Bruce H. Fireman, MA

People

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3459 (phone)

Kaiser Permanente Researcher Profiles

Bruce Fireman is a biostatistician and research scientist at the Division of Research, Kaiser Permanente Northern California. His research interests include assessment of the effectiveness and safety of vaccines and drugs, and the costs and outcomes of healthcare delivery systems. He works with population-based data, comparing the effectiveness of alternative treatments and alternative ways of delivering healthcare. He has evaluated disease management programs, Web-based care and primary care teams. He has collaborated with Kaiser Permanente clinicians and administrators in efforts to improve health services.

Current Position(s):

Biostatistician III, Division of Research, Kaiser Permanente Northern California

Section Affiliations:

Primary Research Interests:

Outcomes of medical care
Vaccine safety and effectiveness
Costs of care
Survival analysis
Sequential analysis
Exact statistics, permutation tests

Studies

Mini-Sentinel Efforts to Develop the Sentinel Initiative: The Use of Propensity-Score Matching for Estimating Hazard Ratios in Post-Market Surveillance with Heavy Censoring

Mini-Sentinel Task Order
Investigator: Fireman, Bruce
Funder: U.S. Food and Drug Administration

M-S Evaluating the Performance of Mini-Sentinel Analytic Modules Using Simulation Experiments

Investigator: Fireman, Bruce
Funder: U.S. Food and Drug Administration

Methods for Safety Evaluation of Vaccination Schedules

In this project, we will develop, evaluate and illustrate a wide variety of new epidemiological methods for studying the safety of childhood vaccination schedules, with respect to a wide variety of different features and components of the vaccine schedule. These include the timing of individual vaccines; the timing between doses of the same vaccine; the interaction effect between vaccines and concurrent health conditions or pharmaceutical medications; the interaction effects of different vaccines given on the same day; the ordering of different vaccines; and the effect of cumulative summary metrics such as the total number of vaccines or the total amount of some vaccine ingredient. Study designs for the comparative evaluation of one or more complete schedules are also covered. Methods will be developed for both for adverse events with an early onset, which are the easiest to study, and for adverse events with a late onset, including serious chronic conditions.
Investigator: Fireman, Bruce
Funder: National Institute of Allergy and Infectious Diseases

Highlighted Publications

No results found matching criteria

Publications

A broad assessment of covid-19 vaccine safety using tree-based data-mining in the vaccine safety datalink

Author(s): Yih, W Katherine; McClure, David; Maro, Judith C; et al.

Vaccine. 2023 Jan 16;41(3):826-835. Epub 2022-12-16.

Current Position(s):

Section Affiliations:

Primary Research Interests:

Studies

Mini-Sentinel Efforts to Develop the Sentinel Initiative: The Use of Propensity-Score Matching for Estimating Hazard Ratios in Post-Market Surveillance with Heavy Censoring

M-S Evaluating the Performance of Mini-Sentinel Analytic Modules Using Simulation Experiments

Methods for Safety Evaluation of Vaccination Schedules

Highlighted Publications

Publications

A broad assessment of covid-19 vaccine safety using tree-based data-mining in the vaccine safety datalink

A safety study evaluating non-COVID-19 mortality risk following COVID-19 vaccination

Tree-based data mining for safety assessment of first COVID-19 booster doses in the Vaccine Safety Datalink

Early Estimates of Bivalent mRNA Vaccine Effectiveness in Preventing COVID-19-Associated Emergency Department or Urgent Care Encounters and Hospitalizations Among Immunocompetent Adults - VISION Network, Nine States, September-November 2022

Incidence of Myocarditis/Pericarditis Following mRNA COVID-19 Vaccination Among Children and Younger Adults in the United States

Protection of 2 and 3 mRNA Vaccine Doses Against Severe Outcomes Among Adults Hospitalized with COVID-19 - VISION Network, August 2021 - March 2022

Retrospective cohort study to assess the association between treatment with tocilizumab and mortality among mechanically ventilated patients with COVID-19

Prescribing for different antibiotic classes across age groups in the Kaiser Permanente Northern California population in association with influenza incidence, 2010-2018

Effectiveness of COVID-19 mRNA Vaccines Against COVID-19-Associated Hospitalizations Among Immunocompromised Adults During SARS-CoV-2 Omicron Predominance - VISION Network, 10 States, December 2021-August 2022

Maternal SARS-CoV-2 Vaccination and Infant Protection Against SARS-CoV-2 During the First 6 Months of Life

Waning of vaccine effectiveness against moderate and severe covid-19 among adults in the US from the VISION network: test negative, case-control study

Estimation of COVID-19 mRNA Vaccine Effectiveness Against Medically Attended COVID-19 in Pregnancy During Periods of Delta and Omicron Variant Predominance in the United States

Risk of myocarditis and pericarditis following BNT162b2 and mRNA-1273 COVID-19 vaccination

Adults hospitalized with breakthrough COVID-19 have lower mortality than matched unvaccinated adults

Safety of COVID-19 Vaccination in US Children Ages 5-11 Years

Myocarditis and/or pericarditis risk after mRNA COVID-19 vaccination: A Canadian head to head comparison of BNT162b2 and mRNA-1273 vaccines

Effectiveness of 2, 3, and 4 COVID-19 mRNA Vaccine Doses Among Immunocompetent Adults During Periods when SARS-CoV-2 Omicron BA.1 and BA.2/BA.2.12.1 Sublineages Predominated - VISION Network, 10 States, December 2021-June 2022

Lessons from a mature acellular pertussis vaccination program and strategies to overcome suboptimal vaccine effectiveness

Association of Physician Adenoma Detection Rates With Postcolonoscopy Colorectal Cancer

