Developing a Prognostic Information System for Personalized Care in Real Time
Electronic medical records hold promise to transform clinical practice. However, technological and other barriers may preclude using them to guide care in real time. We used the Virtual Data Warehouse (VDW) to develop a tool that enables physicians to gen...
Author(s): Lieu TA; Herrinton LJ; Liu L; Neugebauer R; Ng D; Prausnitz S; Van Den Eeden SK; Baer DM; et al.
EGEMS (Wash DC). 2019 Mar 25;7(1):2. Epub 2019-03-25.
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Newborn vitamin D levels in relation to autism spectrum disorders and intellectual disability: A case-control study in california
Vitamin D deficiency has been increasing concurrently with prevalence of autism spectrum disorders (ASD), and emerging evidence suggests vitamin D is involved in brain development. Most prior studies of ASD examined vitamin D levels in children already di...
Author(s): Windham GC; Pearl M; Anderson MC; Poon V; Eyles D; Jones KL; Lyall K; Kharrazi M; Croen LA
Autism Res. 2019 Mar 18.
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Prenatal exposure to endocrine disrupting chemicals in relation to autism spectrum disorder and intellectual disability
Exposure to endocrine disruptors is unavoidable. Many such compounds are suspected to impact neurological development of children, but most studies conducted have considered effects of individual chemicals in isolation. Because exposures co-occur, it is i...
Author(s): Hamra GB; Lyall K; Windham GC; Calafat AM; Sjödin A; Volk H; Croen LA
Epidemiology. 2019 Feb 15.
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Preventing Perinatal Depression to Improve Maternal and Child Health-a Health Care Imperative
Author(s): Avalos LA; Flanagan T; Li DK
JAMA Pediatr. 2019 Feb 12.
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Strategies for Building Delivery Science in an Integrated Health Care System
Health systems today have increasing opportunities and imperatives to conduct delivery science, which is applied research that evaluates clinical or organizational practices that systems can implement or encourage. Examples include research on eliminating...
Author(s): Lieu TA; Madvig PR
J Gen Intern Med. 2019 Jan 25.
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Poor diet quality in pregnancy is associated with increased risk of excess fetal growth: a prospective multi-racial/ethnic cohort study
Nutritional perturbations during pregnancy may impact fetal and long-term childhood growth, although there are limited data on overall diet quality. We investigated whether diet quality, measured by the Healthy Eating Index-2010 (HEI-2010), during pregnan...
Author(s): Zhu Y; Hedderson MM; Sridhar S; Xu F; Feng J; Ferrara A
Int J Epidemiol. 2018 Dec 26.
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Central Obesity Increases the Risk of Gestational Diabetes Partially Through Increasing Insulin Resistance
This study examined the associations of central obesity measures, waist to hip ratio (WHR) and waist circumference (WC), in early pregnancy with subsequent risk of gestational diabetes mellitus (GDM) and evaluated the potential mediating role of insulin r...
Author(s): Zhu Y; Hedderson MM; Quesenberry CP; Feng J; Ferrara A
Obesity (Silver Spring). 2018 Nov 21.
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Weight estimation among multi-racial/ethnic infants and children aged 0-5·9 years in the USA: simple tools for a critical measure
In resource-constrained facilities or during resuscitation, immediate paediatric weight estimation remains a fundamental challenge. We aimed to develop and validate weight estimation models based on ulna length and forearm width and circumference measured...
Author(s): Zhu Y; Hernandez LM; Dong Y; Himes JH; Caulfield LE; Kerver JM; Arab L; Voss P; Hirschfeld S; Forman MR
Public Health Nutr. 2018 Oct 18:1-10.
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Omega 3 polyunsaturated fatty acids and healthy ageing
Author(s): Zhu Y; Ferrara A; Forman MR
BMJ. 2018 Oct 17;363:k4263. Epub 2018-10-17.
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Risk of cardiovascular disease in women with BRCA1 and BRCA2 mutations
Estimate the prevalence of cardiovascular disease risk factors and endpoints in women with BRCA mutations. Women, age 40 and older, with BRCA mutations identified in Kaiser Permanente Northern California completed a questionnaire and underwent a lipid and...
