variation in patients with sporadic brain arteriovenous malformation
Brain arteriovenous malformations (BAVM) are clusters of abnormal blood vessels, with shunting of blood from the arterial to venous circulation…
Cardiovascular Predictors of Long-Term Outcomes After Non-Traumatic Subarachnoid Hemorrhage
BACKGROUND AND PURPOSE: Cardiac injury is common after subarachnoid hemorrhage (SAH) and is associated with adverse early outcomes, but long-term…
G Protein-Coupled Receptor 124 (GPR124) Gene Polymorphisms and Risk of Brain Arteriovenous Malformation
Abnormal endothelial proliferation and angiogenesis may contribute to brain arteriovenous malformation (BAVM) formation. G protein-coupled receptor 124 (GPR124) mediates embryonic…
Recent trauma and acute infection as risk factors for childhood arterial ischemic stroke
OBJECTIVE: Trauma and acute infection have been associated with stroke in adults, and are prevalent exposures in children. We hypothesized…
Hormone therapy and Alzheimer disease dementia: New findings from the Cache County Study
OBJECTIVES: Observational studies suggest reduced risk of Alzheimer disease (AD) in users of hormone therapy (HT), but trials show higher…
Does primary stroke center certification change ED diagnosis, utilization, and disposition of patients with acute stroke?
BACKGROUND AND PURPOSE: We examined the impact of primary stroke center (PSC) certification on emergency department (ED) use and outcomes…
High critical care usage due to pediatric stroke: Results of a population-based study
OBJECTIVES: To measure intensive care unit (ICU) admission, intubation, decompressive craniotomy, and outcomes at discharge in a large population-based study…
Plasma signaling proteins in persons at genetic risk for Alzheimer disease: influence of APOE genotype.
OBJECTIVE:To study the effect of familial Alzheimer disease (FAD) mutations and APOE genotype on plasma signaling protein levels.DESIGN:Cross-sectional comparison of…
Practice variation in neuroimaging to evaluate dizziness in the ED
BACKGROUND: The appropriate role of neuroimaging to evaluate emergency department (ED) patients with dizziness is not established by guidelines or…
Estimating sample sizes for predementia Alzheimer’s trials based on the Alzheimer’s Disease Neuroimaging Initiative
This study modeled predementia Alzheimer's disease clinical trials. Longitudinal data from cognitively normal (CN) and mild cognitive impairment (MCI) participants…
A High-Density Genome-Wide Association Screen of Sporadic ALS in US Veterans
Following reports of an increased incidence of amyotrophic lateral sclerosis (ALS) in U.S. veterans, we have conducted a high-density genome-wide…
Urgent neurology consultation from the ED for transient ischemic attack
OBJECTIVE: The objective of this study was to evaluate the association between urgent neurology consultation and outcomes for patients with…
Coffee; ADORA2A; and CYP1A2: the caffeine connection in Parkinson’s disease
BACKGROUND AND PURPOSE: In 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine animal models of Parkinson's disease (PD), caffeine protects neurons by blocking the adenosine receptor…
Vascular risk factors and cognitive impairment in chronic kidney disease: the Chronic Renal Insufficiency Cohort (CRIC) study
BACKGROUND AND OBJECTIVES: Cognitive impairment is common among persons with chronic kidney disease, but the extent to which nontraditional vascular…
Executive Function in Preschool Children: Test-Retest Reliability
Research suggests that executive function (EF) may distinguish between children who are well- or ill-prepared for kindergarten, however, little is…
Angiopoietin-like 4 (ANGPTL4) gene polymorphisms and risk of brain arteriovenous malformations
BACKGROUND: Brain arteriovenous malformations (BAVM) are high-flow vascular lesions prone to intracranial hemorrhage (ICH). Abnormal angiogenesis is a key characteristic…
The MCCB impairment profile for schizophrenia outpatients: results from the MATRICS psychometric and standardization study
The MATRICS Psychometric and Standardization Study was conducted as a final stage in the development of the MATRICS Consensus Cognitive…
Familial aggregation of Parkinson’s disease in a multiethnic community-based case-control study
To assess the familial aggregation of Parkinson's disease (PD), we compared the cumulative incidence of PD among first-degree relatives of…
Comorbid cancer in Parkinson’s disease
The aim of this article was to evaluate cancer occurrence before and after diagnosis of Parkinson's disease (PD). We investigated…
Comparison of 2 approaches for determining the natural history risk of brain arteriovenous malformation rupture
Estimating risk of intracranial hemorrhage (ICH) for patients with unruptured brain arteriovenous malformations (AVMs) in the natural course is essential…
Cognitive decline in schizophrenia from childhood to midlife: a 33-year longitudinal birth cohort study
BACKGROUND: We examined cognitive deficits before and after onset of schizophrenia in a longitudinal study that: 1) covers a long…
