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Women's and Children's Health Studies

 

Maternal Inflammation during Pregnancy and Neurodevelopmental Disorders

​This study will utilize the Pregnancy Cohort from the Kaiser Permanente Northern California Research Program on Genes, Environment and Health to characterize the maternal immune profile over pregnancy and evaluate whether there are specific longitudin...
Funder: National Institute of Child Health and Human Development
Investigator: Croen, Lisa

Optimizing Social Communication Measurement with the Social Responsiveness Scale

​This project aims to: 1) compare the psychometric characteristics (including distributional properties, agreement with gold-standard diagnostic measures, and sensitivity and specificity) of short versus full Social Responsiveness Scale (SRS) score...
Funder: 
Investigator: Croen, Lisa

Incidence and Trend of Ectopic Pregnancy and Contraceptive Use

​Incidence and management of ectopic pregnancy have undergone significant changes in recent decades. There is a general consensus that available effective contraceptive methods reduce the absolute risk of ectopic pregnancy. Ectopic pregnancy incidence ...
Funder: Bayer AG
Investigator: Raine-Bennett, Tina

Improving Post-Discharge Bilirubin Management in Newborns

There is variation and overuse in bilirubin testing among newborns. Multiple repeat testing occurs despite most newborns being at low risk for reaching bilirubin levels that would require phototherapy. Among the Kaiser Permanente birth population, 45 perc...
Funder: Northern California Community Benefit Programs
Investigator: Kuzniewicz, Michael

Extremely Premature Births Cohort Study

The goal of this study is to understand the incidence of extremely preterm birth and associated adverse health conditions and growth abnormality.
Funder: Shire plc
Investigator: Li, De-Kun

Email Management Strategies and Stress Among Primary Care Physicians

Email between patients and physicians has enhanced health care service but has made many primary care physicians feel overloaded. Many physicians multitask throughout the day by responding to email while seeing patients for in-person, telephone, and video...
Funder: The Permanente Medical Group
Investigator: Lieu, Tracy

Risk Prediction of Gestational Diabetes Treatment Modalities Utilizing Clinical and Laboratory Data in the EHR

This study will utilize data from the Kaiser Permanente Northern California Gestational Diabetes and Pregnancy Glucose Tolerance Registry for a cohort of 25,000 women diagnosed with gestational diabetes. The goal is to determine whether clinical and labor...
Funder: National Institutes of Health
Investigator: Zhu, Yeyi

Development and Testing of a Mobile-Health (m-health) Intervention tool to Help Obese Women Achieve Appropriate Gestational Weight Gain

To determine whether a mobile-health (m-health) tool (accessible via smartphone or website) intervention for obese pregnant improves patient satisfaction with their gestational weight gain, quality of life, stress and depression during pregnancy. Provider...
Funder: The Permanente Medical Group
Investigator: Hedderson, Monique

Iodinated Contrast Agents and Risk of Hypothyroidism in Young Children in the United States

This study will estimate the incidence of pulmonary hypothyroid in a pediatric population of children under age 4, based on data from the US-based Kaiser Permanente Northern California database, who were exposed to iodinated contrast agent through having ...
Funder: Bayer AG
Investigator: Hedderson, Monique

Pregravid Biomarkers and Risk of Gestational Diabetes Mellitus Risk, Fetal Growth and Progression to Diabetes

This study will examine pregravid biomarkers of metabolic risk (adiponectin, high molecular weight adiponectin, c-reactive protein, liver enzymes, fetuin-A and LDL particle size) in relation to risk of gestational diabetes mellitus among women who partici...
Funder: National Institute of Child Health and Human Development
Investigator: Hedderson, Monique

Autism Adaptive Community-Based Treatment to Improve Outcomes Using Navigators (ACTION) Network

One of the greatest challenges in autism treatment is how to bridge the health care science-to-service gap and address disparities in access to evidence-based early intervention for children with autism spectrum disorder. This project will establish a new...
Funder: National Institutes of Health
Investigator: Croen, Lisa

Barriers to Health Care in a Latino Population with Autism Spectrum Disorder

This study will identify barriers to the use of recommended assessment, diagnostic, and treatment services among Latino children and adolescents with autism spectrum disorder. The study population will comprise Kaiser Permanente Northern California Latino...
Funder: Northern California Community Benefit Programs
Investigator: Croen, Lisa; Gordon, Nancy

Understanding Patient Engagement in Lifestyle Programs for Diabetes Prevention among Women with a Recent History of GDM

While lifestyle programs to prevent type 2 diabetes are increasingly available, the drivers of patient engagement in them remain poorly understood. This study aims to identify characteristics of patient subgroups at risk for poor engagement, providing a b...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Brown, Susan

