Lisa J. Herrinton, PhD

People

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3714 (phone)
lisa.herrinton@kp.org
Kaiser Permanente Researcher Profiles

Lisa Herrinton, PhD, is a senior research scientist and epidemiologist at the Kaiser Permanente Northern California Division of Research. She is a standing member of the Healthcare Outcomes and Effectiveness study section at the Agency for Healthcare Research and Quality (AHRQ) and has served on study section for the Centers for Disease Control, National Eye Institute, National Cancer Institute, and other federal agencies. Dr. Herrinton has 20 years of experience using a diverse range of research methods to investigate important questions in public health and health services. Most recently, she is conducing a program in implementation research, working with Kaiser Permanente physicians and health plan leaders to identify high priority topics suitable for integrating care delivery, quality improvement, and research. In addition, Dr. Herrinton is focused on using innovative approaches to realizing value from Kaiser Permanente's electronic medical record. These efforts cover diverse clinical areas including cataract surgery, oncology, and registry building across medical and surgical specialties. Earlier, she elucidated risk factors in the development of breast, ovarian, lung, and colorectal cancer, as well as lymphoma. In autoimmune disease, she built registries in inflammatory bowel disease, rheumatology, and psoriasis. Dr. Herrinton received her doctoral training at the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle, Washington, and her master's training at Harvard University. She has published more than 160 peer-reviewed publications and several book chapters. In addition, she has led numerous collaborative activities and mentored many scientists and physician-investigators. Before her training in epidemiology, she was an environmental health manager. She also served as a high school science and math teacher through the Peace Corps in Swaziland, Africa. Besides her work, Dr. Herrinton enjoys her family and friends, hiking, biking, and swimming.

Current Position(s):

Research Scientist III, Division of Research, Kaiser Permanente Northern California
Associate Editor, American Journal of Epidemiology

Section Affiliations:

Health Care Delivery and Policy

Primary Research Interests:

Inflammatory bowel disease
Cancer
Etiology factors
Quality of care outcomes
Epidemiology methods
Outcomes research

Studies

Health Outcomes of Interest Validation of Serious Infections Among an Immunocompromised Population

Kaiser Permanente Northern California will participate with the FDA Sentinel to validate the diagnosis of health outcomes of interest.
Investigator: Herrinton, Lisa
Funder: U.S. Food and Drug Administration

Comparative Effectiveness of Virtual Care in Dermatology for Diagnosing Rash

The benefit of teledermatology for triaging skin rashes is not adequately understood. The study will assess how implementation of teledermatology (technology and staffing) improves the effectiveness and efficiency of diagnosis, including wait time to diagnosis, therapies, and need for follow-up visits.
Investigator: Herrinton, Lisa
Funder: The Permanente Medical Group

Evaluation of the Effectiveness and Implementation of Regionalized Care of Testicular Cancer

This study has three primary aims: 1) to evaluate the effectiveness of Testicular Cancer Redesign on rates of use of guideline-adherent and avoidable utilization; 2) to evaluate users’ ability to adopt and maintain use of Testicular Cancer Redesign workflow changes and tools, guided by the RE-AIM framework, using information from audits, key-stakeholder interviews, and surveys; and 3) to identify contextual factors at the medical-center level that mediate the effectiveness and sustainability of implementation using interviews and surveys of key stakeholders, testing the hypothesis that implementation of the intervention will vary across medical centers because of differences in local context.
Investigator: Herrinton, Lisa
Funder: The Permanente Medical Group

The Role of Bariatric Surgery in the Management of Nonalcoholic Fatty Liver Disease

This project is proposed by University of California, San Francisco (UCSF) gastroenterology fellow Suzanne Sharpton, who is also earning an M.S. in public health. She is supported by Kaiser Permanente gastroenterologist Varun Saxton and bariatric surgeon Robert Li, as well as her UCSF mentor. The project has three specific aims. The first is to examine changes in hepatic fibrosis at baseline, 6, and 12 months post-surgery among morbidly obese adults who underwent bariatric surgery and had nonalcoholic steatohepatitis on a liver biopsy at baseline. The second is to compare the change in nonalcoholic fatty liver disease fibrosis score between Roux-en-Y gastric bypass versus sleeve gastrectomy. The third aim is to compare the rate of cardiovascular morbidity after bariatric surgery in morbidly obese adults with and without histologic evidence of nonalcoholic steatohepatitis at baseline.
Investigator: Herrinton, Lisa
Funder: East Bay Community Foundation

