Cynthia I. Campbell, PhD, MPH

cynthia.i.campbell@kp.org

Dr. Cynthia Campbell is a Senior Research Scientist at the Division of Research, Kaiser Permanente Northern California, where she co-directs the Center for Addiction and Mental Health Research. She is also an Adjunct Professor in the Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, and an Associate Professor at the Bernard J. Tyson School of Medicine. With two decades of experience, Dr. Campbell’s research on substance use and comorbidity leverages electronic health record data, patient surveys, and pragmatic trials. Her work focuses on access to care, pain and substance use, prescription opioid and cannabis use, and related health policies. Her research has been funded by the National Institute on Drug Abuse, National Institute on Alcohol Abuse and Alcoholism, and the Patient-Centered Outcomes Research Institute. She is one of the principal investigators of the Health Systems Node of the NIDA Clinical Trials Network, along with Dr. Katharine Bradley at Kaiser Permanente Washington Research Institute. Dr. Campbell received her doctorate in Health Services, Organization and Policy at the University of Michigan, and conducted her postdoctoral work at UCSF in a NIDA-funded fellowship on Substance Abuse and Health Services.

Current Positions

Research Scientist III, Division of Research, Kaiser Permanente Northern California
Adjunct Associate Professor, University of California, San Francisco, Department of Psychiatry
Co-director, Center for Addiction and Mental Health Research

Section Affiliations

Primary Research Interests

Alcohol and drug treatment
Chronic pain and prescription opioid misuse
Adolescents
Mental health
Health services
Benefit design
Access to treatment

Related Websites

Studies

Health Systems Node of the NIDA Clinical Trials Network

Continued support for infrastructure of the Health Systems Node, which includes 18 health systems, including Kaiser Permanente Northern California, Washington, and Colorado, and other community and university based health systems.

Investigator: Campbell, Cynthia

Funder: National Institute on Drug Abuse

Role of Health Care in Addressing Unhealthy Alcohol Use and Disparities among Aging Women

The use of alcohol among older women, particularly binge drinking, has been steadily increasing in recent years, leaving them vulnerable to associated health conditions. This mixed methods study uses KPNC’s EHR based alcohol registry and screening data to examine unhealthy alcohol use, and disparities in use, in women over age 50. We will also examine patterns of health care utilization associated with select health conditions among older women with unhealthy alcohol use and conduct qualitative interviews with addiction medicine staff about the changing needs of older women with unhealthy alcohol use.

Investigator: Campbell, Cynthia

Funder: National Institute on Alcohol Abuse and Alcoholism

Buprenorphine Effect on Suicidal Behavior

Large observational study to evaluate the effects of initiating buprenorphine treatment on subsequent suicidal behavior among people with opioid use disorder.

Investigator: Campbell, Cynthia

Funder: National Institute of Mental Health

Alcohol-Related Care and HCV Treatment among Patients with Problematic Alcohol Use and HCV

This study will examine substance use treatment among patients with hepatitis C who have unhealthy alcohol use and how well they engage in appropriate and timely hepatitis C care. The findings will be used to conduct an intervention study aimed at improving engagement with substance use treatment and hepatitis C care in this population.

Investigator: Campbell, Cynthia

Funder: Northern California Community Benefit Programs

Developing a Prescription Opioid Registry in Diverse Health Systems

Building on past research, this project will establish the infrastructure to expand a prescription opioid registry across diverse health systems in the Addiction Research Network. Harmonized electronic health record data elements will be used to examine how changes in opioid use are associated with other patient outcomes, such as emergency department service utilization, benzodiazepine use, and use of other non-opioid medications (e.g., nonsteroidal anti-inflammatory drugs [NSAIDs] and gabapentin), and how this may vary by patient characteristics and across health systems.

Investigator: Campbell, Cynthia

Funder: National Institute on Drug Abuse

A Prospective, Observational Study Designed to Quantify the Serious Risks of Misuse, Abuse and Addiction Associated with Long-Term Use of Opioid Analgesics for Management of Chronic Pain Among Patients Prescribed ER/LA Opioid Analgesics

The goal of this Food and Drug Administration-mandated study is to provide quantitative estimates of the serious risks of misuse, abuse, addiction, overdose, and death associated with long-term use of opioid analgesics for management of chronic pain, among patients prescribed extended-release and long-acting (ER/LA) opioid products. Patients will be recruited and interviewed across several health system sites.

Investigator: Campbell, Cynthia

Funder: Syneos Health

Impact of the Regional Opioid Safety Initiative on Patients and the Health System

Investigator: Campbell, Cynthia

Funder: The Permanente Medical Group

Recreational and Medical Use of Cannabis in a Time of Legalization and Changing Attitudes

This study will survey a sample of patients with pain about their use of medical marijuana. The goal is to describe patterns of use, mode, medical conditions, or symptoms for which medical marijuana is used, as well as perceived benefits, side effects, and patient experience of communication about its use with providers.

Investigator: Campbell, Cynthia

Funder: Northern California Community Benefit Programs

Prescription Opioid Management in Chronic Pain Patients: A Patient-Centered Activation Intervention

This randomized trial of a patient activation approach to self-management is based in primary care and focuses on management of prescription opioids among patients with chronic pain.

