Monique M. Hedderson, PhD

People

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3580 (phone)
Monique.m.hedderson@kp.org
Kaiser Permanente Researcher Profiles

Monique Hedderson, PhD, is a research scientist at the Kaiser Permanente Northern California Division of Research. She received her Master's in public health from the University of Washington in 2000 and her PhD in epidemiology from the University of Washington in 2005. Dr. Hedderson’s research interests lie principally, but not exclusively, in the field of maternal and child health. Her research portfolio investigates the influence of preconception, prenatal and early childhood exposures on maternal and child health. Specifically, she has sought to understand how potentially modifiable factors before and during early pregnancy contribute to the risk of metabolic complications in women during pregnancy and postpartum, as well as their children. Dr. Hedderson has a long-standing interest in developing innovative targeted prevention and treatment strategies for high risk populations, especially interventions among reproductive aged women that can be implemented into clinical practice. She is also interested in the pharmacogenetics of glycemic response to metformin among patients with type 2 diabetes. This area of research has the potential to inform data-driven prescribing and precision medicine for antidiabetic drug therapy.

Current Position(s):

Research Scientist III, Division of Research, Kaiser Permanente Northern California

Section Affiliations:

Primary Research Interests:

Reproductive and perinatal epidemiology
Gestational diabetes
In utero behavioral and environmental exposures related to maternal and child health

Studies

Can hydroxychloroquine prevent preeclampsia and preterm delivery in lupus pregnancy?

Pregnant women with lupus are at high risk to develop preeclampsia and preterm delivery. This work leverages three large population-based databases with detailed prescription and clinical data to determine whether use of hydroxychloroquine during pregnancy among women with lupus reduces the risk of preeclampsia and preterm delivery disentangling these outcomes from the effects of potential mediators. This study will provide key information on hydroxychloroquine use and prescription practices to improve the analytic paradigm and inform our clinical understanding hydroxychloroquine use in lupus pregnancy.
Investigator: Hedderson, Monique
Funder: National Institute of Arthritis and Musculoskeletal and Skin Diseases

The Study of Women's Health Across the Nation (SWAN)

SWAN VI aims to elucidate menopause transition characteristics and trajectories of midlife health markers (inflammation, metabolic and cardiovascular risk factors, body composition, and bone, genitourinary, and vascular health) that are related to the preservation of physical and cognitive functioning, avoidance or delay of adverse health outcomes, and enhancement of social and psychological well-being, all of which will optimize successful aging.
Investigator: Hedderson, Monique
Funder: National Institute on Aging

Understanding racial-ethnic disparities in preterm birth sub-types and prenatal care utilization

The study will examine racial-ethnic disparities in the risk of preterm birth overall and by preterm birth sub-types. It will also study whether the racial-ethnic disparities in preterm births and preterm birth sub-types are modified by the level of prenatal care received.
Investigator: Hedderson, Monique
Funder: Northern California Community Benefit Programs

Cluster-randomized Trial of a Mobile Health Intervention to Achieve Appropriate Gestational Weight Gain in Overweight and Obese Women

This randomized trial will test whether the implementation of an mHealth tool in the health-plan setting increases the proportion of overweight and obese women with appropriate total gestational weight gain, according to Institute of Medicine (IOM) guidelines in comparison to usual care. Primary outcomes include the proportion of women with total gestational weight gain meeting the IOM guidelines and the rate of gain from the first trimester to delivery (in kilograms per week).
Investigator: Hedderson, Monique
Funder: National Institute of Diabetes and Digestive and Kidney Diseases

Atopic Dermatitis Standing Cohort Using a Cohort of Kaiser Permanente Northern California Members

A cohort study of Kaiser Permanente Northern California patients with moderate-to-severe atopic dermatitis (AD) will be used to estimate baseline characteristics and background incidence rates of safety events. Data from this study will provide valuable information regarding the current incidence rates of adverse outcomes among patients with AD. Safety events of interest include: viral reactivation, malignancies, lymphoproliferative disorders, thrombocytopenia, major/minor bleeding events, major adverse cardiovascular events, alterations in lipid profiles, and thromboembolism.
Investigator: Hedderson, Monique
Funder: Pfizer Inc.

