Carlos Iribarren, MD, MPH, PhD

People

Community-based, Longitudinal Cohort of Patients with Interstitial Lung Disease (ILD) in the Kaiser Permanente Northern California (KPNC) Health System

The KPNC-ILD cohort will consist of approximately 10,000 patients with interstitial lung disease. It will be built through electronic health recordbased case identification using an algorithm that will be further developed. We anticipate optimizing the existing KPNC-ILD algorithm and having a fully operational case identification process. The KPNC-ILD algorithm will be useful to clinical researchers worldwide who are interested in using large electronic health recordbased datasets to identify ILD cohorts.
Investigator: Iribarren, Carlos
Funder: Genentech, Inc.

Community-Based, Longitudinal cohort of Patients with Interstitial Lung Disease in the Kaiser Permanente Northern California Health System

The study aim is to optimize the Kaiser Permanente Northern California (KPNC) Interstitial Lung Disease (ILD) algorithm and establish the KPNC-ILD cohort. The KPNC-ILD cohort will consist of approximately 10,000 patients with ILD. It will be built through electronic health record-based case identification using an algorithm. We will optimize the existing algorithm and have a fully operational case identification process to build the cohort. The algorithm will be useful to clinical researchers worldwide who are interested in using large, electronic health record-based datasets to identify ILD cohorts.
Investigator: Iribarren, Carlos
Funder: Genentech, Inc.

MINERVA Biomarkers Substudy

The purpose of this study is to conduct assays of a selected panel of cardiac/metabolic/cancer biomarkers in blood samples already collected by the MINERVA Study (n = 4,491), currently stored at the Kaiser Permanente Research Bank. The biomarker data will be merged with the study datasets to perform association analyses with risk factors and outcomes. The biomarker panel will include Cystatin C, apolipoprotein A1, apolipoprotein B, Lp(a), BNP, Gamma prime fibrinogen, SuPAR, Galectin-3, hs-troponin, and a cancer biomarker panel.
Investigator: Iribarren, Carlos
Funder: Abbott Laboratories

Population-Based Pharmacogenomic Assessment of QT Prolongation

​Cardiotoxicity of commonly prescribed medications, typically assessed by electrocardiographic features such as prolongation of the QT interval, has regulatory effects and is associated with potentially fatal outcomes. This project aims to advance understanding of the genetic basis for drug cardiotoxicity and its downstream consequences by leveraging the extensive data resources of the Kaiser Permanente Northern California Research Program on Genes, Environment and Health (RPGEH), and the ability to link these data to other health plan databases, namely Kaiser Permanente Northern California’s pharmacy, electrocardiogram, and outpatient/inpatient utilization databases. Longitudinal analyses of the QT interval over up to 20 years will be conducted in the large and ethnically diverse Genetic Epidemiology Research in Adult Health and Aging (GERA) cohort of the RPGEH. Genetic loci that influence adverse drug reactions will be identified and characterized, and the associated biological pathways and tissues will be investigated. This study will also examine: a) genetic predictors of adverse outcomes (e.g., ventricular arrhythmias and Torsade de Pointes), b) whether the identified gene-by-drug interactions are associated with these adverse outcomes, and c) degree of mediation by QTc prolongation.

Investigator: Iribarren, Carlos
Funder: National Heart, Lung, and Blood Institute

Multiethnic Study of Breast Arterial Calcium Gradation and CVD

Specific study aims are: 1) To establish a multi-ethnic cohort between the ages of 60 and 79 years with equal representation of white, African-American, Asian and Hispanic/Latina women. All participants will be recruited at the time of their regular screening mammography and will be free of clinical CVD at baseline. A new, validated densitometry method will be used to estimate BAC mass (in milligrams) using digital mammograms; 2) To document race/ethnic variation in BAC mass and to examine associations of BAC mass with sociodemographic background, family history of CVD, traditional and novel CVD risk factors, reproductive health factors, psychosocial factors, selected mineral metabolism factors, selected medication use (statins and nitrogen-containing bisphosphonates), breast size and sleep-related factors; and 3) To elucidate the role of BAC mass in the prediction of coronary heart disease (CHD), cerebrovascular disease, heart failure, peripheral vascular disease and total CVD and to determine whether adding BAC mass to prediction models based on traditional risk factors improves classification of risk for total CVD and its components. Accomplishing these aims will provide novel insights into the utility of BAC mass as a screening tool to assess CVD risk.
Investigator: Iribarren, Carlos
Funder: National Heart, Lung, and Blood Institute

Pharmacogenomics of Statin Therapy

This study involves statin users with: 1) a major acute coronary event, 2) new onset type 2 diabetes, 3) statin-induced myopathy, and controls free of all three conditions. The objective is to conduct genetic, transcriptomic, proteomic and/or metabolic profiling studies to identify biomarkers of statin response and side effects.
Investigator: Iribarren, Carlos
Funder: National Institute of General Medical Sciences

Genomics of Blood Pressure-induced Target Organ Damage

The study’s aims are to: 1) ascertain the genomic contribution of common genetic variants to blood pressure (BP) variation within and between multiple ethnic groups; 2) conduct Mendelian randomization experiments using all new and known BP-associated variants to investigate the interplay of genetic BP risk with hypertensive target organ damage including left ventricular hypertrophy, renal dysfunction, and clinical cardiovascular disease across ethnic groups; and 3) perform deep whole-genome sequencing in very extreme individuals for systolic blood pressure to uncover the entire spectrum of allele frequencies.
Investigator: Iribarren, Carlos
Funder: National Heart, Lung, and Blood Institute

Defining a Comprehensive Reference Profile of Circulating Human Extracellular RNA: A CARDIA Ancillary Study

Blood and other body fluids harbor abundant and stable extracellular RNAs (exRNA) which are increasingly recognized as novel potential biomarkers of disease. This study has the main objective of generating reference profiles of both short and long non-coding regulatory exRNA, including environmentally-derived exRNA, from 720 plasma samples collected at the 10-year CARDIA visit. These healthy subjects will be stratified as follows: 180 subjects in each of the following 4 groups: male Caucasian, female Caucasian, male African American, female African American.
Investigator: Iribarren, Carlos
Funder: National Heart, Lung, and Blood Institute

Lung Function Decline and Disease Risk from Young Adulthood to Middle Age

This study will take advantage of longitudinal data collection in CARDIA to evaluate the association between lung function and risk of future lung disease and cardiovascular disease. The study will perform spirometry in all CARDIA participants at the year 30 examination, and test the hypothesis that individuals with accelerated decline in lung function are at risk for both pulmonary (COPD) and cardiovascular (hypertension, diastolic heart dysfunction, coronary artery disease, and heart failure) diseases.
Investigator: Iribarren, Carlos
Funder: National Heart, Lung, and Blood Institute

Clinical Utility of Multi-marker Genetic Risk Scores for Prediction of Incident Coronary Heart Disease; A Cohort Study among over 51 Thousand Individuals of European Ancestry

Author(s): Iribarren C; Lu M; Jorgenson E; Martinez M; Lluis-Ganella C; Subirana I; Salas E; Elosua R

Circ Cardiovasc Genet. 2016 Oct 25.

PubMed abstract

High-sensitivity cardiac troponin I and incident coronary heart disease among asymptomatic older adults

Author(s): Iribarren C; Chandra M; Rana JS; Hlatky MA; Fortmann SP; Quertermous T; Go AS

Heart. 2016 Mar 30.

PubMed abstract

Adult Life-Course Trajectories of Lung Function and the Development of Emphysema: The CARDIA Lung Study

Author(s): Washko GR; Iribarren C; Kalhan R; et al.

Am J Med. 2019 Jul 29.

PubMed abstract

Evaluation of commonly used ectoderm markers in iPSC trilineage differentiation

Author(s): Kuang YL; Sanchez G; Iribarren C; Medina MW; et al.

Stem Cell Res. 2019 Apr 10;37:101434. Epub 2019-04-10.

PubMed abstract

Kidney function, proteinuria and breast arterial calcification in women without clinical cardiovascular disease: The MINERVA study

Author(s): Parikh RV; Iribarren C; Lee C; Levine-Hall T; Tan TC; Sanchez G; Ding H; Bidgoli FA; Molloi S; Go AS

PLoS ONE. 2019;14(1):e0210973. Epub 2019-01-17.

PubMed abstract

Large-scale, multi-ethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults

Author(s): Dahlin A; Iribarren C; Lu M; Jorgenson E; Wu AC; et al.

J Allergy Clin Immunol. 2018 Dec 19.

PubMed abstract

Inflammation and Endothelial Activation in Early Adulthood are Associated with Future Emphysema: The CARDIA Lung Study

Author(s): Wells JM; Colangelo LA; Sivarajan L; Thyagarajan B; Dransfield MT; Iribarren C; Reyfman PA; Jacobs DR; Washko GR; Kalhan R

Eur Respir J. 2018 Nov 21.

PubMed abstract

Closing the Evidence Gap in Interstitial Lung Disease: The Promise of Real World Data

Author(s): Farrand E; Anstrom KJ; Bernard G; Butte AJ; Iribarren C; Ley B; Martinez F; Collard HR

Am J Respir Crit Care Med. 2018 Nov 19.

PubMed abstract

Association of Breast Arterial Calcification Presence and Gradation with the Ankle-Brachial Index among Postmenopausal Women

Author(s): Iribarren C; Sanchez G; Lu M; Bidgoli FA; Cho HM; Ding H; Molloi S

Eur J Cardiovasc Med. 2018 Nov;5(5):544-551. Epub 2018-11-16.

PubMed abstract

Characterization of Statin Low-Density Lipoprotein Cholesterol Dose-Response Using Electronic Health Records in a Large Population-Based Cohort

Author(s): Oni-Orisan A; Hoffmann TJ; Ranatunga D; Medina MW; Jorgenson E; Schaefer C; Krauss RM; Iribarren C; Risch N

Circ Genom Precis Med. 2018 Sep;11(9):e002043.

PubMed abstract

Weighted Multi-marker Genetic Risk Scores for Incident Coronary Heart Disease among Individuals of African, Latino and East-Asian Ancestry

Author(s): Iribarren C; Lu M; Jorgenson E; Martínez M; Lluis-Ganella C; Subirana I; Salas E; Elosua R

Sci Rep. 2018 May 01;8(1):6853. Epub 2018-05-01.

PubMed abstract

A large electronic-health-record-based genome-wide study of serum lipids

Author(s): Hoffmann TJ; Theusch E; Haldar T; Ranatunga DK; Jorgenson E; Medina MW; Kvale MN; Kwok PY; Schaefer C; Krauss RM; Iribarren C; Risch N

Nat Genet. 2018 Mar;50(3):401-413. Epub 2018-03-05.

PubMed abstract

Respiratory Symptoms in Young Adults and Future Lung Disease: The CARDIA Lung Study

Author(s): Kalhan R; Iribarren C; Sidney S; Washko GR; et al

Am J Respir Crit Care Med. 2018 Jan 25.

PubMed abstract

A functional splicing variant associated with decreased asthma risk abolishes the ability of gasdermin B (GSMDB) to induce epithelial cell pyroptosis

Author(s): Panganiban RA; Iribarren C; Jorgenson E; Lu Q; et al

J Allergy Clin Immunol. 2018 Jan 09.