Prenatal Exposure to Metals and Risk for Autism Spectrum Disorder in MARBLES and EARLI

The peri-conceptual and prenatal periods of gestation are the most likely window of susceptibility for ASD; thus, maternal exposures and maternal genetic susceptibility are critical targets of investigation. Maternal exposure to heavy metals has been reco...
Funder: National Institute of Environmental Health Sciences
Investigator: Croen, Lisa

Health System Integration of Tools to Improve Primary Care for Autistic Adults

The objective of this project is to use a CBPR approach to understand how to best integrate the AASPIRE Healthcare Toolkit, an online healthcare toolkit aimed at improving primary care services for autistic adults, into the KP Northern CA healthcare syste...
Funder: National Institute of Mental Health
Investigator: Croen, Lisa

Understanding Family Economic Impact of Chronic Child Health Conditions

This study will address an important knowledge gap by estimating financial and time costs for families of children with autism. We will recruit 1,500 families of children 3-17 years old from geographically and ethnically diverse integrated health systems&...
Funder: National Institute of Child Health and Human Development
Investigator: Croen, Lisa

Risk of NTD among Live Births Exposed to Maternal Rx Opioids during Early Pregnancy

The objectives of this study are: 1) To measure the association between in utero exposure to prescription opioids during early pregnancy and primary neurulation defects. 2) To evaluate whether the risk of primary neurulation defects (i.e., craniorachi...
Funder: U.S. Food and Drug Administration
Investigator: Li, De-Kun

Prenatal SSRI Exposure, Maternal and Child Genotype, and Autism Spectrum Disorders

The prevalence of Autism Spectrum Disorders (ASD) has increased rapidly over recent decades. Among many environmental exposures that have also increased in frequency is the use of anti-depressant medications during pregnancy. Approximately 10% of pregnant...
Funder: National Institute of Child Health and Human Development
Investigator: Croen, Lisa

Prospective Evaluation of Air Pollution, Cognition and Autism from Birth Onward

This study will examine the relationship between perinatal and early life air pollution exposure and early longitudinal measures of cognitive ability and ASD in two prospective samples - Markers of Autism Risk in Babies, Learning Early Signs (MARBLES) and...
Funder: National Institute of Environmental Health Sciences
Investigator: Croen, Lisa

Neurodevelopment of Cognitive Control in Autism: Adolescence to Young Adulthood

This study compares the developmental trajectory of behavioral measures of cognitive control from adolescence into young adulthood in typical individuals (TYP) and individuals with Autism Spectrum Disorder (ASD). We predict that approximately 2/3 of those...
Funder: National Institute of Mental Health
Investigator: Croen, Lisa

Prenatal, Intrapartum and Infant Antibiotic Use and Atopic Diseases in Childhood

This study has the following aims: 1) Assess prenatal, intrapartum and infant antibiotic exposure in relation to atopic dermatitis, allergic rhinitis and asthma. 2) Assess bias due to reverse causality, confounding by early life respiratory infections...
Funder: National Institute of Allergy and Infectious Diseases
Investigator: Li, De-Kun

Discovery of Pharmacogenomic Biomarkers for Metformin Response

The primary goal of this multi-site study is to identify genetic variants that impact response to metformin in patients with diabetes from multiple ethnic groups in the U.S. and Europe
Funder: National Institute of General Medical Sciences
Investigator: Hedderson, Monique

Incidence of Osteoporosis and Abnormal Lipid Profiles in Women Over Age 40, Who Test Positive for a BRCA1 or BRCA2 Mutation and Have Had a Risk-Reducing Salpingo-oophorectomy

This cohort study will use DXA scans to: 1) establish the incidence of abnormal DXA scans in women post testing positive for BRCA1 or 2 mutations who have undergone risk-reducing salpingo-oophorectomy (RRSO); and 2) identify risk factors for abnormal ...
Funder: Kaiser Permanente Institutional Planned Giving
Investigator: Raine-Bennett, Tina

Kaiser Permanente and Strategic Partners Patient Outcomes Research to Advance Learning (PORTAL)

This network participates in PCORI's Clinical Data Research Network (CDRN) program to enhance the nation's capacity to conduct comparative effectiveness research by creating a national electronic data infrastructure. This program promotes the development ...
Funder: Patient-Centered Outcomes Research Institute
Investigator: Lieu, Tracy

Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and Neurodevelopment

We hypothesize that in-utero exposures to commonly used endocrine disrupting chemicals, such as PFCs and PBDEs, individually and/or in combination, have adverse effects on child obesity and neurodevelopment through possible common pathways. Our aims are&#...
Funder: National Institutes of Health
Investigator: Croen, Lisa; Ferrara, Assiamira
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