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Women's and Children's Health Publications


Developing a Prognostic Information System for Personalized Care in Real Time

Electronic medical records hold promise to transform clinical practice. However, technological and other barriers may preclude using them to guide care in real time. We used the Virtual Data Warehouse (VDW) to develop a tool that enables physicians to gen...
Author(s): Lieu TA; Herrinton LJ; Liu L; Neugebauer R; Ng D; Prausnitz S; Van Den Eeden SK; Baer DM; et al.

EGEMS (Wash DC). 2019 Mar 25;7(1):2. Epub 2019-03-25.

PubMed abstract

Newborn vitamin D levels in relation to autism spectrum disorders and intellectual disability: A case-control study in california

Vitamin D deficiency has been increasing concurrently with prevalence of autism spectrum disorders (ASD), and emerging evidence suggests vitamin D is involved in brain development. Most prior studies of ASD examined vitamin D levels in children already di...
Author(s): Windham GC; Pearl M; Anderson MC; Poon V; Eyles D; Jones KL; Lyall K; Kharrazi M; Croen LA

Autism Res. 2019 Mar 18.

PubMed abstract

Prenatal exposure to endocrine disrupting chemicals in relation to autism spectrum disorder and intellectual disability

Exposure to endocrine disruptors is unavoidable. Many such compounds are suspected to impact neurological development of children, but most studies conducted have considered effects of individual chemicals in isolation. Because exposures co-occur, it is i...
Author(s): Hamra GB; Lyall K; Windham GC; Calafat AM; Sjödin A; Volk H; Croen LA

Epidemiology. 2019 Feb 15.

PubMed abstract

Preventing Perinatal Depression to Improve Maternal and Child Health-a Health Care Imperative

Author(s): Avalos LA; Flanagan T; Li DK

JAMA Pediatr. 2019 Feb 12.

PubMed abstract

Strategies for Building Delivery Science in an Integrated Health Care System

Health systems today have increasing opportunities and imperatives to conduct delivery science, which is applied research that evaluates clinical or organizational practices that systems can implement or encourage. Examples include research on eliminating...
Author(s): Lieu TA; Madvig PR

J Gen Intern Med. 2019 Jan 25.

PubMed abstract

Poor diet quality in pregnancy is associated with increased risk of excess fetal growth: a prospective multi-racial/ethnic cohort study

Nutritional perturbations during pregnancy may impact fetal and long-term childhood growth, although there are limited data on overall diet quality. We investigated whether diet quality, measured by the Healthy Eating Index-2010 (HEI-2010), during pregnan...
Author(s): Zhu Y; Hedderson MM; Sridhar S; Xu F; Feng J; Ferrara A

Int J Epidemiol. 2018 Dec 26.

PubMed abstract

Central Obesity Increases the Risk of Gestational Diabetes Partially Through Increasing Insulin Resistance

This study examined the associations of central obesity measures, waist to hip ratio (WHR) and waist circumference (WC), in early pregnancy with subsequent risk of gestational diabetes mellitus (GDM) and evaluated the potential mediating role of insulin r...
Author(s): Zhu Y; Hedderson MM; Quesenberry CP; Feng J; Ferrara A

Obesity (Silver Spring). 2018 Nov 21.

PubMed abstract

Weight estimation among multi-racial/ethnic infants and children aged 0-5·9 years in the USA: simple tools for a critical measure

In resource-constrained facilities or during resuscitation, immediate paediatric weight estimation remains a fundamental challenge. We aimed to develop and validate weight estimation models based on ulna length and forearm width and circumference measured...
Author(s): Zhu Y; Hernandez LM; Dong Y; Himes JH; Caulfield LE; Kerver JM; Arab L; Voss P; Hirschfeld S; Forman MR

Public Health Nutr. 2018 Oct 18:1-10.

PubMed abstract

Omega 3 polyunsaturated fatty acids and healthy ageing

Author(s): Zhu Y; Ferrara A; Forman MR

BMJ. 2018 Oct 17;363:k4263. Epub 2018-10-17.

