Paola Gilsanz, ScD

Race/ethnicity and Environmental Stressors: POtential drivers of Dementia and stroke inequities (RESPOnD)

Time-varying exposome metrics will be linked to residential addresses during mid-adulthood to develop high spatio-temporal resolution exposome metrics in 3 cohorts: Kaiser Healthy Aging and Diverse Life Experiences, the Study of Healthy Aging in African Americans, and Reasons for Geographic and Racial Differences in Stroke.  The study will quantify how environmental stressors are associated with vascular risk factors of dementia; quantify how environmental stressors are associated with cognitive level, cognitive decline, neuroimaging biomarkers; and estimate total reduction in the burden of stroke and Alzheimer€™s Disease and Related Dementias that might be achieved by joint interventions on environmental stressors and vascular risk factors of dementia in midlife.

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Investigator: Gilsanz, Paola

Funder: National Institute of Neurological Disorders and Stroke

Improving Causal Inference in Alzheimer’s Disease Prevention Research on Modifiable Risk Factors: The Triangulation of Innovative Methods to EndAD (TIME-AD) Project: Project 4. Social Isolation

The TIME-AD project aims to systematically compare results from different study populations and designs to better estimate the impact of various modifiable risk factors on dementia including social isolation, alcohol use, visual and hearing impairments, depression and chronic pain.

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Investigator: Gilsanz, Paola

Funder: National Institute on Aging

Study of Healthy Aging in African Americans

Study of Healthy Aging in African Americans
The Study of Healthy Aging in African Americans (STAR), initiated in 2018, is an ongoing cohort of Black or African American individuals examining lifecourse risk and protective factors of cognitive aging. Goals of the study are to understand the trajectory of normal cognitive aging from midlife to late life, the burden of cognitive impairment among this population, and identify risk and protective factors related to healthy brain aging among Black and African American individuals, an understudied and rapidly expanding segment of the elderly population at higher risk for dementia.
Funder: National Institute on Aging

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Investigator: Gilsanz, Paola

Funder: National Institute on Aging

Brain pathologies, reserve, and cognition in aging and dementia

This study is examining racial/ethnic group similarities and differences in brain mechanisms underlying cognitive reserve and functional reserve, and their life course determinants, by conducting secondary data analysis and harmonization of existing data from 4 ongoing longitudinal studies: Alzheimer’s Disease Center cohort at UCD, KHANDLE at DOR/UCD, STAR at DOR/UCD, and LA 90 at DOR/UCD. The combined data from these 4 studies will be used to examine MRI derived brain imaging variables associated with cognitive and functional decline; develop measures of functional reserve; examine potentially modifiable factors measured in mid-life that can build cognitive and functional reserve and promote cognitive health and functional independence.

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Investigator: Gilsanz, Paola

Funder: National Institute on Aging

Epidemiology of Age-related Dementia, Mild Cognitive Impairment and Brain Pathology in a Multiethnic Cohort of Oldest-Old

The LifeAfter90 Study (LA90) is a collaborative study between DOR, UC Davis, and UC Irvine following a diverse cohort of approximately 1,000 KPNC members age 90 and over to examine life course risk factors of cognitive decline and dementia risk. This study is evaluating differences in dementia incidence and rate of cognitive decline by race/ethnicity; evaluating how life course experiences are related to dementia incidence and cognitive decline; and examining life course factors associated with biomarkers from braining imaging and pathology. In 2022, we intend to begin to enroll an additional 500 KPNC members age 90 and over.

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Investigator: Gilsanz, Paola

Funder: National Institute on Aging

Lifecourse health, cerebral pathology and ethnic disparities in dementia (KHANDLE Study)

The Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) Study, a collaborative study between DOR and UC Davis, follows a diverse cohort of Kaiser Permanente Northern California members who participated in at least one optional check-up (Multiphasic Health Checkups) during midlife. This study is evaluating differences in dementia incidence and rate of cognitive decline across racial/ethnic group and sexes. It uses over five decades of data to examine how early life experience, life course health, and genetics influence differences in cognitive decline and dementia by race/ethnicity and sex.

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Investigator: Gilsanz, Paola

Funder: National Institute on Aging

Glycemic Control and Dementia: The Role of Pharmacotherapy and Vascular Complications

About 25% of people over the age of 65 are living with diabetes, with 90% of them managing type 2 diabetes. Studies have shown that older individuals with type 2 diabetes have a 51-62% higher risk of dementia than those without type 2 diabetes. This study will investigate factors for dementia among Kaiser Permanente Northern California individuals with type 2 diabetes to determine which pattern of glycemic control reduces dementia risk, adjusting for factors such as diabetes treatment and comorbidities.

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Investigator: Gilsanz, Paola

Contributions of Educational Quality and Occupational Complexity on Racial and Ethnic Inequities in Brain Health and Alzheimer’s Disease and Related Dementia

This study utilizes a lifecourse approach to evaluate the roles of education quality and occupational complexity on dementia risk and cognitive decline and to examine if patterns of educational quality and occupational complexity across the lifecourse drive racial and ethnic disparities present in dementia and late-life brain health. This study leverages information from the Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) study, which follows a diverse group of long-term members of Kaiser Permanente Northern California to evaluate the role of lifecourse health on cognitive decline, dementia, and brain imaging markers.

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Investigator: Gilsanz, Paola

Funder: National Institute on Aging

The Importance of Racially and Ethnically Inclusive Gait Speed Reference Values in Individuals 90 Years and Older: LifeAfter90

Authors: Colcord, Katherine A;Gilsanz, Paola;George, Kristen M;Kawas, Claudia H;Jiang, Luohua;Whitmer, Rachel A;Corrada, María M

J Geriatr Phys Ther. 2024 Oct-Dec 01;47(4):202-213. Epub 2024-09-18.

PubMed abstract

Gender differences in the association between education and late-life cognitive function in the LifeAfter90 Study: A multiethnic cohort of the oldest-old

Authors: Lam, Jennifer O;Whitmer, Rachel A;Corrada, Maria M;Kawas, Claudia H;Vieira, Katherine E;Quesenberry, Charles P;Gilsanz, Paola

Alzheimers Dement. 2024 Sep 10.

