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Monique M. Hedderson, PhD

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Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3580 (phone)
Monique.m.hedderson@kp.org
Kaiser Permanente Researcher Profiles


Monique Hedderson, PhD, is a research scientist at the Kaiser Permanente Northern California Division of Research. She received her Master's in public health from the University of Washington in 2000 and her PhD in epidemiology from the University of Washington in 2005. Dr. Hedderson’s research interests lie principally, but not exclusively, in the field of maternal and child health. Her research portfolio investigates the influence of preconception, prenatal and early childhood exposures on maternal and child health. Specifically, she has sought to understand how potentially modifiable factors before and during early pregnancy contribute to the risk of metabolic complications in women during pregnancy and postpartum, as well as their children. Dr. Hedderson has a long-standing interest in developing innovative targeted prevention and treatment strategies for high risk populations, especially interventions among reproductive aged women that can be implemented into clinical practice. She is also interested in the pharmacogenetics of glycemic response to metformin among patients with type 2 diabetes. This area of research has the potential to inform data-driven prescribing and precision medicine for antidiabetic drug therapy.

Current Position(s):

  • Research Scientist II, Division of Research, Kaiser Permanente Northern California

Section Affiliations:

Primary Research Interests:

  • Reproductive and perinatal epidemiology
  • Gestational diabetes
  • In utero behavioral and environmental exposures related to maternal and child health

    Development and Testing of a Mobile-Health (m-health) Intervention tool to Help Obese Women Achieve Appropriate Gestational Weight Gain

    To determine whether a mobile-health (m-health) tool (accessible via smartphone or website) intervention for obese pregnant improves patient satisfaction with their gestational weight gain, quality of life, stress and depression during pregnancy. Provider satisfaction with discussing gestational weight gain among their patients who used the m-health tool will also be assessed.
    Investigator: Hedderson, Monique
    Funder: The Permanente Medical Group

    Glyburide Versus Insulin for the Treatment of Women with Gestational Diabetes in Kaiser Permanente Northern California

    We aim to compare the effectiveness and safety of glyburide and insulin at improving neonatal and maternal outcomes among women with gestational diabetes mellitus (GDM) requiring medication therapy in Kaiser Permanente Northern California from 2007 to 2016. We will use a cohort study design including women with GDM diagnosed from 2007 to 2016 where treatment groups contrasted are defined by therapy regimens (i.e., insulin versus glyburide or early versus late initiation of glyburide). This project will overcome shortcomings of past studies conducted in this area by using modern statistical methods that allow us to take advantage of variation in treatment patterns after the implementation of the universal Perinatal Center referral policy in 2007. More specifically, our approach consists of a cohort study with time-varying exposure to insulin and glyburide during pregnancy.
    Investigator: Hedderson, Monique
    Funder: 

    Iodinated Contrast Agents and Risk of Hypothyroidism in Young Children in the United States

    This study will estimate the incidence of pulmonary hypothyroid in a pediatric population of children under age 4, based on data from the US-based Kaiser Permanente Northern California database, who were exposed to iodinated contrast agent through having a diagnostic procedure.
    Investigator: Hedderson, Monique
    Funder: Bayer AG

    Pregravid Biomarkers and Risk of Gestational Diabetes Mellitus Risk, Fetal Growth and Progression to Diabetes

    This study will examine pregravid biomarkers of metabolic risk (adiponectin, high molecular weight adiponectin, c-reactive protein, liver enzymes, fetuin-A and LDL particle size) in relation to risk of gestational diabetes mellitus among women who participated in the Kaiser Permanente Northern California (KPNC) multiphasic health check-up (1985-1996) and had a subsequent pregnancy in KPNC.
    Investigator: Hedderson, Monique
    Funder: National Institute of Child Health and Human Development

    Discovery of Pharmacogenomic Biomarkers for Metformin Response

    The primary goal of this multi-site study is to identify genetic variants that impact response to metformin in patients with diabetes from multiple ethnic groups in the U.S. and Europe
    Investigator: Hedderson, Monique
    Funder: National Institute of General Medical Sciences

    Pharmacogenomics Study of Extreme Response to Metformin

    In this collaboration with GlaxoSmithKline, University of California San Francisco and Kaiser Permanente Northern California, we propose to perform a genome-wide association study in 1,000 patients of European ancestry with extreme response phenotypes to metformin using genomewide array and human exome chip, which include rare nonsynonymous variants. Our aim is to determine whether rare variants, either acting alone or in combination, explain much of the variation in response to metformin, particularly in the extreme responder and non-responder groups.
    Investigator: Hedderson, Monique
    Funder: GlaxoSmithKline PLC
    No results found matching criteria

    A cohort study of maternal cardiometabolic risk factors and primary cesarean delivery in an integrated health system

    Author(s): Hedderson MM; Xu F; Sridhar SB; Han ES; Quesenberry CP; Crites Y

    PLoS ONE. 2018;13(7):e0199932. Epub 2018-07-03.

