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Enid M. Hunkeler, MA

Enid  Hunkeler, MA

Enid Hunkeler, MA, is an emeritus research scientist at the Kaiser Permanente Northern California Division of Research. Her research interests include the development, implementation and dissemination of innovative models of care for depression, bipolar disorder, behavioral health, violence prevention (both community and domestic); and Internet-based programs for bipolar disorder, depression, diabetes and hypertension. She is also interested in issues related to suicide. Ms. Hunkeler has authored or co-authored more than fifty articles and book chapters.

Current Positions

  • Emeritus Research Scientist, Division of Research, Kaiser Permanente Northern California

Primary Research Interests

  • Internet-based treatment
  • Health services research in mental health
  • Depression
  • Domestic violence prevention
  • Alcohol, smoking and drug abuse programs
  • Behavioral health


Suicide Attempts Among a Cohort of Transgender and Gender Diverse People

Authors: Mak, Josephine; Hunkeler, Enid M; Silverberg, Michael J; Goodman, Michael; et al.

Am J Prev Med. 2020 10;59(4):570-577. Epub 2020-08-12.

PubMed abstract

Patterns of Health Care Utilization Before First Episode Psychosis in Racial and Ethnic Groups

Authors: Coleman KJ; Yarborough BJ; Beck A; Lynch FL; Stewart C; Penfold RS; Hunkeler EM; Operskalski BH; Simon GE

Ethn Dis. 2019 Fall;29(4):609-616. Epub 2019-10-17.

PubMed abstract

Agreement between medical records and self-reports: Implications for transgender health research

Authors: Gerth J; Hunkeler EM; Silverberg MJ; Goodman M; et al.

Rev Endocr Metab Disord. 2018 09;19(3):263-269.

PubMed abstract

Cross-sex Hormones and Acute Cardiovascular Events in Transgender Persons: A Cohort Study

Authors: Getahun D; Hunkeler E; Silverberg MJ; Goodman M; et al.

Ann Intern Med. 2018 08 21;169(4):205-213. Epub 2018-07-10.

PubMed abstract

Mental Health of Transgender and Gender Nonconforming Youth Compared With Their Peers

Authors: Becerra-Culqui TA; Hunkeler EM; Silverberg MJ; Goodman M; et al.

Pediatrics. 2018 05;141(5). Epub 2018-04-16.

PubMed abstract

Near Real-time Surveillance for Consequences of Health Policies Using Sequential Analysis

Authors: Lu CY; Hunkeler EM; Kulldorff M; et al.

Med Care. 2018 05;56(5):365-372.

PubMed abstract

Care Pathways Before First Diagnosis of a Psychotic Disorder in Adolescents and Young Adults

Authors: Simon GE; Stewart C; Hunkeler EM; Yarborough BJ; Lynch F; Coleman KJ; Beck A; Operskalski BH; Penfold RB; Carrell DS

Am J Psychiatry. 2018 05 01;175(5):434-442. Epub 2018-01-24.

PubMed abstract

Association Between Gender Confirmation Treatments and Perceived Gender Congruence, Body Image Satisfaction, and Mental Health in a Cohort of Transgender Individuals

Authors: Owen-Smith AA; Hunkeler E; Silverberg MJ; Goodman M; et al.

J Sex Med. 2018 Apr;15(4):591-600. Epub 2018-02-17.

PubMed abstract

Mortality Rates After the First Diagnosis of Psychotic Disorder in Adolescents and Young Adults

Authors: Simon GE; Stewart C; Yarborough BJ; Lynch F; Coleman KJ; Beck A; Operskalski BH; Penfold RB; Hunkeler EM

JAMA Psychiatry. 2018 03 01;75(3):254-260.

PubMed abstract

Cohort profile: Study of Transition, Outcomes and Gender (STRONG) to assess health status of transgender people

Authors: Quinn VP; Hunkeler E; Silverberg MJ; Goodman M; et al.

BMJ Open. 2017 12 27;7(12):e018121. Epub 2017-12-27.

