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Women's and Children's Health Studies

 

Examining the Factors for the Rapid Rise of Colorectal Cancer in Young Adults: Does Increased Medical Use of Radiation and Imaging Technology Contribute to the Rise?

This study is examining whether the secular increase in use of medical radiation therapy and diagnostic imaging technology is associated with the corresponding secular increase in the risk of colorectal cancer among young adults age 50 and under.
Funder: Northern California Community Benefit Programs
Investigator: Li, De-Kun

Motivational Determinants of Postpartum Lifestyle Behaviors, Weight Retention, and Metabolic Syndrome

The proposed study aims to identify affective influences on key lifestyle behaviors (healthy eating and objectively measured self-weighing and physical activity) associated with postpartum weight retention and cardiometabolic profile (e.g., metabolic synd...
Funder: National Heart, Lung, and Blood Institute
Investigator: Ferrara, Assiamira

Comparative Effectiveness of Treating Genital Herpes Infection to Reduce Racial Disparities in the Risk of Severe Maternal Morbidity (SMM)

The goals of the study are to determine whether treating GHSV infection in pregnancy, especially earlier in pregnancy, is effective in mitigating the racial disparities in SMM, and GHSV infection, if untreated, contribute to racial disparities in the risk...
Funder: Patient-Centered Outcomes Research Institute
Investigator: Li, De-Kun

The Impact of Racial Residential Segregation on the Mental Health of Pregnant Women

We will create a large diverse cohort of more than 360,000 pregnant Black, Hispanic, Asian and white women to: examine the relationship between racial residential segregation and prenatal depression, anxiety and trauma (Aim 1); and prenatal depressive sev...
Funder: Northern California Community Benefit Programs
Investigator: Avalos, Lyndsay

Harnessing Electronic Health Records to Identify Participants and to Study Health Outcomes in Transition-Age Youth and Adults with Autism Spectrum Disorder

The goal of this K18 award is to determine changes in prevalence of common medical and psychiatric conditions and measures of health care utilization in an existing longitudinal cohort of autistic transition age youth (TAY) and adults within the Kaiser Pe...
Funder: National Institute of Mental Health
Investigator: Croen, Lisa

Optimizing a Scalable Intervention to Maximize Guideline-Recommended Diabetes Testing after GDM

We will leverage the multiphase optimization strategy (MOST) to efficiently identify, in a single experiment, which of four components of an outreach intervention motivate women with gestational diabetes to complete a recommended oral glucose tolerance te...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Ferrara, Assiamira

Predictive Analytics for Newborn Bilirubin Management

Our objective is to integrate the bilirubin risk prediction model into the automated bilirubin assessment in the laboratory results and provide follow-up guidance on timing of repeat bilirubin testing. We hypothesize that integration of this model will le...
Funder: Northern California Community Benefit Programs
Investigator: Kuzniewicz, Michael

Treatment Initiation for New Episodes of Depression in Pregnant Women

This study will use rigorous methods and rich health care data from a diverse, multi-site study population to study psychotherapy and antidepressant treatments for new episodes of depression during pregnancy. Analyses will include examination of infant ou...
Funder: National Institute of Child Health and Human Development
Investigator: Avalos, Lyndsay

Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and Neurodevelopment

This study is evaluating whether in-utero exposures to maternal PFCs and PBDEs, individually and/or in combination, are associated with infant growth, adiposity, and neurodevelopment; metabolic determinants of obesity; and neurodevelopment and infant patt...
Funder: National Institutes of Health, Office of the Director
Investigator: Ferrara, Assiamira

mHealth Mindfulness Intervention for Pregnant Black and Latina Women at Risk of Postpartum Depression

This randomized controlled trial of an mHealth mindfulness intervention designed for Black and Latinx pregnant women at risk of developing postpartum depression will compare outcomes (depression, stress, sleep) of participants in the intervention with tho...
Funder: National Institute of Mental Health
Investigator: Avalos, Lyndsay; Kubo, Ai

Understanding Barriers to Reproductive Health Care among Women with Autism Spectrum Disorder

This project will examine both reproductive health disparities and OB/GYN health care gaps for 2300 adolescent and adult women with Autism Spectrum Disorder (ASD) receiving care at Kaiser Permanente Northern California, paying particular attention to diff...
Funder: National Institute of Child Health and Human Development
Investigator: Ames, Jennifer

Interactions of Environmental Chemical Mixtures, Genetics, and Immune Pathways in Autism Spectrum Disorder

The goal of this K99/R00 Pathway to Independence Award is to receive mentored training in polygenic GWAS tools and complex mixtures modeling to position my career toward understanding the roles of GxE interactions and immune disruption in the etiology of ...
Funder: National Institute of Environmental Health Sciences
Investigator: Ames, Jennifer