FY16 Sentinel Infrastructure, Methods and Surveillance

This project consists of tasks required for data partners in the Food and Drug Administration’s Sentinel Initiative under the initiative’s “Year 4 Infrastructure” statement of work. Most of the requirements involve data partner staff running data requests or returning data and documents of various types to the Sentinel Coordinating Center via the Sentinel PopMedNet Distributed Query Tool System.
Investigator: Herrinton, Lisa
Funder: U.S. Food and Drug Administration

Predicting Final Visual Acuity Following Cataract Surgery

The objective of this study is to predict visual acuity and incidence rates of complications after cataract surgery.
Investigator: Herrinton, Lisa
Funder: National Eye Institute

Long-term Benefits and Risks of Bariatric Surgery in Integrated Care Systems

The objective of this study is to provide surveillance of bariatric surgery outcomes and safety.
Investigator: Herrinton, Lisa
Funder:

M-S Data Expansion: Integration of Kaiser Permanente Hospital Data to the Sentinel Distributed Database

Investigator: Herrinton, Lisa
Funder: U.S. Food and Drug Administration

Highlighted Publications

No results found matching criteria

Publications

Proton Pump Inhibitors, H2 Blocker Use, and Risk of Inflammatory Bowel Disease in Children

Author(s): Schwartz NRM; Hutfless S; Herrinton LJ; Amsden LB; Fevrier HB; Giefer M; Lee D; Suskind DL; Delaney JAC; Phipps AI

J Pediatr Pharmacol Ther. 2019 Nov-Dec;24(6):489-496.

Current Position(s):

Section Affiliations:

Primary Research Interests:

Studies

Health Outcomes of Interest Validation of Serious Infections Among an Immunocompromised Population

Comparative Effectiveness of Virtual Care in Dermatology for Diagnosing Rash

Evaluation of the Effectiveness and Implementation of Regionalized Care of Testicular Cancer

The Role of Bariatric Surgery in the Management of Nonalcoholic Fatty Liver Disease

FY16 Sentinel Infrastructure, Methods and Surveillance

Predicting Final Visual Acuity Following Cataract Surgery

Long-term Benefits and Risks of Bariatric Surgery in Integrated Care Systems

M-S Data Expansion: Integration of Kaiser Permanente Hospital Data to the Sentinel Distributed Database

Highlighted Publications

Publications

Proton Pump Inhibitors, H2 Blocker Use, and Risk of Inflammatory Bowel Disease in Children

Development of an algorithm to detect methotrexate wrong frequency error using computerized health care data

Five-year Longitudinal Cohort Study of Reinterventions After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass

Lack of Standardized Terminology in Ultrasound Reports for Ovarian Cysts

Developing a Prognostic Information System for Personalized Care in Real Time

Long-term follow-up of pediatric open and laparoscopic inguinal hernia repair

Understanding Non-Adherence with Hydroxychloroquine Therapy in Systemic Lupus Erythematosus

Comparative Effectiveness Study of Face-to-Face and Teledermatology Workflows for Diagnosing Skin Cancer

Visual outcomes after cataract surgery in patients with type 2 diabetes

Anti-TNF and Physiologic Measures of Metabolic Disease in Rheumatoid Arthritis

An Observational Study of Cardiovascular Risks Associated with Rheumatoid Arthritis Therapies: A Comparison of Two Analytical Approaches

Reducing risk of Clostridium difficile infection and overall use of antibiotic in the outpatient treatment of urinary tract infection

Association of Inflammatory Markers with Disease Progression in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors

Large-Scale Implementation of Structured Reporting of Adnexal Masses on Ultrasound

Improving the quality of care and patient experience of care during the diagnosis of lupus: a qualitative study of primary care

Immediate sequential bilateral cataract surgery: surgeon preferences and concerns

The Incidence and Prevalence of Systemic Lupus Erythematosus in San Francisco County, California: The California Lupus Surveillance Project

Predictors of Bowel Function in Long-term Rectal Cancer Survivors with Anastomosis

Participation in Activities Associated With Quality of Life for Long-Term Survivors of Rectal Cancer

Immediate Sequential vs. Delayed Sequential Bilateral Cataract Surgery: Retrospective Comparison of Postoperative Visual Outcomes