PubMed abstract

MultIethNic Study of BrEast ARterial Calcium Gradation and CardioVAscular Disease: cohort recruitment and baseline characteristics

Author(s): Iribarren C; Sanchez G; Husson G; Levine-Hall T; Quesenberry C; Sam DL; Maier J; Chaudhary RS; Patel M; Sadeghi B; Javan H; Cho HM; Ding H; Molloi S

Ann Epidemiol. 2017 Dec 05.

PubMed abstract

Cohort Study of ECG Left Ventricular Hypertrophy Trajectories: Ethnic Disparities, Associations With Cardiovascular Outcomes, and Clinical Utility

Author(s): Iribarren C; Round AD; Lu M; Okin PM; McNulty EJ

J Am Heart Assoc. 2017 Oct 05;6(10). Epub 2017-10-05.

PubMed abstract

Trends in health care utilization for asthma exacerbations among diverse populations with asthma in the United States

Author(s): Stone C; Gebretsadik T; Lee RL; Evans AM; Hartert TV; Mitchel E; Morrow J; Wu AC; Iribarren C; Butler MG; Larkin EK; Turi KN; Wu P

J Allergy Clin Immunol Pract. 2017 Sep 18.

PubMed abstract

Seasonal patterns of Asthma medication fills among diverse populations of the United States

Author(s): Turi KN; Gebretsadik T; Lee RL; Hartert TV; Evans AM; Stone C; Sicignano NM; Wu AC; Iribarren C; Butler MG; Mitchel E; Morrow J; Larkin EK; Wu P

J Asthma. 2017 Sep 07:1-7.

PubMed abstract

Code-Based Diagnostic Algorithms for Idiopathic Pulmonary Fibrosis: Case Validation and Improvement

Author(s): Ley B; Urbania T; Husson G; Vittinghoff E; Brush DR; Eisner MD; Iribarren C; Collard HR

Ann Am Thorac Soc. 2017 Mar 29.

PubMed abstract

Cardiovascular and cerebrovascular events among patients receiving omalizumab: Pooled analysis of patient-level data from 25 randomized, double-blind, placebo-controlled clinical trials

Author(s): Iribarren C; Rothman KJ; Bradley MS; Carrigan G; Eisner MD; Chen H

J Allergy Clin Immunol. 2017 Jan 17.

PubMed abstract

Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation

Author(s): Hoffmann TJ; Ehret GB; Nandakumar P; Ranatunga D; Schaefer C; Kwok PY; Iribarren C; Chakravarti A; Risch N

Nat Genet. 2016 Nov 14.

PubMed abstract

Clinical Utility of Multi-marker Genetic Risk Scores for Prediction of Incident Coronary Heart Disease; A Cohort Study among over 51 Thousand Individuals of European Ancestry

Author(s): Iribarren C; Lu M; Jorgenson E; Martinez M; Lluis-Ganella C; Subirana I; Salas E; Elosua R

Circ Cardiovasc Genet. 2016 Oct 25.

PubMed abstract

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Author(s): Ehret GB; Ferreira T; Chasman DI; Jackson AU; Schmidt EM; Johnson T; Thorleifsson G; Luan J; Donnelly LA; Kanoni S; Petersen AK; Pihur V; Strawbridge RJ; Shungin D; Hughes MF; Meirelles O; Kaakinen M; Bouatia-Naji N; Kristiansson K; Shah S; Kleber ME; Guo X; Lyytikäinen LP; Fava C; Eriksson N; Nolte IM; Magnusson PK; Salfati EL; Rallidis LS; Theusch E; Smith AJ; Folkersen L; Witkowska K; Pers TH; Joehanes R; Kim SK; Lataniotis L; Jansen R; Johnson AD; Warren H; Kim YJ; Zhao W; Wu Y; Tayo BO; Bochud M; CHARGE-EchoGen Consortium; CHARGE-HF Consortium; Wellcome Trust Case Control Consortium; Absher D; Adair LS; Amin N; Arking DE; Axelsson T; Baldassarre D; Balkau B; Bandinelli S; Barnes MR; Barroso I; Bevan S; Bis JC; Bjornsdottir G; Boehnke M; Boerwinkle E; Bonnycastle LL; Boomsma DI; Bornstein SR; Brown MJ; Burnier M; Cabrera CP; Chambers JC; Chang IS; Cheng CY; Chines PS; Chung RH; Collins FS; Connell JM; Döring A; Dallongeville J; Danesh J; de Faire U; Delgado G; Dominiczak AF; Doney AS; Drenos F; Edkins S; Eicher JD; Elosua R; Enroth S; Erdmann J; Eriksson P; Esko T; Evangelou E; Evans A; Fall T; Farrall M; Felix JF; Ferrières J; Ferrucci L; Fornage M; Forrester T; Franceschini N; Franco OH; Franco-Cereceda A; Fraser RM; Ganesh SK; Gao H; Gertow K; Gianfagna F; Gigante B; Giulianini F; Goel A; Goodall AH; Goodarzi MO; Gorski M; Gräßler J; Groves CJ; Gudnason V; Gyllensten U; Hallmans G; Hartikainen AL; Hassinen M; Havulinna AS; Hayward C; Hercberg S; Herzig KH; Hicks AA; Hingorani AD; Hirschhorn JN; Hofman A; Holmen J; Holmen OL; Hottenga JJ; Howard P; Hsiung CA; Hunt SC; Ikram MA; Illig T; Iribarren C; Jensen RA; Kähönen M; Kang HM; Kathiresan S; Keating BJ; Khaw KT; Kim YK; Kim E; Kivimaki M; Klopp N; Kolovou G; Komulainen P; Kooner JS; Kosova G; Krauss RM; Kuh D; Kutalik Z; Kuusisto J; Kvaløy K; Lakka TA; Lee NR; Lee IT; Lee WJ; Levy D; Li X; Liang KW; Lin H; Lin L; Lindström J; Lobbens S; Männistö S; Müller G; Müller-Nurasyid M; Mach F; Markus HS; Marouli E; McCarthy MI; McKenzie CA; Meneton P; Menni C; Metspalu A; Mijatovic V; Moilanen L; Montasser ME; Morris AD; Morrison AC; Mulas A; Nagaraja R; Narisu N; Nikus K; O'Donnell CJ; O'Reilly PF; Ong KK; Paccaud F; Palmer CD; Parsa A; Pedersen NL; Penninx BW; Perola M; Peters A; Poulter N; Pramstaller PP; Psaty BM; Quertermous T; Rao DC; Rasheed A; Rayner NW; Renström F; Rettig R; Rice KM; Roberts R; Rose LM; Rossouw J; Samani NJ; Sanna S; Saramies J; Schunkert H; Sebert S; Sheu WH; Shin YA; Sim X; Smit JH; Smith AV; Sosa MX; Spector TD; Stan?áková A; Stanton AV; Stirrups KE; Stringham HM; Sundstrom J; Swift AJ; Syvänen AC; Tai ES; Tanaka T; Tarasov KV; Teumer A; Thorsteinsdottir U; Tobin MD; Tremoli E; Uitterlinden AG; Uusitupa M; Vaez A; Vaidya D; van Duijn CM; van Iperen EP; Vasan RS; Verwoert GC; Virtamo J; Vitart V; Voight BF; Vollenweider P; Wagner A; Wain LV; Wareham NJ; Watkins H; Weder AB; Westra HJ; Wilks R; Wilsgaard T; Wilson JF; Wong TY; Yang TP; Yao J; Yengo L; Zhang W; Zhao JH; Zhu X; Bovet P; Cooper RS; Mohlke KL; Saleheen D; Lee JY; Elliott P; Gierman HJ; Willer CJ; Franke L; Hovingh GK; Taylor KD; Dedoussis G; Sever P; Wong A; Lind L; Assimes TL; Njølstad I; Schwarz PE; Langenberg C; Snieder H; Caulfield MJ; Melander O; Laakso M; Saltevo J; Rauramaa R; Tuomilehto J; Ingelsson E; Lehtimäki T; Hveem K; Palmas W; März W; Kumari M; Salomaa V; Chen YD; Rotter JI; Froguel P; Jarvelin MR; Lakatta EG; Kuulasmaa K; Franks PW; Hamsten A; Wichmann HE; Palmer CN; Stefansson K; Ridker PM; Loos RJ; Chakravarti A; Deloukas P; Morris AP; Newton-Cheh C; Munroe PB

Nat Genet. 2016 Oct;48(10):1171-84. Epub 2016-09-12.

PubMed abstract

Cardiovascular and cerebrovascular events among patients receiving omalizumab: Results from EXCELS, a prospective cohort study of moderate-to-severe asthma

Author(s): Iribarren C; Rahmaoui A; Long AA; Szefler SJ; Bradley MS; Carrigan G; Eisner MD; Chen H; Omachi TA; Farkouh ME; Rothman KJ

J Allergy Clin Immunol. 2016 Sep 14.

PubMed abstract

High-sensitivity cardiac troponin I and incident coronary heart disease among asymptomatic older adults

Author(s): Iribarren C; Chandra M; Rana JS; Hlatky MA; Fortmann SP; Quertermous T; Go AS

Heart. 2016 Mar 30.

PubMed abstract

Age-related somatic structural changes in the nuclear genome of human blood cells

Author(s): Forsberg LA; Rasi C; Razzaghian HR; Pakalapati G; Waite L; Thilbeault KS; Ronowicz A; Wineinger NE; Tiwari HK; Boomsma D; Westerman MP; Harris JR; Lyle R; Essand M; Eriksson F; Assimes TL; Iribarren C; Strachan E; O'Hanlon TP; Rider LG; Miller FW; Giedraitis V; Lannfelt L; Ingelsson M; Piotrowski A; Pedersen NL; Absher D; Dumanski JP

Am J Hum Genet. 2012 Feb 10;90(2):217-28. Epub 2012 Feb 2.

PubMed abstract

Intake of fish and long-chain omega-3 polyunsaturated fatty acids and incidence of metabolic syndrome among American young adults: a 25-year follow-up study

Author(s): Kim YS; Xun P; Iribarren C; Van Horn L; Steffen L; Daviglus ML; Siscovick D; Liu K; He K

Eur J Nutr. 2016 Jan 27.

PubMed abstract

Susceptibility Loci for Clinical CAD and Subclinical Coronary Atherosclerosis Throughout the Life-Course

Author(s): Salfati E; Nandkeolyar S; Fortmann SP; Sidney S; Hlatky MA; Quertermous T; Go AS; Iribarren C; Herrington DM; Goldstein BA; Assimes TL

Circ Cardiovasc Genet. 2015 Sep 28.

PubMed abstract

Television viewing and hostile personality trait increase the risk of injuries

Author(s): Fabio A; Chen CY; Dearwater S; Jacobs DR; Erickson D; Matthews KA; Iribarren C; Sidney S; Pereira MA

Int J Inj Contr Saf Promot. 2015 Aug 14:1-10.

