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Women's and Children's Health Studies

 

GEARs Combining advances in Genomics and Environmental science to accelerate Actionable Research and practice in ASD

The Autism Centers of Excellence (ACE) program is a trans-NIH initiative that supports large-scale studies on autism spectrum disorder. A priority area for the ACE program is work that will advance our understanding of the biologic mechanisms underlying g...
Funder: National Institute of Environmental Health Sciences
Investigator: Croen, Lisa

Evaluation of the EmbrACE Intervention for Pregnant Adults with a History of Adverse Childhood Experiences

Feasibility study of a 6-week virtual intervention for pregnant women with high adverse childhood experience (ACE) exposure and moderate to moderate-severe depression to reduce perinatal depression symptoms. Study will enroll and randomize participants to...
Funder: TPMG Delivery Science Projects Program
Investigator: Avalos, Lyndsay

Wellness coaching during pregnancy and maternal weight outcomes

Study to determine if individuals who participated in Wellness Coaching have lower risk of high gestational weight gain and postpartum weight retention compared with individuals who did not participate in Wellness Coaching. Electronic health record data w...
Funder: KP National Office of Community Health
Investigator: Badon, Sylvia

Associations between Glycemic Control Trajectories among Individuals with Gestational Diabetes and Obesity Risk and Growth Trajectories in the Offspring

The study will examine the association between glycemic control trajectories among individuals with gestational diabetes (GDM) included in the GDM registry and the risk of childhood obesity and growth trajectories in the offspring. Glycemic control trajec...
Funder: KP National Office of Community Health
Investigator: Chehab, Rana

Prenatal medication exposure in autism, birth complications and developmental disabilities

Systematically investigate the effects of maternal medication use in pregnancy on offspring autism spectrum disorder (ASD) risk. Test the mechanisms underlying the associations between maternal medication use and ASD. Establish the specificity and general...
Funder: National Institute of Child Health and Human Development
Investigator: Croen, Lisa

Evaluating patient engagement in "KP Connected Pregnancy Care" and its association with utilization, perinatal outcomes and patient satisfaction.

This cohort study evaluates a new prenatal care delivery pathway, KP Connected Pregnancy Care (KPCPC). KPCPC is an opt-in hybrid in-person and virtual care model using digital tools to expand remote patient monitoring and virtual visits for low-risk prena...
Funder: TPMG Delivery Science Projects Program
Investigator: Hedderson, Monique

Healthcare transition outcomes among autistic youth at KPNC

The study follows a cohort of autistic and non-autistic youth longitudinally to examine several transition indicators measurable in the EHR including: continuation of medications and other treatments during the transition years; length of time elapsed bet...
Funder: Northern California Community Benefit Programs
Investigator: Ames, Jennifer

SEED Follow-Up Study

SEED is a case-control study comparing children aged 2-5 years with autism spectrum disorder to children with other developmental disabilities. The SEED Follow-up Study is a longitudinal study designed to improve understanding of risk factors and expressi...
Funder: Centers for Disease Control and Prevention
Investigator: Croen, Lisa

Examining the Factors for the Rapid Rise of Colorectal Cancer in Young Adults: Does Increased Medical Use of Radiation and Imaging Technology Contribute to the Rise?

This study is examining whether the secular increase in use of medical radiation therapy and diagnostic imaging technology is associated with the corresponding secular increase in the risk of colorectal cancer among young adults age 50 and under.
Funder: Northern California Community Benefit Programs
Investigator: Li, De-Kun

Motivational Determinants of Postpartum Lifestyle Behaviors, Weight Retention, and Metabolic Syndrome

The proposed study aims to identify affective influences on key lifestyle behaviors (healthy eating and objectively measured self-weighing and physical activity) associated with postpartum weight retention and cardiometabolic profile (e.g., metabolic synd...
Funder: National Heart, Lung, and Blood Institute
Investigator: Ferrara, Assiamira

Comparative Effectiveness of Treating Genital Herpes Infection to Reduce Racial Disparities in the Risk of Severe Maternal Morbidity (SMM)

The goals of the study are to determine whether treating GHSV infection in pregnancy, especially earlier in pregnancy, is effective in mitigating the racial disparities in SMM, and GHSV infection, if untreated, contribute to racial disparities in the risk...
Funder: Patient-Centered Outcomes Research Institute
Investigator: Li, De-Kun

The Impact of Racial Residential Segregation on the Mental Health of Pregnant Women

We will create a large diverse cohort of more than 360,000 pregnant Black, Hispanic, Asian and white women to: examine the relationship between racial residential segregation and prenatal depression, anxiety and trauma (Aim 1); and prenatal depressive sev...
Funder: Northern California Community Benefit Programs
Investigator: Avalos, Lyndsay