PubMed abstract

Heterogeneity in the effect of type 2 diabetes on dementia incidence in a diverse cohort of Asian American and non-Latino White older adults

Authors: Hayes-Larson, Eleanor;Zhou, Yixuan;Wu, Yingyan;Mobley, Taylor M;Gee, Gilbert C;Brookmeyer, Ron;Whitmer, Rachel A;Gilsanz, Paola;Kanaya, Alka M;Mayeda, Elizabeth Rose

Am J Epidemiol. 2024 Sep 03;193(9):1261-1270.

PubMed abstract

Life course financial mobility and later-life memory function and decline by gender, and race and ethnicity: an intersectional analysis of the US KHANDLE and STAR cohort studies

Authors: Kobayashi, Lindsay C;Peterson, Rachel L;Yu, Xuexin;Avila-Rieger, Justina;Amofa-Ho, Priscilla A;Vila-Castelar, Clara;Meza, Erika;Shaaban, C Elizabeth;Whitmer, Rachel A;Gilsanz, Paola;Mayeda, Elizabeth Rose

Lancet Healthy Longev. 2024 Sep;5(9):100613. Epub 2024-08-30.

PubMed abstract

HbA1c variability associated with dementia risk in people with type 2 diabetes

Authors: Moran, Chris;Whitmer, Rachel A;Dove, Zoe;Lacy, Mary E;Soh, Yenee;Tsai, Ai-Lin;Quesenberry, Charles P;Karter, Andrew J;Adams, Alyce S;Gilsanz, Paola

Alzheimers Dement. 2024 Aug;20(8):5561-5569. Epub 2024-07-03.

PubMed abstract

School-based racial segregation, social support, and late-life cognitive function in the Study of Healthy Aging in African Americans (STAR)

Authors: Gutierrez, Sirena;Gilsanz, Paola;Gilsanz, Paola;et al.

Alzheimers Dement. 2024 Jul 25.

PubMed abstract

Estimating dementia incidence in insured older Asian Americans and Pacific Islanders in California: an application of inverse odds of selection weights

Authors: Hayes-Larson, Eleanor;Zhou, Yixuan;Wu, Yingyan;Rojas-Saunero, Paloma L;Seamans, Marissa J;Gee, Gilbert C;Brookmeyer, Ron;Gilsanz, Paola;Whitmer, Rachel A;Mayeda, Elizabeth Rose

Am J Epidemiol. 2024 Jul 05.

PubMed abstract

School racial composition, effect modification by caring teacher/staff presence, and mid/late-life depressive symptoms: findings from the Study of Healthy Aging among African Americans

Authors: Mobley, Taylor M;Hayes-Larson, Eleanor;Wu, Yingyan;Peterson, Rachel L;George, Kristen M;Gilsanz, Paola;Glymour, M Maria;Thomas, Marilyn D;Barnes, Lisa L;Whitmer, Rachel A;Mayeda, Elizabeth Rose

Am J Epidemiol. 2024 Apr 17.

PubMed abstract

The Association Between Physical Activity and Cognition in a Racially/Ethnically Diverse Cohort of Older Adults: Results From the Kaiser Healthy Aging and Diverse Life Experiences Study

Authors: Almeida, Mariana L;Gilsanz, Paola;Glymour, M Maria;et al.

Alzheimer Dis Assoc Disord. 2024 Mar 27.

PubMed abstract

Racial and ethnic differences in the association between depressive symptoms and cognitive outcomes in older adults: Findings from KHANDLE and STAR

Authors: Jimenez, Marcia P;Gilsanz, Paola;Glymour, Medellena Maria;et al.

Alzheimers Dement. 2024 Mar 13.

PubMed abstract

Racial and Ethnic Variation in Dementia Prevalence in a Diverse Cohort of Adults with Hip Fracture

Authors: Lee, David R;Lo, Joan C;Chandra, Malini;Lee, Catherine;Gilsanz, Paola

J Gen Intern Med. 2024 Mar;39(4):716-719. Epub 2023-12-24.

PubMed abstract

Race, community disadvantage, and cognitive decline: Findings from KHANDLE and STAR

Authors: Peterson, Rachel L;Pejak, Rebecca;George, Kristen M;Gilsanz, Paola;Ko, Michelle;Meyer, Oanh L;Mayeda, Elizabeth Rose;Kind, Amy;Whitmer, Rachel A

Alzheimers Dement. 2024 Feb;20(2):904-913. Epub 2023-10-10.

PubMed abstract

Evaluation of racial and ethnic heterogeneity in the associations of sleep quality and sleep apnea risk with cognitive function and cognitive decline

Authors: Chen, Ruijia;Gilsanz, Paola;Glymour, M Maria;et al.

Alzheimers Dement (N Y). 2024 Jan-Mar;10(1):e12441. Epub 2024-02-11.

PubMed abstract

Timing and level of educational attainment and late-life cognition in the KHANDLE study

Authors: Soh, Yenee;Quesenberry, Charles P;Gilsanz, Paola;Gilsanz, Paola;et al.

Alzheimers Dement. 2024 Jan;20(1):593-600. Epub 2023-09-26.

PubMed abstract

Low- and High-Density Lipoprotein Cholesterol and Dementia Risk Over 17 Years of Follow-up Among Members of a Large Health Care Plan

Authors: Ferguson, Erin L;Gilsanz, Paola;Schaefer, Catherine A;Glymour, M Maria;et al.

Neurology. 2023 Nov 21;101(21):e2172-e2184. Epub 2023-10-04.

PubMed abstract

What is the association between adverse childhood experiences and late-life cognitive decline? Study of Healthy Aging in African Americans (STAR) cohort study

Authors: Lor, Yi;George, Kristen M;Gilsanz, Paola;Meunier, Claire C;Peterson, Rachel L;Hayes-Larson, Eleanor;Barnes, Lisa L;Mungas, Dan;Whitmer, Rachel A

BMJ Open. 2023 Nov 02;13(11):e072961. Epub 2023-11-02.

