The Autism Centers of Excellence (ACE) program is a trans-NIH initiative that supports large-scale studies on autism spectrum disorder. A priority area for the ACE program is work that will advance our understanding of the biologic mechanisms underlying g...
Funder: National Institute of Environmental Health Sciences
Investigator: Croen, Lisa
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Feasibility study of a 6-week virtual intervention for pregnant women with high adverse childhood experience (ACE) exposure and moderate to moderate-severe depression to reduce perinatal depression symptoms. Study will enroll and randomize participants to...
Funder: TPMG Delivery Science Projects Program
Investigator: Avalos, Lyndsay
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Study to determine if individuals who participated in Wellness Coaching have lower risk of high gestational weight gain and postpartum weight retention compared with individuals who did not participate in Wellness Coaching. Electronic health record data w...
Funder: KP National Office of Community Health
Investigator: Badon, Sylvia
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The study will examine the association between glycemic control trajectories among individuals with gestational diabetes (GDM) included in the GDM registry and the risk of childhood obesity and growth trajectories in the offspring. Glycemic control trajec...
Funder: KP National Office of Community Health
Investigator: Chehab, Rana
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Systematically investigate the effects of maternal medication use in pregnancy on offspring autism spectrum disorder (ASD) risk. Test the mechanisms underlying the associations between maternal medication use and ASD. Establish the specificity and general...
Funder: National Institute of Child Health and Human Development
Investigator: Croen, Lisa
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This cohort study evaluates a new prenatal care delivery pathway, KP Connected Pregnancy Care (KPCPC). KPCPC is an opt-in hybrid in-person and virtual care model using digital tools to expand remote patient monitoring and virtual visits for low-risk prena...
Funder: TPMG Delivery Science Projects Program
Investigator: Hedderson, Monique
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The study follows a cohort of autistic and non-autistic youth longitudinally to examine several transition indicators measurable in the EHR including: continuation of medications and other treatments during the transition years; length of time elapsed bet...
Funder: Northern California Community Benefit Programs
Investigator: Ames, Jennifer
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SEED is a case-control study comparing children aged 2-5 years with autism spectrum disorder to children with other developmental disabilities. The SEED Follow-up Study is a longitudinal study designed to improve understanding of risk factors and expressi...
Funder: Centers for Disease Control and Prevention
Investigator: Croen, Lisa
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This study is examining whether the secular increase in use of medical radiation therapy and diagnostic imaging technology is associated with the corresponding secular increase in the risk of colorectal cancer among young adults age 50 and under.
Funder: Northern California Community Benefit Programs
Investigator: Li, De-Kun
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The proposed study aims to identify affective influences on key lifestyle behaviors (healthy eating and objectively measured self-weighing and physical activity) associated with postpartum weight retention and cardiometabolic profile (e.g., metabolic synd...
Funder: National Heart, Lung, and Blood Institute
Investigator: Ferrara, Assiamira
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The goals of the study are to determine whether treating GHSV infection in pregnancy, especially earlier in pregnancy, is effective in mitigating the racial disparities in SMM, and GHSV infection, if untreated, contribute to racial disparities in the risk...
Funder: Patient-Centered Outcomes Research Institute
Investigator: Li, De-Kun
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We will create a large diverse cohort of more than 360,000 pregnant Black, Hispanic, Asian and white women to: examine the relationship between racial residential segregation and prenatal depression, anxiety and trauma (Aim 1); and prenatal depressive sev...
Funder: Northern California Community Benefit Programs
Investigator: Avalos, Lyndsay
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The goal of this K18 award is to determine changes in prevalence of common medical and psychiatric conditions and measures of health care utilization in an existing longitudinal cohort of autistic transition age youth (TAY) and adults within the Kaiser Pe...
Funder: National Institute of Mental Health
Investigator: Croen, Lisa
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We will leverage the multiphase optimization strategy (MOST) to efficiently identify, in a single experiment, which of four components of an outreach intervention motivate women with gestational diabetes to complete a recommended oral glucose tolerance te...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Ferrara, Assiamira
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Our objective is to integrate the bilirubin risk prediction model into the automated bilirubin assessment in the laboratory results and provide follow-up guidance on timing of repeat bilirubin testing. We hypothesize that integration of this model will le...
Funder: Northern California Community Benefit Programs
Investigator: Kuzniewicz, Michael
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This study will use rigorous methods and rich health care data from a diverse, multi-site study population to study psychotherapy and antidepressant treatments for new episodes of depression during pregnancy. Analyses will include examination of infant ou...
Funder: National Institute of Child Health and Human Development
Investigator: Avalos, Lyndsay
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This study is evaluating whether in-utero exposures to maternal PFCs and PBDEs, individually and/or in combination, are associated with infant growth, adiposity, and neurodevelopment; metabolic determinants of obesity; and neurodevelopment and infant patt...
Funder: National Institutes of Health, Office of the Director
Investigator: Ferrara, Assiamira
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This randomized controlled trial of an mHealth mindfulness intervention designed for Black and Latinx pregnant women at risk of developing postpartum depression will compare outcomes (depression, stress, sleep) of participants in the intervention with tho...
Funder: National Institute of Mental Health
Investigator: Avalos, Lyndsay; Kubo, Ai
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This project will examine both reproductive health disparities and OB/GYN health care gaps for 2300 adolescent and adult women with Autism Spectrum Disorder (ASD) receiving care at Kaiser Permanente Northern California, paying particular attention to diff...
Funder: National Institute of Child Health and Human Development
Investigator: Ames, Jennifer
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The goal of this K99/R00 Pathway to Independence Award is to receive mentored training in polygenic GWAS tools and complex mixtures modeling to position my career toward understanding the roles of GxE interactions and immune disruption in the etiology of ...
Funder: National Institute of Environmental Health Sciences
Investigator: Ames, Jennifer
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Establish an interdisciplinary Autism Intervention Research Network on Physical Health node that will lead, promote, and coordinate national research activities to improve the physical health and well-being of individuals with autism spectrum disorder acr...
Funder: Health Resources and Services Administration
Investigator: Croen, Lisa
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This study will examine potential differences in DNA methylation (DNAm) in early life, from birth through age 5, between children who are ultimately diagnosed with autism spectrum disorder and those typically developing. Results from this work will inform...
Funder: National Institute of Child Health and Human Development
Investigator: Croen, Lisa
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This study will systematically identify maternal diagnoses in pregnancy associated with autism spectrum disorder (ASD) in offspring; test if the association between maternal diagnoses and ASD is due to shared genetic factors using family data; and test th...
Funder: National Institute of Mental Health
Investigator: Croen, Lisa
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Pregnant women with lupus are at high risk to develop preeclampsia and preterm delivery. This work leverages three large population-based databases with detailed prescription and clinical data to determine whether use of hydroxychloroquine during pregnanc...
Funder: National Institute of Arthritis and Musculoskeletal and Skin Diseases
Investigator: Hedderson, Monique
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SWAN VI aims to elucidate menopause transition characteristics and trajectories of midlife health markers (inflammation, metabolic and cardiovascular risk factors, body composition, and bone, genitourinary, and vascular health) that are related to the pre...
Funder: National Institute on Aging
Investigator: Hedderson, Monique
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