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Women's and Children's Health Studies


Barriers to Obstetric/Gynecological Health Care for Women with Autism Spectrum Disorders

This study will identify the sociodemographic and health factors associated with low utilization of obstetrics/gynecology services among adult women with autism spectrum disorders and explore whether these women are at higher risk of adverse maternal and ...
Funder: Northern California Community Benefit Programs
Investigator: Ames, Jennifer

Using a 24-Hour Movement Framework to Improve Pregnancy Outcomes

The goal of this K99/R00 Pathway to Independence Award is to better understand associations of 24-hour movement profiles during pregnancy (consisting of physical activity, sedentary behavior, and sleep) and maternal and infant outcomes. This Award include...
Funder: National Institute of Child Health and Human Development
Investigator: Badon, Sylvia

Comparing the Effects of Prenatal Depression and its Treatment on Developmental Outcomes of the Offspring

This study will test the hypothesis that the underlying prenatal depression and use of SSRIs are independent risk factors for adverse neurodevelopmental outcomes. The aims of this study are: 1) evaluate the effect of untreated prenatal depression, compar...
Funder: National Institute of Child Health and Human Development
Investigator: Avalos, Lyndsay

Racial/Ethnic Disparities in Perinatal Depression Treatment Utilization

The study will characterize racial/ethnic differences in perinatal depression treatment utilization, treatment engagement, and continued care by assembling a retrospective cohort of KPNC members entering prenatal care between 2012-2016. The study will als...
Funder: Northern California Community Benefit Programs
Investigator: Avalos, Lyndsay

Understanding racial-ethnic disparities in preterm birth sub-types and prenatal care utilization

The study will examine racial-ethnic disparities in the risk of preterm birth overall and by preterm birth sub-types. It will also study whether the racial-ethnic disparities in preterm births and preterm birth sub-types are modified by the level of prena...
Funder: Northern California Community Benefit Programs
Investigator: Hedderson, Monique

COVID-19 Response Grant

Adults with intellectual or developmental disabilities may be especially impacted by the ways the COVID-19 pandemic has led to drastic changes in usual daily routines and the way healthcare encounters have been transitioned to virtual (video, telephone) v...
Funder: Special Hope Foundation
Investigator: Croen, Lisa

Impact of In Utero Marijuana Exposure on Neurodevelopment, Behavior and Mental Health: A Longitudinal Birth Cohort Study

This study will investigate whether maternal prenatal marijuana use increases the risk of impairments in a child's executive functioning and mental health, after accounting for other factors such as tobacco, alcohol, and other drug use; socioeconomic stat...
Funder: National Institute on Drug Abuse
Investigator: Avalos, Lyndsay; Young-Wolff, Kelly

MAESTRA: Maternal Antecedents of Encephalopathy in Term Infants

This study tests the hypothesis that established NICHD-approved electronic fetal monitoring (EFM) features used as standard care in the U.S. and other developed countries can exhibit improved sensitivity and specificity for predicting HIE when they are co...
Funder: National Institute of Child Health and Human Development
Investigator: Kuzniewicz, Michael

Neurodevelopmental outcomes in infants receiving opioid-replacement

Infants with Neonatal Opioid Withdrawal Syndrome (NOWS) are often treated with prolonged opioid-replacement pharmacotherapy. Whether opioid exposure in-utero or significant opioid exposure used to treat withdrawal symptoms impacts neurodevelopmental outco...
Investigator: Kuzniewicz, Michael

Does Centering Pregnancy impact patient satisfaction with prenatal care and maternal health and behavioral outcomes?

This longitudinal study of 350 women seeking prenatal care in Kaiser Permanente Northern California will compare patient satisfaction with prenatal care, maternal health and behavioral outcomes between women in group prenatal care (Centering Pregnancy) an...
Funder: TPMG Delivery Science Projects Program
Investigator: Avalos, Lyndsay

Preventing Postpartum Depression: Exercise as Medicine

This intervention study will randomize 200 postpartum women at increased risk of postpartum depression to an eHealth physical activity intervention and assess the efficacy of the intervention on increasing physical activity and decreasing postpartum depre...
Funder: KP-NBA Partnership
Investigator: Avalos, Lyndsay; Badon, Sylvia

Exogenous surfactant utilization for respiratory failure in late and moderately preterm infants: impact on short- and long-term outcomes

The goal is to define and refine the current epidemiology, clinical characteristics, and treatment practices in respiratory failure in late and moderately preterm Infants. Specific aims include determining the incidence and epidemiology of respiratory fai...
Funder: Chiesi USA
Investigator: Kuzniewicz, Michael

