Bruce H. Fireman, MA

People

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3459 (phone)

Kaiser Permanente Researcher Profiles

Bruce Fireman is a biostatistician and research scientist at the Division of Research, Kaiser Permanente Northern California. His research interests include assessment of the effectiveness and safety of vaccines and drugs, and the costs and outcomes of healthcare delivery systems. He works with population-based data, comparing the effectiveness of alternative treatments and alternative ways of delivering healthcare. He has evaluated disease management programs, Web-based care and primary care teams. He has collaborated with Kaiser Permanente clinicians and administrators in efforts to improve health services.

Current Position(s):

Biostatistician III, Division of Research, Kaiser Permanente Northern California

Section Affiliations:

Primary Research Interests:

Outcomes of medical care
Vaccine safety and effectiveness
Costs of care
Survival analysis
Sequential analysis
Exact statistics, permutation tests

Studies

Mini-Sentinel Efforts to Develop the Sentinel Initiative: The Use of Propensity-Score Matching for Estimating Hazard Ratios in Post-Market Surveillance with Heavy Censoring

Mini-Sentinel Task Order
Investigator: Fireman, Bruce
Funder: U.S. Food and Drug Administration

M-S Evaluating the Performance of Mini-Sentinel Analytic Modules Using Simulation Experiments

Investigator: Fireman, Bruce
Funder: U.S. Food and Drug Administration

Methods for Safety Evaluation of Vaccination Schedules

In this project, we will develop, evaluate and illustrate a wide variety of new epidemiological methods for studying the safety of childhood vaccination schedules, with respect to a wide variety of different features and components of the vaccine schedule. These include the timing of individual vaccines; the timing between doses of the same vaccine; the interaction effect between vaccines and concurrent health conditions or pharmaceutical medications; the interaction effects of different vaccines given on the same day; the ordering of different vaccines; and the effect of cumulative summary metrics such as the total number of vaccines or the total amount of some vaccine ingredient. Study designs for the comparative evaluation of one or more complete schedules are also covered. Methods will be developed for both for adverse events with an early onset, which are the easiest to study, and for adverse events with a late onset, including serious chronic conditions.
Investigator: Fireman, Bruce
Funder: National Institute of Allergy and Infectious Diseases

Highlighted Publications

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Publications

Effectiveness of Homologous and Heterologous COVID-19 Booster Doses Following 1 Ad.26.COV2.S (Janssen [Johnson & Johnson]) Vaccine Dose Against COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults - VISION Network, 10 States, December 2021-March 2022

Author(s): Natarajan K; Klein NP; Fireman B; Zerbo O; Dixon BE; et al.

MMWR Morb Mortal Wkly Rep. 2022 Apr 01;71(13):495-502. Epub 2022-04-01.

Current Position(s):

Section Affiliations:

Primary Research Interests:

Studies

Mini-Sentinel Efforts to Develop the Sentinel Initiative: The Use of Propensity-Score Matching for Estimating Hazard Ratios in Post-Market Surveillance with Heavy Censoring

M-S Evaluating the Performance of Mini-Sentinel Analytic Modules Using Simulation Experiments

Methods for Safety Evaluation of Vaccination Schedules

Highlighted Publications

Publications

Effectiveness of Homologous and Heterologous COVID-19 Booster Doses Following 1 Ad.26.COV2.S (Janssen [Johnson & Johnson]) Vaccine Dose Against COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults - VISION Network, 10 States, December 2021-March 2022

Incidence of Guillain-Barré Syndrome After COVID-19 Vaccination in the Vaccine Safety Datalink

Safety of measles and pertussis-containing vaccines in children with autism spectrum disorders

Effectiveness of COVID-19 Pfizer-BioNTech BNT162b2 mRNA Vaccination in Preventing COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Nonimmunocompromised Children and Adolescents Aged 5-17 Years - VISION Network, 10 States, April 2021-January 2022

Waning 2-Dose and 3-Dose Effectiveness of mRNA Vaccines Against COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance - VISION Network, 10 States, August 2021-January 2022

Effectiveness of a Third Dose of mRNA Vaccines Against COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance - VISION Network, 10 States, August 2021-January 2022

Effectiveness of two-dose vaccination with mRNA COVID-19 vaccines against COVID-19-associated hospitalizations among immunocompromised adults-Nine States, January-September 2021

Self-controlled assessment of thromboembolic event (TEE) risk following intravenous immune globulin (IGIV) in the U.S. (2006-2012)

Effectiveness of 2-Dose Vaccination with mRNA COVID-19 Vaccines Against COVID-19-Associated Hospitalizations Among Immunocompromised Adults - Nine States, January-September 2021

Laboratory-Confirmed COVID-19 Among Adults Hospitalized with COVID-19-Like Illness with Infection-Induced or mRNA Vaccine-Induced SARS-CoV-2 Immunity - Nine States, January-September 2021

Lessons from a mature acellular pertussis vaccination program and strategies to overcome suboptimal vaccine effectiveness

Effectiveness of Covid-19 Vaccines in Ambulatory and Inpatient Care Settings

Surveillance for Adverse Events After COVID-19 mRNA Vaccination

Population-based assessment of risks for severe COVID-19 disease outcomes

Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination

COVID-19 Vaccination Coverage Among Insured Persons Aged ≥16 Years, by Race/Ethnicity and Other Selected Characteristics - Eight Integrated Health Care Organizations, United States, December 14, 2020-May 15, 2021

Hydrochlorothiazide and risk of melanoma subtypes

A Risk Score to Predict Clostridioides difficile Infection

Building Predictive Models for Clinical Care-Where to Build and What to Predict?