Autism Intervention Research Network on Physical Health

Establish an interdisciplinary Autism Intervention Research Network on Physical Health node that will lead, promote, and coordinate national research activities to improve the physical health and well-being of individuals with autism spectrum disorder acr...
Funder: Health Resources and Services Administration
Investigator: Croen, Lisa

Autism Specific Patterns of DNA Methylation from Birth to Age 5

This study will examine potential differences in DNA methylation (DNAm) in early life, from birth through age 5, between children who are ultimately diagnosed with autism spectrum disorder and those typically developing. Results from this work will inform...
Funder: National Institute of Child Health and Human Development
Investigator: Croen, Lisa

Maternal Health in Pregnancy and Autism Risk - Genetic and Non-genetic Mechanisms

This study will systematically identify maternal diagnoses in pregnancy associated with autism spectrum disorder (ASD) in offspring; test if the association between maternal diagnoses and ASD is due to shared genetic factors using family data; and test th...
Funder: National Institute of Mental Health
Investigator: Croen, Lisa

Can hydroxychloroquine prevent preeclampsia and preterm delivery in lupus pregnancy?

Pregnant women with lupus are at high risk to develop preeclampsia and preterm delivery. This work leverages three large population-based databases with detailed prescription and clinical data to determine whether use of hydroxychloroquine during pregnanc...
Funder: National Institute of Arthritis and Musculoskeletal and Skin Diseases
Investigator: Hedderson, Monique

The Study of Women's Health Across the Nation (SWAN)

SWAN VI aims to elucidate menopause transition characteristics and trajectories of midlife health markers (inflammation, metabolic and cardiovascular risk factors, body composition, and bone, genitourinary, and vascular health) that are related to the pre...
Funder: National Institute on Aging
Investigator: Hedderson, Monique

The Epidemiology of SARS-CoV-2 in Pregnancy and Infancy (ESPI) Network: ESPI-Electronic Cohort

Multisite study to describe the incidence, clinical presentation, treatment, clinical course, and outcomes of COVID-19 among pregnant women and up to six months postpartum, and estimate the incidence of COVID-19 hospitalizations and medically attended amb...
Funder: Centers for Disease Control and Prevention
Investigator: Li, De-Kun

Strategies for optimizing video care in a diverse population

This study will describe factors associated with the effective adoption of video visits in adult and family medicine after the start of the Covid-19 pandemic; identify medical centers and primary care physicians with higher-than-expected video visit rates...
Funder: TPMG Delivery Science Projects Program
Investigator: Lieu, Tracy

Blood Pressure, Obesity, and Diabetes in Relation to Perinatal and Postpartum Complications

By leveraging the KPNC Gestational diabetes and Glucose Tolerance Registry, which includes rich data on blood glucose levels, obesity, gestational weight gain, we will add blood pressure levels for the earliest years to evaluate the individual and joint i...
Funder: National Heart, Lung, and Blood Institute
Investigator: Zhu, Yeyi

COVID-19 Related Changes in Health Care Delivery and Health Outcomes Among Pregnant Women and Their Newborns

This study will examine the impacts that COVID-19 pandemic related changes in health care delivery had on health outcomes among pregnant women and their newborns in Kaiser Permanente Northern California. The study will also evaluate the clinical course of...
Funder: TPMG Delivery Science Projects Program
Investigator: Ferrara, Assiamira

Barriers to Obstetric/Gynecological Health Care for Women with Autism Spectrum Disorders

This study will identify the sociodemographic and health factors associated with low utilization of obstetrics/gynecology services among adult women with autism spectrum disorders and explore whether these women are at higher risk of adverse maternal and ...
Funder: Northern California Community Benefit Programs
Investigator: Ames, Jennifer

Using a 24-Hour Movement Framework to Improve Pregnancy Outcomes

The goal of this K99/R00 Pathway to Independence Award is to better understand associations of 24-hour movement profiles during pregnancy (consisting of physical activity, sedentary behavior, and sleep) and maternal and infant outcomes. This Award include...
Funder: National Institute of Child Health and Human Development
Investigator: Badon, Sylvia

Comparing the Effects of Prenatal Depression and its Treatment on Developmental Outcomes of the Offspring

This study will test the hypothesis that the underlying prenatal depression and use of SSRIs are independent risk factors for adverse neurodevelopmental outcomes. The aims of this study are: 1) evaluate the effect of untreated prenatal depression, compar...
Funder: National Institute of Child Health and Human Development
Investigator: Avalos, Lyndsay

Racial/Ethnic Disparities in Perinatal Depression Treatment Utilization

The study will characterize racial/ethnic differences in perinatal depression treatment utilization, treatment engagement, and continued care by assembling a retrospective cohort of KPNC members entering prenatal care between 2012-2016. The study will als...
Funder: Northern California Community Benefit Programs
Investigator: Avalos, Lyndsay
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