Safety of measles and pertussis-containing vaccines in children with autism spectrum disorders

Effectiveness of Homologous and Heterologous COVID-19 Booster Doses Following 1 Ad.26.COV2.S (Janssen [Johnson & Johnson]) Vaccine Dose Against COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults - VISION Network, 10 States, December 2021-March 2022

Incidence of Guillain-Barré Syndrome After COVID-19 Vaccination in the Vaccine Safety Datalink

Effectiveness of COVID-19 Pfizer-BioNTech BNT162b2 mRNA Vaccination in Preventing COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Nonimmunocompromised Children and Adolescents Aged 5-17 Years - VISION Network, 10 States, April 2021-January 2022

Antibiotic prescribing across age groups in the Kaiser Permanente Northern California population in association with different diagnoses, and with influenza incidence, 2010-2018

Waning 2-Dose and 3-Dose Effectiveness of mRNA Vaccines Against COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance - VISION Network, 10 States, August 2021-January 2022

Self-controlled assessment of thromboembolic event (TEE) risk following intravenous immune globulin (IGIV) in the U.S. (2006-2012)

Effectiveness of a Third Dose of mRNA Vaccines Against COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance - VISION Network, 10 States, August 2021-January 2022

Population-based assessment of risks for severe COVID-19 disease outcomes

Effectiveness of two-dose vaccination with mRNA COVID-19 vaccines against COVID-19-associated hospitalizations among immunocompromised adults-Nine States, January-September 2021

Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination

Effectiveness of 2-Dose Vaccination with mRNA COVID-19 Vaccines Against COVID-19-Associated Hospitalizations Among Immunocompromised Adults - Nine States, January-September 2021

Laboratory-Confirmed COVID-19 Among Adults Hospitalized with COVID-19-Like Illness with Infection-Induced or mRNA Vaccine-Induced SARS-CoV-2 Immunity - Nine States, January-September 2021

Surveillance for Adverse Events After COVID-19 mRNA Vaccination

Effectiveness of Covid-19 Vaccines in Ambulatory and Inpatient Care Settings

Hydrochlorothiazide and risk of melanoma subtypes

COVID-19 Vaccination Coverage Among Insured Persons Aged ≥16 Years, by Race/Ethnicity and Other Selected Characteristics - Eight Integrated Health Care Organizations, United States, December 14, 2020-May 15, 2021

A Risk Score to Predict Clostridioides difficile Infection

Building Predictive Models for Clinical Care-Where to Build and What to Predict?

Individual and Neighborhood Factors Associated with Failure to Vaccinate against Influenza during Pregnancy

Consequences of depletion of susceptibles for hazard ratio estimators based on propensity scores

Conducting prospective sequential surveillance in real-world dynamic distributed databases

Determining Which of Several Simultaneously Administered Vaccines Increase Risk of an Adverse Event

Inpatient-outpatient shared electronic health records: telemedicine and laboratory follow-up after hospital discharge

Evaluation of a Vaccine-Communication Tool for Physicians

Inverse probability weighted Cox model in multi-site studies without sharing individual-level data

Proton Pump Inhibitor Use and Risk of Gastric, Colorectal, Liver, and Pancreatic Cancers in a Community-Based Population

If Influenza Vaccines Wane Can We Delay Vaccination Without Compromising Coverage?

Depletion of Susceptibles Bias in Analyses of Intra-season Waning of Influenza Vaccine Effectiveness

Long-term Risk of Colorectal Cancer and Related Death After Adenoma Removal in a Large, Community-based Population

Association of Mobile Patient Portal Access With Diabetes Medication Adherence and Glycemic Levels Among Adults With Diabetes

Use of Time-Dependent Propensity Scores to Adjust Hazard Ratio Estimates in Cohort Studies with Differential Depletion of Susceptibles

Vaccine effectiveness of cell-culture relative to egg-based inactivated influenza vaccine during the 2017-18 influenza season

A primer on quantitative bias analysis with positive predictive values in research using electronic health data

Depletion-of-susceptibles bias in influenza vaccine waning studies: how to ensure robust results

Haloperidol and Prostate Cancer Prevention: More Epidemiologic Research Needed

Long-term effectiveness of zoster vaccine live for postherpetic neuralgia prevention

Anti-TNF and Physiologic Measures of Metabolic Disease in Rheumatoid Arthritis

Acellular Pertussis Vaccine Effectiveness Over Time

Intra-season Waning of Influenza Vaccine Effectiveness

Privacy-Protecting Analytical Methods Using Only Aggregate-Level Information to Conduct Multivariable-Adjusted Analysis in Distributed Data Networks

Use of three summary measures of pediatric vaccination for studying the safety of the childhood immunization schedule

Long-term Risk of Colorectal Cancer and Related Deaths After a Colonoscopy With Normal Findings

Index colonoscopy-related risk factors for postcolonoscopy colorectal cancers

Potential Effects Of Eliminating The Individual Mandate Penalty In California

Effects of Organized Colorectal Cancer Screening on Cancer Incidence and Mortality in a Large, Community-based Population

Adverse Selection into and within the Individual Health Insurance Market in California in 2014

Comparison of privacy-protecting analytic and data-sharing methods: A simulation study

Relative Performance of Propensity Score Matching Strategies for Subgroup Analyses

Erratum: High-dimensional propensity score adjustment in studies of treatment effects using health care claims data

Birth outcomes following immunization of pregnant women with pandemic H1N1 influenza vaccine 2009-2010

Live Attenuated Influenza Vaccination Prior To Age 3 Years and Subsequent Development of Asthma: A 14-Year Follow-Up Study