Douglas A. Corley, MD, PhD

People

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3811 (phone)
douglas.corley@kp.org
Kaiser Permanente Researcher Profiles

Douglas A. Corley, MD, PhD, MPH, has been a research scientist at the Kaiser Permanente Northern California Division of Research since 2002. He is also a board-certified gastroenterologist who practices at the Kaiser Permanente, San Francisco Medical Center. Dr. Corley’s research interests include outcomes and epidemiologic research in gastroenterology, with a particular emphasis on gastrointestinal cancer epidemiology, cancer surveillance, pharmacoepidemiology, and nutritional epidemiology. Current active research projects include evaluations of Barrett’s esophagus, esophageal adenocarcinoma, gastroesophageal reflux disease, serologic markers for gastrointestinal neoplasia, the long-term effects of gastrointestinal medications (such as anti-acid medications), the intersection between nutrition and gastrointestinal disorders, and the carcinogenic effects of obesity. Dr. Corley is lead investigator for the colon cancer component of the National Cancer Institute's Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) consortium, a multisite effort to evaluate and improve cancer-screening processes.

After completing medical school at the University of Pennsylvania, Dr. Corley completed an internal medicine residency at the Brigham & Women’s Hospital of the Harvard Medical School in Boston, Massachusetts; and a gastroenterology fellowship at the University of California, San Francisco (UCSF). Dr. Corley subsequently obtained a master’s degree in public health and a doctorate in epidemiology at the University of California, Berkeley, School of Public Health. Prior to joining the Division of Research, he was on the full-time gastroenterology faculty at UCSF, where he was the chief of the UCSF GI Faculty Practice.

Current Position(s):

Research Scientist III, Division of Research, Kaiser Permanente Northern California
Attending Gastroenterologist, Kaiser Permanente, San Francisco Medical Center
Associate Member, University of California, San Francisco Comprehensive Cancer Center
Clinical Professor of Medicine, University of California, San Francisco

Section Affiliations:

Cancer

Studies

NRG Oncology NCORP Research Base - NRG-CC005 FORTE (supplement)

In the initial phase of this study, we will manually review patients for eligibility for initial contact; complete a patient identification and tracking database; and develop and submit supplemental electronic IRB/email consent documents.
Investigator: Corley, Douglas
Funder: National Cancer Institute

NRG Oncology NCORP Research Base

This is a non-inferiority trial design comparing colorectal cancer incidence in trial participants with 1-2 non-advanced adenomas randomized to recommendation for a 5- and 10-year surveillance colonoscopy exam vs. a 10-year surveillance colonoscopy exam.
Investigator: Corley, Douglas
Funder: National Cancer Institute

System-Level Capture of Family History Data to Assess Risk of Cancer and Provide Longitudinal Care Coordination

Genetic risk and family history, which includes personal medical history, increasingly influence medical care, but optimal methods for capturing the hereditary risk of disease and the outcomes of such assessments are unknown. Using inherited cancer as a model, this study will: 1) Test scalable interventions for integrating family and genetic risk data into the care of large populations; 2) Evaluate significant patient-centered and medical-outcomes resulting from systems-level family history assessment; and 3) Determine the resources needed for such interventions.
Investigator: Corley, Douglas
Funder: Patient-Centered Outcomes Research Institute

Gene Dependent Cancer Risk and Optimal Cancer Prevention Strategies in Lynch Syndrome

As part of a “K” training award from the National Institutes of Health, and within the overall colorectal cancer research program at Kaiser Permanente Northern California, this project will support additional analyses regarding the identification of persons at high hereditary risk for colorectal cancer (e.g., Lynch syndrome) and their use of preventive and treatment modalities.
Investigator: Corley, Douglas
Funder: National Cancer Institute

Validation and Extension of the Michigan Barrett’s Esophagus pREdiction Tool (M-BERET)

This project will validate whether a clinical tool can predict the presence of Barrett's esophagus and the development of esophageal adenocarcinoma.
Investigator: Corley, Douglas
Funder: U.S. Department of Veterans Affairs

Optimizing Colorectal Cancer Screening PREcision and Outcomes in CommunIty-baSEd Populations (PRECISE)

