Stacey E. Alexeeff, PhD

stacey.alexeeff@kp.org

Stacey E. Alexeeff, PhD, is a research scientist/biostatistician at the Kaiser Permanente Northern California Division of Research. She earned her MSc in Statistics at Carnegie Mellon University in 2009 and her PhD in Biostatistics from Harvard University in 2013. Dr. Alexeeff’s methodological areas of interest include spatial models, mixed effects modeling, longitudinal analysis techniques, measurement error, and gene-environment interaction tests. Her research in environmental epidemiology has focused on the health effects of ambient air pollution exposures across cardiovascular and respiratory systems, with particular emphasis on spatial models of air pollution and measurement error properties of these prediction models. Currently, Dr. Alexeeff is involved with ongoing research projects at the Division of Research, including studies of genetic and environmental risk factors for disease, intervention studies, and diagnostic prediction modeling.

Current Positions

Research Scientist II

Section Affiliations

Biostatistics

Primary Research Interests

Genetic and environmental risk factors for disease
Health effects of air pollution
Longitudinal and mixed effects modeling
Risk scores and prediction modeling

Studies

Impact of wildfire air pollution on rates of cardiovascular events and mortality

There is an increasing frequency of large wildfires in California. Smoke from these wildfires can drastically increase short-term exposure to harmful air pollutants, especially particulate matter (PM), and some KPNC members may be at greater risk of the adverse health effects of wildfire smoke due to underlying comorbidities. We aim to investigate the health effects of wildfire-PM on cardiovascular events and mortality, and to determine which populations with underlying comorbidities may be at greatest risk during these wildfire events. By identifying clinical comorbidities that confer increased susceptibility to these deleterious effects, KPNC members who have higher risks could be targeted for specific interventions by their providers.

Investigator: Alexeeff, Stacey

Funder: Northern California Community Benefit Programs

Particulate Air Pollution, Cardiovascular Events, and Susceptibility Factors (PACES)

This is a retrospective cohort study of 5 million adult members of Kaiser Permanente Northern California during 2000 to 2012, linked to state-of-the-art estimates of exposure to PM2.5 (particulate matter less than 2.5 micrometers in diameter) generated at 1km x 1km resolution using a novel hybrid model that incorporates meteorologic, land-use, and satellite measures. This project will quantify the associations between ambient PM2.5 exposure and risk of cardiovascular disease events, and determine whether demographic characteristics (age, sex, race/ethnicity, and socioeconomic status) and clinical comorbidities (obesity, diabetes, hypertension, and hyperlipidemia) are susceptibility factors that confer elevated risk to the effects of PM2.5.

Investigator: Alexeeff, Stacey

Funder: National Institute of Environmental Health Sciences

Publications

Association of psychiatric and substance use disorders with cannabis use and cannabis use disorder during early pregnancy in northern California

Authors: Young-Wolff, Kelly C;Chi, Felicia W;Campbell, Cynthia I;Does, Monique B;Brown, Qiana L;Alexeeff, Stacey E;Ansley, Deborah;Wang, Xiaoming;Lapham, Gwen T

Addiction. 2024 Nov;119(11):1987-1997. Epub 2024-07-31.

Stacey E. Alexeeff, PhD

Current Positions

Section Affiliations

Primary Research Interests

Studies

Impact of wildfire air pollution on rates of cardiovascular events and mortality

Particulate Air Pollution, Cardiovascular Events, and Susceptibility Factors (PACES)

Publications

Association of psychiatric and substance use disorders with cannabis use and cannabis use disorder during early pregnancy in northern California

Do small effects matter more in vulnerable populations? an investigation using Environmental influences on Child Health Outcomes (ECHO) cohorts

Excess Mortality in Persons with Concurrent HIV and Cancer Diagnoses: A Retrospective Cohort Study

Clinician perspectives on adolescent cannabis-related beliefs and behaviors following recreational cannabis legalization

A validation study for measuring Asian- and Hispanic-serving sociocultural institutions in neighborhoods using business listing data and potential implications for health

Prenatal Cannabis Use and Maternal Pregnancy Outcomes

Changes in Prenatal Cannabis Use Among Pregnant Individuals From 2012 to 2022

Reply by Authors

Clinically recognized sleep disorders in people living with HIV

Prospective Evaluation of the Kaiser Permanente Prostate Cancer Risk Calculator in Biopsy-Naïve Men with Mild PSA Elevations

Rationale and design of the KP ENRICH trial: A food is medicine intervention in low-income high-risk adults with diabetes within Kaiser Permanente

Mammographic density mediates the protective effect of early-life body size on breast cancer risk

Association of Adverse Childhood Experiences and Resilience With Depression and Anxiety During Pregnancy

Differences in Smoking Behavior by Nativity, Race/Ethnicity, and Education Among Women Diagnosed with Breast Cancer

Changes in Body Mass Index Over Time in People With and Without HIV Infection

Telehealth Collaborative Care Led by Clinical Pharmacists for People With Psychosis or Bipolar Disorder: A Propensity Weighted Comparison With Usual Psychiatric Care

Cardiovascular Disease Risk Factor Control in People With and Without Human Immunodeficiency Virus

Inflammatory Conditions During Pregnancy and Risk of Autism and Other Neurodevelopmental Disorders

Agreement Between Self-reports and Urine Toxicology Measures of Illicit Methamphetamine and Cocaine Use During Early Pregnancy

Fracture Risk and Association With TDF Use Among People With HIV in Large Integrated Health Systems

Postpartum defects in inflammatory response after gestational diabetes precede progression to type 2 diabetes: a nested case-control study within the SWIFT study

Neonatal Outcomes Associated with In Utero Cannabis Exposure: A Population-Based Retrospective Cohort Study