Standardized discharge orders after stroke: results of the quality improvement in stroke prevention (QUISP) cluster randomized trial
OBJECTIVE: Proven strategies to reduce risk of stroke recurrence are under-utilized. We sought to evaluate the impact of standardized stroke…
The 5-year direct medical cost of neonatal and childhood stroke in a population-based cohort
BACKGROUND: Despite increasing awareness of the long-term impact of pediatric stroke, there are few estimates of the costs of care.…
Psychiatric disorders and cognitive dysfunction among older, postmenopausal women: results from the Women’s Health Initiative Memory Study
OBJECTIVE: To estimate the frequency of depressive symptoms and selected psychiatric disorders in the Women's Health Initiative Memory Study (WHIMS)…
Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis
Brain arteriovenous malformations (BAVMs) are a rare but potentially devastating hemorrhagic disease. Transforming growth factor-beta signaling is required for proper…
COPD and cognitive impairment: the role of hypoxemia and oxygen therapy
BACKGROUND: several studies have shown an association between chronic obstructive pulmonary disease (COPD) and cognitive impairment. These studies have been…
Ten-year detection rate of brain arteriovenous malformations in a large, multiethnic, defined population
BACKGROUND AND PURPOSE: To evaluate whether increased neuroimaging use is associated with increased brain arteriovenous malformation (BAVM) detection, we examined…
Cognitive functioning is related to physical functioning in a longitudinal study of women at midlife
BACKGROUND: Studies have reported declines with age in cognitive or physical functioning, but rarely identify whether these are parallel or…
Clinical features in early Parkinson disease and survival
OBJECTIVE: To examine the association between demographic and clinical features in early Parkinson disease (PD) and length of survival in…
Serum uric acid and risk of multiple sclerosis
Because of evidence implicating oxidative stress in multiple sclerosis pathogenesis, it has been postulated that high levels of urate, a…
Use of the motor performance checklist to study motor outcomes in 5-year-olds
AIM: To report findings about the Motor Performance Checklist (MPC) for 5-year-olds, a simple 12-item instrument for assessing gross and…
Chiari type I malformation in a pediatric population
The natural history of Chiari I malformation in children remains unclear. A population-based retrospective cohort study was therefore conducted. Radiology…
Utilization of TCD screening for primary stroke prevention in children with sickle cell disease
BACKGROUND: In 1998, the Stroke Prevention Trial in Sickle Cell Anemia showed a >90% reduction in stroke rates after blood…
The importance of cerebral aneurysms in childhood hemorrhagic stroke: a population-based study
BACKGROUND AND PURPOSE: Prior population-based studies of pediatric hemorrhagic stroke (HS) had too few incident cases to assess predictors of…
Increased risk of adverse neurological development for late preterm infants
OBJECTIVE: To assess the risks of moderate prematurity for cerebral palsy (CP), developmental delay/mental retardation (DD/MR), and seizure disorders in…
Meeting report: consensus statement-Parkinson’s disease and the environment: collaborative on health and the environment and Parkinson’s Action Network (CHE PAN) conference 26-28 June 2007
BACKGROUND: Parkinson's disease (PD) is the second most common neurodegenerative disorder. People with PD, their families, scientists, health care providers,…
Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation
BACKGROUND: Polymorphisms in the proinflammatory cytokine interleukin (IL)-1beta gene have been associated with systemic atherogenesis, thrombosis and rupture. The aim…
Higher ABCD2 score predicts patients most likely to have true transient ischemic attack
BACKGROUND AND PURPOSE: Some patients diagnosed with transient ischemic attack (TIA) in the emergency department may actually have alternative diagnoses…
Cardiac autonomic control and the effects of age, race, and sex: the CARDIA study
BACKGROUND: Stratification variables of age, race, and sex figure prominently in the assessment of cardiovascular disease risk. Similarly, cardiac autonomic…
Population stratification in a case-control study of brain arteriovenous malformation in Latinos
BACKGROUND: Genetic association studies conducted in admixed populations may be confounded by population stratification resulting in spurious associations. The purpose…
Racial/Ethnic differences in longitudinal risk of intracranial hemorrhage in brain arteriovenous malformation patients
BACKGROUND AND PURPOSE: Race/ethnicity is associated with overall incidence of intracranial hemorrhage (ICH), but its impact in patients with brain…
Five-year neurodevelopmental outcome of neonatal dehydration
OBJECTIVE: To determine the long-term outcome of neonatal dehydration. STUDY DESIGN: We identified 182 newborns who were rehospitalized with dehydration…
Pooled analysis of tobacco use and risk of Parkinson disease