This study is part of the Population-Based Research Optimizing Screening through Personalized Regimens (PROSPR) program, which aims to enhance understanding of the implementation and effects of screening as practiced in multiple, heterogeneous health care environments in the United States. Within this program, proposed research projects must cover long-term observations of diverse cohorts of patients who are eligible for screening. In addition to observational research to evaluate factors that affect the quality of the screening process, projects must also develop and pilot-test interventions aimed at improving the screening process. This study of colorectal cancer screening precision and outcomes will build upon work completed and in progress from the first five years of PROSPR.
Investigator: Corley, Douglas
Funder: National Cancer Institute

Effectiveness of Screening for Colorectal Cancer in Average Risk Adults: Colonoscopy vs. Fecal Immunochemical Test (FIT)

This project will evaluate the effectiveness of screening fecal immunochemical testing (FIT) versus screening colonoscopy in reducing the risk of death from colorectal cancer in average risk men and women who receive their care in community settings. We will also develop new statistical methods to account for levels of adherence to recommended screening intervals when comparing tests.
Investigator: Corley, Douglas
Funder: National Cancer Institute

Comprehensive Colorectal Cancer Risk Prediction to Inform Personalized Screening

The aims of this study are: 1) To build a comprehensive risk-prediction model for colorectal cancer and advanced adenoma in 45,000 colorectal tumors and 45,000 controls based on existing common and rare genome-wide genetic variants, demographic characteristics, and lifestyle and environmental risk factors. 2) To evaluate the risk-prediction models by calibrating and validating the models in the community-based RPGEH cohort and compare it with current screening guidelines and published risk prediction models. 3) To translate abstract risk prediction estimates into individually tailored recommendations that can be used in public health and clinical settings. We will use our developed absolute risk estimates to recommend age to start intervention and the type of screening modality. We will also incorporate a cost-benefit in the decision curve analysis to help clinical decision making.
Investigator: Corley, Douglas
Funder: National Cancer Institute

Kaiser Permanente PROSPR Cervical Cancer Prevention and Screening (CCaPS) Center

The purpose of this project is to expand PROSPR's activities related to screening women for cervical cancer. PROSPR is the National Cancer Institute's Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) consortium. This specific application will extend an existing collaboration between Kaiser Permanente’s Northern and Southern California regions to include data collection and analyses on cervical cancer with co-principal investigators Michael Silverberg (KPNC) and Chun Chao (KPSC).
Investigator: Corley, Douglas
Funder: National Cancer Institute

Retrospective Validation of MeScore for Identification of Colorectal Cancer

The purpose of this study is to assess the efficacy of the computational method MeScore CRC in risk stratification for colorectal cancer in a seemingly healthy population (average risk).
Investigator: Corley, Douglas
Funder: Medial Research

Effectiveness of Screening Colonoscopy in Reducing Deaths from Colorectal Cancer (SCOLAR)

A case-control study to evaluate the associations between commonly performed tests (e.g. colonoscopy) and mortality from colon cancer.
Investigator: Corley, Douglas
Funder: National Cancer Institute

Optimizing Colonoscopy and Fecal Immunochemical Tests for Community-Based Screening, COLOFIT(S)

An evaluation of the entire colorectal cancer screening process to optimize end results. The study includes evaluation of screen-failures (persons who had cancer detected outside of screening), failures of colonoscopy detection (and causes), and differences between screen detected and non-screen detected cancers.
Investigator: Corley, Douglas
Funder: National Cancer Institute

A New Lab-Based Algorithm for HCC Surveillance in Patients with Cirrhosis

The objective of this study is to optimize and test the predictive value of a model in predicting the occurrence of HCC and the performance characteristics of cancer screening tests among patients with cirrhosis and hepatitis C infection.
Investigator: Corley, Douglas
Funder: National Cancer Institute

Long-Term, Prospective, Observational Study of the Risk of Cancer Among Pantoprazole (Protonix) Users

The objective of this study is to determine if there is an increased risk of cancer with pantoprazole (Protonix®), relative to other proton pump inhibitors.
Investigator: Corley, Douglas
Funder: Wyeth-Lederle S.p.A.