Association between maternal prenatal cannabis use and missed child preventive care visits in an integrated health care delivery system in Northern California

PFAS concentrations in early and mid-pregnancy and risk of gestational diabetes mellitus in a nested case-control study within the ethnically and racially diverse PETALS cohort

Examination of fully automated mammographic density measures using LIBRA and breast cancer risk in a cohort of 21,000 non-Hispanic white women

Early Pregnancy Systolic Blood Pressure Patterns Predict Early- and Later-Onset Preeclampsia and Gestational Hypertension Among Ostensibly Low-to-Moderate Risk Groups

Screening for Prostate Cancer

Effectiveness of Bundled Hyperpolypharmacy Deprescribing Compared With Usual Care Among Older Adults: A Randomized Clinical Trial

Current tobacco smoking and risk of SARS-CoV-2 infection and hospitalization: Evaluating the role of socio-demographic factors and comorbidities

Health conditions in autism: Defining the trajectory from adolescence to early adulthood

Heterogeneity in Early Postpartum Metabolic Profiles Among Women with GDM Who Progressed to Type 2 Diabetes During 10-Year Follow-Up: The SWIFT Study

TP53 Gain-of-Function and Non-Gain-of-Function Mutations Are Associated With Differential Prognosis in Advanced Pancreatic Ductal Adenocarcinoma

Patterns of Substance Use During Early Pregnancy and Associations With Behavioral Health Characteristics

Association of the COVID-19 Pandemic With Unstable and/or Unsafe Living Situations and Intimate Partner Violence Among Pregnant Individuals

Association of Long-term Exposure to Particulate Air Pollution With Cardiovascular Events in California

Association of cannabis use during pregnancy with severe acute respiratory syndrome coronavirus 2 infection: a retrospective cohort study

MiXcan: a framework for cell-type-aware transcriptome-wide association studies with an application to breast cancer

Cigarette Smoking and Risk of SARS-CoV-2 infection and Disease Severity Among Adults in an Integrated Health Care System in California

Trends in Self-reported and Biochemically Verified Cocaine and Methamphetamine Use Among Pregnant Individuals in Northern California, 2011-2019

The effect of the COVID-19 pandemic on prenatal cannabis use by pre-conception depression and anxiety status

Urinary Phenols in Early to Mid-Pregnancy and Risk of Gestational Diabetes: A Longitudinal Study in a Multiracial Cohort

Geographic Accessibility of Retail Cannabis in Northern California and Prenatal Cannabis Use During the COVID-19 Pandemic

Patterns of Substance Use During Early Pregnancy and Associations With Behavioral Health Characteristics

Assessment of genetic susceptibility to multiple primary cancers through whole-exome sequencing in two large multi-ancestry studies

Disparities in the Incidence of Ectopic Pregnancy in a Large Health Care System in California, 2010-2019

Electronic cigarette use and risk of COVID-19 among young adults without a history of cigarette smoking

Maternal autoantibody profiles as biomarkers for ASD and ASD with co-occurring intellectual disability

Prolactin and maternal metabolism in women with a recent GDM pregnancy and links to future T2D: the SWIFT study

Trends in Cannabis Polysubstance Use During Early Pregnancy Among Patients in a Large Health Care System in Northern California

Effect of Lifestyle Coaching or Enhanced Pharmacotherapy on Blood Pressure Control Among Black Adults With Persistent Uncontrolled Hypertension: A Cluster Randomized Clinical Trial

Association between residential green cover and direct healthcare costs in Northern California: An individual level analysis of 5 million persons

Joint associations between neighborhood walkability, greenness, and particulate air pollution on cardiovascular mortality among adults with a history of stroke or acute myocardial infarction

Association of teledermatology workflows with standardising co-management of rashes by primary care physicians and dermatologists

Early Pregnancy Blood Pressure Patterns Identify Risk of Hypertensive Disorders of Pregnancy Among Racial and Ethnic Groups

Cohort and Nested Case-Control Study of Cutaneous Squamous Cell Carcinoma in Solid Organ Transplant Recipients, by Medication

TP53 Gain-of-Function and Non-Gain-of-Function Mutations Are Differentially Associated With Sidedness-Dependent Prognosis in Metastatic Colorectal Cancer

Ectopic Pregnancy Prevention: Further Evidence of Benefits of Prescription Contraceptives

Predicting adolescent alcohol and other drug problems using electronic health records data

Reply by Authors

Race-Specific Trends in Prostate Cancer Screening and Presentation before and after the 2012 United States Preventive Services Task Force Statement

Comanagement of Rashes by Primary Care Providers and Dermatologists: A Retrospective Study

Rates of Prenatal Cannabis Use Among Pregnant Women Before and During the COVID-19 Pandemic

Prospective validation of the Kaiser Permanente prostate cancer risk calculator in a contemporary, racially diverse, referral population

Intensive lactation among women with recent gestational diabetes significantly alters the early postpartum circulating lipid profile: the SWIFT study

Impact of 2012 Prostate Cancer Screening Statement

Particulate Matter and Cardiovascular Risk in Adults with Chronic Obstructive Pulmonary Disease

Visual Outcomes After Cataract Surgery: Topical NSAID Prophylaxis Compared with Prednisolone

Particulate Air Pollution and Risk of Cardiovascular Events Among Adults With a History of Stroke or Acute Myocardial Infarction

Ten-Year Follow-up of Persons With Sun-Damaged Skin Associated With Subsequent Development of Cutaneous Squamous Cell Carcinoma

Intraocular Pressure Reduction After Phacoemulsification: A Matched Cohort Study

Comparison of dementia risk after age 50 between individuals with and without HIV infection

Clustering of Social and Physical Pain Variables and Their Association With Mortality in Two Population-Based Cohorts