Author(s): Powell CB; Alabaster A; Armstrong MA; Stoller N; Raine-Bennett T
Gynecol Oncol. 2018 Oct 09.
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Liver Enzymes in Early to Mid-pregnancy, Insulin Resistance, and Gestational Diabetes Risk: A Longitudinal Analysis
Background: Liver enzymes may be implicated in glucose homeostasis; liver enzymes progressively change during pregnancy but longitudinal data during pregnancy in relation to insulin resistance and gestational diabetes (GDM) risk are lacking. We invest...
Author(s): Zhu Y; Hedderson MM; Quesenberry CP; Feng J; Ferrara A
Front Endocrinol (Lausanne). 2018;9:581. Epub 2018-10-02.
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A Pre-Pregnancy Biomarker Risk Score Improves Prediction of Future Gestational Diabetes
Previous studies have not examined the ability of multiple preconception biomarkers, considered together, to improve prediction of gestational diabetes mellitus (GDM). To develop a preconception biomarker risk score and assess its association with subsequ...
Author(s): Badon SE; Zhu Y; Sridhar SB; Xu F; Lee C; Ehrlich SF; Quesenberry CP; Hedderson MM
J Endocr Soc. 2018 Oct 01;2(10):1158-1169. Epub 2018-09-13.
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Hyperbilirubinemia, Phototherapy, and Childhood Asthma
Our aim was to quantify the associations of both hyperbilirubinemia and phototherapy with childhood asthma using a population-based cohort with total serum bilirubin (TSB) levels. Retrospective cohort study of infants born at ≥35 weeks' gestation in the K...
Author(s): Kuzniewicz MW; Niki H; Walsh EM; McCulloch CE; Newman TB
Pediatrics. 2018 Sep 12.
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Contraception after Abortion and Risk of Repeated Unintended Pregnancy among Health Plan Members
Optimizing access to effective contraception at the time of abortion can reduce repeated unintended pregnancies. To assess contraception initiation and repeated unintended pregnancies among women receiving abortions in Kaiser Permanente Northern Californi...
Author(s): Postlethwaite D; Merchant M; Alabaster A; Raine-Bennett T
Perm J. 2018 Sep 10;22. Epub 2018-09-10.
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Data Enclaves for Sharing Information Derived From Clinical and Administrative Data
The promise that big data will transform health care has yet to be fulfilled. Even though essentially all medical care now leaves an electronic trail, data are underused as a way to create knowledge about the safety and effectiveness of medical treatments...
Author(s): Platt R; Lieu T
JAMA. 2018 Aug 28;320(8):753-754.
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AHR gene-dioxin interactions and birthweight in the Seveso Second Generation Health Study.
Background: 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) is proposed to interfere with fetal growth via altered activity of the aryl hydrocarbon receptor (protein: AHR; gene: AHR) pat...
Author(s): Ames, Jennifer J; Warner, Marcella M; Mocarelli, Paolo P; Brambilla, Paolo P; Signorini, Stefano S; Siracusa, Claudia C; Huen, Karen K; Holland, Nina N; Eskenazi, Brenda B
International journal of epidemiology. 2018 Aug 14;162(Pt 1):55-62. Epub 2018-08-14.
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Scientific abstracts featured research at the 2018 North American Forum on Family Planning
The Society of Family Planning (SFP), Planned Parenthood Federation of America (PPFA), and the Association of Reproductive Health Professionals (ARHP) are delighted to host the eighth annual North American Forum on Family Planning (the Forum) in New Orlea...
Author(s): Teal S; Borrero S; Hubacher D; Madden T; Raine-Bennett T
Contraception. 2018 Jul 19.
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A cohort study of maternal cardiometabolic risk factors and primary cesarean delivery in an integrated health system
Maternal cardiometabolic risk factors (i.e., hyperglycemia, pre-existing hypertension and high body mass index) impact fetal growth and risk of having a cesarean delivery. However, the independent and joint contribution of maternal cardiometabolic risk fa...
