Colorectal cancer (CRC) screening is widely recommended, but underused. To increase screening rates, we need to implement organized and population-based systems to promote CRC screening among people in a single region, health plan, or health system. This is ideally accomplished using fecal immunochemical tests (FITs), which can be sent through a mass mailing. The study by Levi and colleagues shows that patients using aspirin, non-steroidal anti-inflammatory drugs (NSAIDs), anti-platelet agents, or anti-coagulants do not need to stop these medications while doing the fecal collection. This makes the testing more convenient for patients, and avoids the risk of adverse cardiovascular events caused by stopping these medications.