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Alyce S. Adams, PhD

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Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-5921 (phone)
alyce.s.adams@kp.org
Kaiser Permanente Researcher Profiles


Dr. Adams' work has focused on the determinants of suboptimal use of potentially beneficial health care services among disparities populations, including racial differences in medication adherence and the impact of changes in health policy on access to high quality health services and health outcomes for vulnerable patients. Dr. Adams is a member of the Kaiser Permanente Disparities Working Group and the Advisory Committee on Quality for the California Health Families Program.

Current Position(s):

  • Research Scientist III, Division of Research, Kaiser Permanente Northern California

Section Affiliations:

Primary Research Interests:

  • Healthcare Disparities/Vulnerable Populations
  • Health Services and Policy Research

    Predictive Modeling to Aid Clinical Decision-Making and Improve Diabetic Peripheral Neuropathy Outcomes

    This 18-month research project will bring together a multidisciplinary team of scientists and clinicians from four Kaiser Permanente regions (Kaiser Permanente Northern California, Kaiser Permanente Colorado, Kaiser Permanente Hawaii, and Kaiser Permanente of the Mid-Atlantic States) to identify patients most likely to benefit from intensive monitoring of diabetic peripheral neuropathy symptoms using predictive modeling strategies. The long-term goal of this study is to improve medical management of diabetic peripheral neuropathy while enhancing both the patient and provider experience and reducing healthcare costs.
    Investigator: Adams, Alyce
    Funder: Garfield Memorial Fund

    Does Free Medicines Coverage Improve Diabetes Self-Care and Outcomes for Diverse Populations?

    This is a quasi-experimental longitudinal study to evaluate the impact of Kaiser Permanente Hawaii WellRx — a program intended to engage patients more effectively in their self-care — among a diverse cohort of patients with diabetes. The study evaluates a natural experiment in which select employers and patients were offered zero dollar cost sharing for chronic disease medications. This study will use Kaiser Permanente Hawaii data only.
    Investigator: Adams, Alyce
    Funder: National Institute of Diabetes and Digestive and Kidney Diseases

    Balancing Treatment Outcomes and Medication Burden among Patients with Symptomatic Diabetic Peripheral Neuropathy

    This project is a continuation of a study we recently conducted to identify and prioritize treatment outcomes of relevance to patients with diabetic peripheral neuropathy (DPN). DPN affects 30% to 50% of all adults with diabetes and symptoms such as pain, tingling, numbness or a burning sensation in the extremities can be sudden and severe. Currently, only two prescription medications are approved for treatment of DPN symptoms, though many more are routinely used in practice. Clinical trials suggest that commonly used therapies have similar efficacy with respect to pain relief. However, side effects are common and little is known about the relative efficacy of these medications in addressing other patient-valued outcomes (e.g., quality of life). The goal of the proposal is to evaluate whether a clinical decision aid that includes information on patient treatment preferences can improve treatment persistence and outcomes that are important to patients.
    Investigator: Adams, Alyce
    Funder: Patient-Centered Outcomes Research Institute

    The Diabetes Telephone Study; Design and challenges of a pragmatic cluster randomized trial to improve diabetic peripheral neuropathy treatment

    Author(s): Adams AS; Bayliss EA; Schmittdiel JA; Altschuler A; Dyer W; Neugebauer R; Jaffe M; Young JD; Kim E; Grant RW; Diabetes Telephone Study Team

    Clin Trials. 2016 Mar 31.

    PubMed abstract

    Effects of Eliminating Drug Caps on Racial Differences in Antidepressant Use Among Dual Enrollees With Diabetes and Depression

    Author(s): Adams AS; Soumerai SB; Zhang F; Gilden D; Burns M; Huskamp HA; Trinacty C; Alegria M; LeCates RF; Griggs JJ; Ross-Degnan D; Madden JM

    Clin Ther. 2015 Jan 22.

    PubMed abstract

    Changes in Use of Lipid-lowering Medications Among Black and White Dual Enrollees With Diabetes Transitioning From Medicaid to Medicare Part D Drug Coverage

    Author(s): Adams AS; Madden JM; Zhang F; Soumerai SB; Gilden D; Griggs J; Trinacty CM; Bishop C; Ross-Degnan D

    Med Care. 2014 Aug;52(8):695-703.

