Stacey Alexeeff, PhD

People

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

510-891-3863 (phone)
stacey.alexeeff@kp.org
Kaiser Permanente Researcher Profiles

Stacey E. Alexeeff, PhD, is a research scientist/biostatistician at the Kaiser Permanente Northern California Division of Research. She earned her MSc in Statistics at Carnegie Mellon University in 2009 and her PhD in Biostatistics from Harvard University in 2013. Dr. Alexeeff's methodological areas of interest include spatial models, mixed effects modeling, longitudinal analysis techniques, measurement error, and gene-environment interaction tests. Her research in environmental epidemiology has focused on the health effects of ambient air pollution exposures across cardiovascular and respiratory systems, with particular emphasis on spatial models of air pollution and measurement error properties of these prediction models. Currently, Dr. Alexeeff is involved with ongoing research projects at the Division of Research, including studies of genetic and environmental risk factors for disease, intervention studies, and diagnostic prediction modeling.

Current Position(s):

Research Scientist II

Section Affiliations:

Biostatistics Core

Primary Research Interests:

Genetic and environmental risk factors for disease
Health effects of air pollution
Longitudinal and mixed effects modeling
Risk scores and prediction modeling

Studies

Impact of wildfire air pollution on rates of cardiovascular events and mortality

There is an increasing frequency of large wildfires in California. Smoke from these wildfires can drastically increase short-term exposure to harmful air pollutants, especially particulate matter (PM), and some KPNC members may be at greater risk of the adverse health effects of wildfire smoke due to underlying comorbidities. We aim to investigate the health effects of wildfire-PM on cardiovascular events and mortality, and to determine which populations with underlying comorbidities may be at greatest risk during these wildfire events. By identifying clinical comorbidities that confer increased susceptibility to these deleterious effects, KPNC members who have higher risks could be targeted for specific interventions by their providers.
Investigator: Alexeeff, Stacey
Funder: Northern California Community Benefit Programs

Particulate Air Pollution, Cardiovascular Events, and Susceptibility Factors (PACES)

This is a retrospective cohort study of 5 million adult members of Kaiser Permanente Northern California during 2000 to 2012, linked to state-of-the-art estimates of exposure to PM2.5 (particulate matter less than 2.5 micrometers in diameter) generated at 1km x 1km resolution using a novel hybrid model that incorporates meteorologic, land-use, and satellite measures. This project will quantify the associations between ambient PM2.5 exposure and risk of cardiovascular disease events, and determine whether demographic characteristics (age, sex, race/ethnicity, and socioeconomic status) and clinical comorbidities (obesity, diabetes, hypertension, and hyperlipidemia) are susceptibility factors that confer elevated risk to the effects of PM2.5.
Investigator: Alexeeff, Stacey
Funder: National Institute of Environmental Health Sciences

Highlighted Publications

No results found matching criteria

Publications

TP53 Gain-of-Function and Non-Gain-of-Function Mutations Are Differentially Associated With Sidedness-Dependent Prognosis in Metastatic Colorectal Cancer

Author(s): Pan M; Alexeeff S; Habel LA; et al.

J Clin Oncol. 2021 Nov 29:JCO2102014.

Current Position(s):

Section Affiliations:

Primary Research Interests:

Studies

Impact of wildfire air pollution on rates of cardiovascular events and mortality

Particulate Air Pollution, Cardiovascular Events, and Susceptibility Factors (PACES)

Highlighted Publications

Publications

TP53 Gain-of-Function and Non-Gain-of-Function Mutations Are Differentially Associated With Sidedness-Dependent Prognosis in Metastatic Colorectal Cancer

Intensive lactation among women with recent gestational diabetes significantly alters the early postpartum circulating lipid profile: the SWIFT study

Rates of Prenatal Cannabis Use Among Pregnant Women Before and During the COVID-19 Pandemic

Ectopic Pregnancy Prevention: Further Evidence of Benefits of Prescription Contraceptives

Cohort and Nested Case-Control Study of Cutaneous Squamous Cell Carcinoma in Solid Organ Transplant Recipients, by Medication

Impact of 2012 Prostate Cancer Screening Statement

Predicting adolescent alcohol and other drug problems using electronic health records data

Particulate Air Pollution and Risk of Cardiovascular Events Among Adults With a History of Stroke or Acute Myocardial Infarction

Prospective validation of the Kaiser Permanente prostate cancer risk calculator in a contemporary, racially diverse, referral population

Clustering of Social and Physical Pain Variables and Their Association With Mortality in Two Population-Based Cohorts

Ten-Year Follow-up of Persons With Sun-Damaged Skin Associated With Subsequent Development of Cutaneous Squamous Cell Carcinoma

Particulate Matter and Cardiovascular Risk in Adults with Chronic Obstructive Pulmonary Disease

Association of Cannabis Retailer Proximity and Density With Cannabis Use Among Pregnant Women in Northern California After Legalization of Cannabis for Recreational Use

Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts

The relationship of smoking and unhealthy alcohol use to the HIV care continuum among people with HIV in an integrated health care system

Long-Term PM2.5 Exposure and Risks of Ischemic Heart Disease and Stroke Events: Review and Meta-Analysis

Comparison of dementia risk after age 50 between individuals with and without HIV infection

Maternal immune response and air pollution exposure during pregnancy: insights from the Early Markers for Autism (EMA) study

Visual Outcomes After Cataract Surgery: Topical NSAID Prophylaxis Compared with Prednisolone

Validation Study of Kaiser Permanente Bedside Dysphagia Screening Tool in Acute Stroke Patients

Development and Validation of Machine Learning Models: Electronic Health Record Data To Predict Visual Acuity After Cataract Surgery