    PubMed abstract

    A Tailored Letter Based on Electronic Health Record Data Improves Gestational Weight Gain Among Women With Gestational Diabetes: The Gestational Diabetes' Effects on Moms (GEM) Cluster-Randomized Controlled Trial

    Author(s): Hedderson MM; Brown SD; Ehrlich SF; Tsai AL; Zhu Y; Quesenberry CP; Crites Y; Ferrara A

    Diabetes Care. 2018 Apr 18.

    PubMed abstract

    Genetic Variants in CPA6 and PRPF31 are Associated with Variation in Response to Metformin in Individuals with Type 2 Diabetes

    Author(s): Rotroff DM; Hedderson MM; MetGen Investigators and the ACCORD/ACCORDion Investigators; et al.

    Diabetes. 2018 Apr 12.

    PubMed abstract

    The Pregnancy Environment and Lifestyle Study (PETALS); a population-based longitudinal multi-racial birth cohort

    Author(s): Zhu Y; Hedderson MM; Feng J; Mevi AA; Ferrara A

    BMC Pregnancy Childbirth. 2017 Apr 17;17(1):122. Epub 2017-04-17.

    PubMed abstract

    Perceived psychosocial stress and gestational weight gain among women with gestational diabetes

    Author(s): Kubo A; Ferrara A; Brown SD; Ehrlich SF; Tsai AL; Quesenberry CP; Crites Y; Hedderson MM

    PLoS ONE. 2017;12(3):e0174290. Epub 2017-03-28.

    PubMed abstract

    The Kaiser Permanente Northern California research program on genes, environment, and health (RPGEH) pregnancy cohort; study design, methodology and baseline characteristics.

    Author(s): Hedderson MM; Ferrara A; Avalos LA; Van den Eeden SK; Gunderson EP; Li DK; Altschuler A; Woo S; Rowell S; Choudhary V; Xu F; Flanagan T; Schaefer C; Croen LA;

    ​BMC Pregnancy Childbirth. 2016 Nov 29;16(1):381.

    PubMed abstract

    Variants in Pharmacokinetic Transporters and Glycaemic Response to Metformin: A MetGen Meta-Analysis

    Author(s): Dujic T; Zhou K; Yee SW; van Leeuwen N; de Keyser CE; Javorský M; Goswami S; Zaharenko L; Hougaard Christensen MM; Out M; Tavendale R; Kubo M; Hedderson MM; van der Heijden AA; Klimčáková L; Pirags V; Kooy A; Brøsen K; Klovins J; Semiz S; Tkáč I; Stricker BH; Palmer C; 't Hart LM; Giacomini KM; Pearson ER;

    Clin Pharmacol Ther. 2016 Nov 10.

    PubMed abstract

    Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

    Author(s): Zhou K; Yee SW; Seiser EL; van Leeuwen N; Tavendale R; Bennett AJ; Groves CJ; Coleman RL; van der Heijden AA; Beulens JW; de Keyser CE; Zaharenko L; Rotroff DM; Out M; Jablonski KA; Chen L; Javorsk? M; ?idzik J; Levin AM; Williams LK; Dujic T; Semiz S; Kubo M; Chien HC; Maeda S; Witte JS; Wu L; Tk?? I; Kooy A; van Schaik RH; Stehouwer CD; Logie L; MetGen Investigators; DPP Investigators; ACCORD Investigators; Sutherland C; Klovins J; Pirags V; Hofman A; Stricker BH; Motsinger-Reif AA; Wagner MJ; Innocenti F; Hart LM; Holman RR; McCarthy MI; Hedderson MM; Palmer CN; Florez JC; Giacomini KM; Pearson ER

    Nat Genet. 2016 Sep;48(9):1055-9. Epub 2016-08-08.

    PubMed abstract

    Trimester-Specific Gestational Weight Gain and Infant Size for Gestational Age

    Author(s): Sridhar SB; Xu F; Hedderson MM

    PLoS ONE. 2016;11(7):e0159500. Epub 2016-07-21.

    PubMed abstract

    A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin

    Author(s): Goswami S; Yee SW; Xu F; Sridhar SB; Mosley JJ; Takahashi A; Kubo M; Maeda S; Davis RL; Roden DM; Hedderson MM; Giacomini KM; Savic RM

    Clin Pharmacol Ther. 2016 Jul 14.