    PubMed abstract

    Health System Factors and Antihypertensive Adherence in a Racially and Ethnically Diverse Cohort of New Users

    Author(s): Adams AS; Uratsu C; Dyer W; Magid D; O'Connor P; Beck A; Butler M; Ho PM; Schmittdiel JA

    JAMA Intern Med. 2013 Jan 14;173(1):54-61.

    PubMed abstract

    Medication adherence and racial differences in A1C control

    Author(s): Adams AS; Trinacty CM; Zhang F; Kleinman K; Grant RW; Meigs JB; Soumerai SB; Ross-Degnan D

    ​​Diabetes Care. 2008 May;31(5):916-21. doi: 10.2337/dc07-1924. Epub 2008 Jan 30.

    PubMed abstract

    Depression in type 1 diabetes and risk of dementia

    Author(s): Gilsanz P; Schnaider Beeri M; Karter AJ; Quesenberry CP; Adams AS; Whitmer RA

    Aging Ment Health. 2018 Apr 10:1-7.

    PubMed abstract

    Disparities in Prostate, Lung, Breast, and Colorectal Cancer Survival and Comorbidity Status among Urban American Indians and Alaskan Natives

    Author(s): Emerson MA; Banegas MP; Chawla N; Achacoso N; Alexeeff SE; Adams AS; Habel LA

    Cancer Res. 2017 Dec 01;77(23):6770-6776. Epub 2017-11-29.

    PubMed abstract

    The Delivery Science Rapid Analysis Program: A Research and Operational Partnership at Kaiser Permanente Northern California

    Author(s): Schmittdiel JA; Dlott R; Young JD; Rothmann MB; Dyer W; Adams AS

    Learn Health Syst. 2017 Oct;1(4). Epub 2017-07-12.

    PubMed abstract

    Effects of Transitioning to Medicare Part D on Access to Drugs for Medical Conditions among Dual Enrollees with Cancer

    Author(s): Adams AS; Madden JM; Zhang F; Lu CY; Ross-Degnan D; Lee A; Soumerai SB; Gilden D; Chawla N; Griggs JJ

    Value Health. 2017 Dec;20(10):1345-1354. Epub 2017-07-06.

    PubMed abstract

    Effect of Out-of-Pocket Cost on Medication Initiation, Adherence, and Persistence among Patients with Type 2 Diabetes: The Diabetes Study of Northern California (DISTANCE)

    Author(s): Karter AJ; Parker MM; Solomon MD; Lyles CR; Adams AS; Moffet HH; Reed ME

    Health Serv Res. 2017 May 05.

    PubMed abstract

    Population Health Management for Diabetes: Health Care System-Level Approaches for Improving Quality and Addressing Disparities

    Author(s): Schmittdiel JA; Gopalan A; Lin MW; Banerjee S; Chau CV; Adams AS

    Curr Diab Rep. 2017 May;17(5):31.

    PubMed abstract

    Predicting Adherence and Persistence with Oral Bisphosphonate Therapy in an Integrated Health Care Delivery System

    Author(s): Hui RL; Adams AL; Niu F; Ettinger B; Yi DK; Chandra M; Lo JC

    J Manag Care Spec Pharm. 2017 Apr;23(4):503-512.

    PubMed abstract

    Depressive symptoms and adherence to cardiometabolic therapies across phases of treatment among adults with diabetes: the Diabetes Study of Northern California (DISTANCE)

    Author(s): Bauer AM; Parker MM; Moffet HH; Schillinger D; Adler NE; Adams AS; Schmittdiel JA; Katon WJ; Karter AJ

    Patient Prefer Adherence. 2017;11:643-652. Epub 2017-03-24.

    PubMed abstract

    Association of the Affordable Care Act With Smoking and Tobacco Treatment Utilization Among Adults Newly Enrolled in Health Care

    Author(s): Young-Wolff KC; Klebaner D; Campbell CI; Weisner C; Satre DD; Adams AS

    Med Care. 2017 Mar 10.