Author(s): Hedderson MM; Xu F; Sridhar SB; Han ES; Quesenberry CP; Crites Y
PLoS ONE. 2018;13(7):e0199932. Epub 2018-07-03.
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Maternal sedentary behavior during pre-pregnancy and early pregnancy and mean offspring birth size: a cohort study
Sedentary behavior is associated with adverse health outcomes in the general population. Whether sedentary behavior during pregnancy is associated with newborn outcomes, such as birth size, is not established, and previous studies have been inconsistent. ...
Author(s): Badon SE; Littman AJ; Chan KCG; Williams MA; Enquobahrie DA
BMC Pregnancy Childbirth. 2018 Jun 27;18(1):267. Epub 2018-06-27.
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A prospective and longitudinal study of plasma phospholipid saturated fatty acid profile in relation to cardiometabolic biomarkers and the risk of gestational diabetes
Data on saturated fatty acids (SFAs) in relation to metabolic function and glucose homeostasis remain controversial. Such data are lacking among pregnant women. We prospectively investigated objectively measured individual and subclasses of plasma phospho...
Author(s): Zhu Y; Tsai MY; Sun Q; Hinkle SN; Rawal S; Mendola P; Ferrara A; Albert PS; Zhang C
Am J Clin Nutr. 2018 Jun 01;107(6):1017-1026.
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The Relationship Between Prescription Copayments and Contraceptive Adherence in a New-user Cohort
Contraceptive nonadherence is an important contributor to unintended pregnancy in the United States. While the elimination of patient cost sharing has been cited as means to improve contraceptive access, little is known about the relationship between cost...
Author(s): Marshall C; Schmittdiel J; Chandra M; Calhoun A; Raine-Bennett T
Med Care. 2018 May 29.
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A Tailored Letter Based on Electronic Health Record Data Improves Gestational Weight Gain Among Women With Gestational Diabetes: The Gestational Diabetes' Effects on Moms (GEM) Cluster-Randomized Controlled Trial
Evaluate whether a tailored letter improved gestational weight gain (GWG) and whether GWG mediated a multicomponent intervention's effect on postpartum weight retention among women with gestational diabetes mellitus (GDM). A cluster-randomized controlled ...
Author(s): Hedderson MM; Brown SD; Ehrlich SF; Tsai AL; Zhu Y; Quesenberry CP; Crites Y; Ferrara A
Diabetes Care. 2018 Apr 18.
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Psychiatric and Medical Conditions in Transition-Aged Individuals With ASD
Children with autism spectrum disorder (ASD) have a variety of medical and psychiatric conditions and an increased use of health care services. There is limited information about the prevalence of psychiatric and medical conditions in adolescents and youn...
Author(s): Davignon MN; Qian Y; Massolo M; Croen LA
Pediatrics. 2018 Apr;141(Suppl 4):S335-S345.
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Bone loss in women with BRCA1 and BRCA2 mutations
Estimate the prevalence and identify risk factors for bone loss in women with BRCA mutations. Women, age 40 and older, with BRCA mutations identified from the Breast Cancer Surveillance database at Kaiser Permanente Northern California were invited to par...
Author(s): Powell CB; Alabaster A; Stoller N; Armstrong MA; Salyer C; Hamilton I; Raine-Bennett T
Gynecol Oncol. 2018 Mar;148(3):535-539.
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Prenatal Maternal Serum Concentrations of Per- and Polyfluoroalkyl Substances in Association with Autism Spectrum Disorder and Intellectual Disability
Emerging work has examined neurodevelopmental outcomes following prenatal exposure to per- and polyfluoroalkyl substances (PFAS), but few studies have assessed associations with autism spectrum disorder (ASD). Our objective was to estimate associations of...
Author(s): Lyall K; Yau VM; Hansen R; Kharrazi M; Yoshida CK; Calafat AM; Windham G; Croen LA
Environ Health Perspect. 2018 Jan 02;126(1):017001. Epub 2018-01-02.
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