    PubMed abstract

    Lifestyle behaviors and ethnic identity among diverse women at high risk for type 2 diabetes

    Author(s): Brown SD; Ehrlich SF; Kubo A; Tsai AL; Hedderson MM; Quesenberry CP; Ferrara A

    Soc Sci Med. 2016 May 14;160:87-93. Epub 2016-5-14.

    PubMed abstract

    ​The Comparative Effectiveness of Diabetes Prevention Strategies to Reduce Postpartum Weight Retention in Women With Gestational Diabetes Mellitus; The Gestational Diabetes' Effects on Moms (GEM) Cluster Randomized Controlled Trial.

    Author(s): Ferrara A; Hedderson MM; Brown SD; Albright CL; Ehrlich SF; Tsai AL; Caan BJ; Sternfeld B; Gordon NP; Schmittdiel JA; Gunderson EP; Mevi AA; Herman WH; Ching J; Crites Y; Quesenberry CP Jr;

    Diabetes Care. 2016 Jan;39(1):65-74. doi: 10.2337/dc15-1254. Epub 2015 Dec 9.

    PubMed abstract

    Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes

    Author(s): Lewis JD; Habel LA; Quesenberry CP; Strom BL; Peng T; Hedderson MM; Ehrlich SF; Mamtani R; Bilker W; Vaughn DJ; Nessel L; Van Den Eeden SK; Ferrara A

    JAMA. 2015 Jul 21;314(3):265-77.

    PubMed abstract

    Outreach to diversify clinical trial participation: A randomized recruitment study

    Author(s): Brown SD; Partee PN; Feng J; Quesenberry CP; Hedderson MM; Ehrlich SF; Kiernan M; Ferrara A

    Clin Trials. 2015 Jun;12(3):205-11. Epub 2015-02-02.

    PubMed abstract

    Response to Comment on Hedderson et al. Prepregnancy SHBG Concentrations and Risk for Subsequently Developing Gestational Diabetes Mellitus. Diabetes Care 2014;37:1296-1303

    Author(s): Hedderson MM; Ferrara A

    Diabetes Care. 2014 Dec;37(12):e280.

    PubMed abstract

    Genetic Variants in Transcription Factors Are Associated With the Pharmacokinetics and Pharmacodynamics of Metformin

    Author(s): Goswami S; Yee SW; Stocker S; Mosley JD; Kubo M; Castro R; Mefford JA; Wen C; Liang X; Witte J; Brett C; Maeda S; Simpson MD; Hedderson MM; Davis RL; Roden DM; Giacomini KM; Savic RM

    Clin Pharmacol Ther. 2014 Sep;96(3):370-9. Epub 2014-05-22.

    PubMed abstract

    Maternal gestational weight gain and offspring risk for childhood overweight or obesity

    Author(s): Sridhar SB; Darbinian J; Ehrlich SF; Markman MA; Gunderson EP; Ferrara A; Hedderson MM

    Am J Obstet Gynecol. 2014 Sep;211(3):259.e1-8. Epub 2014-04-13.

    PubMed abstract

    A Call to Increase Physical Activity Among Women of Reproductive Age: Is It Possible?

    Author(s): Hedderson M; Ferrara A

    JAMA Intern Med. 2014 Jul;174(7):1056-7.

    PubMed abstract

    Pregravid Liver Enzyme Levels and Risk of Gestational Diabetes During a Subsequent Pregnancy

    Author(s): Sridhar SB; Xu F; Darbinian J; Quesenberry CP; Ferrara A; Hedderson MM

    Diabetes Care. 2014 Jul;37(7):1878-84. Epub 2014-05-02.

    PubMed abstract

    Proteinuria testing among patients with diabetes mellitus is associated with bladder cancer diagnosis: potential for unmeasured confounding in studies of pioglitazone and bladder cancer

    Author(s): Lewis JD; Habel L; Quesenberry C; Mamtani R; Peng T; Bilker WB; Hedderson M; Nessel L; Vaughn DJ; Strom BL; Ferrara A

    Pharmacoepidemiol Drug Saf. 2014 Jun;23(6):636-45. Epub 2014-04-25.

    PubMed abstract

    Post-partum weight loss and glucose metabolism in women with gestational diabetes: the DEBI Study

    Author(s): Ehrlich SF; Hedderson MM; Quesenberry CP; Feng J; Brown SD; Crites Y; Ferrara A

    Diabet Med. 2014 Jul;31(7):862-7. Epub 2014-03-25.