Inpatient-outpatient shared electronic health records: telemedicine and laboratory follow-up after hospital discharge

Consequences of depletion of susceptibles for hazard ratio estimators based on propensity scores

Individual and Neighborhood Factors Associated with Failure to Vaccinate against Influenza during Pregnancy

Determining Which of Several Simultaneously Administered Vaccines Increase Risk of an Adverse Event

Evaluation of a Vaccine-Communication Tool for Physicians

Conducting prospective sequential surveillance in real-world dynamic distributed databases

Proton Pump Inhibitor Use and Risk of Gastric, Colorectal, Liver, and Pancreatic Cancers in a Community-Based Population

Vaccine effectiveness of cell-culture relative to egg-based inactivated influenza vaccine during the 2017-18 influenza season

Association of Mobile Patient Portal Access With Diabetes Medication Adherence and Glycemic Levels Among Adults With Diabetes

Depletion-of-susceptibles bias in influenza vaccine waning studies: how to ensure robust results

Haloperidol and Prostate Cancer Prevention: More Epidemiologic Research Needed

Long-term Risk of Colorectal Cancer and Related Death After Adenoma Removal in a Large, Community-based Population.

Use of Time-Dependent Propensity Scores to Adjust Hazard Ratio Estimates in Cohort Studies with Differential Depletion of Susceptibles

Inverse probability weighted Cox model in multi-site studies without sharing individual-level data

A primer on quantitative bias analysis with positive predictive values in research using electronic health data

Depletion of Susceptibles Bias in Analyses of Intra-season Waning of Influenza Vaccine Effectiveness

Long-term effectiveness of zoster vaccine live for postherpetic neuralgia prevention

If Influenza Vaccines Wane Can We Delay Vaccination Without Compromising Coverage?

Acellular Pertussis Vaccine Effectiveness Over Time

Use of three summary measures of pediatric vaccination for studying the safety of the childhood immunization schedule

Potential Effects Of Eliminating The Individual Mandate Penalty In California

Long-term Risk of Colorectal Cancer and Related Deaths After a Colonoscopy With Normal Findings

Anti-TNF and Physiologic Measures of Metabolic Disease in Rheumatoid Arthritis

Intra-season Waning of Influenza Vaccine Effectiveness

Index colonoscopy-related risk factors for postcolonoscopy colorectal cancers.

An Observational Study of Cardiovascular Risks Associated with Rheumatoid Arthritis Therapies: A Comparison of Two Analytical Approaches

Effects of Organized Colorectal Cancer Screening on Cancer Incidence and Mortality in a Large, Community-based Population.

Comparison of privacy-protecting analytic and data-sharing methods: A simulation study

Privacy-Protecting Analytical Methods Using Only Aggregate-Level Information to Conduct Multivariable-Adjusted Analysis in Distributed Data Networks

Erratum: High-dimensional propensity score adjustment in studies of treatment effects using health care claims data

Adverse Selection into and within the Individual Health Insurance Market in California in 2014

Vaccination Patterns in Children After Autism Spectrum Disorder Diagnosis and in Their Younger Siblings

Relative Performance of Propensity Score Matching Strategies for Subgroup Analyses

Methods for addressing "innocent bystanders" when evaluating safety of concomitant vaccines

Prospective surveillance pilot of rivaroxaban safety within the US Food and Drug Administration Sentinel System

Bias from outcome misclassification in immunization schedule safety research

Long-Term Effectiveness of the Live Zoster Vaccine in Preventing Shingles: A Cohort Study

Prospective Postmarketing Surveillance of Acute Myocardial Infarction in New Users of Saxagliptin: A Population-Based Study

A review of the performance of different methods for propensity score matched subgroup analyses and a summary of their application in peer-reviewed research studies

Birth outcomes following immunization of pregnant women with pandemic H1N1 influenza vaccine 2009-2010

Live Attenuated Influenza Vaccination Prior To Age 3 Years and Subsequent Development of Asthma: A 14-Year Follow-Up Study

Waning protection following 5 doses of a 3-component diphtheria, tetanus, and acellular pertussis vaccine

No association between influenza vaccination during pregnancy and adverse birth outcomes

Effectiveness of Vaccination During Pregnancy to Prevent Infant Pertussis

Association Between Time to Colonoscopy After a Positive Fecal Test Result and Risk of Colorectal Cancer and Cancer Stage at Diagnosis.

Risk factors and familial clustering for fever 7-10 days after the first dose of measles vaccines

Nearly One-Third Of Enrollees In California's Individual Market Missed Opportunities To Receive Financial Assistance

Association Between Influenza Infection and Vaccination During Pregnancy and Risk of Autism Spectrum Disorder

Statins and Reduced Risk of Liver Cancer: Evidence for Confounding

Risk of underlying chronic medical conditions for invasive pneumococcal disease in adults

Evaluation of propensity scores, disease risk scores, and regression in confounder adjustment for the safety of emerging treatment with group sequential monitoring

Pre-visit prioritization for complex patients with Diabetes; Randomized Trial Design and Implementation within an Integrated Health Care system