Bruce H. Fireman, MA

People

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3459 (phone)

Kaiser Permanente Researcher Profiles

Bruce Fireman is a biostatistician and research scientist at the Division of Research, Kaiser Permanente Northern California. His research interests include assessment of the effectiveness and safety of vaccines and drugs, and the costs and outcomes of healthcare delivery systems. He works with population-based data, comparing the effectiveness of alternative treatments and alternative ways of delivering healthcare. He has evaluated disease management programs, Web-based care and primary care teams. He has collaborated with Kaiser Permanente clinicians and administrators in efforts to improve health services.

Current Position(s):

Biostatistician III, Division of Research, Kaiser Permanente Northern California

Section Affiliations:

Primary Research Interests:

Outcomes of medical care
Vaccine safety and effectiveness
Costs of care
Survival analysis
Sequential analysis
Exact statistics, permutation tests

Studies

Mini-Sentinel Efforts to Develop the Sentinel Initiative: The Use of Propensity-Score Matching for Estimating Hazard Ratios in Post-Market Surveillance with Heavy Censoring

Mini-Sentinel Task Order
Investigator: Fireman, Bruce
Funder: U.S. Food and Drug Administration

M-S Evaluating the Performance of Mini-Sentinel Analytic Modules Using Simulation Experiments

Investigator: Fireman, Bruce
Funder: U.S. Food and Drug Administration

Methods for Safety Evaluation of Vaccination Schedules

In this project, we will develop, evaluate and illustrate a wide variety of new epidemiological methods for studying the safety of childhood vaccination schedules, with respect to a wide variety of different features and components of the vaccine schedule. These include the timing of individual vaccines; the timing between doses of the same vaccine; the interaction effect between vaccines and concurrent health conditions or pharmaceutical medications; the interaction effects of different vaccines given on the same day; the ordering of different vaccines; and the effect of cumulative summary metrics such as the total number of vaccines or the total amount of some vaccine ingredient. Study designs for the comparative evaluation of one or more complete schedules are also covered. Methods will be developed for both for adverse events with an early onset, which are the easiest to study, and for adverse events with a late onset, including serious chronic conditions.
Investigator: Fireman, Bruce
Funder: National Institute of Allergy and Infectious Diseases

Highlighted Publications

No results found matching criteria

Publications

Intra-season Waning of Influenza Vaccine Effectiveness

Author(s): Ray GT; Lewis N; Klein NP; Daley MF; Wang SV; Kulldorff M; Fireman B

Clin Infect Dis. 2018 Sep 10.

Current Position(s):

Section Affiliations:

Primary Research Interests:

Studies

Mini-Sentinel Efforts to Develop the Sentinel Initiative: The Use of Propensity-Score Matching for Estimating Hazard Ratios in Post-Market Surveillance with Heavy Censoring

M-S Evaluating the Performance of Mini-Sentinel Analytic Modules Using Simulation Experiments

Methods for Safety Evaluation of Vaccination Schedules

Highlighted Publications

Publications

Intra-season Waning of Influenza Vaccine Effectiveness

Index colonoscopy-related risk factors for postcolonoscopy colorectal cancers.

An Observational Study of Cardiovascular Risks Associated with Rheumatoid Arthritis Therapies: A Comparison of Two Analytical Approaches

Effects of Organized Colorectal Cancer Screening on Cancer Incidence and Mortality in a Large, Community-based Population.

Comparison of privacy-protecting analytic and data-sharing methods: A simulation study

Erratum: High-dimensional propensity score adjustment in studies of treatment effects using health care claims data

Adverse Selection into and within the Individual Health Insurance Market in California in 2014

Vaccination Patterns in Children After Autism Spectrum Disorder Diagnosis and in Their Younger Siblings

Relative Performance of Propensity Score Matching Strategies for Subgroup Analyses

Methods for addressing "innocent bystanders" when evaluating safety of concomitant vaccines

Prospective surveillance pilot of rivaroxaban safety within the US Food and Drug Administration Sentinel System

Bias from outcome misclassification in immunization schedule safety research

Long-Term Effectiveness of the Live Zoster Vaccine in Preventing Shingles: A Cohort Study

Prospective Postmarketing Surveillance of Acute Myocardial Infarction in New Users of Saxagliptin: A Population-Based Study

A review of the performance of different methods for propensity score matched subgroup analyses and a summary of their application in peer-reviewed research studies

Birth outcomes following immunization of pregnant women with pandemic H1N1 influenza vaccine 2009-2010

Live Attenuated Influenza Vaccination Prior To Age 3 Years and Subsequent Development of Asthma: A 14-Year Follow-Up Study

Waning protection following 5 doses of a 3-component diphtheria, tetanus, and acellular pertussis vaccine

No association between influenza vaccination during pregnancy and adverse birth outcomes

Effectiveness of Vaccination During Pregnancy to Prevent Infant Pertussis

Association Between Time to Colonoscopy After a Positive Fecal Test Result and Risk of Colorectal Cancer and Cancer Stage at Diagnosis.