PubMed abstract

Metformin Cessation and Dementia Incidence

Authors: Zimmerman, Scott C;Whitmer, Rachel A;Gilsanz, Paola;Schaefer, Catherine;Ackley, Sarah F;et al.

JAMA Netw Open. 2023 Oct 02;6(10):e2339723. Epub 2023-10-02.

PubMed abstract

Association of primary lifetime occupational cognitive complexity and cognitive decline in a diverse cohort: Results from the KHANDLE study

Authors: Soh, Yenee;Eng, Chloe W;Mayeda, Elizabeth Rose;Whitmer, Rachel A;Lee, Catherine;Peterson, Rachel L;Mungas, Dan M;Glymour, M Maria;Gilsanz, Paola

Alzheimers Dement. 2023 Sep;19(9):3926-3935. Epub 2023-04-14.

PubMed abstract

Pragmatic approaches to handling practice effects in longitudinal cognitive aging research

Authors: Chen, Ruijia;Mayeda, Elizabeth Rose;Glymour, M Maria;et al.

Alzheimers Dement. 2023 Sep;19(9):4028-4036. Epub 2023-05-18.

PubMed abstract

Glycemic Control Over Multiple Decades and Dementia Risk in People With Type 2 Diabetes

Authors: Moran, Chris;Lacy, Mary E;Whitmer, Rachel A;Tsai, Ai-Lin;Quesenberry, Charles P;Karter, Andrew J;Adams, Alyce S;Gilsanz, Paola

JAMA Neurol. 2023 Jun 01;80(6):597-604.

PubMed abstract

Undiagnosed Cognitive Impairment and Impact on Instrumental Activities of Daily Living Among People With HIV Infection in Primary Care

Authors: Lam, Jennifer O;Hou, Craig E;Gilsanz, Paola;Lee, Catherine;Lea, Alexandra N;Satre, Derek D;Silverberg, Michael J

Open Forum Infect Dis. 2023 Jun;10(6):ofad284. Epub 2023-05-20.

PubMed abstract

Assessing cognitive impairment in an ethnically diverse cohort of oldest-old: the life after 90 study

Authors: Petrosyan, Diana; Gilsanz, Paola; DeCarli, Charles; et al.

Aging Clin Exp Res. 2023 May;35(5):979-986. Epub 2023-03-04.

PubMed abstract

Association of Early Adulthood Hypertension and Blood Pressure Change With Late-Life Neuroimaging Biomarkers

Authors: George, Kristen M;Maillard, Pauline;DeCarli, Charles;Whitmer, Rachel A;et al.

JAMA Netw Open. 2023 Apr 03;6(4):e236431. Epub 2023-04-03.

PubMed abstract

State-Level Indicators of Childhood Educational Quality and Incident Dementia in Older Black and White Adults

Authors: Soh, Yenee; Whitmer, Rachel A; Mayeda, Elizabeth Rose; Glymour, M Maria; Peterson, Rachel L; Eng, Chloe W; Quesenberry, Charles P; Manly, Jennifer J; Gilsanz, Paola

JAMA Neurol. 2023 Apr 01;80(4):352-359.

PubMed abstract

Association of Education With Dementia Incidence Stratified by Ethnicity and Nativity in a Cohort of Older Asian American Individuals

Authors: Hayes-Larson, Eleanor; Ikesu, Ryo; Fong, Joseph; Mobley, Taylor M; Gee, Gilbert C; Brookmeyer, Ron; Whitmer, Rachel A; Gilsanz, Paola; Mayeda, Elizabeth Rose

JAMA Netw Open. 2023 Mar 01;6(3):e231661. Epub 2023-03-01.

PubMed abstract

The impact of attending historically Black colleges and universities on cognitive decline in Black adults: A longitudinal analysis in the KHANDLE and STAR cohorts

Authors: Thomas, Marilyn D; Calmasini, Camilla; Khela, Harmon; Mobley, Taylor M; Mayeda, Elizabeth Rose; Mangurian, Christina; Barnes, Lisa L; Gilsanz, Paola; Whitmer, Rachel A; Glymour, M Maria

Alzheimers Dement. 2023 Feb 17.

PubMed abstract

Evaluating interpersonal discrimination and depressive symptoms as partial mediators of the effects of education on cognition: Evidence from the Study of Healthy Aging in African Americans (STAR)

Authors: Cintron, Dakota W; Calmasini, Camilla; Barnes, Lisa L; Mungas, Dan M; Whitmer, Rachel A; Eng, Chloe W; Gilsanz, Paola; George, Kristen M; Peterson, Rachel L; Glymour, M Maria

Alzheimers Dement. 2023 Feb 01.

PubMed abstract

Rural residence across the life course and late-life cognitive decline in KHANDLE: A causal inference study

Authors: Peterson, Rachel L; Gilsanz, Paola; Lor, Yi; George, Kristen M; Ko, Michelle; Wagner, Jenny; Soh, Yenee; Meyer, Oanh L; Glymour, M Maria; Whitmer, Rachel A

Alzheimers Dement (Amst). 2023 Jan-Mar;15(1):e12399. Epub 2023-02-03.

PubMed abstract

Neighborhood disadvantage and dementia incidence in a cohort of Asian American and non-Latino White older adults in Northern California

Authors: Mobley, Taylor M; Shaw, Crystal; Hayes-Larson, Eleanor; Fong, Joseph; Gilsanz, Paola; Gee, Gilbert C; Brookmeyer, Ron; Whitmer, Rachel A; Casey, Joan A; Mayeda, Elizabeth Rose

Alzheimers Dement. 2023 Jan;19(1):296-306. Epub 2022-04-06.

PubMed abstract

Generation and age of immigration on later life cognitive performance in KHANDLE

Authors: Meyer, Oanh L; Eng, Chloe W; Ko, Michelle J; Chan, Michelle L; Ngo, Uyen; Gilsanz, Paola; Glymour, M Maria; Mayeda, Elizabeth Rose; Mungas, Dan M; Whitmer, Rachel A

Int Psychogeriatr. 2023 Jan;35(1):17-28. Epub 2020-12-23.

