This proposal uses a novel holistic framework that leverages both targeted and untargeted metabolomics approach, electronic health records data, and bioinformatics analytics to investigate the mechanisms by which the in-utero environment may infer risk of...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Zhu, Yeyi
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This randomized trial will test whether the implementation of an mHealth tool in the health-plan setting increases the proportion of overweight and obese women with appropriate total gestational weight gain, according to Institute of Medicine (IOM) guidel...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Hedderson, Monique
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This project aims to demonstrate that sufficient, high quality glycemic control data are available for investigating the determinants of and barriers to glycemic control among women with gestational diabetes in a cohort of 30,000 women at Kaiser Permanent...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Zhu, Yeyi
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This study aims to utilize data from the Kaiser Permanente Northern California Gestational Diabetes and Pregnancy Glucose Tolerance Registry for a cohort of 25,000 women diagnosed with gestational diabetes. The goal is to determine whether clinical and la...
Funder: National Institutes of Health
Investigator: Zhu, Yeyi
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A cohort study of Kaiser Permanente Northern California patients with moderate-to-severe atopic dermatitis (AD) will be used to estimate baseline characteristics and background incidence rates of safety events. Data from this study will provide valuable i...
Funder: Pfizer Inc.
Investigator: Hedderson, Monique
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The Pregnancy Environment and Lifestyle Study-2 (PETALS-2) aims to identify psychosocial influences on healthy lifestyle behaviors — such as healthy eating, self-weighing, and physical activity — and examine their relation to weight retention and cardiome...
Funder: National Heart, Lung, and Blood Institute
Investigator: Brown, Susan
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Dedicated quantitative analytic support for obstetrics has not been available in Kaiser Permanente Northern California. An unusual opportunity has appeared: as a result of a project to develop a predictive model for obstetric complications, considerab...
Funder: Kaiser Permanente Program Offices
Investigator: Kuzniewicz, Michael
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Guideline-recommended postpartum screening is a critical step toward diabetes prevention after a diagnosis of gestational diabetes mellitus (GDM). However, patient uptake of postpartum screening remains suboptimal and uneven across racial/ethnic groups. T...
Funder: Northern California Community Benefit Programs
Investigator: Brown, Susan
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This study will utilize the Pregnancy Cohort from the Kaiser Permanente Northern California Research Program on Genes, Environment and Health to characterize the maternal immune profile over pregnancy and evaluate whether there are specific longitudin...
Funder: National Institute of Child Health and Human Development
Investigator: Croen, Lisa
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This project aims to: 1) compare the psychometric characteristics (including distributional properties, agreement with gold-standard diagnostic measures, and sensitivity and specificity) of short versus full Social Responsiveness Scale (SRS) score...
Funder: National Institutes of Health, Office of the Director
Investigator: Croen, Lisa
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Incidence and management of ectopic pregnancy have undergone significant changes in recent decades. There is a general consensus that available effective contraceptive methods reduce the absolute risk of ectopic pregnancy. Ectopic pregnancy incidence ...
Funder: Bayer AG
Investigator: Raine-Bennett, Tina
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There is variation and overuse in bilirubin testing among newborns. Multiple repeat testing occurs despite most newborns being at low risk for reaching bilirubin levels that would require phototherapy. Among the Kaiser Permanente birth population, 45 perc...
Funder: Northern California Community Benefit Programs
Investigator: Kuzniewicz, Michael
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The goal of this study is to understand the incidence of extremely preterm birth and associated adverse health conditions and growth abnormality.
Funder: Shire plc
Investigator: Li, De-Kun
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Email between patients and physicians has enhanced health care service but has made many primary care physicians feel overloaded. Many physicians multitask throughout the day by responding to email while seeing patients for in-person, telephone, and video...
Funder: The Permanente Medical Group
Investigator: Lieu, Tracy
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To determine whether a mobile-health (m-health) tool (accessible via smartphone or website) intervention for obese pregnant improves patient satisfaction with their gestational weight gain, quality of life, stress and depression during pregnancy. Provider...
Funder: The Permanente Medical Group
Investigator: Hedderson, Monique
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This study will estimate the incidence of pulmonary hypothyroid in a pediatric population of children under age 4, based on data from the US-based Kaiser Permanente Northern California database, who were exposed to iodinated contrast agent through having ...
Funder: Bayer AG
Investigator: Hedderson, Monique
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This study will examine pregravid biomarkers of metabolic risk (adiponectin, high molecular weight adiponectin, c-reactive protein, liver enzymes, fetuin-A and LDL particle size) in relation to risk of gestational diabetes mellitus among women who partici...
Funder: National Institute of Child Health and Human Development
Investigator: Hedderson, Monique
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One of the greatest challenges in autism treatment is how to bridge the health care science-to-service gap and address disparities in access to evidence-based early intervention for children with autism spectrum disorder. This project will establish a new...
Funder: National Institutes of Health
Investigator: Croen, Lisa
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This study will identify barriers to the use of recommended assessment, diagnostic, and treatment services among Latino children and adolescents with autism spectrum disorder. The study population will comprise Kaiser Permanente Northern California Latino...
Funder: Northern California Community Benefit Programs
Investigator: Croen, Lisa; Gordon, Nancy
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While lifestyle programs to prevent type 2 diabetes are increasingly available, the drivers of patient engagement in them remain poorly understood. This study aims to identify characteristics of patient subgroups at risk for poor engagement, providing a b...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Brown, Susan
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The peri-conceptual and prenatal periods of gestation are the most likely window of susceptibility for ASD; thus, maternal exposures and maternal genetic susceptibility are critical targets of investigation. Maternal exposure to heavy metals has been reco...
Funder: National Institute of Environmental Health Sciences
Investigator: Croen, Lisa
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The objective of this project is to use a CBPR approach to understand how to best integrate the AASPIRE Healthcare Toolkit, an online healthcare toolkit aimed at improving primary care services for autistic adults, into the KP Northern CA healthcare syste...
Funder: National Institute of Mental Health
Investigator: Croen, Lisa
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This study will address an important knowledge gap by estimating financial and time costs for families of children with autism. We will recruit 1,500 families of children 3-17 years old from geographically and ethnically diverse integrated health systems&...
Funder: National Institute of Child Health and Human Development
Investigator: Croen, Lisa
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The objectives of this study are: 1) To measure the association between in utero exposure to prescription opioids during early pregnancy and primary neurulation defects. 2) To evaluate whether the risk of primary neurulation defects (i.e., craniorachi...
Funder: U.S. Food and Drug Administration
Investigator: Li, De-Kun
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The prevalence of Autism Spectrum Disorders (ASD) has increased rapidly over recent decades. Among many environmental exposures that have also increased in frequency is the use of anti-depressant medications during pregnancy. Approximately 10% of pregnant...
Funder: National Institute of Child Health and Human Development
Investigator: Croen, Lisa
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