Highlighted Publications

Factors Influencing Variation in Physician Adenoma Detection Rates: a Theory-Based Approach for Performance Improvement

Author(s): Atkins L; Hunkeler EM; Jensen CD; Michie S; Lee JK; Doubeni CA; Zauber AG; Levin TR; Quinn VP; Corley DA

Gastrointest Endosc. 2016 Mar;83(3):617-26.e2. Epub 2015-09-11.

Current Position(s):

Section Affiliations:

Studies

NRG Oncology NCORP Research Base - NRG-CC005 FORTE (supplement)

NRG Oncology NCORP Research Base

System-Level Capture of Family History Data to Assess Risk of Cancer and Provide Longitudinal Care Coordination

Gene Dependent Cancer Risk and Optimal Cancer Prevention Strategies in Lynch Syndrome

Validation and Extension of the Michigan Barrett’s Esophagus pREdiction Tool (M-BERET)

Optimizing Colorectal Cancer Screening PREcision and Outcomes in CommunIty-baSEd Populations (PRECISE)

Effectiveness of Screening for Colorectal Cancer in Average Risk Adults: Colonoscopy vs. Fecal Immunochemical Test (FIT)

Comprehensive Colorectal Cancer Risk Prediction to Inform Personalized Screening

Kaiser Permanente PROSPR Cervical Cancer Prevention and Screening (CCaPS) Center

Retrospective Validation of MeScore for Identification of Colorectal Cancer

Effectiveness of Screening Colonoscopy in Reducing Deaths from Colorectal Cancer (SCOLAR)

Optimizing Colonoscopy and Fecal Immunochemical Tests for Community-Based Screening, COLOFIT(S)

A New Lab-Based Algorithm for HCC Surveillance in Patients with Cirrhosis

Long-Term, Prospective, Observational Study of the Risk of Cancer Among Pantoprazole (Protonix) Users

Highlighted Publications

Factors Influencing Variation in Physician Adenoma Detection Rates: a Theory-Based Approach for Performance Improvement

Impact of Endoscopic Surveillance on Mortality from Barrett's Esophagus-Associated Esophageal Adenocarcinomas

Publications

Impact of a scalable training program on the quality of colonoscopy performance and risk of post-colonoscopy colorectal cancer

Test performance metrics for breast, cervical, colon and lung cancer screening: a systematic review

Provider- and Facility-Level Variation in Pre-Cancerous Cervical Biopsy Diagnoses

Overall and Annual Post-Colonoscopy Colorectal Cancer Rates in a Large Integrated Healthcare Setting: A Cross-sectional Study

Risk-stratified screening for colorectal cancer using genetic and environmental risk factors: A cost-effectiveness analysis based on real-world data

Validation of a genetic-enhanced risk prediction model for colorectal cancer in a large community-based cohort

Post-Colonoscopy Colorectal Cancer Etiologies in a Large Integrated US Health Care Setting

Biopsy of Non-tumor Sites After Biopsy of a Colorectal Cancer is not Associated With Metachronous Cancers: A Case-control Study

Gaps in the screening process for women diagnosed with cervical cancer in four diverse US health care settings

Combining Asian-European Genome-Wide Association Studies of Colorectal Cancer Improves Risk Prediction Across Race and Ethnicity

Risk of colorectal cancer and colorectal cancer mortality beginning ten years after a negative colonoscopy, among screen-eligible adults 76-85 years old

Informative presence in electronic health record data: a challenge in implementing study exclusion criteria

Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Limitations to Health Care Quality Measurement: Assessing Hospital Variation in Risk of Cardiac Events After Noncardiac Surgery

Evaluation of Harms Reporting in U.S. Cancer Screening Guidelines

Physician Adenoma Detection Rates and Colorectal Cancer-Reply

Assessment of genetic susceptibility to multiple primary cancers through whole-exome sequencing in two large multi-ancestry studies

Developing Meaningful Health Care Quality Metrics: An Example From Colonoscopy and Adenoma Detection

eQTL set-based association analysis identifies novel susceptibility loci for Barrett's esophagus and esophageal adenocarcinoma