Risk factors and familial clustering for fever 7-10 days after the first dose of measles vaccines

Nearly One-Third Of Enrollees In California's Individual Market Missed Opportunities To Receive Financial Assistance

Association Between Influenza Infection and Vaccination During Pregnancy and Risk of Autism Spectrum Disorder

Statins and Reduced Risk of Liver Cancer: Evidence for Confounding

Risk of underlying chronic medical conditions for invasive pneumococcal disease in adults

Evaluation of propensity scores, disease risk scores, and regression in confounder adjustment for the safety of emerging treatment with group sequential monitoring

Pre-visit prioritization for complex patients with Diabetes; Randomized Trial Design and Implementation within an Integrated Health Care system

Lack of association between childhood immunizations and encephalitis in California, 1998-2008

The introduction of generic risperidone in Medicare Part D

A Description of Midlife Women Experiencing Intimate Partner Violence Using Electronic Medical Record Information

TWO AUTHORS REPLY

Network meta-analysis incorporating randomized controlled trials and non-randomized comparative cohort studies for assessing the safety and effectiveness of medical treatments: challenges and opportunities

Intravenous immune globulin and thromboembolic adverse events in patients with hematologic malignancy

Immune mediated conditions in autism spectrum disorders

A Vaccine Study Design Selection Framework for the Postlicensure Rapid Immunization Safety Monitoring Program

Balancing Score Adjusted Targeted Minimum Loss-based Estimation

Safety of Measles-Containing Vaccines in 1-Year-Old Children

Adjusting for Patient Demographics Has Minimal Effects on Rates of Adenoma Detection in a Large, Community-based Setting

Integrating database knowledge and epidemiological design to improve the implementation of data mining methods that evaluate vaccine safety in large healthcare databases

Impact of Vaccination on the Epidemiology of Varicella: 1995-2009

Adenoma detection rate and risk of colorectal cancer and death

Effect of Age on the Risk of Fever and Seizures Following Immunization With Measles-Containing Vaccines in Children

Do Medicare Advantage plans select enrollees in higher margin clinical categories?

Multivariable confounding adjustment in distributed data networks without sharing of patient-level data

Impact of Specific Glucose-Control Strategies on Microvascular and Macrovascular Outcomes in 58,000 Adults With Type 2 Diabetes

Targeted maximum likelihood estimation in safety analysis

Confounding adjustment in comparative effectiveness research conducted within distributed research networks

Super learning to hedge against incorrect inference from arbitrary parametric assumptions in marginal structural modeling

Long-term Effectiveness of Varicella Vaccine: A 14-Year, Prospective Cohort Study

Lack of Association of Guillain-Barre Syndrome with Vaccinations

Variation of Adenoma Prevalence by Age, Sex, Race, and Colon Location in a Large Population: Implications for Screening and Quality Programs

A Web-Delivered Care Management and Patient Self-Management Program for Recurrent Depression: A Randomized Trial

Safety of Zostavax-A cohort study in a managed care organization

Outpatient electronic health records and the clinical care and outcomes of patients with diabetes mellitus

Waning protection after fifth dose of acellular pertussis vaccine in children

Biologically plausible and evidence-based risk intervals in immunization safety research

Improving treatment intensification to reduce cardiovascular disease risk: a cluster randomized trial

Risk of Confirmed Guillain-Barre Syndrome Following Receipt of Monovalent Inactivated Influenza A (H1N1) and Seasonal Influenza Vaccines in the Vaccine Safety Datalink Project, 2009-2010

Dynamic marginal structural modeling to evaluate the comparative effectiveness of more or less aggressive treatment intensification strategies in adults with type 2 diabetes

Safety of Zoster Vaccine in Adults from a Large Managed Care Cohort: A Vaccine Safety Datalink Study

Measles-Containing Vaccines and Febrile Seizures in Children Age 4 to 6 Years

Immunization and Bell's Palsy in Children: A Case-Centered Analysis

Rowhani-Rahbar et al. Respond to 'Immunization and Bell's Palsy in Children'

When should case-only designs be used for safety monitoring of medical products?

Design considerations in an active medical product safety monitoring system

Challenges in the design and analysis of sequentially monitored postmarket safety surveillance evaluations using electronic observational health care data

A protocol for active surveillance of acute myocardial infarction in association with the use of a new antidiabetic pharmaceutical agent

ADHD medications and risk of serious cardiovascular events in young and middle-aged adults

ADHD drugs and serious cardiovascular events in children and young adults

Monitoring the safety of quadrivalent human papillomavirus vaccine: Findings from the Vaccine Safety Datalink