PubMed abstract

Consideration of sex and gender in Alzheimer’s disease and related disorders from a global perspective

Authors: Mielke, Michelle M; Gilsanz, Paola; Diversity and Disparity Professional Interest Area Sex and Gender Special Interest Group,; et al.

Alzheimers Dement. 2022 Dec;18(12):2707-2724. Epub 2022-04-08.

PubMed abstract

Accounting for lack of representation in dementia research: Generalizing KHANDLE study findings on the prevalence of cognitive impairment to the California older population

Authors: Hayes-Larson, Eleanor; Mobley, Taylor M; Mungas, Dan; Seamans, Marissa J; Glymour, M Maria; Gilsanz, Paola; DeCarli, Charles; Whitmer, Rachel A; Mayeda, Elizabeth Rose

Alzheimers Dement. 2022 Nov;18(11):2209-2217. Epub 2022-02-01.

PubMed abstract

Association of Social Integration with Cognitive Status in a Multi-Ethnic Cohort: Results From the Kaiser Healthy Aging and Diverse Life Experiences Study

Authors: Calmasini, Camilla; Swinnerton, Kaitlin N; Zimmerman, Scott C; Peterson, Rachel L; George, Kristen M; Gilsanz, Paola; Hayes-Larson, Eleanor; Mayeda, Elizabeth Rose; Mungas, Dan M; Whitmer, Rachel A; Glymour, Medellena Maria

J Geriatr Psychiatry Neurol. 2022 11;35(6):789-799. Epub 2022-01-25.

PubMed abstract

The role of nativity in heterogeneous dementia incidence in a large cohort of three Asian American groups and white older adults in California

Authors: Hayes-Larson, Eleanor; Fong, Joseph; Mobley, Taylor M; Gilsanz, Paola; Whitmer, Rachel A; Gee, Gilbert C; Brookmeyer, Ron; Mayeda, Elizabeth Rose

Alzheimers Dement. 2022 Aug;18(8):1580-1585. Epub 2022-02-01.

PubMed abstract

Prevalence of Instrumental Activities of Daily Living (IADL) Difficulties and Associated Cognitive Predictors Across Racial/Ethnic Groups: Findings from the KHANDLE Study

Authors: Chan, Michelle L; Eng, Chloe W; Gilsanz, Paola; Whitmer, Rachel A; Mungas, Dan; Meyer, Oanh; Farias, Sarah Tomaszewski

J Gerontol B Psychol Sci Soc Sci. 2022 05 05;77(5):885-894.

PubMed abstract

Comparison of dementia incidence and prevalence between individuals with and without HIV infection in primary care from 2000 to 2016

Authors: Lam, Jennifer O; Lee, Catherine; Gilsanz, Paola; Hou, Craig E; Leyden, Wendy A; Satre, Derek D; Flamm, Jason A; Towner, William J; Horberg, Michael A; Silverberg, Michael J

AIDS. 2022 03 01;36(3):437-445.

PubMed abstract

Comparison of cognitive function in older adults with type 1 diabetes, type 2 diabetes, and no diabetes: results from the Study of Longevity in Diabetes (SOLID)

Authors: Lacy, Mary E; Moran, Chris; Gilsanz, Paola; Beeri, Michal S; Karter, Andrew J; Whitmer, Rachel A

BMJ Open Diabetes Res Care. 2022 03;10(2).

PubMed abstract

Perceived Discrimination, Nativity, and Cognitive Performance in a Multi-ethnic Study of Older Adults: Findings from the Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) Study

Authors: Meza, Erika; Peterson, Rachel; Gilsanz, Paola; George, Kristen M; Miles, Sunita J; Eng, Chloe W; Mungas, Dan M; Mayeda, Elizabeth Rose; Glymour, M Maria; Whitmer, Rachel A

J Gerontol A Biol Sci Med Sci. 2022 02 03;77(2):e65-e73.

PubMed abstract

Measuring cognitive health in ethnically diverse older adults

Authors: Hernandez Saucedo, Hector; Whitmer, Rachel A; Glymour, Maria; DeCarli, Charles; Mayeda, Elizabeth-Rose; Gilsanz, Paola; Miles, Sunita Q; Bhulani, Nihal; Farias, Sarah Tomaszewski; Olichney, John; Mungas, Dan

J Gerontol B Psychol Sci Soc Sci. 2022 02 03;77(2):261-271.

PubMed abstract

Marginal structural models for life-course theories and social epidemiology: Definitions, sources of bias, and simulated illustrations

Authors: Gilsanz, Paola; Young, Jessica G; Glymour, M Maria; Tchetgen Tchetgen, Eric J; Eng, Chloe W; Koenen, Karestan C; Kubzansky, Laura D

Am J Epidemiol. 2022 01 24;191(2):349-359.

PubMed abstract

Stroke Belt Birth State and Late-life Cognition in The Study of Healthy Aging in African Americans (STAR)

Authors: George, Kristen M; Peterson, Rachel L; Gilsanz, Paola; Barnes, Lisa L; Mayeda, Elizabeth Rose; Glymour, M Maria; Mungas, Dan M; DeCarli, Charles S; Whitmer, Rachel A

Ann Epidemiol. 2021 12;64:26-32. Epub 2021-09-09.

PubMed abstract

Association of Timing of School Desegregation in the United States With Late-Life Cognition in the Study of Healthy Aging in African Americans (STAR) Cohort

Authors: Peterson, Rachel L; George, Kristen M; Barnes, Lisa L; Gilsanz, Paola; Mayeda, Elizabeth Rose; Glymour, M Maria; Mungas, Dan M; Whitmer, Rachel A

JAMA Netw Open. 2021 10 01;4(10):e2129052. Epub 2021-10-01.

PubMed abstract

Impact of Cardiovascular Risk Factors in Adolescence, Young Adulthood, and Midlife on Late-Life Cognition: Study of Healthy Aging in African Americans

Authors: George, Kristen M; Gilsanz, Paola; Peterson, Rachel L; Barnes, Lisa L; DeCarli, Charles S; Mayeda, Elizabeth Rose; Mungas, Dan M; Whitmer, Rachel A

J Gerontol A Biol Sci Med Sci. 2021 08 13;76(9):1692-1698.