PubMed abstract

Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

Author(s): Kvale MN; Hesselson S; Hoffmann TJ; Cao Y; Chan D; Connell S; Croen LA; Dispensa BP; Eshragh J; Finn A; Gollub J; Iribarren C; Jorgenson E; Kushi LH; Lao R; Lu Y; Ludwig D; Mathauda GK; McGuire WB; Mei G; Miles S; Mittman M; Patil M; Quesenberry CP Jr; Ranatunga D; Rowell S; Sadler M; Sakoda LC; Shapero M; Shen L; Shenoy T; Smethurst D; Somkin CP; Van Den Eeden SK; Walter L; Wan E; Webster T; Whitmer RA; Wong S; Zau C; Zhan Y; Schaefer C; Kwok PY; Risch N;

​​Genetics. 2015 Aug;200(4):1051-60. doi: 10.1534/genetics.115.178905. Epub 2015 Jun 19.

PubMed abstract

Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

Author(s): Banda Y; Kvale MN; Hoffmann TJ; Hesselson SE; Ranatunga D; Tang H; Sabatti C; Croen LA; Dispensa BP; Henderson M; Iribarren C; Jorgenson E; Kushi LH; Ludwig D; Olberg D; Quesenberry CP Jr; Rowell S; Sadler M; Sakoda LC; Sciortino S; Shen L; Smethurst D; Somkin CP; Van Den Eeden SK; Walter L; Whitmer RA; Kwok PY; Schaefer C; Risch N;

​Genetics. 2015 Aug;200(4):1285-95. doi: 10.1534/genetics.115.178616. Epub 2015 Jun 19.

PubMed abstract

Short QT in a Cohort of 1.7 Million Persons: Prevalence, Correlates, and Prognosis

Author(s): Iribarren C; Round AD; Peng JA; Lu M; Klatsky AL; Zaroff JG; Holve TJ; Prasad A; Stang P

Ann Noninvasive Electrocardiol. 2014 Sep;19(5):490-500. Epub 2014-05-14.

PubMed abstract

Incidence of malignancy in patients with moderate-to-severe asthma treated with or without omalizumab.

Author(s): Long A; Rahmaoui A; Rothman KJ; Guinan E; Eisner M; Bradley MS; Iribarren C; Chen H; Carrigan G; Rosén K; Szefler SJ

J Allergy Clin Immunol. 2014 Sep;134(3):560-567.e4. Epub 2014-03-27.

PubMed abstract

Hostility Modifies the Association between TV Viewing and Cardiometabolic Risk

Author(s): Fabio A; Chen CY; Kim KH; Erickson D; Jacobs DR; Zgibor JC; Chung T; Matthews KA; Sidney S; Iribarren C; Pereira MA

J Obes. 2014;2014:784594. Epub 2014-06-23.

PubMed abstract

Discovery and refinement of loci associated with lipid levels

Author(s): Global Lipids Genetics Consortium; Willer CJ; Schmidt EM; Sengupta S; Peloso GM; Gustafsson S; Kanoni S; Ganna A; Chen J; Buchkovich ML; Mora S; Beckmann JS; Bragg-Gresham JL; Chang HY; Demirkan A; Den Hertog HM; Do R; Donnelly LA; Ehret GB; Esko T; Feitosa MF; Ferreira T; Fischer K; Fontanillas P; Fraser RM; Freitag DF; Gurdasani D; Heikkilä K; Hyppönen E; Isaacs A; Jackson AU; Johansson A; Johnson T; Kaakinen M; Kettunen J; Kleber ME; Li X; Luan J; Lyytikäinen LP; Magnusson PK; Mangino M; Mihailov E; Montasser ME; Müller-Nurasyid M; Nolte IM; O'Connell JR; Palmer CD; Perola M; Petersen AK; Sanna S; Saxena R; Service SK; Shah S; Shungin D; Sidore C; Song C; Strawbridge RJ; Surakka I; Tanaka T; Teslovich TM; Thorleifsson G; Van den Herik EG; Voight BF; Volcik KA; Waite LL; Wong A; Wu Y; Zhang W; Absher D; Asiki G; Barroso I; Been LF; Bolton JL; Bonnycastle LL; Brambilla P; Burnett MS; Cesana G; Dimitriou M; Doney AS; Döring A; Elliott P; Epstein SE; Eyjolfsson GI; Gigante B; Goodarzi MO; Grallert H; Gravito ML; Groves CJ; Hallmans G; Hartikainen AL; Hayward C; Hernandez D; Hicks AA; Holm H; Hung YJ; Illig T; Jones MR; Kaleebu P; Kastelein JJ; Khaw KT; Kim E; Klopp N; Komulainen P; Kumari M; Langenberg C; Lehtimäki T; Lin SY; Lindström J; Loos RJ; Mach F; McArdle WL; Meisinger C; Mitchell BD; Müller G; Nagaraja R; Narisu N; Nieminen TV; Nsubuga RN; Olafsson I; Ong KK; Palotie A; Papamarkou T; Pomilla C; Pouta A; Rader DJ; Reilly MP; Ridker PM; Rivadeneira F; Rudan I; Ruokonen A; Samani N; Scharnagl H; Seeley J; Silander K; Stancáková A; Stirrups K; Swift AJ; Tiret L; Uitterlinden AG; van Pelt LJ; Vedantam S; Wainwright N; Wijmenga C; Wild SH; Willemsen G; Wilsgaard T; Wilson JF; Young EH; Zhao JH; Adair LS; Arveiler D; Assimes TL; Bandinelli S; Bennett F; Bochud M; Boehm BO; Boomsma DI; Borecki IB; Bornstein SR; Bovet P; Burnier M; Campbell H; Chakravarti A; Chambers JC; Chen YD; Collins FS; Cooper RS; Danesh J; Dedoussis G; de Faire U; Feranil AB; Ferrières J; Ferrucci L; Freimer NB; Gieger C; Groop LC; Gudnason V; Gyllensten U; Hamsten A; Harris TB; Hingorani A; Hirschhorn JN; Hofman A; Hovingh GK; Hsiung CA; Humphries SE; Hunt SC; Hveem K; Iribarren C; Järvelin MR; Jula A; Kähönen M; Kaprio J; Kesäniemi A; Kivimaki M; Kooner JS; Koudstaal PJ; Krauss RM; Kuh D; Kuusisto J; Kyvik KO; Laakso M; Lakka TA; Lind L; Lindgren CM; Martin NG; März W; McCarthy MI; McKenzie CA; Meneton P; Metspalu A; Moilanen L; Morris AD; Munroe PB; Njølstad I; Pedersen NL; Power C; Pramstaller PP; Price JF; Psaty BM; Quertermous T; Rauramaa R; Saleheen D; Salomaa V; Sanghera DK; Saramies J; Schwarz PE; Sheu WH; Shuldiner AR; Siegbahn A; Spector TD; Stefansson K; Strachan DP; Tayo BO; Tremoli E; Tuomilehto J; Uusitupa M; van Duijn CM; Vollenweider P; Wallentin L; Wareham NJ; Whitfield JB; Wolffenbuttel BH; Ordovas JM; Boerwinkle E; Palmer CN; Thorsteinsdottir U; Chasman DI; Rotter JI; Franks PW; Ripatti S; Cupples LA; Sandhu MS; Rich SS; Boehnke M; Deloukas P; Kathiresan S; Mohlke KL; Ingelsson E; Abecasis GR

Nat Genet. 2013 Nov;45(11):1274-83. Epub 2013-10-06.

PubMed abstract

Validation of a population-based method to assess drug-induced alterations in the QT interval: a self-controlled crossover study

Author(s): Iribarren C; Round AD; Peng JA; Lu M; Zaroff JG; Holve TJ; Prasad A; Stang P

Pharmacoepidemiol Drug Saf. 2013 Nov;22(11):1222-32. Epub 2013-07-16.

PubMed abstract

Common variants associated with plasma triglycerides and risk for coronary artery disease

Author(s): Do R; Willer CJ; Schmidt EM; Sengupta S; Gao C; Peloso GM; Gustafsson S; Kanoni S; Ganna A; Chen J; Buchkovich ML; Mora S; Beckmann JS; Bragg-Gresham JL; Chang HY; Demirkan A; Den Hertog HM; Donnelly LA; Ehret GB; Esko T; Feitosa MF; Ferreira T; Fischer K; Fontanillas P; Fraser RM; Freitag DF; Gurdasani D; Heikkilä K; Hyppönen E; Isaacs A; Jackson AU; Johansson A; Johnson T; Kaakinen M; Kettunen J; Kleber ME; Li X; Luan J; Lyytikäinen LP; Magnusson PK; Mangino M; Mihailov E; Montasser ME; Müller-Nurasyid M; Nolte IM; O'Connell JR; Palmer CD; Perola M; Petersen AK; Sanna S; Saxena R; Service SK; Shah S; Shungin D; Sidore C; Song C; Strawbridge RJ; Surakka I; Tanaka T; Teslovich TM; Thorleifsson G; Van den Herik EG; Voight BF; Volcik KA; Waite LL; Wong A; Wu Y; Zhang W; Absher D; Asiki G; Barroso I; Been LF; Bolton JL; Bonnycastle LL; Brambilla P; Burnett MS; Cesana G; Dimitriou M; Doney AS; Döring A; Elliott P; Epstein SE; Eyjolfsson GI; Gigante B; Goodarzi MO; Grallert H; Gravito ML; Groves CJ; Hallmans G; Hartikainen AL; Hayward C; Hernandez D; Hicks AA; Holm H; Hung YJ; Illig T; Jones MR; Kaleebu P; Kastelein JJ; Khaw KT; Kim E; Klopp N; Komulainen P; Kumari M; Langenberg C; Lehtimäki T; Lin SY; Lindström J; Loos RJ; Mach F; McArdle WL; Meisinger C; Mitchell BD; Müller G; Nagaraja R; Narisu N; Nieminen TV; Nsubuga RN; Olafsson I; Ong KK; Palotie A; Papamarkou T; Pomilla C; Pouta A; Rader DJ; Reilly MP; Ridker PM; Rivadeneira F; Rudan I; Ruokonen A; Samani N; Scharnagl H; Seeley J; Silander K; Stančáková A; Stirrups K; Swift AJ; Tiret L; Uitterlinden AG; van Pelt LJ; Vedantam S; Wainwright N; Wijmenga C; Wild SH; Willemsen G; Wilsgaard T; Wilson JF; Young EH; Zhao JH; Adair LS; Arveiler D; Assimes TL; Bandinelli S; Bennett F; Bochud M; Boehm BO; Boomsma DI; Borecki IB; Bornstein SR; Bovet P; Burnier M; Campbell H; Chakravarti A; Chambers JC; Chen YD; Collins FS; Cooper RS; Danesh J; Dedoussis G; de Faire U; Feranil AB; Ferrières J; Ferrucci L; Freimer NB; Gieger C; Groop LC; Gudnason V; Gyllensten U; Hamsten A; Harris TB; Hingorani A; Hirschhorn JN; Hofman A; Hovingh GK; Hsiung CA; Humphries SE; Hunt SC; Hveem K; Iribarren C; Järvelin MR; Jula A; Kähönen M; Kaprio J; Kesäniemi A; Kivimaki M; Kooner JS; Koudstaal PJ; Krauss RM; Kuh D; Kuusisto J; Kyvik KO; Laakso M; Lakka TA; Lind L; Lindgren CM; Martin NG; März W; McCarthy MI; McKenzie CA; Meneton P; Metspalu A; Moilanen L; Morris AD; Munroe PB; Njølstad I; Pedersen NL; Power C; Pramstaller PP; Price JF; Psaty BM; Quertermous T; Rauramaa R; Saleheen D; Salomaa V; Sanghera DK; Saramies J; Schwarz PE; Sheu WH; Shuldiner AR; Siegbahn A; Spector TD; Stefansson K; Strachan DP; Tayo BO; Tremoli E; Tuomilehto J; Uusitupa M; van Duijn CM; Vollenweider P; Wallentin L; Wareham NJ; Whitfield JB; Wolffenbuttel BH; Altshuler D; Ordovas JM; Boerwinkle E; Palmer CN; Thorsteinsdottir U; Chasman DI; Rotter JI; Franks PW; Ripatti S; Cupples LA; Sandhu MS; Rich SS; Boehnke M; Deloukas P; Mohlke KL; Ingelsson E; Abecasis GR; Daly MJ; Neale BM; Kathiresan S

Nat Genet. 2013 Nov;45(11):1345-52. Epub 2013-10-06.

