Richard W. Grant, MD, MPH

People

CTSI Institutional Career Development Core

The Clinical and Translational Science Institute (CTSI) facilitates the rapid translation of research to improvements in patient and community health. It is a cross-school, campus-wide institute with scientist leaders at its helm. To achieve its goals, CTSI provides infrastructure, services and training to support clinical and translational research. To advance its mission, it develops broad coalitions and partnerships at the local and national levels to enable a transformation of the research environment.
Investigator: Grant, Richard
Funder: National Center for Advancing Translational Sciences

Mentored Research to Improve Care for Complex Patients With Diabetes

K24 Midcareer Investigator Awards in Patient-Oriented Research are designed to support established scientists with a track record of mentoring to devote time to research mentorship for junior investigators. The overarching goal of this K24 award is to develop innovative approaches to improving the care of complex patients with type 2 diabetes, including the growing number of Latinos with diabetes, by developing new care models and innovative tools to support patients and providers in achieving more effective diabetes primary care. Specific research aims are to: 1) Examine the relationship between patient visit priorities and PCP care plans; 2) Adapt pre-visit prioritization for Low-English-Proficiency and Spanish-speaking Latinos; and 3) Learn how to effectively implement alternative health IT platforms such as smart phones, interactive voice response, and other novel modalities for pre-visit prioritization. The project will provide ample mentored research opportunities for highly promising mentees with an interest and passion for patient-oriented research to improve the care of patients with type 2 diabetes.
Investigator: Grant, Richard
Funder: National Institute of Diabetes and Digestive and Kidney Diseases

Multi-Component Behavioral Intervention for Complex Patients with CVD Risk

Disease management programs have had success in CVD risk factor control among uncomplicated patients but often fall short in more complex patients. New approaches are needed to address the multiple barriers faced by CVD patients with complex medical and behavioral comorbidity. We propose to develop and implement a multi-component intervention that includes patient activation, patient engagement, broad brush screening for undiagnosed behavioral health conditions, and creation of personal care plans tailored to each individuals unique set of barriers, motivators, and clinical goals. By focusing on core health skills and cross-cutting barriers to care in high risk patients not meeting clinical treatment goals, we are designing this intervention to be widely generalizable to all patients with multiple complex chronic conditions. We will conduct a randomized clinical trial of the intervention vs. usual care to examine effectiveness on proximal outcomes and CVD risk factor control.
Investigator: Grant, Richard
Funder: National Heart, Lung, and Blood Institute

Aligning the Visit Priorities of Complex Patients and their Primary Care Providers

The primary care visit is a key opportunity for catalyzing changes in care for complex patients with multiple heath issues. With too many items to address in the time allotted, however, the decision of which items to focus on requires prioritization. Prior studies have shown that: 1) patients and providers often have discordant priorities, 2) this discordance is associated with less effective care (e.g., poor adherence, lack of medication intensification), and, conversely, 3) collaborative interactions with informed, activated patients and prepared providers lead to better clinical outcomes. We hypothesize that a systematic approach that enables patients and providers to align visit priorities will result in more effective, patient-centered care because explicitly negotiated management decisions that address both patient and provider priorities are more likely to be adopted. This project will include focus groups and a pilot clinical trial examining impact on patient-centered outcomes.
Investigator: Grant, Richard
Funder: Patient-Centered Outcomes Research Institute (PCORI)

​Defining patient complexity from the primary care physician's perspective: a cohort study.

Author(s): Grant RW; Ashburner JM; Hong CS; Chang Y; Barry MJ; Atlas SJ;
PubMed abstract

Practice-linked online personal health records for type 2 diabetes mellitus: a randomized controlled trial

Author(s): Grant RW; Wald JS; Schnipper JL; Gandhi TK; Poon EG; Orav EJ; Williams DH; Volk LA; Middleton B;
PubMed abstract

Overcoming barriers to diabetic polyneuropathy management in primary care

Author(s): Adams AS; Callaghan B; Grant RW
PubMed abstract

Transforming Care for Complex Patients: Addressing Interconnected Medical, Social, and Behavioral Challenges

Author(s): Zulman DM; Grant RW
PubMed abstract

User-Centered Design of a Tablet Waiting Room Tool for Complex Patients to Prioritize Discussion Topics for Primary Care Visits

Author(s): Lyles CR; Altschuler A; Chawla N; Kowalski C; McQuillan D; Bayliss E; Heisler M; Grant RW
PubMed abstract

Community Health Workers: A Missing Piece of the Puzzle for Complex Patients With Diabetes?