Impact of the COVID-19 pandemic on fecal immunochemical testing, colonoscopy services, and colorectal neoplasia detection in a large United States community-based population

Age-stratified prevalence and predictors of neoplasia among US adults undergoing screening colonoscopy in a national endoscopy registry

Estimating Cancer Screening Sensitivity and Specificity Using Healthcare Utilization Data: Defining the Accuracy Assessment Interval

Evaluating and Improving Cancer Screening Process Quality in a Multilevel Context: The PROSPR II Consortium Design and Research Agenda

Risk of severe clinical outcomes among persons with SARS-CoV-2 infection with differing levels of vaccination during widespread Omicron (B.1.1.529) and Delta (B.1.617.2) variant circulation in Northern California: A retrospective cohort study

Association of Physician Adenoma Detection Rates With Postcolonoscopy Colorectal Cancer

Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort Studies

Declining Colectomy Rates for Nonmalignant Colorectal Polyps in a Large, Ethnically Diverse, Community-based Population

Risk Stratification for Early-Onset Colorectal Cancer Using a Combination of Genetic and Environmental Risk Scores: An International Multi-Center Study

Association between Improved Colorectal Screening and Racial Disparities

The association of bowel function, participation in life activities, and quality of life in rectal cancer survivors

POST-ENDOSCOPY ESOPHAGEAL NEOPLASIA IN BARRETT'S ESOPHAGUS: CONSENSUS STATEMENTS FROM AN INTERNATIONAL EXPERT PANEL

Program components and results from an organized colorectal cancer screening program using annual fecal immunochemical testing

Rising Early-Onset Colorectal Cancer Incidence is Not an Artifact of Increased Screening Colonoscopy Use in a Large, Diverse Healthcare System

Advancing Diversity, Equity, and Inclusion in Scientific Publishing

The learning health system: the tools are here, why aren't we moving forward? Embedding researchers and delivery science for accelerating health care change

Cancer screening in the U.S. through the COVID-19 pandemic, recovery, and beyond

Risk stratification for colorectal cancer in individuals with subtypes of serrated polyps

Validation of the Updated Hepatocellular Carcinoma Early Detection Screening Algorithm in a Community-based Cohort of Patients With Cirrhosis of Multiple Etiologies

The effect of using fecal testing after a negative sigmoidoscopy on the risk of death from colorectal cancer

Editors in Chief, Gastroenterology

Validation of Tools for Predicting Incident Adenocarcinoma of the Esophagus or Esophagogastric Junction

COVID-19: Guidance for What Clinicians and Scientists Should Do and When

Germline variation in the insulin-like growth factor pathway and risk of Barrett's esophagus and esophageal adenocarcinoma

Response to Li and Hopper

Natural language processing for the accurate identification of colorectal cancer mismatch repair status in Lynch syndrome screening

Cancer Screening during COVID-19: A Perspective from NCI's PROSPR consortium

Paradigm-Shifting Research in Gastroenterology, Hepatology, and Nutrition: A Top 20 List of Articles Published in 2020

Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts

Influence of Telemedicine-First Intervention on Patient Visit Choice, Post-Visit Care, and Patient Satisfaction in Gastroenterology

Sex-Specific Genetic Associations for Barrett's Esophagus and Esophageal Adenocarcinoma

Association Between Levels of Hormones and Risk of Esophageal Adenocarcinoma and Barrett's Esophagus

Standardized reporting and management of suspicious findings on chest computed tomography is associated with improved lung cancer diagnosis in an observational study

Early Screening of African Americans (45-50 Years Old) in a Fecal Immunochemical Test-based Colorectal Cancer Screening Program

Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts

Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk

Increased Risk of Colorectal Cancer in Individuals With a History of Serrated Polyps

Association of Azithromycin Use With Cardiovascular Mortality

ANALYSES OF PREVENTIVE CARE MEASURES WITH INCOMPLETE HISTORICAL DATA IN ELECTRONIC MEDICAL RECORDS: AN EXAMPLE FROM COLORECTAL CANCER SCREENING

Validation of an Algorithm to Identify Patients at Risk for Colorectal Cancer Based on Laboratory Test and Demographic Data in Diverse, Community-Based Population