PubMed abstract

African American race but not genome-wide ancestry is negatively associated with atrial fibrillation among postmenopausal women in the Women's Health Initiative

Author(s): Perez MV; Hoffmann TJ; Tang H; Thornton T; Stefanick ML; Larson JC; Kooperberg C; Reiner AP; Caan B; Iribarren C; Risch N

Am Heart J. 2013 Sep;166(3):566-72.

PubMed abstract

Risk Adjustment for Health Care Financing in Chronic Disease: What Are We Missing By Failing to Account for Disease Severity?

Author(s): Omachi TA; Gregorich SE; Eisner MD; Penaloza RA; Tolstykh IV; Yelin EH; Iribarren C; Dudley RA; Blanc PD

Med Care. 2013 Aug;51(8):740-7.

PubMed abstract

Oral Contraceptive Use and the ECG: Evidence of an Adverse QT Effect on Corrected QT Interval

Author(s): Sedlak T; Shufelt C; Iribarren C; Lyon LL; Bairey Merz CN

Ann Noninvasive Electrocardiol. 2013 Jul;18(4):389-98. Epub 2013-05-03.

PubMed abstract

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

Author(s): den Hoed M; Eijgelsheim M; Esko T; Brundel BJ; Peal DS; Evans DM; Nolte IM; Segre AV; Holm H; Handsaker RE; Westra HJ; Johnson T; Isaacs A; Yang J; Lundby A; Zhao JH; Kim YJ; Go MJ; Almgren P; Bochud M; Boucher G; Cornelis MC; Gudbjartsson D; Hadley D; van der Harst P; Hayward C; den Heijer M; Igl W; Jackson AU; Kutalik Z; Luan J; Kemp JP; Kristiansson K; Ladenvall C; Lorentzon M; Montasser ME; Njajou OT; O'Reilly PF; Padmanabhan S; St Pourcain B; Rankinen T; Salo P; Tanaka T; Timpson NJ; Vitart V; Waite L; Wheeler W; Zhang W; Draisma HH; Feitosa MF; Kerr KF; Lind PA; Mihailov E; Onland-Moret NC; Song C; Weedon MN; Xie W; Yengo L; Absher D; Albert CM; Alonso A; Arking DE; de Bakker PI; Balkau B; Barlassina C; Benaglio P; Bis JC; Bouatia-Naji N; Brage S; Chanock SJ; Chines PS; Chung M; Darbar D; Dina C; Dorr M; Elliott P; Felix SB; Fischer K; Fuchsberger C; de Geus EJ; Goyette P; Gudnason V; Harris TB; Hartikainen AL; Havulinna AS; Heckbert SR; Hicks AA; Hofman A; Holewijn S; Hoogstra-Berends F; Hottenga JJ; Jensen MK; Johansson A; Junttila J; Kaab S; Kanon B; Ketkar S; Khaw KT; Knowles JW; Kooner AS; Kors JA; Kumari M; Milani L; Laiho P; Lakatta EG; Langenberg C; Leusink M; Liu Y; Luben RN; Lunetta KL; Lynch SN; Markus MR; Marques-Vidal P; Mateo Leach I; McArdle WL; McCarroll SA; Medland SE; Miller KA; Montgomery GW; Morrison AC; Muller-Nurasyid M; Navarro P; Nelis M; O'Connell JR; O'Donnell CJ; Ong KK; Newman AB; Peters A; Polasek O; Pouta A; Pramstaller PP; Psaty BM; Rao DC; Ring SM; Rossin EJ; Rudan D; Sanna S; Scott RA; Sehmi JS; Sharp S; Shin JT; Singleton AB; Smith AV; Soranzo N; Spector TD; Stewart C; Stringham HM; Tarasov KV; Uitterlinden AG; Vandenput L; Hwang SJ; Whitfield JB; Wijmenga C; Wild SH; Willemsen G; Wilson JF; Witteman JC; Wong A; Wong Q; Jamshidi Y; Zitting P; Boer JM; Boomsma DI; Borecki IB; van Duijn CM; Ekelund U; Forouhi NG; Froguel P; Hingorani A; Ingelsson E; Kivimaki M; Kronmal RA; Kuh D; Lind L; Martin NG; Oostra BA; Pedersen NL; Quertermous T; Rotter JI; van der Schouw YT; Verschuren WM; Walker M; Albanes D; Arnar DO; Assimes TL; Bandinelli S; Boehnke M; de Boer RA; Bouchard C; Caulfield WL; Chambers JC; Curhan G; Cusi D; Eriksson J; Ferrucci L; van Gilst WH; Glorioso N; de Graaf J; Groop L; Gyllensten U; Hsueh WC; Hu FB; Huikuri HV; Hunter DJ; Iribarren C; Isomaa B; Jarvelin MR; Jula A; Kahonen M; Kiemeney LA; Van der Klauw MM; Kooner JS; Kraft P; Iacoviello L; Lehtimaki T; Lokki ML; Mitchell BD; Navis G; Nieminen MS; Ohlsson C; Poulter NR; Qi L; Raitakari OT; Rimm EB; Rioux JD; Rizzi F; Rudan I; Salomaa V; Sever PS; Shields DC; Shuldiner AR; Sinisalo J; Stanton AV; Stolk RP; Strachan DP; Tardif JC; Thorsteinsdottir U; Tuomilehto J; van Veldhuisen DJ; Virtamo J; Viikari J; Vollenweider P; Waeber G; Widen E; Cho YS; Olsen JV; Visscher PM; Willer C; Franke L; Global BPgen Consortium; CARDIoGRAM Consortium; Erdmann J; Thompson JR; PR GWAS Consortium; Pfeufer A

Nat Genet. 2013 Jun;45(6):621-31. Epub 2013 Apr 14.

PubMed abstract

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Author(s): Randall JC; Winkler TW; Kutalik Z; Berndt SI; Jackson AU; Monda KL; Kilpelainen TO; Esko T; Magi R; Li S; Workalemahu T; Feitosa MF; Croteau-Chonka DC; Day FR; Fall T; Ferreira T; Gustafsson S; Locke AE; Mathieson I; Scherag A; Vedantam S; Wood AR; Liang L; Steinthorsdottir V; Thorleifsson G; Dermitzakis ET; Dimas AS; Karpe F; Min JL; Nicholson G; Clegg DJ; Person T; Krohn JP; Bauer S; Buechler C; Eisinger K; DIAGRAM Consortium; Bonnefond A; Froguel P; MAGIC Investigators; Hottenga JJ; Prokopenko I; Waite LL; Harris TB; Smith AV; Shuldiner AR; McArdle WL; Caulfield MJ; Munroe PB; Gronberg H; Chen YD; Li G; Beckmann JS; Johnson T; Thorsteinsdottir U; Teder-Laving M; Khaw KT; Wareham NJ; Zhao JH; Amin N; Oostra BA; Kraja AT; Province MA; Cupples LA; Heard-Costa NL; Kaprio J; Ripatti S; Surakka I; Collins FS; Saramies J; Tuomilehto J; Jula A; Salomaa V; Erdmann J; Hengstenberg C; Loley C; Schunkert H; Lamina C; Wichmann HE; Albrecht E; Gieger C; Hicks AA; Johansson A; Pramstaller PP; Kathiresan S; Speliotes EK; Penninx B; Hartikainen AL; Jarvelin MR; Gyllensten U; Boomsma DI; Campbell H; Wilson JF; Chanock SJ; Farrall M; Goel A; Medina-Gomez C; Rivadeneira F; Estrada K; Uitterlinden AG; Hofman A; Zillikens MC; den Heijer M; Kiemeney LA; Maschio A; Hall P; Tyrer J; Teumer A; Volzke H; Kovacs P; Tonjes A; Mangino M; Spector TD; Hayward C; Rudan I; Hall AS; Samani NJ; Attwood AP; Sambrook JG; Hung J; Palmer LJ; Lokki ML; Sinisalo J; Boucher G; Huikuri H; Lorentzon M; Ohlsson C; Eklund N; Eriksson JG; Barlassina C; Rivolta C; Nolte IM; Snieder H; Van der Klauw MM; Van Vliet-Ostaptchouk JV; Gejman PV; Shi J; Jacobs KB; Wang Z; Bakker SJ; Mateo Leach I; Navis G; van der Harst P; Martin NG; Medland SE; Montgomery GW; Yang J; Chasman DI; Ridker PM; Rose LM; Lehtimaki T; Raitakari O; Absher D; Iribarren C; Basart H; Hovingh KG; Hypponen E; Power C; Anderson D; Beilby JP; Hui J; Jolley J; Sager H; Bornstein SR; Schwarz PE; Kristiansson K; Perola M; Lindstrom J; Swift AJ; Uusitupa M; Atalay M; Lakka TA; Rauramaa R; Bolton JL; Fowkes G; Fraser RM; Price JF; Fischer K; Krjuta Kov K; Metspalu A; Mihailov E; Langenberg C; Luan J; Ong KK; Chines PS; Keinanen-Kiukaanniemi SM; Saaristo TE; Edkins S; Franks PW; Hallmans G; Shungin D; Morris AD; Palmer CN; Erbel R; Moebus S; Nothen MM; Pechlivanis S; Hveem K; Narisu N; Hamsten A; Humphries SE; Strawbridge RJ; Tremoli E; Grallert H; Thorand B; Illig T; Koenig W; Muller-Nurasyid M; Peters A; Boehm BO; Kleber ME; Marz W; Winkelmann BR; Kuusisto J; Laakso M; Arveiler D; Cesana G; Kuulasmaa K; Virtamo J; Yarnell JW; Kuh D; Wong A; Lind L; de Faire U; Gigante B; Magnusson PK; Pedersen NL; Dedoussis G; Dimitriou M; Kolovou G; Kanoni S; Stirrups K; Bonnycastle LL; Njolstad I; Wilsgaard T; Ganna A; Rehnberg E; Hingorani A; Kivimaki M; Kumari M; Assimes TL; Barroso I; Boehnke M; Borecki IB; Deloukas P; Fox CS; Frayling T; Groop LC; Haritunians T; Hunter D; Ingelsson E; Kaplan R; Mohlke KL; O'Connell JR; Schlessinger D

PLoS Genet. 2013 Jun;9(6):e1003500. Epub 2013 Jun 6.