CONTEXT: Epidemiologic studies have reported that cigarette smoking is inversely associated with Parkinson disease (PD). However, questions remain regarding the…
Effect of non-steroidal anti-inflammatory medications on the risk of amyotrophic lateral sclerosis
Inflammatory processes may be involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). We examined the association of non-steroidal anti-inflammatory…
The epidemiology of autism spectrum disorders
Autism spectrum disorders (ASDs) are complex, lifelong, neurodevelopmental conditions of largely unknown cause. They are much more common than previously…
Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson’s disease: a large-scale international study
BACKGROUND: A genome-wide association study identified 13 single-nucleotide polymorphisms (SNPs) significantly associated with Parkinson's disease. Small-scale replication studies were largely…
Cerebral palsy in a term population: risk factors and neuroimaging findings
OBJECTIVE: The purpose of this work was to study risk factors and neuroimaging characteristics of cerebral palsy in term and…
Epstein-Barr virus and multiple sclerosis: evidence of association from a prospective study with long-term follow-up
OBJECTIVE: To determine whether serum titers of anti-Epstein-Barr virus (EBV) antibodies are elevated in blood specimens collected up to 30…
Outcomes among newborns with total serum bilirubin levels of 25 mg per deciliter or more
BACKGROUND: The neurodevelopmental risks associated with high total serum bilirubin levels in newborns are not well defined. METHODS: We identified…
Effect of reproductive factors and postmenopausal hormone use on the risk of Parkinson disease
OBJECTIVE: Parkinson disease (PD) is less common in women possibly because of hormonal or reproductive influences. The objective of this…
Predictors of outcome in perinatal arterial stroke: a population-based study
Some infants with perinatal arterial ischemic stroke (PAS) experience development of cerebral palsy (CP), epilepsy, and cognitive impairment, whereas others…
Prevalence of motor abnormalities among healthy 5-year old children
The prevalence of motor examination abnormalities among a general pediatric population is unknown. We determined the frequency of motor abnormalities…
Perinatal stroke in children with motor impairment: a population-based study
OBJECTIVE: Risk factors for perinatal arterial stroke (PAS) are poorly understood. Most previous studies lack an appropriate control group and…
A prospective study of Chlamydia pneumoniae infection and risk of MS in two US cohorts
BACKGROUND: Chlamydia pneumoniae (Cpn) has been proposed as a possible etiologic agent in multiple sclerosis (MS). However, previous studies were…
Cohort study of exposure to environmental tobacco smoke and risk of first ischemic stroke and transient ischemic attack
The independent effect of exposure to environmental tobacco smoke (ETS; passive smoking) on the risk of stroke is not well…
Chorioamnionitis and cerebral palsy in term and near-term infants
CONTEXT: Half of all cases of cerebral palsy (CP) occur in term infants, for whom risk factors have not been…
Incidence of Parkinson’s disease: variation by age, gender, and race/ethnicity
The goal of this study was to estimate the incidence of Parkinson's disease by age, gender, and ethnicity. Newly diagnosed…
Oral magnesium oxide prophylaxis of frequent migrainous headache in children: a randomized, double-blind, placebo-controlled trial
OBJECTIVE: To assess whether, in children, oral magnesium oxide reduces migrainous headache frequency, severity, and associated features compared to placebo.…
A comparison of risk factors for recurrent TIA and stroke in patients diagnosed with TIA
BACKGROUND: Some spells consistent with TIA may be benign, such as those produced by migraine or migraine accompaniments in the…
Alcohol drinking and risk of hemorrhagic stroke
In view of conflicting prior reports, we prospectively studied associations between alcohol consumption and subsequent hospitalization for hemorrhagic stroke (HS)…
The epidemiology of mental retardation of unknown cause
OBJECTIVE: To describe selected infant and maternal characteristics for children with mild and severe mental retardation (MR) of unknown cause.…
Congenital abnormalities among children with cerebral palsy: More evidence for prenatal antecedents
OBJECTIVES: To investigate the association between cerebral palsy (CP) and congenital abnormalities among children with very low, low, and normal…
Maternal exposure to nitrate from drinking water and diet and risk for neural tube defects
In this population-based case-control study conducted in California between June 1989 and May 1991, the authors investigated the association between…
Stroke and cocaine or amphetamine use
The association of cocaine and amphetamine use with hemorrhagic and ischemic stroke is based almost solely on data from case…
Transient neurologic symptoms after spinal anesthesia: an epidemiologic study of 1,863 patients
BACKGROUND: Recent evidence suggests that transient neurologic symptoms commonly follow lidocaine spinal anesthesia. However, information concerning factors that affect their…