Investigator: Weisner, Constance; Campbell, Cynthia

Funder: Patient-Centered Outcomes Research Institute

Integrating Addiction Research in Health Systems: The Addiction Research Network

This cooperative agreement supports addiction research in 15 health systems from across the U.S. by establishing the Health Systems Network (HSN) node of the NIDA Clinical Trials Network. HSN research includes a range of study designs and settings, but emphasizes integrating addiction treatment into medical settings and health systems.

Investigator: Campbell, Cynthia

Funder: National Institute on Drug Abuse

Buprenorphine and Substance Abuse Services for Prescription Opioid Dependence

This study is a randomized trial of adjunctive substance abuse services in combination with buprenorphine treatment for opioid abuse/dependence. We will examine treatment as usual vs. case management/telephonic support, and outcomes of medication compliance, substance use and psychiatric severity.

Investigator: Campbell, Cynthia; Constance Weisner

Funder: National Institute on Drug Abuse

The Impact of Health Care Reform on Addiction and HIV Services

To examine the impact of the ACA on treatment for individuals with drug use disorders and who are HIV+. We will examine how this population changes after 2014 enrollment, and subsequent substance abuse treatment and HIV treatment utilization. We will examine findings for different coverage groups, and explore organizational response to changes in this population. The study uses EMR data supplemented by qualitative interviews with patients and providers.

Investigator: Campbell, Cynthia

Funder: National Institute on Drug Abuse

Publications

Association of psychiatric and substance use disorders with cannabis use and cannabis use disorder during early pregnancy in northern California

Authors: Young-Wolff, Kelly C;Chi, Felicia W;Campbell, Cynthia I;Does, Monique B;Brown, Qiana L;Alexeeff, Stacey E;Ansley, Deborah;Wang, Xiaoming;Lapham, Gwen T

Addiction. 2024 Nov;119(11):1987-1997. Epub 2024-07-31.

Cynthia I. Campbell, PhD, MPH

Current Positions

Section Affiliations

Primary Research Interests

Related Websites

Studies

Health Systems Node of the NIDA Clinical Trials Network

Role of Health Care in Addressing Unhealthy Alcohol Use and Disparities among Aging Women

Buprenorphine Effect on Suicidal Behavior

Alcohol-Related Care and HCV Treatment among Patients with Problematic Alcohol Use and HCV

Developing a Prescription Opioid Registry in Diverse Health Systems

A Prospective, Observational Study Designed to Quantify the Serious Risks of Misuse, Abuse and Addiction Associated with Long-Term Use of Opioid Analgesics for Management of Chronic Pain Among Patients Prescribed ER/LA Opioid Analgesics

Impact of the Regional Opioid Safety Initiative on Patients and the Health System

Recreational and Medical Use of Cannabis in a Time of Legalization and Changing Attitudes

Prescription Opioid Management in Chronic Pain Patients: A Patient-Centered Activation Intervention

Integrating Addiction Research in Health Systems: The Addiction Research Network

Buprenorphine and Substance Abuse Services for Prescription Opioid Dependence

The Impact of Health Care Reform on Addiction and HIV Services

Publications

Association of psychiatric and substance use disorders with cannabis use and cannabis use disorder during early pregnancy in northern California

Prevalence and trends of suspected cannabinoid hyperemesis syndrome over an 11-year period in Northern California: An electronic health record study

Prospective changes in drinking during the COVID-19 pandemic among adults with unhealthy alcohol use

Clinician perspectives on adolescent cannabis-related beliefs and behaviors following recreational cannabis legalization

Changes in Prenatal Cannabis Use Among Pregnant Individuals From 2012 to 2022

Opioid Administration Practice Patterns in Patients With Acute Respiratory Failure Who Undergo Invasive Mechanical Ventilation

Offering nurse care management for opioid use disorder in primary care: Impact on emergency and hospital utilization in a cluster-randomized implementation trial

Intravenous Opioid Administration During Mechanical Ventilation and Use After Hospital Discharge

Unhealthy Alcohol Use among Adults with Depression or Anxiety: Changes During COVID-19 and Associations with Mental Health Treatment

Association of Adverse Childhood Experiences and Resilience With Depression and Anxiety During Pregnancy

Self-reported pain severity and use of cannabis and opioids in persons with HIV in an urban primary care setting in Northern California: A cross-sectional study

Tools to implement measurement-based care (MBC) in the treatment of opioid use disorder (OUD): toward a consensus

Addiction Medicine Treatment Utilization by Race/Ethnicity Among Adolescents With Substance Use Problems Before Versus During the COVID-19 Pandemic

Association of initial opioid prescription duration and an opioid refill by pain diagnosis: Evidence from outpatient settings in ten US health systems

A patient activation intervention in primary care for patients with chronic pain on long term opioid therapy: results from a randomized control trial

Nurse Care Management for Opioid Use Disorder Treatment: The PROUD Cluster Randomized Clinical Trial

Prescription Opioid Dose Reductions and Potential Adverse Events: a Multi-site Observational Cohort Study in Diverse US Health Systems