PubMed abstract

Operationalizing Social Environments in Cognitive Aging and Dementia Research: A Scoping Review

Authors: Peterson, Rachel L; George, Kristen M; Tran, Duyen; Malladi, Pallavi; Gilsanz, Paola; Kind, Amy J H; Whitmer, Rachel A; Besser, Lilah M; Meyer, Oanh L

Int J Environ Res Public Health. 2021 07 04;18(13). Epub 2021-07-04.

PubMed abstract

Participant education, spousal education and dementia risk in a diverse cohort of members of an integrated health care delivery system in Northern California

Authors: Gilsanz, Paola; Mayeda, Elizabeth Rose; Eng, Chloe W; Meyer, Oanh L; Glymour, M Maria; Quesenberry, Charles P; Whitmer, Rachel A

BMJ Open. 2021 06 18;11(6):e040233. Epub 2021-06-18.

PubMed abstract

Association of Type 1 Diabetes and Hypoglycemic and Hyperglycemic Events and Risk of Dementia

Authors: Whitmer, Rachel A; Gilsanz, Paola; Quesenberry, Charles P; Karter, Andrew J; Lacy, Mary E

Neurology. 2021 Jun 02.

PubMed abstract

Impact of Cardiovascular Risk Factors in Adolescence, Young Adulthood, and Midlife on Late-life Cognition: Study of Healthy Aging in African Americans (STAR)

Authors: George, Kristen M; Gilsanz, Paola; Peterson, Rachel L; Barnes, Lisa L; DeCarli, Charles S; Mayeda, Elizabeth Rose; Mungas, Dan M; Whitmer, Rachel A

J Gerontol A Biol Sci Med Sci. 2021 May 18.

PubMed abstract

Lifecourse socioeconomic changes and late-life cognition in a cohort of U.S.-born and U.S. immigrants: findings from the KHANDLE study

Authors: Peterson, Rachel L; George, Kristen M; Gilsanz, Paola; Mayeda, Elizabeth Rose; Glymour, M Maria; Meyer, Oanh L; Mungas, Dan M; DeCarli, Charles; Whitmer, Rachel A

BMC Public Health. 2021 05 13;21(1):920. Epub 2021-05-13.

PubMed abstract

Temporal Trends in Stroke-Related Memory Change: Results From a US National Cohort 1998-2016

Authors: Eng, Chloe W; Mayeda, Elizabeth R; Gilsanz, Paola; Whitmer, Rachel A; Kim, Anthony S; Glymour, M Maria

Stroke. 2021 05;52(5):1702-1711. Epub 2021-03-16.

PubMed abstract

Comparison of dementia risk after age 50 between individuals with and without HIV infection

Authors: Lam, Jennifer O; Hou, Craig E; Hojilla, J Carlo; Anderson, Alexandra N; Gilsanz, Paola; Alexeeff, Stacey E; Levine-Hall, Tory; Hood, Nicole; Lee, Catherine; Satre, Derek D; Silverberg, Michael J

AIDS. 2021 04 01;35(5):821-828.

PubMed abstract

Racial/Ethnic Disparities in Young Adulthood and Midlife Cardiovascular Risk Factors and Late-life Cognitive Domains: The Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) Study

Authors: Peterson, Rachel L; George, Kristen M; Gilsanz, Paola; Ackley, Sarah; Mayeda, Elizabeth R; Glymour, M M; Mungas, Dan M; DeCarli, Charles; Whitmer, Rachel A

Alzheimer Dis Assoc Disord. 2021 Apr-Jun 01;35(2):99-105.

PubMed abstract

Do the Benefits of Educational Attainment for Late-life Cognition Differ by Racial/Ethnic Group?: Evidence for Heterogenous Treatment Effects in the Kaiser Healthy Aging and Diverse Life Experience (KHANDLE) Study

Authors: Eng, Chloe W; Glymour, Medellena Maria; Gilsanz, Paola; Mungas, Dan M; Mayeda, Elizabeth R; Meyer, Oanh L; Whitmer, Rachel A

Alzheimer Dis Assoc Disord. 2021 Apr-Jun 01;35(2):106-113.

PubMed abstract

Are adverse childhood experiences associated with late-life cognitive performance across racial/ethnic groups: results from the Kaiser Healthy Aging and Diverse Life Experiences study baseline

Authors: Gold, Audra L; Meza, Erika; Ackley, Sarah F; Mungas, Dan M; Whitmer, Rachel A; Mayeda, Elizabeth Rose; Miles, Sunita; Eng, Chloe W; Gilsanz, Paola; Glymour, M Maria

BMJ Open. 2021 02 05;11(2):e042125. Epub 2021-02-05.

PubMed abstract

Fitting a shared frailty illness-death model to left-truncated semi-competing risks data to examine the impact of education level on incident dementia

Authors: Lee, Catherine; Gilsanz, Paola; Haneuse, Sebastien

BMC Med Res Methodol. 2021 01 11;21(1):18. Epub 2021-01-11.

PubMed abstract

Physical Performance and Cognition in a Diverse Cohort: Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) Study

Authors: George KM; Gilsanz P; Peterson RL; Glymour MM; Mayeda ER; Mungas DM; Miles SQ; Whitmer RA

Alzheimer Dis Assoc Disord. 2021 Jan 11.

PubMed abstract

Cognitive impairment in racially/ethnically diverse older adults: Accounting for sources of diagnostic bias

Authors: Mungas, Dan; Shaw, Crystal; Hayes-Larson, Eleanor; DeCarli, Charles; Farias, Sarah Tomaszewski; Olichney, John; Saucedo, Hector Hernandez; Gilsanz, Paola; Glymour, M Maria; Whitmer, Rachel A; Mayeda, Elizabeth Rose

Alzheimers Dement (Amst). 2021;13(1):e12265. Epub 2021-12-31.