PubMed abstract

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Author(s): Berndt SI; Gustafsson S; Magi R; Ganna A; Wheeler E; Feitosa MF; Justice AE; Monda KL; Croteau-Chonka DC; Day FR; Esko T; Fall T; Ferreira T; Gentilini D; Jackson AU; Luan J; Randall JC; Vedantam S; Willer CJ; Winkler TW; Wood AR; Workalemahu T; Hu YJ; Lee SH; Liang L; Lin DY; Min JL; Neale BM; Thorleifsson G; Yang J; Albrecht E; Amin N; Bragg-Gresham JL; Cadby G; den Heijer M; Eklund N; Fischer K; Goel A; Hottenga JJ; Huffman JE; Jarick I; Johansson A; Johnson T; Kanoni S; Kleber ME; Konig IR; Kristiansson K; Kutalik Z; Lamina C; Lecoeur C; Li G; Mangino M; McArdle WL; Medina-Gomez C; Muller-Nurasyid M; Ngwa JS; Nolte IM; Paternoster L; Pechlivanis S; Perola M; Peters MJ; Preuss M; Rose LM; Shi J; Shungin D; Smith AV; Strawbridge RJ; Surakka I; Teumer A; Trip MD; Tyrer J; Van Vliet-Ostaptchouk JV; Vandenput L; Waite LL; Zhao JH; Absher D; Asselbergs FW; Atalay M; Attwood AP; Balmforth AJ; Basart H; Beilby J; Bonnycastle LL; Brambilla P; Bruinenberg M; Campbell H; Chasman DI; Chines PS; Collins FS; Connell JM; Cookson WO; de Faire U; de Vegt F; Dei M; Dimitriou M; Edkins S; Estrada K; Evans DM; Farrall M; Ferrario MM; Ferrieres J; Franke L; Frau F; Gejman PV; Grallert H; Gronberg H; Gudnason V; Hall AS; Hall P; Hartikainen AL; Hayward C; Heard-Costa NL; Heath AC; Hebebrand J; Homuth G; Hu FB; Hunt SE; Hypponen E; Iribarren C; Jacobs KB; Jansson JO; Jula A; Kahonen M; Kathiresan S; Kee F; Khaw KT; Kivimaki M; Koenig W; Kraja AT; Kumari M; Kuulasmaa K; Kuusisto J; Laitinen JH; Lakka TA; Langenberg C; Launer LJ; Lind L; Lindstrom J; Liu J; Liuzzi A; Lokki ML; Lorentzon M; Madden PA; Magnusson PK; Manunta P; Marek D; Marz W; Mateo Leach I; McKnight B; Medland SE; Mihailov E; Milani L; Montgomery GW; Mooser V; Muhleisen TW; Munroe PB; Musk AW; Narisu N; Navis G; Nicholson G; Nohr EA; Ong KK; Oostra BA; Palmer CN; Palotie A; Peden JF; Pedersen N; Peters A; Polasek O; Pouta A; Pramstaller PP; Prokopenko I; Putter C; Radhakrishnan A; Raitakari O; Rendon A; Rivadeneira F; Rudan I; Saaristo TE; Sambrook JG; Sanders AR; Sanna S; Saramies J; Schipf S; Schreiber S; Schunkert H; Shin SY; Signorini S; Sinisalo J; Skrobek B; Soranzo N; Stancakova A; Stark K; Stephens JC; Stirrups K; Stolk RP; Stumvoll M; Swift AJ; Theodoraki EV; Thorand B; Tregouet DA; Tremoli E; van der Klauw MM; van Meurs JB; Vermeulen SH; Viikari J; Virtamo J; Vitart V; Waeber G; Wang Z; Widen E; Wild SH; Willemsen G; Winkelmann BR; Witteman JC; Wolffenbuttel BH; Wong A; Wright AF; Zillikens MC; Amouyel P; Boehm BO; Boerwinkle E; Boomsma DI; Caulfield MJ; Chanock SJ; Cupples LA; Cusi D; Dedoussis GV; Erdmann J; Eriksson JG; Franks PW; Froguel P; Gieger C; Gyllensten U; Hamsten A; Harris TB; Hengstenberg C; Hicks AA; Hingorani A; Hinney A; Hofman A; Hovingh KG; Hveem K; Illig T; Jarvelin MR; Jockel KH; Keinanen-Kiukaanniemi SM; Kiemeney LA; Kuh D; Laakso M; Lehtimaki T; Levinson DF; Martin NG; Metspalu A; Morris AD; Nieminen MS; Njølstad I; Ohlsson C; Oldehinkel AJ; Ouwehand WH; Palmer LJ; Penninx B; Power C; Province MA; Psaty BM; Qi L; Rauramaa R; Ridker PM; Ripatti S; Salomaa V; Samani NJ; Snieder H; Sørensen TI; Spector TD; Stefansson K; Tönjes A; Tuomilehto J; Uitterlinden AG; Uusitupa M; van der Harst P; Vollenweider P; Wallaschofski H; Wareham NJ; Watkins H; Wichmann HE; Wilson JF; Abecasis GR; Assimes TL; Barroso I; Boehnke M; Borecki IB; Deloukas P; Fox CS; Frayling T; Groop LC; Haritunian T; Heid IM; Hunter D; Kaplan RC; Karpe F; Moffatt MF; Mohlke KL; O'Connell JR; Pawitan Y; Schadt EE; Schlessinger D; Steinthorsdottir V; Strachan DP; Thorsteinsdottir U; van Duijn CM; Visscher PM; Di Blasio AM; Hirschhorn JN; Lindgren CM; Morris AP; Meyre D; Scherag A; McCarthy MI; Speliotes EK; North KE; Loos RJ; Ingelsson E

Nat Genet. 2013 May;45(5):501-12. Epub 2013 Apr 7.

PubMed abstract

Breast Arterial Calcification: a New Marker of Cardiovascular Risk?

Author(s): Iribarren C; Molloi S

Curr Cardiovasc Risk Rep. 2013 Apr;7(2):126-135. Epub 2013 Feb 3.

PubMed abstract

Intakes of long-chain omega-3 (n-3) PUFAs and fish in relation to incidence of asthma among American young adults: the CARDIA study

Author(s): Li J; Xun P; Zamora D; Sood A; Liu K; Daviglus M; Iribarren C; Jacobs D Jr; Shikany JM; He K

Am J Clin Nutr. 2013 Jan;97(1):173-8. Epub 2012 Nov 28.

PubMed abstract

Large-scale association analysis identifies new risk loci for coronary artery disease

Author(s): CARDIoGRAMplusC4D Consortium; Deloukas P; Kanoni S; Willenborg C; Farrall M; Assimes TL; Thompson JR; Ingelsson E; Saleheen D; Erdmann J; Goldstein BA; Stirrups K; Konig IR; Cazier JB; Johansson A; Hall AS; Lee JY; Willer CJ; Chambers JC; Esko T; Folkersen L; Goel A; Grundberg E; Havulinna AS; Ho WK; Hopewell JC; Eriksson N; Kleber ME; Kristiansson K; Lundmark P; Lyytikainen LP; Rafelt S; Shungin D; Strawbridge RJ; Thorleifsson G; Tikkanen E; Van Zuydam N; Voight BF; Waite LL; Zhang W; Ziegler A; Absher D; Altshuler D; Balmforth AJ; Barroso I; Braund PS; Burgdorf C; Claudi-Boehm S; Cox D; Dimitriou M; Do R; DIAGRAM Consortium; CARDIOGENICS Consortium; Doney AS; El Mokhtari N; Eriksson P; Fischer K; Fontanillas P; Franco-Cereceda A; Gigante B; Groop L; Gustafsson S; Hager J; Hallmans G; Han BG; Hunt SE; Kang HM; Illig T; Kessler T; Knowles JW; Kolovou G; Kuusisto J; Langenberg C; Langford C; Leander K; Lokki ML; Lundmark A; McCarthy MI; Meisinger C; Melander O; Mihailov E; Maouche S; Morris AD; Muller-Nurasyid M; MuTHER Consortium; Nikus K; Peden JF; Rayner NW; Rasheed A; Rosinger S; Rubin D; Rumpf MP; Schafer A; Sivananthan M; Song C; Stewart AF; Tan ST; Thorgeirsson G; van der Schoot CE; Wagner PJ; Wellcome Trust Case Control Consortium; Wells GA; Wild PS; Yang TP; Amouyel P; Arveiler D; Basart H; Boehnke M; Boerwinkle E; Brambilla P; Cambien F; Cupples AL; de Faire U; Dehghan A; Diemert P; Epstein SE; Evans A; Ferrario MM; Ferrieres J; Gauguier D; Go AS; Goodall AH; Gudnason V; Hazen SL; Holm H; Iribarren C; Jang Y; Kahonen M; Kee F; Kim HS; Klopp N; Koenig W; Kratzer W; Kuulasmaa K; Laakso M; Laaksonen R; Lee JY; Lind L; Ouwehand WH; Parish S; Park JE; Pedersen NL; Peters A; Quertermous T; Rader DJ; Salomaa V; Schadt E; Shah SH; Sinisalo J; Stark K; Stefansson K; Tregouet DA; Virtamo J; Wallentin L; Wareham N; Zimmermann ME; Nieminen MS; Hengstenberg C; Sandhu MS; Pastinen T; Syvanen AC; Hovingh GK; Dedoussis G; Franks PW; Lehtimaki T; Metspalu A; Zalloua PA; Siegbahn A; Schreiber S; Ripatti S; Blankenberg SS; Perola M; Clarke R; Boehm BO; O'Donnell C; Reilly MP; Marz W; Collins R; Kathiresan S; Hamsten A; Kooner JS; Thorsteinsdottir U; Danesh J; Palmer CN; Roberts R; Watkins H; Schunkert H; Samani NJ

Nat Genet. 2013 Jan;45(1):25-33. Epub 2012 Dec 2.

PubMed abstract

Adult asthma and risk of coronary heart disease, cerebrovascular disease, and heart failure: a prospective study of 2 matched cohorts

Author(s): Iribarren C; Tolstykh IV; Miller MK; Sobel E; Eisner MD

Am J Epidemiol. 2012 Dec 1;176(11):1014-24. Epub 2012 Nov 8.