Telemedicine-delivered treatment for substance use disorder: A scoping review

Patient Engagement in a Multimodal Digital Phenotyping Study of Opioid Use Disorder

Psychoactive plant derivatives (ayahuasca, ibogaine, kratom) and their application in opioid withdrawal and use disorder – a narrative review

Overall and Telehealth Addiction Treatment Utilization by Age, Race, Ethnicity, and Socioeconomic Status in California After COVID-19 Policy Changes

Cannabis use for medical reasons among patients in a large California health care system after legalization of non-medical use

Disparities in the Receipt of Alcohol Brief Intervention: The Intersectionality of Sex, Age and Race/ethnicity

Accuracy of diagnostic codes for prenatal opioid exposure and neonatal opioid withdrawal syndrome

Cigarette Smoking and Risk of SARS-CoV-2 infection and Disease Severity Among Adults in an Integrated Health Care System in California

Telemedicine along the cascade of care for substance use disorders during the COVID-19 pandemic in the United States

The association between buprenorphine treatment duration and mortality: a multi-site cohort study of people who discontinued treatment

Baseline representativeness of patients in clinics enrolled in the PRimary care Opioid Use Disorders treatment (PROUD) trial: comparison of trial and non-trial clinics in the same health systems

COVID-19 pandemic-related changes in utilization of telehealth and treatment overall for alcohol use problems

Sex Differences in Comorbid Mental and Substance Use Disorders Among Primary Care Patients With Opioid Use Disorder

Geographic Accessibility of Retail Cannabis in Northern California and Prenatal Cannabis Use During the COVID-19 Pandemic

Patterns of Health Care Use 5 Years After an Intervention Linking Patients in Addiction Treatment With a Primary Care Practitioner

Development and Testing of a Communication Intervention to Improve Chronic Pain Management in Primary Care: A Pilot Randomized Clinical Trial

The Opioid Use Disorder Core Outcomes Set (OUD-COS) for treatment research: findings from a Delphi consensus study

Mortality Among Patients Prescribed Buprenorphine for Opioid Use Disorder After Disenrollment from an Insurance Plan and Healthcare System

Development and implementation of a prescription opioid registry across diverse health systems

Alcohol brief intervention, specialty treatment and drinking outcomes at 12 months: Results from a systematic alcohol screening and brief intervention initiative in adult primary care

Comparison of Medical Cannabis Use Reported on a Confidential Survey vs Documented in the Electronic Health Record Among Primary Care Patients

Substance use disorders among primary care patients screening positive for unhealthy alcohol use

Alcohol Use Among Young Adults in Northern California During the COVID-19 Pandemic-An Electronic Health Records-Based Study

The Feasibility and Utility of Harnessing Digital Health to Understand Clinical Trajectories in Medication Treatment for Opioid Use Disorder: D-TECT Study Design and Methodological Considerations

Clinical documentation of patient-reported medical cannabis use in primary care: Toward scalable extraction using natural language processing methods

Attention-Deficit/Hyperactivity Disorder Medication Adherence in the Transition to Adulthood: Associated Adverse Outcomes for Females and Other Disparities

Patient and provider factors associated with receipt and delivery of brief interventions for unhealthy alcohol use in primary care

Receipt of medications for opioid use disorder among youth engaged in primary care: data from 6 health systems

Prevalence of Medical Cannabis Use and Associated Health Conditions Documented in Electronic Health Records Among Primary Care Patients in Washington State

Prevalence and Medication Treatment of Opioid Use Disorder Among Primary Care Patients with Hepatitis C and HIV

Changes in Diagnostic and Demographic Characteristics of Patients Seeking Mental Health Care During the Early COVID-19 Pandemic in a Large, Community-Based Health Care System

PRimary Care Opioid Use Disorders treatment (PROUD) trial protocol: a pragmatic, cluster-randomized implementation trial in primary care for opioid use disorder treatment

Core outcomes set for research on the treatment of opioid use disorder (COS-OUD): the National Institute on Drug Abuse Clinical Trials Network protocol for an e-Delphi consensus study

Treatment for Anxiety and Substance Use Disorders During the COVID-19 Pandemic: Challenges and Strategies

Health care utilization and HIV clinical outcomes among newly enrolled patients following Affordable Care Act implementation in a California integrated health system: a longitudinal study

Healthcare utilization of individuals with substance use disorders following Affordable Care Act implementation in a California healthcare system

The role of substance use disorders in experiencing a repeat opioid overdose, and substance use treatment patterns among patients with a non-fatal opioid overdose

Documented opioid use disorder and its treatment in primary care patients across six U.S. health systems

The application of digital health to the assessment and treatment of substance use disorders: The past, current, and future role of the National Drug Abuse Treatment Clinical Trials Network

Prevalence and treatment of opioid use disorders among primary care patients in six health systems

Chronic pain diagnoses and opioid dispensings among insured individuals with serious mental illness

Long-term opioid therapy definitions and predictors: A systematic review

Benzodiazepine and unhealthy alcohol use among adult outpatients

Postoperative Opioid Use Before and After Enhanced Recovery After Surgery Program Implementation