PubMed abstract

Physical Performance and Cognition in a Diverse Cohort: Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) Study

Authors: George, Kristen M; Gilsanz, Paola; Peterson, Rachel L; Glymour, Medellena Maria; Mayeda, Elizabeth Rose; Mungas, Dan M; Miles, Sunita Q; Whitmer, Rachel A

Alzheimer Dis Assoc Disord. 2021 Jan-Mar 01;35(1):23-29.

PubMed abstract

Sex, diabetes status and cognition: findings from the study of longevity in diabetes

Authors: Moran, Chris; Gilsanz, Paola; Beeri, Michal S; Whitmer, Rachel A; Lacy, Mary E

BMJ Open Diabetes Res Care. 2021 01;9(1).

PubMed abstract

Elevated Depressive Symptoms and the Risk of Stroke among the Mexican Older Population

Authors: Meza, Erika; Eng, Chloe W; Sáenz, Joseph L; Gilsanz, Paola; Glymour, Medellena Maria; Torres, Jacqueline M

J Am Geriatr Soc. 2020 11;68(11):2579-2586. Epub 2020-09-02.

PubMed abstract

Recurrent diabetic ketoacidosis and cognitive function among older adults with type 1 diabetes: findings from the Study of Longevity in Diabetes

Authors: Lacy ME; Gilsanz P; Eng CW; Beeri MS; Karter AJ; Whitmer RA

BMJ Open Diabetes Res Care. 2020 06;8(1).

PubMed abstract

Severe Hypoglycemia and Cognitive Function in Older Adults With Type 1 Diabetes: The Study of Longevity in Diabetes (SOLID)

Authors: Lacy ME; Gilsanz P; Eng C; Beeri MS; Karter AJ; Whitmer RA

Diabetes Care. 2020 03;43(3):541-548. Epub 2019-12-27.

PubMed abstract

Racial/Ethnic Differences in Sleep Quality among Older Adults: Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) Study

Authors: George, Kristen M; Peterson, Rachel L; Gilsanz, Paola; Mungas, Dan M; Glymour, M Maria; Mayeda, Elizabeth Rose; Whitmer, Rachel A

Ethn Dis. 2020 Summer;30(3):469-478. Epub 2020-07-09.

PubMed abstract

Differences in association of leisure time activities and cognition in a racially/ethnically diverse cohort of older adults: Findings from the KHANDLE study

Authors: Peterson RL; Gilsanz P; George KM; Ackley S; Glymour MM; Mungas DM; Whitmer RA

Alzheimers Dement (N Y). 2020;6(1):e12047. Epub 2020-06-26.

PubMed abstract

Sleep Quality and Cognitive Function in Type 1 Diabetes: Findings From the Study of Longevity in Diabetes (SOLID)

Authors: Gilsanz P; Lacy ME; Beeri MS; Karter AJ; Eng CW; Whitmer RA

Alzheimer Dis Assoc Disord. 2020 Jan-Mar;34(1):18-24.

PubMed abstract

Locus of Control and Cognition in Older Adults With Type I Diabetes: Evidence For Sex Differences From the Study of Longevity in Diabetes (SOLID)

Authors: Eng CW; Gilsanz P; Lacy ME; Beeri M; Whitmer RA

Alzheimer Dis Assoc Disord. 2019 Oct 17.

PubMed abstract

Is it possible to overcome the ‘long arm’ of childhood socioeconomic disadvantage through upward socioeconomic mobility?

Authors: Vable AM; Gilsanz P; Kawachi I

J Public Health (Oxf). 2019 09 30;41(3):566-574.

PubMed abstract

Initiation of antidepressant medication and risk of incident stroke: using the Adult Changes in Thought cohort to address time-varying confounding

Authors: Glymour MM; Gilsanz P; Crane PK; et al.

Ann Epidemiol. 2019 07;35:42-47.e1. Epub 2019-05-11.

PubMed abstract

Stressors in Midlife and Risk of Dementia: The Role of Race and Education

Authors: Gilsanz P; Quesenberry CP; Mayeda ER; Glymour MM; Farias ST; Whitmer RA

Alzheimer Dis Assoc Disord. 2019 Jul-Sep;33(3):200-205.

PubMed abstract

Reproductive period and risk of dementia in a diverse cohort of health care members

Authors: Gilsanz P; Lee C; Corrada MM; Kawas CH; Quesenberry CP; Whitmer RA

Neurology. 2019 04 23;92(17):e2005-e2014. Epub 2019-03-28.

PubMed abstract

Incidence of dementia after age 90 in a multiracial cohort

Authors: Gilsanz P; Corrada MM; Kawas CH; Mayeda ER; Glymour MM; Quesenberry CP; Lee C; Whitmer RA

Alzheimers Dement. 2019 04;15(4):497-505. Epub 2019-02-20.

PubMed abstract

Posttraumatic stress disorder symptoms and television viewing patterns in the Nurses’ Health Study II: A longitudinal analysis

Authors: Jung SJ; Winning A; Roberts AL; Nishimi K; Chen Q; Gilsanz P; Sumner JA; Fernandez CA; Rimm EB; Kubzansky LD; Koenen KC

PLoS One. 2019;14(3):e0213441. Epub 2019-03-21.

PubMed abstract

Birth in High Infant Mortality States and Dementia Risk in a Cohort of Elderly African American and White Health Care Members

Authors: Gilsanz P; Mayeda ER; Glymour MM; Quesenberry CP; Mungas D; DeCarli CS; Whitmer RA

Alzheimer Dis Assoc Disord. 2019 Jan-Mar;33(1):1-6.

PubMed abstract

Early Midlife Pulmonary Function and Dementia Risk

Authors: Gilsanz P; Mayeda ER; Flatt J; Glymour MM; Quesenberry CP; Whitmer RA

Alzheimer Dis Assoc Disord. 2018 Oct-Dec;32(4):270-275.

PubMed abstract

Traumatic brain injury associated with dementia risk among people with type 1 diabetes

Authors: Gilsanz P; Albers K; Beeri MS; Karter AJ; Quesenberry CP; Whitmer RA

Neurology. 2018 Sep 26.

PubMed abstract

Long-term Glycemic Control and Dementia Risk in Type 1 Diabetes

Authors: Lacy ME; Gilsanz P; Karter AJ; Quesenberry CP; Pletcher MJ; Whitmer RA

Diabetes Care. 2018 Sep 04.