    PubMed abstract

    Prepregnancy SHBG Concentrations and Risk for Subsequently Developing Gestational Diabetes Mellitus

    Author(s): Hedderson MM; Xu F; Darbinian JA; Quesenberry CP; Sridhar S; Kim C; Gunderson EP; Ferrara A

    Diabetes Care. 2014;37(5):1296-303. Epub 2014-02-21.

    PubMed abstract

    The Multigroup Ethnic Identity Measure-Revised: Measurement Invariance Across Racial and Ethnic Groups

    Author(s): Brown SD; Unger Hu KA; Mevi AA; Hedderson MM; Shan J; Quesenberry CP; Ferrara A

    J Couns Psychol. 2014 Jan;61(1):154-61. Epub 2013-11-04.

    PubMed abstract

    Low Prepregnancy Adiponectin Concentrations Are Associated With a Marked Increase in Risk for Development of Gestational Diabetes Mellitus

    Author(s): Hedderson MM; Darbinian J; Havel PJ; Quesenberry CP; Sridhar S; Ehrlich S; Ferrara A

    Diabetes Care. 2013 Dec;36(12):3930-7. Epub 2013-08-29.

    PubMed abstract

    Risk of Large-for-Gestational-Age Newborns in Women With Gestational Diabetes by Race and Ethnicity and Body Mass Index Categories

    Author(s): Sridhar SB; Ferrara A; Ehrlich SF; Brown SD; Hedderson MM

    Obstet Gynecol. 2013 Jun;121(6):1255-62.

    PubMed abstract

    Pregnancy Glycemia in Mexican-American Women Without Diabetes or Gestational Diabetes and Programming for Childhood Obesity

    Author(s): Ehrlich SF; Rosas LG; Ferrara A; King JC; Abrams B; Harley KG; Hedderson MM; Eskenazi B

    Am J Epidemiol. 2013 Apr 15;177(8):768-75. Epub 2013 Mar 15.

    PubMed abstract

    Pregnancy Glucose Levels in Women without Diabetes or Gestational Diabetes and Childhood Cardiometabolic Risk at 7 Years of Age

    Author(s): Ehrlich SF; Rosas LG; Ferrara A; King JC; Abrams B; Harley KG; Hedderson MM; Eskenazi B

    J Pediatr. 2012 Dec;161(6):1016-21. Epub 2012 Jul 11.

    PubMed abstract

    Sex ratio variations among the offspring of women with diabetes in pregnancy

    Author(s): Ehrlich SF; Eskenazi B; Hedderson MM; Ferrara A

    Diabet Med. 2012 Sep;29(9):e273-8.

    PubMed abstract

    Racial/Ethnic Disparities in the Prevalence of Gestational Diabetes by BMI

    Author(s): Hedderson M; Ehrlich S; Sridhar S; Darbinian J; Moore S; Ferrara A

    Diabetes Care. 2012 Jul;35(7):1492-8. Epub 2012 May 22.

    PubMed abstract

    Prepregnancy cardiometabolic and inflammatory risk factors and subsequent risk of hypertensive disorders of pregnancy

    Author(s): Hedderson MM; Darbinian JA; Sridhar SB; Quesenberry CP

    Am J Obstet Gynecol. 2012 Jul;207(1):68.e1-9. Epub 2012 May 23.

    PubMed abstract

    Referral to telephonic nurse management improves outcomes in women with gestational diabetes

    Author(s): Ferrara A; Hedderson MM; Ching J; Kim C; Peng T; Crites YM

    Am J Obstet Gynecol. 2012 Jun;206(6):491.e1-5. Epub 2012 Apr 24.

    PubMed abstract

    A pregnancy and postpartum lifestyle intervention in women with gestational diabetes mellitus reduces diabetes risk factors: a feasibility randomized control trial

    Author(s): Ferrara A; Hedderson MM; Albright CL; Ehrlich SF; Quesenberry CP Jr; Peng T; Feng J; Ching J; Crites Y

    Diabetes Care. 2011 Jul;34(7):1519-25. Epub 2011 May 3.

    PubMed abstract

    Pregravid cardiometabolic risk profile and risk for gestational diabetes mellitus

    Author(s): Hedderson MM; Darbinian JA; Quesenberry CP; Ferrara A

    Am J Obstet Gynecol. 2011 Jul;205(1):55.e1-7. Epub 2011 May 28.

    PubMed abstract

    Change in body mass index between pregnancies and the risk of gestational diabetes in a second pregnancy

    Author(s): Ehrlich SF; Hedderson MM; Feng J; Davenport ER; Gunderson EP; Ferrara A

    Obstet Gynecol. 2011 Jun;117(6):1323-30.