Prenatal Depression and Antidepressant Exposure: Effects on Child Speech and Language Disorders

The aims of this study are to 1) Assess the relationship between untreated prenatal depression and the risk of speech and language disorders of offspring; 2) Compare the effectiveness of treatment of prenatal depression on speech and language disorders of...
Funder: Northern California Community Benefit Programs
Investigator: Avalos, Lyndsay

Fetal Programming of Growth and Obesity: A Metabolomics Approach

This proposal uses a novel holistic framework that leverages both targeted and untargeted metabolomics approach, electronic health records data, and bioinformatics analytics to investigate the mechanisms by which the in-utero environment may infer risk of...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Zhu, Yeyi

Cluster-randomized Trial of a Mobile Health Intervention to Achieve Appropriate Gestational Weight Gain in Overweight and Obese Women

This randomized trial will test whether the implementation of an mHealth tool in the health-plan setting increases the proportion of overweight and obese women with appropriate total gestational weight gain, according to Institute of Medicine (IOM) guidel...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Hedderson, Monique

Investigation of Prevalence of and Barriers to Achieving Optimal Glycemic Control among Women with Gestational Diabetes

This project aims to demonstrate that sufficient, high quality glycemic control data are available for investigating the determinants of and barriers to glycemic control among women with gestational diabetes in a cohort of 30,000 women at Kaiser Permanent...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Zhu, Yeyi

Risk Prediction of Gestational Diabetes Treatment Modalities Utilizing Clinical and Laboratory Data in the EHR

This study aims to utilize data from the Kaiser Permanente Northern California Gestational Diabetes and Pregnancy Glucose Tolerance Registry for a cohort of 25,000 women diagnosed with gestational diabetes. The goal is to determine whether clinical and la...
Funder: National Institutes of Health
Investigator: Zhu, Yeyi

Atopic Dermatitis Standing Cohort Using a Cohort of Kaiser Permanente Northern California Members

A cohort study of Kaiser Permanente Northern California patients with moderate-to-severe atopic dermatitis (AD) will be used to estimate baseline characteristics and background incidence rates of safety events. Data from this study will provide valuable i...
Funder: Pfizer Inc.
Investigator: Hedderson, Monique

Expansion of Division of Research Perinatal Research Unit (EXPPRU)

Dedicated quantitative analytic support for obstetrics has not been available in Kaiser Permanente Northern California. An unusual opportunity has appeared: as a result of a project to develop a predictive model for obstetric complications, considerable d...
Funder: Kaiser Permanente Program Offices
Investigator: Kuzniewicz, Michael

Maternal Inflammation during Pregnancy and Neurodevelopmental Disorders

​This study will utilize the Pregnancy Cohort from the Kaiser Permanente Northern California Research Program on Genes, Environment and Health to characterize the maternal immune profile over pregnancy and evaluate whether there are specific longitudinal ...
Funder: National Institute of Child Health and Human Development
Investigator: Croen, Lisa

Optimizing Social Communication Measurement with the Social Responsiveness Scale

​This project aims to: 1) compare the psychometric characteristics (including distributional properties, agreement with gold-standard diagnostic measures, and sensitivity and specificity) of short versus full Social Responsiveness Scale (SRS) scores, usin...
Funder: National Institutes of Health, Office of the Director
Investigator: Croen, Lisa

Incidence and Trend of Ectopic Pregnancy and Contraceptive Use

​Incidence and management of ectopic pregnancy have undergone significant changes in recent decades. There is a general consensus that available effective contraceptive methods reduce the absolute risk of ectopic pregnancy. Ectopic pregnancy incidence rat...
Funder: Bayer AG
Investigator: Raine-Bennett, Tina

Improving Post-Discharge Bilirubin Management in Newborns

There is variation and overuse in bilirubin testing among newborns. Multiple repeat testing occurs despite most newborns being at low risk for reaching bilirubin levels that would require phototherapy. Among the Kaiser Permanente birth population, 45 perc...
Funder: Northern California Community Benefit Programs
Investigator: Kuzniewicz, Michael

Extremely Premature Births Cohort Study

The goal of this study is to understand the incidence of extremely preterm birth and associated adverse health conditions and growth abnormality.
Funder: Shire plc
Investigator: Li, De-Kun

Email Management Strategies and Stress Among Primary Care Physicians

Email between patients and physicians has enhanced health care service but has made many primary care physicians feel overloaded. Many physicians multitask throughout the day by responding to email while seeing patients for in-person, telephone, and video...
Funder: The Permanente Medical Group
Investigator: Lieu, Tracy