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Women's and Children's Health Studies


Cervical Cancer Screening Follow-up

This study will use follow-up data on women with cervical specimens collected in the KPNC/NCI HPV biorepository and women in the cervical cancer screening program to investigate novel biomarkers of cervical pre-cancer and epidemiology of disease progressi...
Funder: National Cancer Institute
Investigator: Raine-Bennett, Tina

Understanding Barriers to Reproductive Health Care among Women with Autism Spectrum Disorder

This project will examine both reproductive health disparities and OB/GYN health care gaps for 2300 adolescent and adult women with Autism Spectrum Disorder (ASD) receiving care at Kaiser Permanente Northern California, paying particular attention to diff...
Funder: National Institute of Child Health and Human Development
Investigator: Ames, Jennifer

Interactions of Environmental Chemical Mixtures, Genetics, and Immune Pathways in Autism Spectrum Disorder

The goal of this K99/R00 Pathway to Independence Award is to receive mentored training in polygenic GWAS tools and complex mixtures modeling to position my career toward understanding the roles of GxE interactions and immune disruption in the etiology of ...
Funder: National Institute of Environmental Health Sciences
Investigator: Ames, Jennifer

Autism Intervention Research Network on Physical Health

Establish an interdisciplinary Autism Intervention Research Network on Physical Health node that will lead, promote, and coordinate national research activities to improve the physical health and well-being of individuals with autism spectrum disorder acr...
Funder: Health Resources and Services Administration
Investigator: Croen, Lisa

Autism Specific Patterns of DNA Methylation from Birth to Age 5

This study will examine potential differences in DNA methylation (DNAm) in early life, from birth through age 5, between children who are ultimately diagnosed with autism spectrum disorder and those typically developing. Results from this work will inform...
Funder: National Institute of Child Health and Human Development
Investigator: Croen, Lisa

Maternal Health in Pregnancy and Autism Risk - Genetic and Non-genetic Mechanisms

This study will systematically identify maternal diagnoses in pregnancy associated with autism spectrum disorder (ASD) in offspring; test if the association between maternal diagnoses and ASD is due to shared genetic factors using family data; and test th...
Funder: National Institute of Mental Health
Investigator: Croen, Lisa

Can hydroxychloroquine prevent preeclampsia and preterm delivery in lupus pregnancy?

Pregnant women with lupus are at high risk to develop preeclampsia and preterm delivery. This work leverages three large population-based databases with detailed prescription and clinical data to determine whether use of hydroxychloroquine during pregnanc...
Funder: National Institute of Arthritis and Musculoskeletal and Skin Diseases
Investigator: Hedderson, Monique

The Study of Women's Health Across the Nation (SWAN)

SWAN VI aims to elucidate menopause transition characteristics and trajectories of midlife health markers (inflammation, metabolic and cardiovascular risk factors, body composition, and bone, genitourinary, and vascular health) that are related to the pre...
Funder: National Institute on Aging
Investigator: Hedderson, Monique

The Epidemiology of SARS-CoV-2 in Pregnancy and Infancy (ESPI) Network: ESPI-Electronic Cohort

Multisite study to describe the incidence, clinical presentation, treatment, clinical course, and outcomes of COVID-19 among pregnant women and up to six months postpartum, and estimate the incidence of COVID-19 hospitalizations and medically attended amb...
Funder: Centers for Disease Control and Prevention
Investigator: Li, De-Kun

Strategies for optimizing video care in a diverse population

This study will describe factors associated with the effective adoption of video visits in adult and family medicine after the start of the Covid-19 pandemic; identify medical centers and primary care physicians with higher-than-expected video visit rates...
Funder: TPMG Delivery Science Projects Program
Investigator: Lieu, Tracy

Blood Pressure, Obesity, and Diabetes in Relation to Perinatal and Postpartum Complications

By leveraging the KPNC Gestational diabetes and Glucose Tolerance Registry, which includes rich data on blood glucose levels, obesity, gestational weight gain, we will add blood pressure levels for the earliest years to evaluate the individual and joint i...
Funder: National Heart, Lung, and Blood Institute
Investigator: Zhu, Yeyi

Barriers to Obstetric/Gynecological Health Care for Women with Autism Spectrum Disorders

This study will identify the sociodemographic and health factors associated with low utilization of obstetrics/gynecology services among adult women with autism spectrum disorders and explore whether these women are at higher risk of adverse maternal and ...
Funder: Northern California Community Benefit Programs
Investigator: Ames, Jennifer

Using a 24-Hour Movement Framework to Improve Pregnancy Outcomes

The goal of this K99/R00 Pathway to Independence Award is to better understand associations of 24-hour movement profiles during pregnancy (consisting of physical activity, sedentary behavior, and sleep) and maternal and infant outcomes. This Award include...
Funder: National Institute of Child Health and Human Development
Investigator: Badon, Sylvia