PubMed abstract

Risk of cardiovascular disease in women with BRCA1 and BRCA2 mutations

Estimate the prevalence of cardiovascular disease risk factors and endpoints in women with BRCA mutations. Women, age 40 and older, with BRCA mutations identified in Kaiser Permanente Northern California completed a questionnaire and underwent a lipid and...
Author(s): Powell CB; Alabaster A; Armstrong MA; Stoller N; Raine-Bennett T

Gynecol Oncol. 2018 Oct 09.

PubMed abstract

Liver Enzymes in Early to Mid-pregnancy, Insulin Resistance, and Gestational Diabetes Risk: A Longitudinal Analysis

Background: Liver enzymes may be implicated in glucose homeostasis; liver enzymes progressively change during pregnancy but longitudinal data during pregnancy in relation to insulin resistance and gestational diabetes (GDM) risk are lacking. We invest...
Author(s): Zhu Y; Hedderson MM; Quesenberry CP; Feng J; Ferrara A

Front Endocrinol (Lausanne). 2018;9:581. Epub 2018-10-02.

PubMed abstract

A Pre-Pregnancy Biomarker Risk Score Improves Prediction of Future Gestational Diabetes

Previous studies have not examined the ability of multiple preconception biomarkers, considered together, to improve prediction of gestational diabetes mellitus (GDM). To develop a preconception biomarker risk score and assess its association with subsequ...
Author(s): Badon SE; Zhu Y; Sridhar SB; Xu F; Lee C; Ehrlich SF; Quesenberry CP; Hedderson MM

J Endocr Soc. 2018 Oct 01;2(10):1158-1169. Epub 2018-09-13.

PubMed abstract

Hyperbilirubinemia, Phototherapy, and Childhood Asthma

Our aim was to quantify the associations of both hyperbilirubinemia and phototherapy with childhood asthma using a population-based cohort with total serum bilirubin (TSB) levels. Retrospective cohort study of infants born at ≥35 weeks' gestation in the K...
Author(s): Kuzniewicz MW; Niki H; Walsh EM; McCulloch CE; Newman TB

Pediatrics. 2018 Sep 12.

PubMed abstract

Contraception after Abortion and Risk of Repeated Unintended Pregnancy among Health Plan Members

Optimizing access to effective contraception at the time of abortion can reduce repeated unintended pregnancies. To assess contraception initiation and repeated unintended pregnancies among women receiving abortions in Kaiser Permanente Northern Californi...
Author(s): Postlethwaite D; Merchant M; Alabaster A; Raine-Bennett T

Perm J. 2018 Sep 10;22. Epub 2018-09-10.

PubMed abstract

Data Enclaves for Sharing Information Derived From Clinical and Administrative Data

The promise that big data will transform health care has yet to be fulfilled. Even though essentially all medical care now leaves an electronic trail, data are underused as a way to create knowledge about the safety and effectiveness of medical treatments...
Author(s): Platt R; Lieu T

JAMA. 2018 Aug 28;320(8):753-754.

PubMed abstract

AHR gene-dioxin interactions and birthweight in the Seveso Second Generation Health Study.




Background: 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) is proposed to interfere with fetal growth via altered activity of the aryl hydrocarbon receptor (protein: AHR; gene: AHR) pat...
Author(s): Ames, Jennifer J; Warner, Marcella M; Mocarelli, Paolo P; Brambilla, Paolo P; Signorini, Stefano S; Siracusa, Claudia C; Huen, Karen K; Holland, Nina N; Eskenazi, Brenda B

International journal of epidemiology. 2018 Aug 14;162(Pt 1):55-62. Epub 2018-08-14.

PubMed abstract

Scientific abstracts featured research at the 2018 North American Forum on Family Planning

The Society of Family Planning (SFP), Planned Parenthood Federation of America (PPFA), and the Association of Reproductive Health Professionals (ARHP) are delighted to host the eighth annual North American Forum on Family Planning (the Forum) in New Orlea...
Author(s): Teal S; Borrero S; Hubacher D; Madden T; Raine-Bennett T

Contraception. 2018 Jul 19.