Identifying Ectopic Pregnancy in a Large Integrated Health Care Delivery System: Algorithm Validation

Presentation of Rash in a Community-Based Health System

Changing Provider PSA Screening Behavior Using Best Practice Advisories: Interventional Study in a Multispecialty Group Practice

Health System-Based Unhealthy Alcohol Use Screening and Treatment Comparing Demographically-Matched Participants With and Without HIV

Intraocular Pressure Reduction After Phacoemulsification: A Matched Cohort Study

Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk

Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts

Association of Low Muscle Mass and Low Muscle Radiodensity With Morbidity and Mortality for Colon Cancer Surgery

Trends and correlates of self-reported alcohol and nicotine use among women before and during pregnancy, 2009-2017

Association of teledermatology workflows with standardising co-management of rashes by primary care physicians and dermatologists

Smoking and cessation treatment among persons with and without HIV in a U.S. integrated health system

Standardized reporting and management of suspicious findings on chest computed tomography is associated with improved lung cancer diagnosis in an observational study

Prospective development of a prostate cancer risk calculator in a racially diverse population: The Kaiser Permanente Prostate Cancer Risk Calculator

Comparison of Overall and Comorbidity-Free Life Expectancy Between Insured Adults With and Without HIV Infection, 2000-2016

Feasibility of Measuring Preferences for Chemotherapy Among Early-Stage Breast Cancer Survivors Using a Direct Rank Ordering Multicriteria Decision Analysis Versus a Time Trade-Off

Increased Risk of Colorectal Cancer in Individuals With a History of Serrated Polyps

Initial Glycemic Control and Care Among Younger Adults Diagnosed With Type 2 Diabetes

Alcohol and tobacco use in relation to mammographic density in 23,456 women

Association of Depression, Anxiety, and Trauma With Cannabis Use During Pregnancy

Outcomes of Robotic Hysterectomy for Treatment of Benign Conditions: Influence of Patient Complexity

Changes in Prostate Cancer Presentation Following the 2012 USPSTF Screening Statement: Observational Study in a Multispecialty Group Practice

Body Composition, Adherence to Anthracycline and Taxane-Based Chemotherapy, and Survival After Nonmetastatic Breast Cancer

Validity of Self-reported Cannabis Use Among Pregnant Females in Northern California

Depot Medroxyprogesterone Acetate, Oral Contraceptive, Intrauterine Device Use, and Fracture Risk

Adipose Tissue Distribution and Cardiovascular Disease Risk Among Breast Cancer Survivors

Use of electronic health record data and machine learning to identify candidates for HIV pre-exposure prophylaxis: a modelling study

Self-reported Daily, Weekly, and Monthly Cannabis Use Among Women Before and During Pregnancy

Colorectal Cancer Screening in People With and Without HIV in an Integrated Health Care Setting

Telomere length and socioeconomic status at neighborhood and individual levels among 80,000 adults in the Genetic Epidemiology Research on Adult Health and Aging cohort

Adipose Tissue Distribution and Survival Among Women with Nonmetastatic Breast Cancer

Reproductive Factors and Mammographic Density: Associations Among 24,840 Women and Comparison of Studies Using Digitized Film-Screen Mammography and Full-Field Digital Mammography

The association of medical and demographic characteristics with sarcopenia and low muscle radiodensity in patients with nonmetastatic colorectal cancer

Prompting Patients with Poorly Controlled Diabetes to Identify Visit Priorities Before Primary Care Visits: a Pragmatic Cluster Randomized Trial

Comparative Effectiveness Study of Face-to-Face and Teledermatology Workflows for Diagnosing Skin Cancer

Trends in marijuana use among pregnant women with and without nausea and vomiting in pregnancy, 2009-2016

Visual outcomes after cataract surgery in patients with type 2 diabetes

Shake Rattle & Roll - Design and rationale for a pragmatic trial to improve blood pressure control among blacks with persistent hypertension

Patterns of medication adherence in a multi-ethnic cohort of prevalent statin users diagnosed with breast, prostate, or colorectal cancer

Prevalence and predictors of delayed clinical diagnosis of Type 2 diabetes: a longitudinal cohort study

High-resolution mapping of traffic related air pollution with Google street view cars and incidence of cardiovascular events within neighborhoods in Oakland, CA

Association of Muscle and Adiposity Measured by Computed Tomography With Survival in Patients With Nonmetastatic Breast Cancer

Trends in Self-reported and Biochemically Tested Marijuana Use Among Pregnant Females in California From 2009-2016

Disparities in Prostate, Lung, Breast, and Colorectal Cancer Survival and Comorbidity Status among Urban American Indians and Alaskan Natives

Muscle mass at the time of diagnosis of nonmetastatic colon cancer and early discontinuation of chemotherapy, delays, and dose reductions on adjuvant FOLFOX: The C-SCANS study

Association of Systemic Inflammation and Sarcopenia With Survival in Nonmetastatic Colorectal Cancer: Results From the C SCANS Study

Age at menarche and late adolescent adiposity associated with mammographic density on processed digital mammograms in 24,840 women

Explaining the Obesity Paradox: The Association between Body Composition and Colorectal Cancer Survival (C-SCANS Study)

Medical Conditions in the First Years of Life Associated with Future Diagnosis of ASD in Children

Immediate Sequential vs. Delayed Sequential Bilateral Cataract Surgery: Retrospective Comparison of Postoperative Visual Outcomes

Spatial measurement error and correction by spatial SIMEX in linear regression models when using predicted air pollution exposures

A Bayesian model for quantifying the change in mortality associated with future ozone exposures under climate change