Development and Testing of a Mobile-Health (m-health) Intervention tool to Help Obese Women Achieve Appropriate Gestational Weight Gain

To determine whether a mobile-health (m-health) tool (accessible via smartphone or website) intervention for obese pregnant improves patient satisfaction with their gestational weight gain, quality of life, stress and depression during pregnancy. Provider satisfaction with discussing gestational weight gain among their patients who used the m-health tool will also be assessed.
Investigator: Hedderson, Monique
Funder: The Permanente Medical Group

Glyburide Versus Insulin for the Treatment of Women with Gestational Diabetes in Kaiser Permanente Northern California

We aim to compare the effectiveness and safety of glyburide and insulin at improving neonatal and maternal outcomes among women with gestational diabetes mellitus (GDM) requiring medication therapy in Kaiser Permanente Northern California from 2007 to 2016. We will use a cohort study design including women with GDM diagnosed from 2007 to 2016 where treatment groups contrasted are defined by therapy regimens (i.e., insulin versus glyburide or early versus late initiation of glyburide). This project will overcome shortcomings of past studies conducted in this area by using modern statistical methods that allow us to take advantage of variation in treatment patterns after the implementation of the universal Perinatal Center referral policy in 2007. More specifically, our approach consists of a cohort study with time-varying exposure to insulin and glyburide during pregnancy.
Investigator: Hedderson, Monique
Funder:

Iodinated Contrast Agents and Risk of Hypothyroidism in Young Children in the United States

This study will estimate the incidence of pulmonary hypothyroid in a pediatric population of children under age 4, based on data from the US-based Kaiser Permanente Northern California database, who were exposed to iodinated contrast agent through having a diagnostic procedure.
Investigator: Hedderson, Monique
Funder: Bayer AG

Pregravid Biomarkers and Risk of Gestational Diabetes Mellitus Risk, Fetal Growth and Progression to Diabetes

This study will examine pregravid biomarkers of metabolic risk (adiponectin, high molecular weight adiponectin, c-reactive protein, liver enzymes, fetuin-A and LDL particle size) in relation to risk of gestational diabetes mellitus among women who participated in the Kaiser Permanente Northern California (KPNC) multiphasic health check-up (1985-1996) and had a subsequent pregnancy in KPNC.
Investigator: Hedderson, Monique
Funder: National Institute of Child Health and Human Development

Discovery of Pharmacogenomic Biomarkers for Metformin Response

The primary goal of this multi-site study is to identify genetic variants that impact response to metformin in patients with diabetes from multiple ethnic groups in the U.S. and Europe
Investigator: Hedderson, Monique
Funder: National Institute of General Medical Sciences

Pharmacogenomics Study of Extreme Response to Metformin

In this collaboration with GlaxoSmithKline, University of California San Francisco and Kaiser Permanente Northern California, we propose to perform a genome-wide association study in 1,000 patients of European ancestry with extreme response phenotypes to metformin using genomewide array and human exome chip, which include rare nonsynonymous variants. Our aim is to determine whether rare variants, either acting alone or in combination, explain much of the variation in response to metformin, particularly in the extreme responder and non-responder groups.
Investigator: Hedderson, Monique
Funder: GlaxoSmithKline PLC

Highlighted Publications

No results found matching criteria

Publications

Development and Validation of an Obstetric Comorbidity Risk Score for Clinical Use

Author(s): Ruppel H; Liu VX; Kipnis P; Hedderson MM; Greenberg M; Forquer H; Lawson B; Escobar GJ

Womens Health Rep (New Rochelle). 2021;2(1):507-515. Epub 2021-11-02.

Current Position(s):

Section Affiliations:

Primary Research Interests:

Studies

Can hydroxychloroquine prevent preeclampsia and preterm delivery in lupus pregnancy?

The Study of Women's Health Across the Nation (SWAN)

Understanding racial-ethnic disparities in preterm birth sub-types and prenatal care utilization

Cluster-randomized Trial of a Mobile Health Intervention to Achieve Appropriate Gestational Weight Gain in Overweight and Obese Women

Atopic Dermatitis Standing Cohort Using a Cohort of Kaiser Permanente Northern California Members

Development and Testing of a Mobile-Health (m-health) Intervention tool to Help Obese Women Achieve Appropriate Gestational Weight Gain

Glyburide Versus Insulin for the Treatment of Women with Gestational Diabetes in Kaiser Permanente Northern California

Iodinated Contrast Agents and Risk of Hypothyroidism in Young Children in the United States

Pregravid Biomarkers and Risk of Gestational Diabetes Mellitus Risk, Fetal Growth and Progression to Diabetes

Discovery of Pharmacogenomic Biomarkers for Metformin Response

Pharmacogenomics Study of Extreme Response to Metformin

Highlighted Publications

Publications

Development and Validation of an Obstetric Comorbidity Risk Score for Clinical Use

Methods-Motivational Interviewing Approach for Enhanced Retention and Attendance

Disparities in Risks of Inadequate and Excessive Intake of Micronutrients during Pregnancy

COVID-19 prevalence, symptoms, and sociodemographic disparities in infection among insured pregnant women in Northern California

Alternative Wear-time Estimation Methods Compared to Traditional Diary Logs for Wrist-Worn ActiGraph Accelerometers in Pregnant Women

Lifestyle-related education and counseling resource utilization and cardiovascular biomarkers in midlife women with low physical activity

Efficacious lifestyle interventions for appropriate gestational weight gain in women with overweight or obesity set in the health care system: a scoping review

Healthy preconception and early-pregnancy lifestyle and risk of preterm birth: a prospective cohort study

Mediating Effects of Cardiometabolic Risk Factors on the Association Between Maternal Race-Ethnicity and Cesarean Delivery Among Low-Risk Women

Dual trajectories of physical activity and blood lipids in midlife women: The Study of Women's Health Across the Nation

Racial and geographic variation in effects of maternal education and neighborhood-level measures of socioeconomic status on gestational age at birth: Findings from the ECHO cohorts

Exercise During the First Trimester of Pregnancy and the Risks of Abnormal Screening and Gestational Diabetes Mellitus

Gestational weight gain and adverse pregnancy outcomes by pre-pregnancy BMI category in women with chronic hypertension: A cohort study

Gestational weight gain, birthweight and early-childhood obesity: between- and within-family comparisons

Impact of nulliparity, hypertensive disorders of pregnancy, and gestational diabetes on vasomotor symptoms in midlife women

A telehealth lifestyle intervention to reduce excess gestational weight gain in pregnant women with overweight or obesity (GLOW): a randomised, parallel-group, controlled trial

Study protocol: Using peer support to aid in prevention and treatment in prediabetes (UPSTART)

Prenatal Depression and Diet Quality During Pregnancy

Understanding childhood obesity in the US: the NIH environmental influences on child health outcomes (ECHO) program

Exercise During the First Trimester and Infant Size at Birth: Targeted Maximum Likelihood Estimation of the Causal Risk Difference

Enhanced Recovery After Surgery to Change Process Measures and Reduce Opioid Use After Cesarean Delivery: A Quality Improvement Initiative.

Prenatal Opioid Exposure: Neurodevelopmental Consequences and Future Research Priorities

Diagnostic thresholds for pregnancy hyperglycemia, maternal weight status and the risk of childhood obesity in a diverse Northern California cohort using health care delivery system data

Pre- and Early Pregnancy Onset Depression and Subsequent Rate of Gestational Weight Gain

Gestational weight gain and optimal wellness (GLOW): rationale and methods for a randomized controlled trial of a lifestyle intervention among pregnant women with overweight or obesity

Poor diet quality in pregnancy is associated with increased risk of excess fetal growth: a prospective multi-racial/ethnic cohort study.

Iodinated Contrast Agents and Risk of Hypothyroidism in Young Children in the United States

Central Obesity Increases the Risk of Gestational Diabetes Partially Through Increasing Insulin Resistance

Dietary Quality and Glycemic Control Among Women with Gestational Diabetes Mellitus

Liver Enzymes in Early to Mid-pregnancy, Insulin Resistance, and Gestational Diabetes Risk: A Longitudinal Analysis

A Pre-Pregnancy Biomarker Risk Score Improves Prediction of Future Gestational Diabetes

A cohort study of maternal cardiometabolic risk factors and primary cesarean delivery in an integrated health system

A Tailored Letter Based on Electronic Health Record Data Improves Gestational Weight Gain Among Women With Gestational Diabetes: The Gestational Diabetes' Effects on Moms (GEM) Cluster-Randomized Controlled Trial

Genetic Variants in CPA6 and PRPF31 are Associated with Variation in Response to Metformin in Individuals with Type 2 Diabetes

The Pregnancy Environment and Lifestyle Study (PETALS); a population-based longitudinal multi-racial birth cohort

Perceived psychosocial stress and gestational weight gain among women with gestational diabetes

The Kaiser Permanente Northern California research program on genes, environment, and health (RPGEH) pregnancy cohort; study design, methodology and baseline characteristics.

Variants in Pharmacokinetic Transporters and Glycaemic Response to Metformin: A MetGen Meta-Analysis

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

Trimester-Specific Gestational Weight Gain and Infant Size for Gestational Age

A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin

Lifestyle behaviors and ethnic identity among diverse women at high risk for type 2 diabetes

​The Comparative Effectiveness of Diabetes Prevention Strategies to Reduce Postpartum Weight Retention in Women With Gestational Diabetes Mellitus; The Gestational Diabetes' Effects on Moms (GEM) Cluster Randomized Controlled Trial.

Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes

Outreach to diversify clinical trial participation: A randomized recruitment study

Response to Comment on Hedderson et al. Prepregnancy SHBG Concentrations and Risk for Subsequently Developing Gestational Diabetes Mellitus. Diabetes Care 2014;37:1296-1303

Genetic Variants in Transcription Factors Are Associated With the Pharmacokinetics and Pharmacodynamics of Metformin

Maternal gestational weight gain and offspring risk for childhood overweight or obesity

A Call to Increase Physical Activity Among Women of Reproductive Age: Is It Possible?

Pregravid Liver Enzyme Levels and Risk of Gestational Diabetes During a Subsequent Pregnancy

Proteinuria testing among patients with diabetes mellitus is associated with bladder cancer diagnosis: potential for unmeasured confounding in studies of pioglitazone and bladder cancer

Post-partum weight loss and glucose metabolism in women with gestational diabetes: the DEBI Study

Prepregnancy SHBG Concentrations and Risk for Subsequently Developing Gestational Diabetes Mellitus

The Multigroup Ethnic Identity Measure-Revised: Measurement Invariance Across Racial and Ethnic Groups

Low Prepregnancy Adiponectin Concentrations Are Associated With a Marked Increase in Risk for Development of Gestational Diabetes Mellitus

Risk of Large-for-Gestational-Age Newborns in Women With Gestational Diabetes by Race and Ethnicity and Body Mass Index Categories

Pregnancy Glycemia in Mexican-American Women Without Diabetes or Gestational Diabetes and Programming for Childhood Obesity

Pregnancy Glucose Levels in Women without Diabetes or Gestational Diabetes and Childhood Cardiometabolic Risk at 7 Years of Age

Sex ratio variations among the offspring of women with diabetes in pregnancy

Racial/Ethnic Disparities in the Prevalence of Gestational Diabetes by BMI

Prepregnancy cardiometabolic and inflammatory risk factors and subsequent risk of hypertensive disorders of pregnancy

Referral to telephonic nurse management improves outcomes in women with gestational diabetes

A pregnancy and postpartum lifestyle intervention in women with gestational diabetes mellitus reduces diabetes risk factors: a feasibility randomized control trial

The Comparative Effectiveness of Diabetes Prevention Strategies to Reduce Postpartum Weight Retention in Women With Gestational Diabetes Mellitus; The Gestational Diabetes' Effects on Moms (GEM) Cluster Randomized Controlled Trial.