    PubMed abstract

    Identification of the joint effect of a dynamic treatment intervention and a stochastic monitoring intervention under the no direct effect assumption

    Author(s): Neugebauer R; Schmittdiel JA; Adams AS; Grant RW; van der Laan MJ

    J Causal Inference. 2017 03;5(1). Epub 2017-01-18.

    PubMed abstract

    Overcoming barriers to diabetic polyneuropathy management in primary care

    Author(s): Adams AS; Callaghan B; Grant RW

    Healthc (Amst). 2016 Dec 06.

    PubMed abstract

    A Learning Behavioral Health Care System; Opportunities to Enhance Research

    Author(s): Stein BD; Adams AS; Chambers DA

    Psychiatr Serv. 2016 May 2:appips201500180.

    PubMed abstract

    Improved Perinatal Depression Screening, Treatment, and Outcomes With a Universal Obstetric Program

    Author(s): Avalos LA; Raine-Bennett T; Chen H; Adams AS; Flanagan T

    Obstet Gynecol. 2016 May;127(5):917-25.

    PubMed abstract

    Communication Barriers and the Clinical Recognition of Diabetic Peripheral Neuropathy in a Diverse Cohort of Adults: The DISTANCE Study

    Author(s): Adams AS; Parker MM; Moffet HH; Jaffe M; Schillinger D; Callaghan B; Piette J; Adler NE; Bauer A; Karter AJ

    J Health Commun. 2016 May;21(5):544-53. Epub 2016-04-26.

    PubMed abstract

    The Diabetes Telephone Study; Design and challenges of a pragmatic cluster randomized trial to improve diabetic peripheral neuropathy treatment

    Author(s): Adams AS; Bayliss EA; Schmittdiel JA; Altschuler A; Dyer W; Neugebauer R; Jaffe M; Young JD; Kim E; Grant RW; Diabetes Telephone Study Team

    Clin Trials. 2016 Mar 31.

    PubMed abstract

    Pre-visit prioritization for complex patients with Diabetes; Randomized Trial Design and Implementation within an Integrated Health Care system

    Author(s): Grant RW; Uratsu CS; Hansen KR; Altschuler A; Kim E; Fireman B; Adams AS; Schmittdiel JA; Heisler M

    Contemp Clin Trials. 2016 Jan 25.

    PubMed abstract

    An algorithm to identify medication nonpersistence using electronic pharmacy databases

    Author(s): Parker MM; Moffet HH; Adams A; Karter AJ

    J Am Med Inform Assoc. 2015 Sep;22(5):957-61. Epub 2015-06-15.

    PubMed abstract

    Patient reported outcomes for diabetic peripheral neuropathy

    Author(s): Bredfeldt C; Altschuler A; Adams AS; Portz JD; Bayliss EA

    J Diabetes Complicat. 2015 Aug 22.

    PubMed abstract

    Ethnic Differences in Geriatric Conditions and Diabetes Complications Among Older, Insured Adults With Diabetes; The Diabetes and Aging Study

    Author(s): Karter AJ; Laiteerapong N; Chin MH; Moffet HH; Parker MM; Sudore R; Adams AS; Schillinger D; Adler NS; Whitmer RA; Piette JD; Huang ES

    J Aging Health. 2015 Aug;27(5):894-918. Epub 2015-02-05.

    PubMed abstract

    Impact of a Pharmacy Benefit Change on New Use of Mail Order Pharmacy among Diabetes Patients; The Diabetes Study of Northern California (DISTANCE)

    Author(s): Karter AJ; Parker MM; Duru OK; Schillinger D; Adler NE; Moffet HH; Adams AS; Chan J; Herman WH; Schmittdiel JA

    Health Serv Res. 2015 Apr;50(2):537-59. Epub 2014-08-15.

    PubMed abstract

    Effects of Eliminating Drug Caps on Racial Differences in Antidepressant Use Among Dual Enrollees With Diabetes and Depression

    Author(s): Adams AS; Soumerai SB; Zhang F; Gilden D; Burns M; Huskamp HA; Trinacty C; Alegria M; LeCates RF; Griggs JJ; Ross-Degnan D; Madden JM

    Clin Ther. 2015 Jan 22.