Harnessing Electronic Health Records to Identify Participants and to Study Health Outcomes in Transition-Age Youth and Adults with Autism Spectrum Disorder

The goal of this K18 award is to determine changes in prevalence of common medical and psychiatric conditions and measures of health care utilization in an existing longitudinal cohort of autistic transition age youth (TAY) and adults within the Kaiser Pe...
Funder: National Institute of Mental Health
Investigator: Croen, Lisa

Optimizing a Scalable Intervention to Maximize Guideline-Recommended Diabetes Testing after GDM

We will leverage the multiphase optimization strategy (MOST) to efficiently identify, in a single experiment, which of four components of an outreach intervention motivate women with gestational diabetes to complete a recommended oral glucose tolerance te...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Ferrara, Assiamira

Predictive Analytics for Newborn Bilirubin Management

Our objective is to integrate the bilirubin risk prediction model into the automated bilirubin assessment in the laboratory results and provide follow-up guidance on timing of repeat bilirubin testing. We hypothesize that integration of this model will le...
Funder: Northern California Community Benefit Programs
Investigator: Kuzniewicz, Michael

Treatment Initiation for New Episodes of Depression in Pregnant Women

This study will use rigorous methods and rich health care data from a diverse, multi-site study population to study psychotherapy and antidepressant treatments for new episodes of depression during pregnancy. Analyses will include examination of infant ou...
Funder: National Institute of Child Health and Human Development
Investigator: Avalos, Lyndsay

Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and Neurodevelopment

This study is evaluating whether in-utero exposures to maternal PFCs and PBDEs, individually and/or in combination, are associated with infant growth, adiposity, and neurodevelopment; metabolic determinants of obesity; and neurodevelopment and infant patt...
Funder: National Institutes of Health, Office of the Director
Investigator: Ferrara, Assiamira

mHealth Mindfulness Intervention for Pregnant Black and Latina Women at Risk of Postpartum Depression

This randomized controlled trial of an mHealth mindfulness intervention designed for Black and Latinx pregnant women at risk of developing postpartum depression will compare outcomes (depression, stress, sleep) of participants in the intervention with tho...
Funder: National Institute of Mental Health
Investigator: Avalos, Lyndsay; Kubo, Ai

Understanding Barriers to Reproductive Health Care among Women with Autism Spectrum Disorder

This project will examine both reproductive health disparities and OB/GYN health care gaps for 2300 adolescent and adult women with Autism Spectrum Disorder (ASD) receiving care at Kaiser Permanente Northern California, paying particular attention to diff...
Funder: National Institute of Child Health and Human Development
Investigator: Ames, Jennifer

Interactions of Environmental Chemical Mixtures, Genetics, and Immune Pathways in Autism Spectrum Disorder

The goal of this K99/R00 Pathway to Independence Award is to receive mentored training in polygenic GWAS tools and complex mixtures modeling to position my career toward understanding the roles of GxE interactions and immune disruption in the etiology of ...
Funder: National Institute of Environmental Health Sciences
Investigator: Ames, Jennifer

Autism Intervention Research Network on Physical Health

Establish an interdisciplinary Autism Intervention Research Network on Physical Health node that will lead, promote, and coordinate national research activities to improve the physical health and well-being of individuals with autism spectrum disorder acr...
Funder: Health Resources and Services Administration
Investigator: Croen, Lisa

Autism Specific Patterns of DNA Methylation from Birth to Age 5

This study will examine potential differences in DNA methylation (DNAm) in early life, from birth through age 5, between children who are ultimately diagnosed with autism spectrum disorder and those typically developing. Results from this work will inform...
Funder: National Institute of Child Health and Human Development
Investigator: Croen, Lisa

Maternal Health in Pregnancy and Autism Risk - Genetic and Non-genetic Mechanisms

This study will systematically identify maternal diagnoses in pregnancy associated with autism spectrum disorder (ASD) in offspring; test if the association between maternal diagnoses and ASD is due to shared genetic factors using family data; and test th...
Funder: National Institute of Mental Health
Investigator: Croen, Lisa

Can hydroxychloroquine prevent preeclampsia and preterm delivery in lupus pregnancy?

Pregnant women with lupus are at high risk to develop preeclampsia and preterm delivery. This work leverages three large population-based databases with detailed prescription and clinical data to determine whether use of hydroxychloroquine during pregnanc...
Funder: National Institute of Arthritis and Musculoskeletal and Skin Diseases
Investigator: Hedderson, Monique

The Study of Women's Health Across the Nation (SWAN)

SWAN VI aims to elucidate menopause transition characteristics and trajectories of midlife health markers (inflammation, metabolic and cardiovascular risk factors, body composition, and bone, genitourinary, and vascular health) that are related to the pre...
Funder: National Institute on Aging
Investigator: Hedderson, Monique
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