skip to Main Content

Prenatal infection and cavum septum pellucidum in adult schizophrenia

Increased length of the cavum septum pellucidum (CSP) and in utero infection are each associated with increased risk of schizophrenia. Hence, we examined whether prenatal infections are related to CSP length in schizophrenia patients. In a well-characterized birth cohort, in utero infection was assessed using serologic biomarkers or physician diagnoses. Magnetic resonance images were acquired, and CSP length was quantified by a standard protocol. In utero infection was associated with increased CSP length in exposed schizophrenia cases compared to unexposed cases, suggesting that prenatal infection plays a role in a neurodevelopmental morphologic anomaly that has been related previously to schizophrenia.

Authors: Brown AS; Deicken RF; Vinogradov S; Kremen WS; Poole JH; Penner JD; Kochetkova A; Kern D; Schaefer CA

Schizophr Res. 2009 Mar;108(1-3):285-7. Epub 2009 Jan 8.

PubMed abstract

Explore all studies and publications

Back To Top