Failure Modes and Effects Analysis of bilateral same-day cataract surgery

Natural language processing to ascertain two key variables from operative reports in ophthalmology

Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease

Rectal Cancer Survivors' Participation in Productive Activities

Pathogens and antibiotic sensitivities in endophthalmitis

Comparative Effectiveness of Antibiotic Prophylaxis in Cataract Surgery

Comparative Effectiveness of Three Prophylactic Strategies to Prevent Clinical Macular Edema after Phacoemulsification Surgery

The Association of Refractive Error with Glaucoma in a Multiethnic Population

Diagnostic Prevalence of Ankylosing Spondylitis Using Computerized Health Care Data, 1996 to 2009: Underrecognition in a US Health Care Setting

The HMO research network

Infections Requiring Hospitalization as Predictors of Pediatric-Onset Crohn's Disease and Ulcerative Colitis

Big Data, Miniregistries: A Rapid-Turnaround Solution to Get Quality Improvement Data into the Hands of Medical Specialists

Sexual Function and Health-Related Quality of Life in Long-Term Rectal Cancer Survivors

Risk of Serious Infection for Patients with Systemic Lupus Erythematosus Starting Glucocorticoids with or without Antimalarials

Association between the initiation of anti-tumor necrosis factor therapy and the risk of herpes zoster

Population Variations in Rheumatoid Arthritis Treatment and Outcomes, Northern California, 1998-2009

Self-reported depression and perceived financial burden among long-term rectal cancer survivors

Dietary and Behavioral Adjustments to Manage Bowel Dysfunction After Surgery in Long-Term Colorectal Cancer Survivors

Comparative Effectiveness of Laparoscopic Adjustable Gastric Banding vs Laparoscopic Gastric Bypass

Reliability and validity of a survey to measure bowel function and quality of life in long-term rectal cancer survivors

Non-viral opportunistic infections in new users of tumour necrosis factor inhibitor therapy: results of the SAfety Assessment of Biologic ThERapy (SABER) Study

Trends in Elective Labor Induction for Six United States Health Plans, 2001-2007

Initiation of TNF inhibitor therapy and change in physiologic measures in psoriasis

New benchmark in preventing phacoemulsification-related endophthalmitis

Pharmacotherapy for Incident Attention-Deficit/Hyperactivity Disorder: Practice Patterns and Quality Metrics

From diagnosis through survivorship: health-care experiences of colorectal cancer survivors with ostomies

Racial and Ethnic Differences in Health Care Utilization and Outcomes Among Ulcerative Colitis Patients in an Integrated Health-Care Organization

Pharmacologic Therapies for the Management of Crohn's Disease: Comparative Effectiveness

Validity of diagnostic codes and prevalence of psoriasis and psoriatic arthritis in a managed care population, 1996-2009

Incidence and Prevalence of Juvenile Idiopathic Arthritis Among Children in a Managed Care Population, 1996-2009

Initiation of Tumor Necrosis Factor Alpha (TNFalpha) antagonists and risk of fractures in patients with selected rheumatic and autoimmune diseases

Drug safety data mining with a tree-based scan statistic

Near real-time adverse drug reaction surveillance within population-based health networks: methodology considerations for data accrual

Association between anti-TNF-alpha therapy and interstitial lung disease

Drug Adverse Event Detection in Health Plan Data Using the Gamma Poisson Shrinker and Comparison to the Tree-based Scan Statistic

Regarding: A Tale of Two Cohorts

Tumor necrosis factor alpha inhibitor therapy and cancer risk in chronic immune mediated diseases

Decreased postoperative endophthalmitis rate after institution of intracameral antibiotics in a Northern California eye department

Surviving Colorectal Cancer: Long-term, Persistent Ostomy-Specific Concerns and Adaptations

Initiation of Anti-TNF Therapy and the Risk of Optic Neuritis; From the Safety Assessment of Biologic ThERapy (SABER) Study

Mycobacterial diseases and antitumour necrosis factor therapy in USA

Association between anti-TNF-alpha therapy and all-cause mortality

The association of psoriasis with autoimmune diseases

Direct medical expenditure associated with rheumatoid arthritis in a nationally representative sample from the medical expenditure panel survey

Irrigation practices in long-term survivors of colorectal cancer with colostomies

Incidence and Mortality of Colorectal Adenocarcinoma in Persons with Inflammatory Bowel Disease from 1998 to 2010