PubMed abstract

FTO genotype is associated with phenotypic variability of body mass index

Author(s): Yang J; Loos RJ; Powell JE; Medland SE; Speliotes EK; Chasman DI; Rose LM; Thorleifsson G; Steinthorsdottir V; Magi R; Waite L; Yerges-Armstrong LM; Monda KL; Hadley D; Mahajan A; Li G; Kapur K; Vitart V; Huffman JE; Wang SR; Palmer C; Esko T; Fischer K; Demirkan A; Isaacs A; Feitosa MF; Luan J; Heard-Costa NL; White C; Jackson AU; Preuss M; Ziegler A; Eriksson J; Kutalik Z; Frau F; Nolte IM; Van Vliet-Ostaptchouk JV; Hottenga JJ; Jacobs KB; Verweij N; Goel A; Medina-Gomez C; Estrada K; Sanna S; Sidore C; Tyrer J; Teumer A; Prokopenko I; Mangino M; Lindgren CM; Assimes TL; Shuldiner AR; Hui J; Beilby JP; McArdle WL; Hall P; Haritunians T; Zgaga L; Kolcic I; Polasek O; Zemunik T; Oostra BA; Gronberg H; Schreiber S; Peters A; Hicks AA; Stephens J; Foad NS; Laitinen J; Pouta A; Kaakinen M; Willemsen G; Vink JM; Wild SH; Navis G; Asselbergs FW; Homuth G; John U; Iribarren C; Harris T; Launer L; Gudnason V; O'Connell JR; Boerwinkle E; Cadby G; Palmer LJ; James AL; Musk AW; Ingelsson E; Psaty BM; Beckmann JS; Waeber G; Vollenweider P; Hayward C; Wright AF; Rudan I; Groop LC; Metspalu A; Tee Khaw K; van Duijn CM; Borecki IB; Province MA; Wareham NJ; Tardif JC; Huikuri HV; Atwood LD; Fox CS; Boehnke M; Collins FS; Mohlke KL; Erdmann J; Schunkert H; Hengstenberg C; Stark K; Lorentzon M; Ohlsson C; Cusi D; Staessen JA; Van der Klauw MM; Pramstaller PP; Kathiresan S; Jolley JD; Ripatti S; Jarvelin MR; de Geus EJ; Boomsma DI; Penninx B; Wilson JF; Campbell H; Chanock SJ; van der Harst P; Hamsten A; Watkins H; Hofman A; Witteman JC; Uitterlinden AG; Rivadeneira F; Kiemeney LA; Vermeulen SH; Abecasis GR; Schlessinger D; Schipf S; Stumvoll M; Tonjes A; Spector TD; North KE; Lettre G; McCarthy MI; Berndt SI; Heath AC; Madden PA; Nyholt DR; Montgomery GW; Martin NG; McKnight B; Strachan DP; Hill WG; Snieder H; Ridker PM; Thorsteinsdottir U; Stefansson K; Frayling TM; Hirschhorn JN; Goddard ME; Visscher PM; Smith AV; Zhao JH; Bragg-Gresham JL; Junttila MJ; Cupples LA; Zillikens MC; Zillikens MC

Nature. 2012 Oct 11;490(7419):267-72. Epub 2012 Sep 16.

PubMed abstract

Sex Hormones and the QT Interval: A Review

Author(s): Sedlak T; Shufelt C; Iribarren C; Merz CN

J Womens Health (Larchmt). 2012 Sep;21(9):933-41. Epub 2012 Jun 4.

PubMed abstract

Both Pulmonary and Extra-Pulmonary Factors Predict the Development of Disability in Chronic Obstructive Pulmonary Disease

Author(s): Singer JP; Katz PP; Iribarren C; Omachi TA; Sanchez G; Yelin EH; Cisternas MG; Blanc PD

Respiration. 2013;85(5):375-83. Epub 2012 Jun 9.

PubMed abstract

Relationship of obesity with respiratory symptoms and decreased functional capacity in adults without established COPD

Author(s): Zutler M; Singer JP; Omachi TA; Eisner M; Iribarren C; Katz P; Blanc PD

Prim Care Respir J. 2012 Jun;21(2):194-201.

PubMed abstract

Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm

Author(s): Hoffmann TJ; Zhan Y; Kvale MN; Hesselson SE; Gollub J; Iribarren C; Lu Y; Mei G; Purdy MM; Quesenberry C; Rowell S; Shapero MH; Smethurst D; Somkin CP; Van den Eeden SK; Walter L; Webster T; Whitmer RA; Finn A; Schaefer C; Kwok PY; Risch N

Genomics. 2011 Dec;98(6):422-30. Epub 2011 Aug 28.

PubMed abstract

Chronic kidney disease and risk for presenting with acute myocardial infarction versus stable exertional angina in adults with coronary heart disease

Author(s): Go AS; Bansal N; Chandra M; Lathon PV; Fortmann SP; Iribarren C; Hsu CY; Hlatky MA; ADVANCE Study Investigators

J Am Coll Cardiol. 2011 Oct 4;58(15):1600-7.

PubMed abstract

Potential role of differential medication use in explaining excess risk of cardiovascular events and death associated with chronic kidney disease: A cohort study

Author(s): Bansal N; Hsu CY; Chandra M; Iribarren C; Fortmann SP; Hlatky MA; Go AS

BMC Nephrol. 2011 Sep 14;12:44.

PubMed abstract

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Author(s): International Consortium for Blood Pressure Genome-Wide Association Studies; Ehret GB; Munroe PB; Rice KM; Bochud M; Johnson AD; Chasman DI; Smith AV; Tobin MD; Verwoert GC; Hwang SJ; Pihur V; Vollenweider P; O'Reilly PF; Amin N; Bragg-Gresham JL; Teumer A; Glazer NL; Launer L; Zhao JH; Aulchenko Y; Heath S; Sober S; Parsa A; Luan J; Arora P; Dehghan A; Zhang F; Lucas G; Hicks AA; Jackson AU; Peden JF; Tanaka T; Wild SH; Rudan I; Igl W; Milaneschi Y; Parker AN; Fava C; Chambers JC; Fox ER; Kumari M; Go MJ; van der Harst P; Kao WH; Sjogren M; Vinay DG; Alexander M; Tabara Y; Shaw-Hawkins S; Whincup PH; Liu Y; Shi G; Kuusisto J; Tayo B; Seielstad M; Sim X; Nguyen KD; Lehtimaki T; Matullo G; Wu Y; Gaunt TR; Onland-Moret NC; Cooper MN; Platou CG; Org E; Hardy R; Dahgam S; Palmen J; Vitart V; Braund PS; Kuznetsova T; Uiterwaal CS; Adeyemo A; Palmas W; Campbell H; Ludwig B; Tomaszewski M; Tzoulaki I; Palmer ND; CARDIoGRAM consortium; CKDGen Consortium; KidneyGen Consortium; EchoGen consortium; CHARGE-HF consortium; Aspelund T; Garcia M; Chang YP; O'Connell JR; Steinle NI; Grobbee DE; Arking DE; Kardia SL; Morrison AC; Hernandez D; Najjar S; McArdle WL; Hadley D; Brown MJ; Connell JM; Hingorani AD; Day IN; Lawlor DA; Beilby JP; Lawrence RW; Clarke R; Hopewell JC; Ongen H; Dreisbach AW; Li Y; Young JH; Bis JC; Kahonen M; Viikari J; Adair LS; Lee NR; Chen MH; Olden M; Pattaro C; Bolton JA; Kottgen A; Bergmann S; Mooser V; Chaturvedi N; Frayling TM; Islam M; Jafar TH; Erdmann J; Kulkarni SR; Bornstein SR; Grassler J; Groop L; Voight BF; Kettunen J; Howard P; Taylor A; Guarrera S; Ricceri F; Emilsson V; Plump A; Barroso I; Khaw KT; Weder AB; Hunt SC; Sun YV; Collins FS; Bonnycastle LL; Scott LJ; Stringham HM; Peltonen L; Perola M; Vartiainen E; Brand SM; Staessen JA; Wang TJ; Burton PR; Artigas MS; Dong Y; Snieder H; Wang X; Zhu H; Lohman KK; Rudock ME; Heckbert SR; Smith NL; Wiggins KL; Doumatey A; Shriner D; Veldre G; Viigimaa M; Kinra S; Prabhakaran D; Tripathy V; Langefeld CD; Rosengren A; Thelle DS; Corsi AM; Singleton A; Forrester T; Hilton G; McKenzie CA; Salako T; Iwai N; Kita Y; Ogihara T; Ohkubo T; Okamura T; Ueshima H; Umemura S; Eyheramendy S; Meitinger T; Wichmann HE; Cho YS; Kim HL; Lee JY; Scott J; Sehmi JS; Zhang W; Hedblad B; Nilsson P; Smith GD; Wong A; Narisu N; Stancakova A; Raffel LJ; Yao J; Kathiresan S; O'Donnell CJ; Schwartz SM; Ikram MA; Longstreth WT Jr; Mosley TH; Seshadri S; Shrine NR; Wain LV; Morken MA; Swift AJ; Laitinen J; Prokopenko I; Zitting P; Cooper JA; Humphries SE; Danesh J; Rasheed A; Goel A; Hamsten A; Watkins H; Bakker SJ; van Gilst WH; Janipalli CS; Mani KR; Yajnik CS; Hofman A; Mattace-Raso FU; Oostra BA; Demirkan A; Isaacs A; Rivadeneira F; Lakatta EG; Orru M; Scuteri A; Ala-Korpela M; Kangas AJ; Lyytikainen LP; Soininen P; Tukiainen T; Wurtz P; Ong RT; Dorr M; Kroemer HK; Volker U; Volzke H; Galan P; Hercberg S; Dehghan A; Hofman A; Meitinger T; Erdmann J; Wichmann HE; O'Donnell CJ; Voight BF; Peltonen L; Kathiresan S; Schwartz SM; Mooser V; Braund PS; Smith NL; Morrison AC; Glazer NL; Dehghan A; Rivadeneira F; Bis JC; Wang TJ; Rice KM; Hofman A; Heckbert SR; Fox ER; O'Donnell CJ; Kottgen A; Pattaro C; Olden M; Glazer NL; Parsa A; Smith AV; O'Connell JR; Tanaka T; Isaacs A; Hwang SJ; Johnson AD; Dehghan A; Teumer A; Aspelund T; Arking DE; Singleton A; Oostra BA; Wichmann HE; Igl W; Wild SH; Campbell H; Rivadeneira F; Hofman A; Volzke H; Kroemer HK; Volker U; Vitart V; Parker AN; Kardia SL; Liu Y; Prokopenko I; Rudan I; Chasman DI; Kao WH; Glazer NL; Smith NL; Dehghan A; Teumer A; Kathiresan S; Bis JC; Rivadeneira F; Erdmann J; Dorr M; Volker U; O'Donnell CJ; Heckbert SR; Hofman A; Meitinger T; Wang TJ; Wichmann HE; Kroemer HK; Volzke H; Chambers JC; Zhang W; van der Harst P; Lawlor DA; Sehmi JS; Bakker SJ; Bochud M; Brown MJ; Connell JM; Hedblad B; Li Y; Luan J; Munroe PB; Parsa A; Peltonen L; Prokopenko I; Sjogren M; Snieder H; Tanaka T; Vollenweider P; Mooser V; Scott J; Bergman R

Nature. 2011 Sep 11;478(7367):103-9.

PubMed abstract

Ethnicity and risk of hospitalization for asthma and chronic obstructive pulmonary disease

Author(s): Tran HN; Siu S; Iribarren C; Udaltsova N; Klatsky AL

Ann Epidemiol. 2011 Aug;21(8):615-22. Epub 2011 Mar 17.