PubMed abstract

A cohort study of maternal cardiometabolic risk factors and primary cesarean delivery in an integrated health system

Maternal cardiometabolic risk factors (i.e., hyperglycemia, pre-existing hypertension and high body mass index) impact fetal growth and risk of having a cesarean delivery. However, the independent and joint contribution of maternal cardiometabolic risk fa...
Author(s): Hedderson MM; Xu F; Sridhar SB; Han ES; Quesenberry CP; Crites Y

PLoS ONE. 2018;13(7):e0199932. Epub 2018-07-03.

PubMed abstract

Maternal sedentary behavior during pre-pregnancy and early pregnancy and mean offspring birth size: a cohort study

Sedentary behavior is associated with adverse health outcomes in the general population. Whether sedentary behavior during pregnancy is associated with newborn outcomes, such as birth size, is not established, and previous studies have been inconsistent. ...
Author(s): Badon SE; Littman AJ; Chan KCG; Williams MA; Enquobahrie DA

BMC Pregnancy Childbirth. 2018 Jun 27;18(1):267. Epub 2018-06-27.

PubMed abstract

A prospective and longitudinal study of plasma phospholipid saturated fatty acid profile in relation to cardiometabolic biomarkers and the risk of gestational diabetes

Data on saturated fatty acids (SFAs) in relation to metabolic function and glucose homeostasis remain controversial. Such data are lacking among pregnant women. We prospectively investigated objectively measured individual and subclasses of plasma phospho...
Author(s): Zhu Y; Tsai MY; Sun Q; Hinkle SN; Rawal S; Mendola P; Ferrara A; Albert PS; Zhang C

Am J Clin Nutr. 2018 Jun 01;107(6):1017-1026.

PubMed abstract

The Relationship Between Prescription Copayments and Contraceptive Adherence in a New-user Cohort

Contraceptive nonadherence is an important contributor to unintended pregnancy in the United States. While the elimination of patient cost sharing has been cited as means to improve contraceptive access, little is known about the relationship between cost...
Author(s): Marshall C; Schmittdiel J; Chandra M; Calhoun A; Raine-Bennett T

Med Care. 2018 May 29.

PubMed abstract

A Tailored Letter Based on Electronic Health Record Data Improves Gestational Weight Gain Among Women With Gestational Diabetes: The Gestational Diabetes' Effects on Moms (GEM) Cluster-Randomized Controlled Trial

Evaluate whether a tailored letter improved gestational weight gain (GWG) and whether GWG mediated a multicomponent intervention's effect on postpartum weight retention among women with gestational diabetes mellitus (GDM). A cluster-randomized controlled ...
Author(s): Hedderson MM; Brown SD; Ehrlich SF; Tsai AL; Zhu Y; Quesenberry CP; Crites Y; Ferrara A

Diabetes Care. 2018 Apr 18.

PubMed abstract

Psychiatric and Medical Conditions in Transition-Aged Individuals With ASD

Children with autism spectrum disorder (ASD) have a variety of medical and psychiatric conditions and an increased use of health care services. There is limited information about the prevalence of psychiatric and medical conditions in adolescents and youn...
Author(s): Davignon MN; Qian Y; Massolo M; Croen LA

Pediatrics. 2018 Apr;141(Suppl 4):S335-S345.

PubMed abstract

Bone loss in women with BRCA1 and BRCA2 mutations

Estimate the prevalence and identify risk factors for bone loss in women with BRCA mutations. Women, age 40 and older, with BRCA mutations identified from the Breast Cancer Surveillance database at Kaiser Permanente Northern California were invited to par...
Author(s): Powell CB; Alabaster A; Stoller N; Armstrong MA; Salyer C; Hamilton I; Raine-Bennett T

Gynecol Oncol. 2018 Mar;148(3):535-539.

PubMed abstract

Prenatal Maternal Serum Concentrations of Per- and Polyfluoroalkyl Substances in Association with Autism Spectrum Disorder and Intellectual Disability

Emerging work has examined neurodevelopmental outcomes following prenatal exposure to per- and polyfluoroalkyl substances (PFAS), but few studies have assessed associations with autism spectrum disorder (ASD). Our objective was to estimate associations of...
Author(s): Lyall K; Yau VM; Hansen R; Kharrazi M; Yoshida CK; Calafat AM; Windham G; Croen LA

Environ Health Perspect. 2018 Jan 02;126(1):017001. Epub 2018-01-02.

PubMed abstract