    PubMed abstract

    Diabetes care and outcomes for American Indians and Alaska natives in commercial integrated delivery systems; a SUrveillance, PREvention, and ManagEment of Diabetes Mellitus (SUPREME-DM) Study

    Author(s): Schmittdiel JA; Steiner JF; Adams AS; Dyer W; Beals J; Henderson WG; Desai J; Morales LS; Nichols GA; Lawrence JM; Waitzfelder B; Butler MG; Pathak RD; Hamman RF; Manson SM

    BMJ Open Diabetes Res Care. 2014;2(1):e000043. Epub 2014-11-17.

    PubMed abstract

    Changes in Use of Lipid-lowering Medications Among Black and White Dual Enrollees With Diabetes Transitioning From Medicaid to Medicare Part D Drug Coverage

    Author(s): Adams AS; Madden JM; Zhang F; Soumerai SB; Gilden D; Griggs J; Trinacty CM; Bishop C; Ross-Degnan D

    Med Care. 2014 Aug;52(8):695-703.

    PubMed abstract

    Associations Between Antidepressant Adherence and Shared Decision-Making, Patient-Provider Trust, and Communication Among Adults with Diabetes; Diabetes Study of Northern California (DISTANCE)

    Author(s): Bauer AM; Parker MM; Schillinger D; Katon W; Adler N; Adams AS; Moffet HH; Karter AJ

    J Gen Intern Med. 2014 Aug;29(8):1139-47.

    PubMed abstract

    Initial Persistence With Antihypertensive Therapies Is Associated With Depression Treatment Persistence, But Not Depression

    Author(s): Schmittdiel JA; Dyer W; Uratsu C; Magid DJ; O'Connor PJ; Beck A; Butler M; Ho MP; Vazquez-Benitez G; Adams AS

    J Clin Hypertens (Greenwich). 2014 Jun;16(6):412-7. Epub 2014-04-10.

    PubMed abstract

    Effects of Medicare Part D on Guideline-Concordant Pharmacotherapy for Bipolar I Disorder Among Dual Beneficiaries

    Author(s): Burns ME; Busch AB; Madden JM; Le Cates RF; Zhang F; Adams AS; Ross-Degnan D; Soumerai SB; Huskamp HA

    Psychiatr Serv. 2014 Mar 1;65(3):323-9.

    PubMed abstract

    Establishing visit priorities for complex patients; A summary of the literature and conceptual model to guide innovative interventions

    Author(s): Grant RW; Adams AS; Bayliss EA; Heisler M

    Healthcare (Amst). 2013 Dec;1(3-4):117-122.

    PubMed abstract

    Differences in the clinical recognition of depression in diabetes patients; the diabetes study of northern california (DISTANCE)

    Author(s): Hudson DL; Karter AJ; Fernandez A; Parker M; Adams AS; Schillinger D; Moffet HH; Zhou J; Adler NE

    Am J Manag Care. 2013 May;19(5):344-52.

    PubMed abstract

    Health Literacy and Antidepressant Medication Adherence Among Adults with Diabetes; The Diabetes Study of Northern California (DISTANCE)

    Author(s): Bauer AM; Schillinger D; Parker MM; Katon W; Adler N; Adams AS; Moffet HH; Karter AJ

    J Gen Intern Med. 2013 Sep;28(9):1181-7. Epub 2013-03-20.

    PubMed abstract

    The top patient safety strategies that can be encouraged for adoption now

    Author(s): Shekelle PG; Pronovost PJ; Wachter RM; McDonald KM; Schoelles K; Dy SM; Shojania K; Reston JT; Adams AS; Angood PB; Bates DW; Bickman L; Carayon P; Donaldson L; Duan N; Farley DO; Greenhalgh T; Haughom JL; Lake E; Lilford R; Lohr KN; Meyer GS; Miller MR; Neuhauser DV; Ryan G; Saint S; Shortell SM; Stevens DP; Walshe K

    Ann Intern Med. 2013 Mar 5;158(5 Pt 2):365-8.