PubMed abstract

Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array.

Author(s): Hoffmann TJ; Kvale MN; Hesselson SE; Zhan Y; Aquino C; Cao Y; Cawley S; Chung E; Connell S; Eshragh J; Ewing M; Gollub J; Henderson M; Hubbell E; Iribarren C; Kaufman J; Lao RZ; Lu Y; Ludwig D; Mathauda GK; McGuire W; Mei G; Miles S; Purdy MM; Quesenberry C; Ranatunga D; Rowell S; Sadler M; Shapero MH; Shen L; Shenoy TR; Smethurst D; Van den Eeden SK; Walter L; Wan E; Wearley R; Webster T; Wen CC; Weng L; Whitmer RA; Williams A; Wong SC; Zau C; Finn A; Schaefer C; Kwok PY; Risch N.;

​​Genomics. 2011 Aug;98(2):79-89. doi: 10.1016/j.ygeno.2011.04.005. Epub 2011 Apr 30.

PubMed abstract

Racial variation in lipoprotein-associated phospholipase A in older adults

Author(s): Lee KK; Fortmann SP; Varady A; Fair JM; Go AS; Quertermous T; Hlatky MA; Iribarren C

BMC Cardiovasc Disord. 2011 Jun 29;11:38.

PubMed abstract

Circulating angiopoietins-1 and -2, angiopoietin receptor Tie-2 and vascular endothelial growth factor-A as biomarkers of acute myocardial infarction: a prospective nested case-control study

Author(s): Iribarren C; Phelps BH; Darbinian JA; McCluskey ER; Quesenberry CP; Hytopoulos E; Vogelman JH; Orentreich N

BMC Cardiovasc Disord. 2011 Jun 14;11:31.

PubMed abstract

Physical activity in older subjects is associated with increased coronary vasodilation: the ADVANCE study

Author(s): Nguyen PK; Terashima M; Fair JM; Varady A; Taylor-Piliae RE; Iribarren C; Go AS; Haskell WL; Hlatky MA; Fortmann SP; McConnell MV

JACC Cardiovasc Imaging. 2011 Jun;4(6):622-9.

PubMed abstract

Ankle brachial index screening in asymptomatic older adults

Author(s): Taylor-Piliae RE; Fair JM; Varady AN; Hlatky MA; Norton LC; Iribarren C; Go AS; Fortmann SP

Am Heart J. 2011 May;161(5):979-85.

PubMed abstract

A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium

Author(s): Kraja AT; Vaidya D; Pankow JS; Goodarzi MO; Assimes TL; Kullo IJ; Sovio U; Mathias RA; Sun YV; Franceschini N; Absher D; Li G; Zhang Q; Feitosa MF; Glazer NL; Haritunians T; Hartikainen AL; Knowles JW; North KE; Iribarren C; Kral B; Yanek L; O'Reilly PF; McCarthy MI; Jaquish C; Couper DJ; Chakravarti A; Psaty BM; Becker LC; Province MA; Boerwinkle E; Quertermous T; Palotie L; Jarvelin MR; Becker DM; Kardia SL; Rotter JI; Chen YD; Borecki IB

Diabetes. 2011 Apr;60(4):1329-39. Epub 2011 Mar 8.

PubMed abstract

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Author(s): Schunkert H; Konig IR; Kathiresan S; Reilly MP; Assimes TL; Holm H; Preuss M; Stewart AF; Barbalic M; Gieger C; Absher D; Aherrahrou Z; Allayee H; Altshuler D; Anand SS; Andersen K; Anderson JL; Ardissino D; Ball SG; Balmforth AJ; Barnes TA; Becker DM; Becker LC; Berger K; Bis JC; Boekholdt SM; Boerwinkle E; Braund PS; Brown MJ; Burnett MS; Buysschaert I; Cardiogenics; Carlquist JF; Chen L; Cichon S; Codd V; Davies RW; Dedoussis G; Dehghan A; Demissie S; Devaney JM; Diemert P; Do R; Doering A; Eifert S; Mokhtari NE; Ellis SG; Elosua R; Engert JC; Epstein SE; de Faire U; Fischer M; Folsom AR; Freyer J; Gigante B; Girelli D; Gretarsdottir S; Gudnason V; Gulcher JR; Halperin E; Hammond N; Hazen SL; Hofman A; Horne BD; Illig T; Iribarren C; Jones GT; Jukema JW; Kaiser MA; Kaplan LM; Kastelein JJ; Khaw KT; Knowles JW; Kolovou G; Kong A; Laaksonen R; Lambrechts D; Leander K; Lettre G; Li M; Lieb W; Loley C; Lotery AJ; Mannucci PM; Maouche S; Martinelli N; McKeown PP; Meisinger C; Meitinger T; Melander O; Merlini PA; Mooser V; Morgan T; Muhleisen TW; Muhlestein JB; Munzel T; Musunuru K; Nahrstaedt J; Nelson CP; Nothen MM; Olivieri O; Patel RS; Patterson CC; Peters A; Peyvandi F; Qu L; Quyyumi AA; Rader DJ; Rallidis LS; Rice C; Rosendaal FR; Rubin D; Salomaa V; Sampietro ML; Sandhu MS; Schadt E; Schafer A; Schillert A; Schreiber S; Schrezenmeir J; Schwartz SM; Siscovick DS; Sivananthan M; Sivapalaratnam S; Smith A; Smith TB; Snoep JD; Soranzo N; Spertus JA; Stark K; Stirrups K; Stoll M; Tang WH; Tennstedt S; Thorgeirsson G; Thorleifsson G; Tomaszewski M; Uitterlinden AG; van Rij AM; Voight BF; Wareham NJ; Wells GA; Wichmann HE; Wild PS; Willenborg C; Witteman JC; Wright BJ; Ye S; Zeller T; Ziegler A; Cambien F; Goodall AH; Cupples LA; Quertermous T; Marz W; Hengstenberg C; Blankenberg S; Ouwehand WH; Hall AS; Deloukas P; Thompson JR; Stefansson K; Roberts R; Thorsteinsdottir U; O'Donnell CJ; McPherson R; Erdmann J; CARDIoGRAM Consortium; Samani NJ

Nat Genet. 2011 Mar 6;43(4):333-8.

PubMed abstract

Respiratory and skeletal muscle strength in chronic obstructive pulmonary disease: impact on exercise capacity and lower extremity function

Author(s): Singer J; Yelin EH; Katz PP; Sanchez G; Iribarren C; Eisner MD; Blanc PD

J Cardiopulm Rehabil Prev. 2011 Mar-Apr;31(2):111-9.

PubMed abstract

Development of disability in chronic obstructive pulmonary disease: beyond lung function

Author(s): Eisner MD; Iribarren C; Blanc PD; Yelin EH; Ackerson L; Byl N; Omachi TA; Sidney S; Katz PP

Thorax. 2011 Feb;66(2):108-14. Epub 2010 Nov 3.

PubMed abstract

Socioeconomic status, race and COPD health outcomes

Author(s): Eisner MD; Blanc PD; Omachi TA; Yelin EH; Sidney S; Katz PP; Ackerson LM; Sanchez G; Tolstykh I; Iribarren C

J Epidemiol Community Health. 2011 Jan;65(1):26-34. Epub 2009 Oct 23.

PubMed abstract

Right coronary wall CMR in the older asymptomatic advance cohort: positive remodeling and associations with type 2 diabetes and coronary calcium

Author(s): Terashima M; Nguyen PK; Rubin GD; Meyer CH; Shimakawa A; Nishimura DG; Ehara S; Iribarren C; Courtney BK; Go AS; Hlatky MA; Fortmann SP; McConnell MV

J Cardiovasc Magn Reson. 2010 Dec 30;12:75.

PubMed abstract

Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies

Author(s): Assimes TL; Holm H; Kathiresan S; Reilly MP; Thorleifsson G; Voight BF; Erdmann J; Willenborg C; Vaidya D; Xie C; Patterson CC; Morgan TM; Burnett MS; Li M; Hlatky MA; Knowles JW; Thompson JR; Absher D; Iribarren C; Go A; Fortmann SP; Sidney S; Risch N; Tang H; Myers RM; Berger K; Stoll M; Shah SH; Thorgeirsson G; Andersen K; Havulinna AS; Herrera JE; Faraday N; Kim Y; Kral BG; Mathias RA; Ruczinski I; Suktitipat B; Wilson AF; Yanek LR; Becker LC; Linsel-Nitschke P; Lieb W; Konig IR; Hengstenberg C; Fischer M; Stark K; Reinhard W; Winogradow J; Grassl M; Grosshennig A; Preuss M; Schreiber S; Wichmann HE; Meisinger C; Yee J; Friedlander Y; Do R; Meigs JB; Williams G; Nathan DM; MacRae CA; Qu L; Wilensky RL; Matthai WH; Qasim AN; Hakonarson H; Pichard AD; Kent KM; Satler L; Lindsay JM; Waksman R; Knouff CW; Waterworth DM; Walker MC; Mooser VE; Marrugat J; Lucas G; Subirana I; Sala J; Ramos R; Martinelli N; Olivieri O; Trabetti E; Malerba G; Pignatti PF; Guiducci C; Mirel D; Parkin M; Hirschhorn JN; Asselta R; Duga S; Musunuru K; Daly MJ; Purcell S; Eifert S; Braund PS; Wright BJ; Balmforth AJ; Ball SG; Ouwehand WH; Deloukas P; Scholz M; Cambien F; Huge A; Scheffold T; Salomaa V; Girelli D; Granger CB; Peltonen L; McKeown PP; Altshuler D; Melander O; Devaney JM; Epstein SE; Rader DJ; Elosua R; Engert JC; Anand SS; Hall AS; Ziegler A; O'Donnell CJ; Spertus JA; Siscovick D; Schwartz SM; Becker D; Thorsteinsdottir U; Stefansson K; Schunkert H; Samani NJ; Quertermous T; Myocardial Infarction Genetics Consortium; Wellcome Trust Case Control Consortium; Cardiogenics

J Am Coll Cardiol. 2010 Nov 2;56(19):1552-63.

PubMed abstract

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Author(s): Heid IM; Jackson AU; Randall JC; Winkler TW; Qi L; Steinthorsdottir V; Thorleifsson G; Zillikens MC; Speliotes EK; Mägi R; Workalemahu T; White CC; Bouatia-Naji N; Harris TB; Berndt SI; Ingelsson E; Willer CJ; Weedon MN; Luan J; Vedantam S; Esko T; Kilpeläinen TO; Kutalik Z; Li S; Monda KL; Dixon AL; Holmes CC; Kaplan LM; Liang L; Min JL; Moffatt MF; Molony C; Nicholson G; Schadt EE; Zondervan KT; Feitosa MF; Ferreira T; Allen HL; Weyant RJ; Wheeler E; Wood AR; MAGIC; Estrada K; Goddard ME; Lettre G; Mangino M; Nyholt DR; Purcell S; Smith AV; Visscher PM; Yang J; McCarroll SA; Nemesh J; Voight BF; Absher D; Amin N; Aspelund T; Coin L; Glazer NL; Hayward C; Heard-Costa NL; Hottenga JJ; Johansson A; Johnson T; Kaakinen M; Kapur K; Ketkar S; Knowles JW; Kraft P; Kraja AT; Lamina C; Leitzmann MF; McKnight B; Morris AP; Ong KK; Perry JR; Peters MJ; Polasek O; Prokopenko I; Rayner NW; Ripatti S; Rivadeneira F; Robertson NR; Sanna S; Sovio U; Surakka I; Teumer A; van Wingerden S; Vitart V; Zhao JH; Cavalcanti-Proença C; Chines PS; Fisher E; Kulzer JR; Lecoeur C; Narisu N; Sandholt C; Scott LJ; Silander K; Stark K; Tammesoo ML; Teslovich TM; Timpson NJ; Watanabe RM; Welch R; Chasman DI; Cooper MN; Jansson JO; Kettunen J; Lawrence RW; Pellikka N; Perola M; Vandenput L; Alavere H; Almgren P; Atwood LD; Bennett AJ; Biffar R; Bonnycastle LL; Bornstein SR; Buchanan TA; Campbell H; Day IN; Dei M; Dörr M; Elliott P; Erdos MR; Eriksson JG; Freimer NB; Fu M; Gaget S; Geus EJ; Gjesing AP; Grallert H; Grässler J; Groves CJ; Guiducci C; Hartikainen AL; Hassanali N; Havulinna AS; Herzig KH; Hicks AA; Hui J; Igl W; Jousilahti P; Jula A; Kajantie E; Kinnunen L; Kolcic I; Koskinen S; Kovacs P; Kroemer HK; Krzelj V; Kuusisto J; Kvaloy K; Laitinen J; Lantieri O; Lathrop GM; Lokki ML; Luben RN; Ludwig B; McArdle WL; McCarthy A; Morken MA; Nelis M; Neville MJ; Paré G; Parker AN; Peden JF; Pichler I; Pietiläinen KH; Platou CG; Pouta A; Ridderstråle M; Samani NJ; Saramies J; Sinisalo J; Smit JH; Strawbridge RJ; Stringham HM; Swift AJ; Teder-Laving M; Thomson B; Usala G; van Meurs JB; van Ommen GJ; Vatin V; Volpato CB; Wallaschofski H; Walters GB; Widen E; Wild SH; Willemsen G; Witte DR; Zgaga L; Zitting P; Beilby JP; James AL; Kähönen M; Lehtimäki T; Nieminen MS; Ohlsson C; Palmer LJ; Raitakari O; Ridker PM; Stumvoll M; Tönjes A; Viikari J; Balkau B; Ben-Shlomo Y; Bergman RN; Boeing H; Smith GD; Ebrahim S; Froguel P; Hansen T; Hengstenberg C; Hveem K; Isomaa B; Jørgensen T; Karpe F; Khaw KT; Laakso M; Lawlor DA; Marre M; Meitinger T; Metspalu A; Midthjell K; Pedersen O; Salomaa V; Schwarz PE; Tuomi T; Tuomilehto J; Valle TT; Wareham NJ; Arnold AM; Beckmann JS; Bergmann S; Boerwinkle E; Boomsma DI; Caulfield MJ; Collins FS; Eiriksdottir G; Gudnason V; Gyllensten U; Hamsten A; Hattersley AT; Hofman A; Hu FB; Illig T; Iribarren C; Jarvelin MR; Kao WH; Kaprio J; Launer LJ; Munroe PB; Oostra B; Penninx BW; Pramstaller PP; Psaty BM; Quertermous T; Rissanen A; Rudan I; Shuldiner AR; Soranzo N; Spector TD; Syvanen AC; Uda M; Uitterlinden A; Völzke H; Vollenweider P; Wilson JF; Witteman JC; Wright AF; Abecasis GR; Boehnke M; Borecki IB; Deloukas P; Frayling TM; Groop LC; Haritunians T; Hunter DJ; Kaplan RC; North KE; O'Connell JR; Peltonen L; Schlessinger D; Strachan DP; Hirschhorn JN; Assimes TL; Wichmann HE; Thorsteinsdottir U; van Duijn CM; Stefansson K; Cupples LA; Loos RJ; Barroso I; McCarthy MI; Fox CS; Mohlke KL; Lindgren CM; MAGIC

Nat Genet. 2010 Nov;42(11):949-60. Epub 2010 Oct 10.

PubMed abstract

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Author(s): Speliotes EK; Willer CJ; Berndt SI; Monda KL; Thorleifsson G; Jackson AU; Allen HL; Lindgren CM; Luan J; Mägi R; Randall JC; Vedantam S; Winkler TW; Qi L; Workalemahu T; Heid IM; Steinthorsdottir V; Stringham HM; Weedon MN; Wheeler E; Wood AR; Ferreira T; Weyant RJ; Segrè AV; Estrada K; Liang L; Nemesh J; Park JH; Gustafsson S; Kilpeläinen TO; Yang J; Bouatia-Naji N; Esko T; Feitosa MF; Kutalik Z; Mangino M; Raychaudhuri S; Scherag A; Smith AV; Welch R; Zhao JH; Aben KK; Absher DM; Amin N; Dixon AL; Fisher E; Glazer NL; Goddard ME; Heard-Costa NL; Hoesel V; Hottenga JJ; Johansson A; Johnson T; Ketkar S; Lamina C; Li S; Moffatt MF; Myers RH; Narisu N; Perry JR; Peters MJ; Preuss M; Ripatti S; Rivadeneira F; Sandholt C; Scott LJ; Timpson NJ; Tyrer JP; van Wingerden S; Watanabe RM; White CC; Wiklund F; Barlassina C; Chasman DI; Cooper MN; Jansson JO; Lawrence RW; Pellikka N; Prokopenko I; Shi J; Thiering E; Alavere H; Alibrandi MT; Almgren P; Arnold AM; Aspelund T; Atwood LD; Balkau B; Balmforth AJ; Bennett AJ; Ben-Shlomo Y; Bergman RN; Bergmann S; Biebermann H; Blakemore AI; Boes T; Bonnycastle LL; Bornstein SR; Brown MJ; Buchanan TA; Busonero F; Campbell H; Cappuccio FP; Cavalcanti-Proença C; Chen YD; Chen CM; Chines PS; Clarke R; Coin L; Connell J; Day IN; Heijer M; Duan J; Ebrahim S; Elliott P; Elosua R; Eiriksdottir G; Erdos MR; Eriksson JG; Facheris MF; Felix SB; Fischer-Posovszky P; Folsom AR; Friedrich N; Freimer NB; Fu M; Gaget S; Gejman PV; Geus EJ; Gieger C; Gjesing AP; Goel A; Goyette P; Grallert H; Grässler J; Greenawalt DM; Groves CJ; Gudnason V; Guiducci C; Hartikainen AL; Hassanali N; Hall AS; Havulinna AS; Hayward C; Heath AC; Hengstenberg C; Hicks AA; Hinney A; Hofman A; Homuth G; Hui J; Igl W; Iribarren C; Isomaa B; Jacobs KB; Jarick I; Jewell E; John U; Jørgensen T; Jousilahti P; Jula A; Kaakinen M; Kajantie E; Kaplan LM; Kathiresan S; Kettunen J; Kinnunen L; Knowles JW; Kolcic I; König IR; Koskinen S; Kovacs P; Kuusisto J; Kraft P; Kvaløy K; Laitinen J; Lantieri O; Lanzani C; Launer LJ; Lecoeur C; Lehtimäki T; Lettre G; Liu J; Lokki ML; Lorentzon M; Luben RN; Ludwig B; MAGIC; Manunta P; Marek D; Marre M; Martin NG; McArdle WL; McCarthy A; McKnight B; Meitinger T; Melander O; Meyre D; Midthjell K; Montgomery GW; Morken MA; Morris AP; Mulic R; Ngwa JS; Nelis M; Neville MJ; Nyholt DR; O'Donnell CJ; O'Rahilly S; Ong KK; Oostra B; Paré G; Parker AN; Perola M; Pichler I; Pietiläinen KH; Platou CG; Polasek O; Pouta A; Rafelt S; Raitakari O; Rayner NW; Ridderstråle M; Rief W; Ruokonen A; Robertson NR; Rzehak P; Salomaa V; Sanders AR; Sandhu MS; Sanna S; Saramies J; Savolainen MJ; Scherag S; Schipf S; Schreiber S; Schunkert H; Silander K; Sinisalo J; Siscovick DS; Smit JH; Soranzo N; Sovio U; Stephens J; Surakka I; Swift AJ; Tammesoo ML; Tardif JC; Teder-Laving M; Teslovich TM; Thompson JR; Thomson B; Tönjes A; Tuomi T; van Meurs JB; van Ommen GJ; Vatin V; Viikari J; Visvikis-Siest S; Vitart V; Vogel CI; Voight BF; Waite LL; Wallaschofski H; Walters GB; Widen E; Wiegand S; Wild SH; Willemsen G; Witte DR; Witteman JC; Xu J; Zhang Q; Zgaga L; Ziegler A; Zitting P; Beilby JP; Farooqi IS; Hebebrand J; Huikuri HV; James AL; Kähönen M; Levinson DF; Macciardi F; Nieminen MS; Ohlsson C; Palmer LJ; Ridker PM; Stumvoll M; Beckmann JS; Boeing H; Boerwinkle E; Boomsma DI; Caulfield MJ; Chanock SJ; Collins FS; Cupples LA; Smith GD; Erdmann J; Froguel P; Grönberg H; Gyllensten U; Hall P; Hansen T; Harris TB; Hattersley AT; Hayes RB; Heinrich J; Hu FB; Hveem K; Illig T; Jarvelin MR; Kaprio J; Karpe F; Khaw KT; Kiemeney LA; Krude H; Laakso M; Lawlor DA; Metspalu A; Munroe PB; Ouwehand WH; Pedersen O; Penninx BW; Peters A; Pramstaller PP; Quertermous T; Reinehr T; Rissanen A; Rudan I; Samani NJ; Schwarz PE; Shuldiner AR; Spector TD; Tuomilehto J; Uda M; Uitterlinden A; Valle TT; Wabitsch M; Waeber G; Wareham NJ; Watkins H; Procardis Consortium; Wilson JF; Wright AF; Zillikens MC; Chatterjee N; McCarroll SA; Purcell S; Schadt EE; Visscher PM; Assimes TL; Borecki IB; Deloukas P; Fox CS; Groop LC; Haritunians T; Hunter DJ; Kaplan RC; Mohlke KL; O'Connell JR; Peltonen L; Schlessinger D; Strachan DP; van Duijn CM; Wichmann HE; Frayling TM; Thorsteinsdottir U; Abecasis GR; Barroso I; Boehnke M; Stefansson K; North KE; McCarthy MI; Hirschhorn JN; Ingelsson E; Loos RJ; MAGIC; Procardis Consortium

Nat Genet. 2010 Nov;42(11):937-48. Epub 2010 Oct 10.

PubMed abstract

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Author(s): Lango Allen H; Estrada K; Lettre G; Berndt SI; Weedon MN; Rivadeneira F; Willer CJ; Jackson AU; Vedantam S; Raychaudhuri S; Ferreira T; Wood AR; