Stacey E. Alexeeff, PhD

People

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

510-891-3863 (phone)
stacey.alexeeff@kp.org
Kaiser Permanente Researcher Profiles

Stacey E. Alexeeff, PhD, is a research scientist/biostatistician at the Kaiser Permanente Northern California Division of Research. She earned her MSc in Statistics at Carnegie Mellon University in 2009 and her PhD in Biostatistics from Harvard University in 2013. Dr. Alexeeff's methodological areas of interest include spatial models, mixed effects modeling, longitudinal analysis techniques, measurement error, and gene-environment interaction tests. Her research in environmental epidemiology has focused on the health effects of ambient air pollution exposures across cardiovascular and respiratory systems, with particular emphasis on spatial models of air pollution and measurement error properties of these prediction models. Currently, Dr. Alexeeff is involved with ongoing research projects at the Division of Research, including studies of genetic and environmental risk factors for disease, intervention studies, and diagnostic prediction modeling.

Current Position(s):

Research Scientist II

Section Affiliations:

Biostatistics Core

Primary Research Interests:

Genetic and environmental risk factors for disease
Health effects of air pollution
Longitudinal and mixed effects modeling
Risk scores and prediction modeling

Studies

Impact of wildfire air pollution on rates of cardiovascular events and mortality

There is an increasing frequency of large wildfires in California. Smoke from these wildfires can drastically increase short-term exposure to harmful air pollutants, especially particulate matter (PM), and some KPNC members may be at greater risk of the adverse health effects of wildfire smoke due to underlying comorbidities. We aim to investigate the health effects of wildfire-PM on cardiovascular events and mortality, and to determine which populations with underlying comorbidities may be at greatest risk during these wildfire events. By identifying clinical comorbidities that confer increased susceptibility to these deleterious effects, KPNC members who have higher risks could be targeted for specific interventions by their providers.
Investigator: Alexeeff, Stacey
Funder: Northern California Community Benefit Programs

Particulate Air Pollution, Cardiovascular Events, and Susceptibility Factors (PACES)

This is a retrospective cohort study of 5 million adult members of Kaiser Permanente Northern California during 2000 to 2012, linked to state-of-the-art estimates of exposure to PM2.5 (particulate matter less than 2.5 micrometers in diameter) generated at 1km x 1km resolution using a novel hybrid model that incorporates meteorologic, land-use, and satellite measures. This project will quantify the associations between ambient PM2.5 exposure and risk of cardiovascular disease events, and determine whether demographic characteristics (age, sex, race/ethnicity, and socioeconomic status) and clinical comorbidities (obesity, diabetes, hypertension, and hyperlipidemia) are susceptibility factors that confer elevated risk to the effects of PM2.5.
Investigator: Alexeeff, Stacey
Funder: National Institute of Environmental Health Sciences

Highlighted Publications

No results found matching criteria

Publications

Current tobacco smoking and risk of SARS-CoV-2 infection and hospitalization: Evaluating the role of socio-demographic factors and comorbidities

Author(s): Young-Wolff, Kelly C; Slama, Natalie; Sakoda, Lori C; Prochaska, Judith J; Fogelberg, Renee; Alexeeff, Stacey E

Prev Med. 2023 Apr 26;172:107523. Epub 2023-04-26.

Current Position(s):

Section Affiliations:

Primary Research Interests:

Studies

Impact of wildfire air pollution on rates of cardiovascular events and mortality

Particulate Air Pollution, Cardiovascular Events, and Susceptibility Factors (PACES)

Highlighted Publications

Publications

Current tobacco smoking and risk of SARS-CoV-2 infection and hospitalization: Evaluating the role of socio-demographic factors and comorbidities

Association of cannabis use during pregnancy with severe acute respiratory syndrome coronavirus 2 infection: a retrospective cohort study

Association of the COVID-19 Pandemic With Unstable and/or Unsafe Living Situations and Intimate Partner Violence Among Pregnant Individuals

Association of Long-term Exposure to Particulate Air Pollution With Cardiovascular Events in California

MiXcan: a framework for cell-type-aware transcriptome-wide association studies with an application to breast cancer

Cigarette Smoking and Risk of SARS-CoV-2 infection and Disease Severity Among Adults in an Integrated Health Care System in California

Urinary Phenols in Early to Mid-Pregnancy and Risk of Gestational Diabetes: A Longitudinal Study in a Multiracial Cohort

The effect of the COVID-19 pandemic on prenatal cannabis use by pre-conception depression and anxiety status

Trends in Self-reported and Biochemically Verified Cocaine and Methamphetamine Use Among Pregnant Individuals in Northern California, 2011-2019

Geographic Accessibility of Retail Cannabis in Northern California and Prenatal Cannabis Use During the COVID-19 Pandemic

Patterns of Substance Use During Early Pregnancy and Associations With Behavioral Health Characteristics

Assessment of genetic susceptibility to multiple primary cancers through whole-exome sequencing in two large multi-ancestry studies

Disparities in the Incidence of Ectopic Pregnancy in a Large Health Care System in California, 2010-2019

Maternal autoantibody profiles as biomarkers for ASD and ASD with co-occurring intellectual disability

Electronic cigarette use and risk of COVID-19 among young adults without a history of cigarette smoking

Prolactin and maternal metabolism in women with a recent GDM pregnancy and links to future T2D: the SWIFT study

Trends in Cannabis Polysubstance Use During Early Pregnancy Among Patients in a Large Health Care System in Northern California

Effect of Lifestyle Coaching or Enhanced Pharmacotherapy on Blood Pressure Control Among Black Adults With Persistent Uncontrolled Hypertension: A Cluster Randomized Clinical Trial

Association between residential green cover and direct healthcare costs in Northern California: An individual level analysis of 5 million persons

Association of teledermatology workflows with standardising co-management of rashes by primary care physicians and dermatologists

Joint associations between neighborhood walkability, greenness, and particulate air pollution on cardiovascular mortality among adults with a history of stroke or acute myocardial infarction

Cohort and Nested Case-Control Study of Cutaneous Squamous Cell Carcinoma in Solid Organ Transplant Recipients, by Medication

Early Pregnancy Blood Pressure Patterns Identify Risk of Hypertensive Disorders of Pregnancy Among Racial and Ethnic Groups

TP53 Gain-of-Function and Non-Gain-of-Function Mutations Are Differentially Associated With Sidedness-Dependent Prognosis in Metastatic Colorectal Cancer

Predicting adolescent alcohol and other drug problems using electronic health records data

Ectopic Pregnancy Prevention: Further Evidence of Benefits of Prescription Contraceptives

Comanagement of Rashes by Primary Care Providers and Dermatologists: A Retrospective Study

Rates of Prenatal Cannabis Use Among Pregnant Women Before and During the COVID-19 Pandemic

Prospective validation of the Kaiser Permanente prostate cancer risk calculator in a contemporary, racially diverse, referral population

Intensive lactation among women with recent gestational diabetes significantly alters the early postpartum circulating lipid profile: the SWIFT study

Impact of 2012 Prostate Cancer Screening Statement

Particulate Matter and Cardiovascular Risk in Adults with Chronic Obstructive Pulmonary Disease

Visual Outcomes After Cataract Surgery: Topical NSAID Prophylaxis Compared with Prednisolone

Particulate Air Pollution and Risk of Cardiovascular Events Among Adults With a History of Stroke or Acute Myocardial Infarction

Intraocular Pressure Reduction After Phacoemulsification: A Matched Cohort Study

Ten-Year Follow-up of Persons With Sun-Damaged Skin Associated With Subsequent Development of Cutaneous Squamous Cell Carcinoma

Clustering of Social and Physical Pain Variables and Their Association With Mortality in Two Population-Based Cohorts

Comparison of dementia risk after age 50 between individuals with and without HIV infection

Association of Cannabis Retailer Proximity and Density With Cannabis Use Among Pregnant Women in Northern California After Legalization of Cannabis for Recreational Use

Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts

The relationship of smoking and unhealthy alcohol use to the HIV care continuum among people with HIV in an integrated health care system

Long-Term PM2.5 Exposure and Risks of Ischemic Heart Disease and Stroke Events: Review and Meta-Analysis

Maternal immune response and air pollution exposure during pregnancy: insights from the Early Markers for Autism (EMA) study

Health System-Based Unhealthy Alcohol Use Screening and Treatment Comparing Demographically-Matched Participants With and Without HIV

Validation Study of Kaiser Permanente Bedside Dysphagia Screening Tool in Acute Stroke Patients

Development and Validation of Machine Learning Models: Electronic Health Record Data To Predict Visual Acuity After Cataract Surgery

Identifying Ectopic Pregnancy in a Large Integrated Health Care Delivery System: Algorithm Validation

Standardized reporting and management of suspicious findings on chest computed tomography is associated with improved lung cancer diagnosis in an observational study

Prospective development of a prostate cancer risk calculator in a racially diverse population: The Kaiser Permanente Prostate Cancer Risk Calculator

Changing Provider PSA Screening Behavior Using Best Practice Advisories: Interventional Study in a Multispecialty Group Practice

Presentation of Rash in a Community-Based Health System

Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk

Feasibility of Measuring Preferences for Chemotherapy Among Early-Stage Breast Cancer Survivors Using a Direct Rank Ordering Multicriteria Decision Analysis Versus a Time Trade-Off

Association of Low Muscle Mass and Low Muscle Radiodensity With Morbidity and Mortality for Colon Cancer Surgery

Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts

Trends and correlates of self-reported alcohol and nicotine use among women before and during pregnancy, 2009-2017

Increased Risk of Colorectal Cancer in Individuals With a History of Serrated Polyps

Smoking and cessation treatment among persons with and without HIV in a U.S. integrated health system

Comparison of Overall and Comorbidity-Free Life Expectancy Between Insured Adults With and Without HIV Infection, 2000-2016

Alcohol and tobacco use in relation to mammographic density in 23,456 women

Initial Glycemic Control and Care Among Younger Adults Diagnosed With Type 2 Diabetes

Association of Depression, Anxiety, and Trauma With Cannabis Use During Pregnancy

Body Composition, Adherence to Anthracycline and Taxane-Based Chemotherapy, and Survival After Nonmetastatic Breast Cancer

Outcomes of Robotic Hysterectomy for Treatment of Benign Conditions: Influence of Patient Complexity

Changes in Prostate Cancer Presentation Following the 2012 USPSTF Screening Statement: Observational Study in a Multispecialty Group Practice

Validity of Self-reported Cannabis Use Among Pregnant Females in Northern California

Comparative Effectiveness Study of Face-to-Face and Teledermatology Workflows for Diagnosing Skin Cancer

Use of electronic health record data and machine learning to identify candidates for HIV pre-exposure prophylaxis: a modelling study

Adipose Tissue Distribution and Cardiovascular Disease Risk Among Breast Cancer Survivors

Depot Medroxyprogesterone Acetate, Oral Contraceptive, Intrauterine Device Use, and Fracture Risk

Self-reported Daily, Weekly, and Monthly Cannabis Use Among Women Before and During Pregnancy

Colorectal Cancer Screening in People With and Without HIV in an Integrated Health Care Setting