Comparing the Effects of Prenatal Depression and its Treatment on Developmental Outcomes of the Offspring

This study will test the hypothesis that the underlying prenatal depression and use of SSRIs are independent risk factors for adverse neurodevelopmental outcomes. The aims of this study are: 1) evaluate the effect of untreated prenatal depression, compar...
Funder: National Institute of Child Health and Human Development
Investigator: Avalos, Lyndsay

Racial/Ethnic Disparities in Perinatal Depression Treatment Utilization

The study will characterize racial/ethnic differences in perinatal depression treatment utilization, treatment engagement, and continued care by assembling a retrospective cohort of KPNC members entering prenatal care between 2012-2016. The study will als...
Funder: Northern California Community Benefit Programs
Investigator: Avalos, Lyndsay

Understanding racial-ethnic disparities in preterm birth sub-types and prenatal care utilization

The study will examine racial-ethnic disparities in the risk of preterm birth overall and by preterm birth sub-types. It will also study whether the racial-ethnic disparities in preterm births and preterm birth sub-types are modified by the level of prena...
Funder: Northern California Community Benefit Programs
Investigator: Hedderson, Monique

COVID-19 Response Grant

Adults with intellectual or developmental disabilities may be especially impacted by the ways the COVID-19 pandemic has led to drastic changes in usual daily routines and the way healthcare encounters have been transitioned to virtual (video, telephone) v...
Funder: Special Hope Foundation
Investigator: Croen, Lisa

Impact of In Utero Marijuana Exposure on Neurodevelopment, Behavior and Mental Health: A Longitudinal Birth Cohort Study

This study will investigate whether maternal prenatal marijuana use increases the risk of impairments in a child's executive functioning and mental health, after accounting for other factors such as tobacco, alcohol, and other drug use; socioeconomic stat...
Funder: National Institute on Drug Abuse
Investigator: Avalos, Lyndsay; Young-Wolff, Kelly

MAESTRA: Maternal Antecedents of Encephalopathy in Term Infants

This study tests the hypothesis that established NICHD-approved electronic fetal monitoring (EFM) features used as standard care in the U.S. and other developed countries can exhibit improved sensitivity and specificity for predicting HIE when they are co...
Funder: National Institute of Child Health and Human Development
Investigator: Kuzniewicz, Michael

Neurodevelopmental outcomes in infants receiving opioid-replacement

Infants with Neonatal Opioid Withdrawal Syndrome (NOWS) are often treated with prolonged opioid-replacement pharmacotherapy. Whether opioid exposure in-utero or significant opioid exposure used to treat withdrawal symptoms impacts neurodevelopmental outco...
Investigator: Kuzniewicz, Michael

Does Centering Pregnancy impact patient satisfaction with prenatal care and maternal health and behavioral outcomes?

This longitudinal study of 350 women seeking prenatal care in Kaiser Permanente Northern California will compare patient satisfaction with prenatal care, maternal health and behavioral outcomes between women in group prenatal care (Centering Pregnancy) an...
Funder: TPMG Delivery Science Projects Program
Investigator: Avalos, Lyndsay

Preventing Postpartum Depression: Exercise as Medicine

This intervention study will randomize 200 postpartum women at increased risk of postpartum depression to an eHealth physical activity intervention and assess the efficacy of the intervention on increasing physical activity and decreasing postpartum depre...
Funder: KP-NBA Partnership
Investigator: Avalos, Lyndsay; Badon, Sylvia

Exogenous surfactant utilization for respiratory failure in late and moderately preterm infants: impact on short- and long-term outcomes

The goal is to define and refine the current epidemiology, clinical characteristics, and treatment practices in respiratory failure in late and moderately preterm Infants. Specific aims include determining the incidence and epidemiology of respiratory fai...
Funder: Chiesi USA
Investigator: Kuzniewicz, Michael

Prenatal Depression and Antidepressant Exposure: Effects on Child Speech and Language Disorders

The aims of this study are to 1) Assess the relationship between untreated prenatal depression and the risk of speech and language disorders of offspring; 2) Compare the effectiveness of treatment of prenatal depression on speech and language disorders of...
Funder: Northern California Community Benefit Programs
Investigator: Avalos, Lyndsay

Fetal Programming of Growth and Obesity: A Metabolomics Approach

This proposal uses a novel holistic framework that leverages both targeted and untargeted metabolomics approach, electronic health records data, and bioinformatics analytics to investigate the mechanisms by which the in-utero environment may infer risk of...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Zhu, Yeyi