Author(s): Garcia ME; Grant RW
PubMed abstract

The Diabetes Telephone Study; Design and challenges of a pragmatic cluster randomized trial to improve diabetic peripheral neuropathy treatment

Author(s): Adams AS; Bayliss EA; Schmittdiel JA; Altschuler A; Dyer W; Neugebauer R; Jaffe M; Young JD; Kim E; Grant RW; Diabetes Telephone Study Team
PubMed abstract

Association of Acculturation and Health Literacy with Prevalent Dysglycemia and Diabetes Control Among Latinos in the Boston Area Community Health (BACH) Survey

Author(s): L?? L; Grant RW; Marceau L; Piccolo R; McKinlay JB; Meigs JB
PubMed abstract

Pre-visit prioritization for complex patients with Diabetes; Randomized Trial Design and Implementation within an Integrated Health Care system

Author(s): Grant RW; Uratsu CS; Hansen KR; Altschuler A; Kim E; Fireman B; Adams AS; Schmittdiel JA; Heisler M
PubMed abstract

Health IT-assisted population-based preventive cancer screening: a cost analysis

Author(s): Levy DE; Munshi VN; Ashburner JM; Zai AH; Grant RW; Atlas SJ
PubMed abstract

Evaluating a Model to Predict Primary Care Physician-Defined Complexity in a Large Academic Primary Care Practice-Based Research Network

Author(s): Hong CS; Atlas SJ; Ashburner JM; Chang Y; He W; Ferris TG; Grant RW
PubMed abstract

Randomized Trial of a Health IT Tool to Support Between-Visit-Based Laboratory Monitoring for Chronic Disease Medication Prescriptions

Author(s): Grant RW; Ashburner JM; Jernigan MC; Chang J; Borowsky LH; Chang Y; Atlas SJ
PubMed abstract

The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH): Design of a pharmacogenetic Resource for Type 2 Diabetes

Author(s): Walford GA; Colomo N; Todd JN; Billings LK; Fernandez M; Chamarthi B; Warner AS; Davis J; Littleton KR; Hernandez AM; Fanelli RR; Lanier A; Barbato C; Ackerman RJ; Khan SQ; Bui R; Garber L; Stolerman ES; Moore AF; Huang C; Kaur V; Harden M; Taylor A; Chen L; Manning AK; Huang P; Wexler D; McCarthy RM; Lo J; Thomas MK; Grant RW; Goldfine A; Hudson MS; Florez JC
PubMed abstract

Changes in physical activity among adults with diabetes: a longitudinal cohort study of inactive patients with Type 2 diabetes who become physically active

Author(s): Palakodeti S; Uratsu CS; Schmittdiel JA; Grant RW
PubMed abstract

Electronic Health Records and the Evolution of Diabetes Care: A Narrative Review

Author(s): Patel V; Reed ME; Grant RW
PubMed abstract

Building Equity Improvement into Quality Improvement: Reducing Socioeconomic Disparities in Colorectal Cancer Screening as Part of Population Health Management

Author(s): Berkowitz SA; Percac-Lima S; Ashburner JM; Chang Y; Zai AH; He W; Grant RW; Atlas SJ
PubMed abstract

Patients who self-monitor blood glucose and their unused testing results

Author(s): Grant RW; Huang ES; Wexler DJ; Laiteerapong N; Warton ME; Moffet HH; Karter AJ
PubMed abstract

Building a Career as a Delivery Science Researcher in a Changing Health Care Landscape

Author(s): Grant RW; Schmittdiel JA
PubMed abstract

Trends in the Evidence Level for the American Diabetes Association's "Standards of Medical Care in Diabetes" From 2005 to 2014

Author(s): Grant RW; Kirkman MS
PubMed abstract

Association of African genetic ancestry with fasting glucose and HbA1c levels in non-diabetic individuals: the Boston Area Community Health (BACH) Prediabetes Study

Author(s): Meigs JB; Grant RW; Piccolo R; López L; Florez JC; Porneala B; Marceau L; McKinlay JB
PubMed abstract

Non-visit-based cancer screening using a novel population management system

Author(s): Atlas SJ; Zai AH; Ashburner JM; Chang Y; Percac-Lima S; Levy DE; Chueh HC; Grant RW
PubMed abstract

Individualizing HbA1c targets for patients with diabetes; impact of an automated algorithm within a primary care network

Author(s): Berkowitz SA; Atlas SJ; Grant RW; Wexler DJ
PubMed abstract

Exercise as a Vital Sign: A Quasi-Experimental Analysis of a Health System Intervention to Collect Patient-Reported Exercise Levels

Author(s): Grant RW; Schmittdiel JA; Neugebauer RS; Uratsu CS; Sternfeld B
PubMed abstract

Novel Use and Utility of Integrated Electronic Health Records to Assess Rates of Prediabetes Recognition and Treatment: Brief Report From an Integrated Electronic Health Records Pilot Study