    PubMed abstract

    Health System Factors and Antihypertensive Adherence in a Racially and Ethnically Diverse Cohort of New Users

    Author(s): Adams AS; Uratsu C; Dyer W; Magid D; O'Connor P; Beck A; Butler M; Ho PM; Schmittdiel JA

    JAMA Intern Med. 2013 Jan 14;173(1):54-61.

    PubMed abstract

    Health-Plan and Employer-Based Wellness Programs to Reduce Diabetes Risk; The Kaiser Permanente Northern California NEXT-D Study

    Author(s): Schmittdiel JA; Brown SD; Neugebauer R; Adams SR; Adams AS; Wiley D; Ferrara A

    Prev Chronic Dis. 2013 Jan;10:E15.

    PubMed abstract

    Elevated Rates of Diabetes in Pacific Islanders and Asian Subgroups; The Diabetes Study of Northern California (DISTANCE)

    Author(s): Karter AJ; Schillinger D; Adams AS; Moffet HH; Liu J; Adler NE; Kanaya AM

    Diabetes Care. 2013 Mar;36(3):574-9. Epub 2012 Oct 15.

    PubMed abstract

    Symptom Burden of Adults with Type 2 Diabetes Across the Disease Course; Diabetes & Aging Study

    Author(s): Sudore RL; Karter AJ; Huang ES; Moffet HH; Laiteerapong N; Schenker Y; Adams A; Whitmer RA; Liu JY; Miao Y; John PM; Schillinger D

    J Gen Intern Med. 2012 Dec;27(12):1674-81. Epub 2012 Aug 2.

    PubMed abstract

    Medicare part d and changes in prescription drug use and cost burden; national estimates for the medicare population, 2000 to 2007

    Author(s): Briesacher BA; Zhao Y; Madden JM; Zhang F; Adams AS; Tjia J; Ross-Degnan D; Gurwitz JH; Soumerai SB

    Med Care. 2011 Sep;49(9):834-41.

    PubMed abstract

    Racial and ethnic disparities in postpartum depression care among low-income women

    Author(s): Kozhimannil KB; Trinacty CM; Busch AB; Huskamp HA; Adams AS

    Psychiatr Serv. 2011 Jun;62(6):619-25.

    PubMed abstract

    Advancing the science of patient safety

    Author(s): Shekelle PG; Pronovost PJ; Wachter RM; Taylor SL; Dy SM; Foy R; Hempel S; McDonald KM; Ovretveit J; Rubenstein LV; Adams AS; Angood PB; Bates DW; Bickman L; Carayon P; Donaldson L; Duan N; Farley DO; Greenhalgh T; Haughom J; Lake ET; Lilford R; Lohr KN; Meyer GS; Miller MR; Neuhauser DV; Ryan G; Saint S; Shojania KG; Shortell SM; Stevens DP; Walshe K

    Ann Intern Med. 2011 May 17;154(10):693-6.

    PubMed abstract

    Adherence to laboratory test requests by patients with diabetes; the Diabetes Study of Northern California (DISTANCE)

    Author(s): Moffet HH; Parker MM; Sarkar U; Schillinger D; Fernandez A; Adler NE; Adams AS; Karter AJ

    Am J Manag Care. 2011 May;17(5):339-44.

    PubMed abstract

    Heterogeneity of diabetes outcomes among asians and pacific islanders in the US; the diabetes study of northern california (DISTANCE)

    Author(s): Kanaya AM; Adler N; Moffet HH; Liu J; Schillinger D; Adams A; Ahmed AT; Karter AJ

    Diabetes Care. 2011 Apr;34(4):930-7. Epub 2011 Feb 24.

    PubMed abstract

    New Jersey's efforts to improve postpartum depression care did not change treatment patterns for women on medicaid

    Author(s): Kozhimannil KB; Adams AS; Soumerai SB; Busch AB; Huskamp HA

    Health Aff (Millwood). 2011 Feb;30(2):293-301.