PubMed abstract

Cohort study of cancer risk among insured transgender people

Authors: Silverberg MJ; Hunkeler E; Goodman M; et al.

Ann Epidemiol. 2017 08;27(8):499-501. Epub 2017-07-22.

PubMed abstract

First Presentation With Psychotic Symptoms in a Population-Based Sample

Authors: Simon GE; Coleman KJ; Yarborough BJH; Operskalski B; Stewart C; Hunkeler EM; Lynch F; Carrell D; Beck A

Psychiatr Serv. 2017 May 01;68(5):456-461. Epub 2017-01-03.

PubMed abstract

Perception of Community Tolerance and Prevalence of Depression among Transgender Persons

Authors: Owen-Smith AA; Quinn VP; Goodman M; et al.

J Gay Lesbian Ment Health. 2017;21(1):64-76. Epub 2016-08-26.

PubMed abstract

Racial-Ethnic Differences in Psychiatric Diagnoses and Treatment Across 11 Health Care Systems in the Mental Health Research Network

Authors: Coleman KJ; Hunkeler EM; Simon GE; et al.

Psychiatr Serv. 2016 Jul 01;67(7):749-57. Epub 2016-04-15.

PubMed abstract

A novel method for estimating transgender status using electronic medical records

Authors: Roblin D; Hunkeler E; Goodman M; et al.

Ann Epidemiol. 2016 Mar;26(3):198-203. Epub 2016-02-04.

PubMed abstract

Factors Influencing Variation in Physician Adenoma Detection Rates: a Theory-Based Approach for Performance Improvement

Authors: Atkins L; Hunkeler EM; Jensen CD; Michie S; Lee JK; Doubeni CA; Zauber AG; Levin TR; Quinn VP; Corley DA

Gastrointest Endosc. 2016 Mar;83(3):617-26.e2. Epub 2015-09-11.

PubMed abstract

Determinants of and Barriers to Hormonal and Surgical Treatment Receipt Among Transgender People

Authors: Sineath RC; Hunkeler E; Goodman M; et al.

Transgend Health. 2016;1(1):129-136. Epub 2016-Jul-01.

PubMed abstract

Perceptions of Barriers to and Facilitators of Participation in Health Research Among Transgender People

Authors: Owen-Smith AA; Woodyatt C; Sineath RC; Hunkeler EM; Barnwell T; Graham A; Stephenson R; Goodman M

Transgend Health. 2016;1(1):187-196. Epub 2016-10-01.

PubMed abstract

Racial/Ethnic differences in health care visits made before suicide attempt across the United States

Authors: Ahmedani BK; Hunkeler EM; Williams K; et al.

Med Care. 2015 May;53(5):430-5.

PubMed abstract

National Prevalence of Receipt of Antidepressant Prescriptions by Persons Without a Psychiatric Diagnosis

Authors: Simon GE; Stewart C; Beck A; Ahmedani BK; Coleman KJ; Whitebird RR; Lynch F; Owen-Smith AA; Waitzfelder BE; Soumerai SB; Hunkeler EM

Psychiatr Serv. 2014 Jul;65(7):944-6.

PubMed abstract

Health Care Contacts in the Year Before Suicide Death

Authors: Ahmedani BK; Hunkeler EM; Solberg LI; et al.

J Gen Intern Med. 2014 Jun;29(6):870-7. Epub 2014-02-25.

PubMed abstract

How complete are E-codes in commercial plan claims databases?

Authors: Lu CY; Hunkeler EM; Soumerai SB; et al.

Pharmacoepidemiol Drug Saf. 2014 Feb;23(2):218-20.

PubMed abstract

Changes in antidepressant use by young people and suicidal behavior after FDA warnings and media coverage: quasi-experimental study

Authors: Lu CY; Hunkeler EM; Soumerai SB; et al.

BMJ. 2014;348:g3596. Epub 2014-06-18.

PubMed abstract

Use of antipsychotic medications in pediatric populations: what do the data say?

Authors: Penfold RB; Hunkeler EM; Simon GE; et al.

Curr Psychiatry Rep. 2013 Dec;15(12):426.

PubMed abstract

A Web-Delivered Care Management and Patient Self-Management Program for Recurrent Depression: A Randomized Trial

Authors: Hunkeler EM; Fireman B; Taylor CB; et al.

Psychiatr Serv. 2012 Nov;63(11):1063-71.

PubMed abstract

Does gender moderate the relationship between childhood maltreatment and adult depression?

Authors: Arnow BA; Blasey CM; Hunkeler EM; Lee J; Hayward C

Child Maltreat. 2011 Aug;16(3):175-83. Epub 2011 Jul 4.

PubMed abstract

Catastrophizing, depression and pain-related disability

Authors: Arnow BA; Blasey CM; Constantino MJ; Robinson R; Hunkeler E; Lee J; Fireman B; Khaylis A; Feiner L; Hayward C

Gen Hosp Psychiatry. 2011 Mar-Apr;33(2):150-6. Epub 2011 Feb 21.

PubMed abstract

Relationships among depression, chronic pain, chronic disabling pain, and medical costs

Authors: Arnow BA; Blasey CM; Lee J; Fireman B; Hunkeler EM; Dea R; Robinson R; Hayward C

Psychiatr Serv. 2009 Mar;60(3):344-50.

PubMed abstract

Collaborative depression care, screening, diagnosis and specificity of depression treatments in the primary care setting

Authors: Alexander JL; Richardson G; Grypma L; Hunkeler EM

Expert Rev Neurother. 2007 Nov;7(11 Suppl):S59-80.

PubMed abstract

Risk of suicide attempt and suicide death in patients treated for bipolar disorder

Authors: Simon GE; Hunkeler E; Fireman B; Lee JY; Savarino J

Bipolar Disord. 2007 Aug;9(5):526-30.

PubMed abstract

Tamoxifen treatment and new-onset depression in breast cancer patients

Authors: Lee KC; Ray GT; Hunkeler EM; Finley PR

Psychosomatics. 2007 May-Jun;48(3):205-10.

PubMed abstract

The prevalence, burden, and treatment of urinary incontinence among women in a managed care plan

Authors: Kinchen KS; Lee J; Fireman B; Hunkeler E; Nehemiah JL; Curtice TG

J Womens Health (Larchmt). 2007 Apr;16(3):415-22.

PubMed abstract

Reducing suicidal ideation in depressed older primary care patients

Authors: Unutzer J; Hunkeler E; for the IMPACT Investigators; et al.

J Am Geriatr Soc. 2006 Oct;54(10):1550-6.

PubMed abstract

Comorbid depression, chronic pain, and disability in primary care

Authors: Arnow BA; Hunkeler EM; Blasey CM; Lee J; Constantino MJ; Fireman B; Kraemer HC; Dea R; Robinson R; Hayward C

Psychosom Med. 2006 Mar-Apr;68(2):262-8.

PubMed abstract

Long term outcomes from the IMPACT randomised trial for depressed elderly patients in primary care

Authors: Hunkeler EM; Unutzer J; et al.

BMJ. 2006 Feb 4;332(7536):259-63. Epub 2006 Jan 20.

PubMed abstract

Depression treatment preferences in older primary care patients

Authors: Gum AM; Arean PA; Hunkeler E; Tang L; Katon W; Hitchcock P; Steffens DC; Dickens J; Unutzer J

Gerontologist. 2006 Feb;46(1):14-22.

PubMed abstract

Cost-effectiveness and net benefit of enhanced treatment of depression for older adults with diabetes and depression

Authors: Katon W; Unutzer J; Fan MY; Williams JW Jr; Schoenbaum M; Lin EH; Hunkeler EM

Diabetes Care. 2006 Feb;29(2):265-70.

PubMed abstract

Improving depression care for older, minority patients in primary care

Authors: Arean PA; Ayalon L; Hunkeler E; Lin EH; Tang L; Harpole L; Hendrie H; Williams JW Jr; Unutzer J; IMPACT Investigators

Med Care. 2005 Apr;43(4):381-90.

PubMed abstract

Treatment of depression improves physical functioning in older adults

Authors: Callahan CM; Kroenke K; Counsell SR; Hendrie HC; Perkins AJ; Katon W; Noel PH; Harpole L; Hunkeler EM; Unutzer J; IMPACT Investigators

J Am Geriatr Soc. 2005 Mar;53(3):367-73.

PubMed abstract

Trends in use of antidepressants, lithium, and anticonvulsants in Kaiser Permanente-insured youths, 1994-2003

Authors: Hunkeler EM; Fireman B; Lee J; Diamond R; Hamilton J; He CX; Dea R; Nowell WB; Hargreaves WA

J Child Adolesc Psychopharmacol. 2005 Feb;15(1):26-37.

PubMed abstract

Depression and comorbid illness in elderly primary care patients: impact on multiple domains of health status and well-being

Authors: Noel PH; Williams JW Jr; Unutzer J; Worchel J; Lee S; Cornell J; Katon W; Harpole LH; Hunkeler E

Ann Fam Med. 2004 Nov-Dec;2(6):555-62.

PubMed abstract

Incidence and duration of side effects and those rated as bothersome with selective serotonin reuptake inhibitor treatment for depression: patient report versus physician estimate

Authors: Hu XH; Bull SA; Hunkeler EM; Ming E; Lee JY; Fireman B; Markson LE

J Clin Psychiatry. 2004 Jul;65(7):959-65.

PubMed abstract

The effectiveness of depression care management on diabetes-related outcomes in older patients

Authors: Williams JW Jr; Hunkeler E; IMPACT Investigators; et al.

Ann Intern Med. 2004 Jun 15;140(12):1015-24.

PubMed abstract

Effect of improving depression care on pain and functional outcomes among older adults with arthritis: a randomized controlled trial

Authors: Lin EH; Hunkeler E; IMPACT Investigators; et al.

JAMA. 2003 Nov 12;290(18):2428-9.

PubMed abstract

Suicide risk in bipolar disorder during treatment with lithium and divalproex

Authors: Goodwin FK; Fireman B; Simon GE; Hunkeler EM; Lee J; Revicki D

JAMA. 2003 Sep 17;290(11):1467-73.

PubMed abstract

Psychiatric symptoms, impaired function, and medical care costs in an HMO setting

Authors: Hunkeler EM; Spector WD; Fireman B; Rice DP; Weisner C

Gen Hosp Psychiatry. 2003 May-Jun;25(3):178-84.

PubMed abstract

Depression treatment in a sample of 1,801 depressed older adults in primary care

Authors: Unutzer J; Hunkeler E; Oishi S; et al.

J Am Geriatr Soc. 2003 Apr;51(4):505-14.

PubMed abstract

Evidence-based care for depression in Maine: dissemination of the Kaiser Permanente Nurse Telecare Program

Authors: Pearson B; Katz SE; Soucie V; Hunkeler E; Meresman J; Rooney T; Amick BC 3rd

Psychiatr Q. 2003 Spring;74(1):91-102.

PubMed abstract

A case report: implementing a nurse telecare program for treating depression in primary care

Authors: Meresman JF; Hunkeler EM; Hargreaves WA; Kirsch AJ; Robinson P; Green A; Mann EZ; Getzell M; Feigenbaum P

Psychiatr Q. 2003 Spring;74(1):61-73.

PubMed abstract

Reaching out and linking up

Authors: Leutz W; Hillier M; Hunkeler E; Nguyen H

In: Leutz W, Greenlick MR, Nonnenkamp L, editors. Linking medical care and community services: Practical models for bridging the gap. New York, NY: Springer Publishing Co; 2003.

Collaborative care management of late-life depression in the primary care setting: a randomized controlled trial

Authors: Unutzer J; Hunkeler E; IMPACT Investigators.Improving Mood-Promoting Access to Collaborative Treatment; et al.

JAMA. 2002 Dec 11;288(22):2836-45.