    PubMed abstract

    Risk of bladder cancer among diabetic patients treated with pioglitazone: interim report of a longitudinal cohort study

    Author(s): Lewis JD; Ferrara A; Peng T; Hedderson M; Bilker WB; Quesenberry CP Jr; Vaughn DJ; Nessel L; Selby J; Strom BL

    Diabetes Care. 2011 Apr;34(4):916-22.

    PubMed abstract

    The risk of large for gestational age across increasing categories of pregnancy glycemia

    Author(s): Ehrlich SF; Crites YM; Hedderson MM; Darbinian JA; Ferrara A

    Am J Obstet Gynecol. 2011 Mar;204(3):240.e1-6. Epub 2011 Jan 17.

    PubMed abstract

    Disparities in the risk of gestational diabetes by race-ethnicity and country of birth

    Author(s): Hedderson MM; Darbinian JA; Ferrara A

    Paediatr Perinat Epidemiol. 2010 Sep;24(5):441-8.

    PubMed abstract

    Gestational weight gain and risk of gestational diabetes mellitus

    Author(s): Hedderson MM; Gunderson EP; Ferrara A

    Obstet Gynecol. 2010 Mar;115(3):597-604.

    PubMed abstract

    Contraception before and after GDM

    Author(s): Hedderson M

    In: Kim C, Ferrara A, editors. Gestational diabetes during and after pregnancy. London: Springer; 2010.

    PubMed abstract

    High blood pressure before and during early pregnancy is associated with an increased risk of gestational diabetes mellitus

    Author(s): Hedderson MM; Ferrara A

    Diabetes Care. 2008 Dec;31(12):2362-7. Epub 2008 Sep 22.

    PubMed abstract

    Body mass index and weight gain prior to pregnancy and risk of gestational diabetes mellitus

    Author(s): Hedderson MM; Williams MA; Holt VL; Weiss NS; Ferrara A

    Am J Obstet Gynecol. 2008 Apr;198(4):409.e1-7. Epub 2008 Feb 20.

    PubMed abstract

    Androgenicity of progestins in hormonal contraceptives and the risk of gestational diabetes mellitus

    Author(s): Hedderson MM; Ferrara A; Williams MA; Holt VL; Weiss NS

    Diabetes Care. 2007 May;30(5):1062-8. Epub 2007 Feb 15.

    PubMed abstract

    Pregnancy plasma glucose levels exceeding the American Diabetes Association thresholds, but below the National Diabetes Data Group thresholds for gestational diabetes mellitus, are related to the risk of neonatal macrosomia, hypoglycaemia and hyperbilirubinaemia

    Author(s): Ferrara A; Weiss NS; Hedderson MM; Quesenberry CP Jr; Selby JV; Ergas IJ; Peng T; Escobar GJ; Pettitt DJ; Sacks DA

    Diabetologia. 2007 Feb;50(2):298-306. Epub 2006 Nov 14.

    PubMed abstract

    Pregnancy weight gain and risk of neonatal complications: macrosomia, hypoglycemia, and hyperbilirubinemia

    Author(s): Hedderson MM; Weiss NS; Sacks DA; Pettitt DJ; Selby JV; Quesenberry CP; Ferrara A

    Obstet Gynecol. 2006 Nov;108(5):1153-61.

    PubMed abstract

    An increase in the incidence of gestational diabetes mellitus: Northern California, 1991-2000

    Author(s): Ferrara A; Kahn HS; Quesenberry CP; Riley C; Hedderson MM

    Obstet Gynecol. 2004 Mar;103(3):526-33.

    PubMed abstract

    Gestational diabetes mellitus and lesser degrees of pregnancy hyperglycemia: association with increased risk of spontaneous preterm birth

    Author(s): Hedderson MM; Ferrara A; Sacks DA

    Obstet Gynecol. 2003 Oct;102(4):850-6.

    PubMed abstract

    Allergy and risk of breast cancer among young women (United States)

    Author(s): Hedderson MM; Malone KE; Daling JR; White E

    Cancer Causes Control. 2003 Sep;14(7):619-26.

    PubMed abstract

    Changes in diet, physical activity, and supplement use among adults diagnosed with cancer

    Author(s): Patterson RE; Neuhouser ML; Hedderson MM; Schwartz SM; Standish LJ; Bowen DJ

    J Am Diet Assoc. 2003 Mar;103(3):323-8.

    PubMed abstract

    Prevalence of gestational diabetes mellitus detected by the national diabetes data group or the carpenter and coustan plasma glucose thresholds

    Author(s): Ferrara A; Hedderson MM; Quesenberry CP; Selby JV

    Diabetes Care. 2002 Sep;25(9):1625-30.

    PubMed abstract