Author(s): Schmittdiel JA; Adams SR; Segal J; Griffin MR; Roumie CL; Ohnsorg K; Grant RW; O'Connor PJ
PubMed abstract

Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus

Author(s): Walford GA; Davis J; Warner AS; Ackerman RJ; Billings LK; Chamarthi B; Fanelli RR; Hernandez AM; Huang C; Khan SQ; Littleton KR; Lo J; McCarthy RM; Rhee EP; Deik A; Stolerman E; Taylor A; Hudson MS; Wang TJ; Altshuler D; Grant RW; Clish CB; Gerszten RE; Florez JC
PubMed abstract

Establishing visit priorities for complex patients; A summary of the literature and conceptual model to guide innovative interventions

Author(s): Grant RW; Adams AS; Bayliss EA; Heisler M
PubMed abstract

Lower blood pressure associated with higher mortality in retrospective study of patients with newly diagnosed type 2 diabetes

Author(s): Grant RW; Wexler DJ
PubMed abstract

Genetic susceptibility testing for chronic disease and intention for behavior change in healthy young adults

Author(s): Vassy JL; Donelan K; Hivert MF; Green RC; Grant RW
PubMed abstract

Characteristics of Primary Care Safety-Net Providers and Their Quality Improvement Attitudes and Activities: Results of a National Survey of Physician Professionalism

Author(s): López L; DesRoches CM; Vogeli C; Grant RW; Iezzoni LI; Campbell EG
PubMed abstract

Intensification of diabetes medication and risk for 30-day readmission

Author(s): Wei NJ; Wexler DJ; Nathan DM; Grant RW
PubMed abstract

Adults with diabetes who perceive family members' behaviour as unsupportive are less adherent to their medication regimen

Author(s): Grant RW; Schmittdiel JA
PubMed abstract

Personalized Genetic Risk Counseling to Motivate Diabetes Prevention: A randomized trial

Author(s): Grant RW; O'Brien KE; Waxler JL; Vassy JL; Delahanty LM; Bissett LG; Green RC; Stember KG; Guiducci C; Park ER; Florez JC; Meigs JB
PubMed abstract

Genetic Counseling as a Tool for Type 2 Diabetes Prevention: A Genetic Counseling Framework for Common Polygenetic Disorders

Author(s): Waxler JL; O'Brien KE; Delahanty LM; Meigs JB; Florez JC; Park ER; Pober BR; Grant RW
PubMed abstract

Effects of an online personal health record on medication accuracy and safety: a cluster-randomized trial

Author(s): Schnipper JL; Gandhi TK; Wald JS; Grant RW; Poon EG; Volk LA; Businger A; Williams DH; Siteman E; Buckel L; Middleton B
PubMed abstract

Diabetes differentially affects depression and self-rated health by age in the U.S

Author(s): Wexler DJ; Porneala B; Chang Y; Huang ES; Huffman JC; Grant RW
PubMed abstract

Characteristics of 'complex' patients with type 2 diabetes mellitus according to their primary care physicians

Author(s): Grant RW; Wexler DJ; Ashburner JM; Hong CS; Atlas SJ
PubMed abstract

Personalized medicine in Type 2 diabetes: what does the future hold?

Author(s): Grant RW; Wexler DJ
PubMed abstract

Implementation of a web-based tool for patient medication self-management: the Medication Self-titration Evaluation Programme (Med-STEP) for blood pressure control

Author(s): Grant RW; Pandiscio JC; Pajolek H; Woulfe A; Pelletier A; Kvedar J; Park ER
PubMed abstract

Closing the gap: eliminating health care disparities among Latinos with diabetes using health information technology tools and patient navigators

Author(s): Lopez L; Grant RW
PubMed abstract

​Defining patient complexity from the primary care physician's perspective: a cohort study.

Author(s): Grant RW; Ashburner JM; Hong CS; Chang Y; Barry MJ; Atlas SJ;
PubMed abstract

Relationship between patient panel characteristics and primary care physician clinical performance rankings.

Author(s): Hong CS; Atlas SJ; Chang Y; Subramanian SV; Ashburner JM; Barry MJ; Grant RW;
PubMed abstract

Practice-linked online personal health records for type 2 diabetes mellitus: a randomized controlled trial

Author(s): Grant RW; Wald JS; Schnipper JL; Gandhi TK; Poon EG; Orav EJ; Williams DH; Volk LA; Middleton B;
PubMed abstract

Medication adherence and racial differences in A1C control

Author(s): Adams AS; Trinacty CM; Zhang F; Kleinman K; Grant RW; Meigs JB; Soumerai SB; Ross-Degnan D
PubMed abstract