PubMed abstract

Discontinuation of use and switching of antidepressants: influence of patient-physician communication

Authors: Bull SA; Hu XH; Hunkeler EM; Lee JY; Ming EE; Markson LE; Fireman B

JAMA. 2002 Sep 18;288(11):1403-9.

PubMed abstract

Discontinuing or switching selective serotonin-reuptake inhibitors

Authors: Bull SA; Hunkeler EM; Lee JY; Rowland CR; Williamson TE; Schwab JR; Hurt SW

Ann Pharmacother. 2002 Apr;36(4):578-84.

PubMed abstract

Women referred for on-site domestic violence services in a managed care organization

Authors: McCaw B; Bauer HM; Berman WH; Mooney L; Holmberg M; Hunkeler E

Women Health. 2002;35(2-3):23-40.

PubMed abstract

Beyond screening for domestic violence: a systems model approach in a managed care setting

Authors: McCaw B; Berman WH; Syme SL; Hunkeler EF

Am J Prev Med. 2001 Oct;21(3):170-6.

PubMed abstract

Alcohol consumption patterns and health care costs in an HMO

Authors: Hunkeler EM; Hung YY; Rice DP; Weisner C; Hu T

Drug Alcohol Depend. 2001 Oct 1;64(2):181-90.

PubMed abstract

Improving primary care for depression in late life: the design of a multicenter randomized trial

Authors: Unutzer J; Hunkeler EM; Langston CA; et al.

Med Care. 2001 Aug;39(8):785-99.

PubMed abstract

Improving alcoholism treatment across the spectrum of services

Authors: Hilton ME; Weisner C; Hunkeler E; Shepard D; et al.

Alcohol Clin Exp Res. 2001 Jan;25(1):128-35.

PubMed abstract

The outcome and cost of alcohol and drug treatment in an HMO: day hospital versus traditional outpatient regimens

Authors: Weisner C; Mertens J; Parthasarathy S; Moore C; Hunkeler EM; Hu T; Selby JV

Health Serv Res. 2000 Oct;35(4):791-812.

PubMed abstract

Addiction severity index data from general membership and treatment samples of HMO members. One case of norming the ASI

Authors: Weisner C; McLellan AT; Hunkeler EM

J Subst Abuse Treat. 2000 Sep;19(2):103-9.

PubMed abstract

Efficacy of nurse telehealth care and peer support in augmenting treatment of depression in primary care

Authors: Hunkeler EM; Berman WH; Salzer M; et al.

Arch Fam Med. 2000 Aug;9(8):700-8.

PubMed abstract

Alcohol drinking patterns and medical care use in an HMO setting

Authors: Rice DP; Conell C; Weisner C; Hunkeler EM; Fireman B; Hu TW

J Behav Health Serv Res. 2000 Feb;27(1):3-16.

PubMed abstract

Drinking patterns and problems of the ‘stably insured’: a study of the membership of a health maintenance organization

Authors: Weisner C; Conell C; Hunkeler EM; Rice D; McLellan AT; Hu TW; Fireman B; Moore C

J Stud Alcohol. 2000 Jan;61(1):121-9.

PubMed abstract

Evaluating hypertension control in a managed care setting

Authors: Alexander M; Tekawa I; Hunkeler E; Fireman B; Rowell R; Selby JV; Massie BM; Cooper W

Arch Intern Med. 1999 Dec 13-27;159(22):2673-7.

PubMed abstract

Role of a psychiatric outcome study in a large scale quality improvement project

Authors: Walter LJ; Schaefer C; Albright L; Parthasarathy S; Hunkeler EM; Westphal J; Williams M

Eval Program Plann. 1999 May;22(2):233-43.

PubMed abstract

Recruitment in the Coronary Artery Disease Risk Development in Young Adults (Cardia) Study

Authors: Hughes GH; Cutter G; Donahue R; Friedman GD; Hulley S; Hunkeler E; Jacobs DR Jr; Liu K; Orden S; Pirie P; et al.

Control Clin Trials. 1987 Dec;8(4 Suppl):68S-73S.

PubMed abstract

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