PubMed abstract

Depression in type 1 diabetes and risk of dementia

Authors: Gilsanz P; Schnaider Beeri M; Karter AJ; Quesenberry CP; Adams AS; Whitmer RA

Aging Ment Health. 2018 Apr 10:1-7.

PubMed abstract

Diabetic Retinopathy and Dementia in Type 1 Diabetes

Authors: Rodill LG; Exalto LG; Gilsanz P; Biessels GJ; Quesenberry CP; Whitmer RA

Alzheimer Dis Assoc Disord. 2018 Apr-Jun;32(2):125-130.

PubMed abstract

Post-traumatic stress disorder and risk of dementia among members of a health care delivery system

Authors: Flatt JD; Gilsanz P; Quesenberry CP; Albers KB; Whitmer RA

Alzheimers Dement. 2018 01;14(1):28-34. Epub 2017-06-13.

PubMed abstract

The Bidirectional Association Between Depression and Severe Hypoglycemic and Hyperglycemic Events in Type 1 Diabetes

Authors: Gilsanz P; Karter AJ; Beeri MS; Quesenberry CP; Whitmer RA

Diabetes Care. 2017 Dec 18.

PubMed abstract

Posttraumatic stress disorder onset and inflammatory and endothelial function biomarkers in women

Authors: Sumner, Jennifer A JA; Chen, Qixuan Q; Roberts, Andrea L AL; Winning, Ashley A; Rimm, Eric B EB; Gilsanz, Paola P; Glymour, M Maria MM; Tworoger, Shelley S SS; Koenen, Karestan C KC; Kubzansky, Laura D LD

Brain, behavior, and immunity. 2018 Mar ;69():203-209. Epub 2017-11-20.

PubMed abstract

Female sex, early-onset hypertension, and risk of dementia

Authors: Gilsanz P; Mayeda ER; Glymour MM; Quesenberry CP; Mungas DM; DeCarli C; Dean A; Whitmer RA

Neurology. 2017 Oct 31;89(18):1886-1893. Epub 2017-10-04.

PubMed abstract

Association Between Birth in a High Stroke Mortality State, Race, and Risk of Dementia

Authors: Gilsanz P; Mayeda ER; Glymour MM; Quesenberry CP; Whitmer RA

JAMA Neurol. 2017 Sep 01;74(9):1056-1062.

PubMed abstract

Alzheimer’s disease genetic risk variants beyondAPOEε4 predict mortality

Authors: Mez, Jesse J; Marden, Jessica R JR; Mukherjee, Shubhabrata S; Walter, Stefan S; Gibbons, Laura E LE; Gross, Alden L AL; Zahodne, Laura B LB; Gilsanz, Paola P; Brewster, Paul P; Nho, Kwangsik K; Crane, Paul K PK; Larson, Eric B EB; Glymour, M Maria MM

Alzheimer's & dementia (Amsterdam, Netherlands). 2017 Mar ;8():188-195. Epub 2017-08-14.

PubMed abstract

Cross-Sectional and Longitudinal Associations of Chronic Posttraumatic Stress Disorder With Inflammatory and Endothelial Function Markers in Women

Authors: Sumner, Jennifer A JA; Chen, Qixuan Q; Roberts, Andrea L AL; Winning, Ashley A; Rimm, Eric B EB; Gilsanz, Paola P; Glymour, M Maria MM; Tworoger, Shelley S SS; Koenen, Karestan C KC; Kubzansky, Laura D LD

Biological psychiatry. 2017 Dec 15;82(12):875-884. Epub 2017-06-27.

PubMed abstract

Posttraumatic stress disorder and accelerated aging: PTSD and leukocyte telomere length in a sample of civilian women

Authors: Roberts, Andrea L AL; Koenen, Karestan C KC; Chen, Qixuan Q; Gilsanz, Paola P; Mason, Susan M SM; Prescott, Jennifer J; Ratanatharathorn, Andrew A; Rimm, Eric B EB; Sumner, Jennifer A JA; Winning, Ashley A; De Vivo, Immaculata I; Kubzansky, Laura D LD

Depression and anxiety. 2017 05 ;34(5):391-400. Epub 2017-04-05.

PubMed abstract

Post-traumatic Stress Disorder and 20-Year Physical Activity Trends Among Women

Authors: Winning, Ashley A; Gilsanz, Paola P; Koenen, Karestan C KC; Roberts, Andrea L AL; Chen, Qixuan Q; Sumner, Jennifer A JA; Rimm, Eric B EB; Maria Glymour, M M; Kubzansky, Laura D LD

American journal of preventive medicine. 2017 Jun ;52(6):753-760. Epub 2017-03-18.

PubMed abstract

Cumulative receipt of an anti-poverty tax credit for families did not impact tobacco smoking among parents

Authors: Pega, Frank F; Gilsanz, Paola P; Kawachi, Ichiro I; Wilson, Nick N; Blakely, Tony T

Social science & medicine (1982). 2017 04 ;179(5):160-165. Epub 2017-03-02.

PubMed abstract

Neighborhood Differences in Post-Stroke Mortality

Authors: Osypuk, Theresa L TL; Ehntholt, Amy A; Moon, J Robin JR; Gilsanz, Paola P; Glymour, M Maria MM

Circulation. Cardiovascular quality and outcomes. 2017 Feb ;10(2):120-128. Epub 2017-02-22.

PubMed abstract

Post-traumatic stress disorder symptom duration and remission in relation to cardiovascular disease risk among a large cohort of women

Authors: Gilsanz, P P; Winning, A A; Koenen, K C KC; Roberts, A L AL; Sumner, J A JA; Chen, Q Q; Glymour, M M MM; Rimm, E B EB; Kubzansky, L D LD

Psychological medicine. 2017 Jun ;47(8):1370-1378. Epub 2017-01-05.

PubMed abstract

Validation of a theoretically motivated approach to measuring childhood socioeconomic circumstances in the Health and Retirement Study

Authors: Vable AM; Gilsanz P; Nguyen TT; Kawachi I; Glymour MM

PLoS ONE. 2017;12(10):e0185898. Epub 2017-10-13.

PubMed abstract

Post-traumatic stress disorder and cardiometabolic disease: improving causal inference to inform practice

Authors: Koenen KC; Sumner JA; Gilsanz P; Glymour MM; Ratanatharathorn A; Rimm EB; Roberts AL; Winning A; Kubzansky LD

​​Psychol Med. 2017 Jan;47(2):209-225. doi: 10.1017/S0033291716002294. Epub 2016 Oct 4.

PubMed abstract

Changes in Depressive Symptoms and Subsequent Risk of Stroke in the Cardiovascular Health Study

Authors: Gilsanz, Paola P; Kubzansky, Laura D LD; Tchetgen Tchetgen, Eric J EJ; Wang, Qianyi Q; Kawachi, Ichiro I; Patton, Kristen K KK; Fitzpatrick, Annette L AL; Kop, Willem J WJ; Longstreth, W T WT; Glymour, M Maria MM

Stroke. 2017 01 ;48(1):43-48. Epub 2016-12-06.

PubMed abstract

Childhood Psychological Distress as a Mediator in the Relationship Between Early-Life Social Disadvantage and Adult Cardiometabolic Risk: Evidence From the 1958 British Birth Cohort

Authors: Winning A; Glymour MM; McCormick MC; Gilsanz P; Kubzansky LD

​Psychosom Med. 2016 Nov/Dec;78(9):1019-1030.

PubMed abstract

Post-traumatic stress disorder symptoms and risk of hypertension over 22 years in a large cohort of younger and middle-aged women

Authors: Sumner JA; Kubzansky LD; Roberts AL; Gilsanz P; Chen Q; Winning A; Forman JP; Rimm EB; Koenen KC

​Psychol Med. 2016 Nov;46(15):3105-3116. Epub 2016 Aug 18.

PubMed abstract

Comparing Variability, Severity, and Persistence of Depressive Symptoms as Predictors of Future Stroke Risk

Authors: Zahodne, Laura B LB; Gilsanz, Paola P; Glymour, M Maria MM; Gibbons, Laura E LE; Brewster, Paul P; Hamilton, Jamie J; Mez, Jesse J; Marden, Jessica R JR; Nho, Kwangsik K; Larson, Eric B EB; Crane, Paul K PK; Gross, Alden L AL

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2017 Feb ;25(2):120-128. Epub 2016-10-24.

PubMed abstract

Associations of Trauma Exposure and Posttraumatic Stress Symptoms With Venous Thromboembolism Over 22 Years in Women

Authors: Sumner JA; Kubzansky LD; Kabrhel C; Roberts AL; Chen Q; Winning A; Gilsanz P; Rimm EB; Glymour MM; Koenen KC

​J Am Heart Assoc. 2016 May 12;5(5). pii: e003197. doi: 10.1161/JAHA.116.003197.

PubMed abstract

Neighborhood-level social processes and substantiated cases of child maltreatment

Authors: Molnar BE; Goerge RM; Gilsanz P; Hill A; Subramanian SV; Holton JK; Duncan DT; Beatriz ED; Beardslee WR

​Child Abuse Negl. 2016 Jan;51:41-53. doi: 10.1016/j.chiabu.2015.11.007. Epub 2015 Dec 9.

PubMed abstract

​Dysregulated Blood Pressure: Can Regulating Emotions Help?

Authors: Trudel-Fitzgerald C; Gilsanz P; Mittleman MA; Kubzansky LD

​Curr Hypertens Rep. 2015 Dec;17(12):92. doi: 10.1007/s11906-015-0605-6.

PubMed abstract

Psychological Distress Across the Life Course and Cardiometabolic Risk: Findings From the 1958 British Birth Cohort Study

Authors: Winning A; Glymour MM; McCormick MC; Gilsanz P; Kubzansky LD

​J Am Coll Cardiol. 2015 Oct 6;66(14):1577-86. doi: 10.1016/j.jacc.2015.08.021.

PubMed abstract

Body mass index and cognitive function: the potential for reverse causation

Authors: Suemoto CK; Gilsanz P; Mayeda ER; Glymour MM

​Int J Obes (Lond). 2015 Sep;39(9):1383-9. doi: 10.1038/ijo.2015.83. Epub 2015 May 8.

PubMed abstract

Changes in Depressive Symptoms and Incidence of First Stroke Among Middle-Aged and Older US Adults

Authors: Gilsanz P; Walter S; Tchetgen Tchetgen EJ; Patton KK; Moon JR; Capistrant BD; Marden JR; Kubzansky LD; Kawachi I; Glymour MM

​J Am Heart Assoc. 2015 May 13;4(5). pii: e001923. doi: 10.1161/JAHA.115.001923.

​Early life predictors of atrial fibrillation-related mortality: evidence from the health and retirement study

Authors: Glymour MM; Benjamin EJ; Kosheleva A; Gilsanz P; Curtis LH; Patton KK

​Health Place. 2013 May;21:133-9. doi: 10.1016/j.healthplace.2012.12.008. Epub 2013 Feb 4.

PubMed abstract

Does the association between depressive symptoms and cardiovascular mortality risk vary by race? Evidence from the Health and Retirement Study

Authors: Capistrant BD; Gilsanz P; Moon JR; Kosheleva A; Patton KK; Glymour MM

​Ethn Dis. 2013 Spring;23(2):155-60.

PubMed abstract

Adiposity predicts carotid intima-media thickness in healthy children and adolescents

Authors: Mittelman SD; Gilsanz P; Mo AO; Wood J; Dorey F; Gilsanz V

​J Pediatr. 2010 Apr;156(4):592-7.e2. doi: 10.1016/j.jpeds.2009.10.014. Epub 2009 Dec 14.

PubMed abstract

Evaluating parent satisfaction of school nursing services

Authors: Read M; Small P; Donaher K; Gilsanz P; Sheetz A

​J Sch Nurs. 2009 Jun;25(3):205-13. doi: 10.1177/1059840509334441. Epub 2009 Apr 10.

PubMed abstract