    PubMed abstract

    Association between prior authorization for medications and health service use by Medicaid patients with bipolar disorder

    Author(s): Lu CY; Adams AS; Ross-Degnan D; Zhang F; Zhang Y; Salzman C; Soumerai SB

    Psychiatr Serv. 2011 Feb;62(2):186-93.

    PubMed abstract

    Impact of prior authorization on the use and costs of lipid-lowering medications among Michigan and Indiana dual enrollees in Medicaid and Medicare; results of a longitudinal, population-based study

    Author(s): Lu CY; Law MR; Soumerai SB; Graves AJ; LeCates RF; Zhang F; Ross-Degnan D; Adams AS

    Clin Ther. 2011 Jan;33(1):135-44.

    PubMed abstract

    Use of well-child visits in high-deductible health plans

    Author(s): Galbraith AA; Ross-Degnan D; Soumerai SB; Abrams AM; Kleinman K; Rosenthal MB; Wharam JF; Adams AS; Miroshnik I; Lieu TA

    Am J Manag Care. 2010 Nov;16(11):833-40.

    PubMed abstract

    Primary non-adherence to prescribed medications

    Author(s): Karter AJ; Parker MM; Adams AS; Moffet HH; Schmittdiel JA; Ahmed AT; Selby JV

    J Gen Intern Med. 2010 Aug;25(8):763; author reply 765.

    PubMed abstract

    Impact of two Medicaid prior-authorization policies on antihypertensive use and costs among Michigan and Indiana residents dually enrolled in Medicaid and Medicare; results of a longitudinal, population-based study

    Author(s): Law MR; Lu CY; Soumerai SB; Graves AJ; LeCates RF; Zhang F; Ross-Degnan D; Adams AS

    Clin Ther. 2010 Apr;32(4):729-41; discussion 716.

    PubMed abstract

    Unintended impacts of a Medicaid prior authorization policy on access to medications for bipolar illness

    Author(s): Lu CY; Soumerai SB; Ross-Degnan D; Zhang F; Adams AS

    Med Care. 2010 Jan;48(1):4-9.

    PubMed abstract

    A new measure of medication affordability

    Author(s): Briesacher B; Ross-Degnan D; Adams A; Wagner A; Gurwitz J; Soumerai S

    Soc Work Public Health. 2009 Nov-Dec;24(6):600-12.

    PubMed abstract

    The population-level impacts of a national health insurance program and franchise midwife clinics on achievement of prenatal and delivery care standards in the Philippines

    Author(s): Kozhimannil KB; Valera MR; Adams AS; Ross-Degnan D

    Health Policy. 2009 Sep;92(1):55-64. Epub 2009 Mar 26.

    PubMed abstract

    Prior authorization for antidepressants in Medicaid; effects among disabled dual enrollees

    Author(s): Adams AS; Zhang F; LeCates RF; Graves AJ; Ross-Degnan D; Gilden D; McLaughlin TJ; Lu C; Trinacty CM; Soumerai SB

    Arch Intern Med. 2009 Apr 27;169(8):750-6.

    PubMed abstract

    Racial differences in long-term adherence to oral antidiabetic drug therapy; a longitudinal cohort study

    Author(s): Trinacty CM; Adams AS; Soumerai SB; Zhang F; Meigs JB; Piette JD; Ross-Degnan D

    BMC Health Serv Res. 2009 Feb 7;9:24.

    PubMed abstract

    Medication adherence and racial differences in A1C control

    Author(s): Adams AS; Trinacty CM; Zhang F; Kleinman K; Grant RW; Meigs JB; Soumerai SB; Ross-Degnan D

    ​​Diabetes Care. 2008 May;31(5):916-21. doi: 10.2337/dc07-1924. Epub 2008 Jan 30.

    PubMed abstract

    Cost-related medication nonadherence and spending on basic needs following implementation of Medicare Part D

    Author(s): Madden JM; Graves AJ; Zhang F; Adams AS; Briesacher BA; Ross-Degnan D; Gurwitz JH; Pierre-Jacques M; Safran DG; Adler GS; Soumerai SB

    JAMA. 2008 Apr 23;299(16):1922-8.

    PubMed abstract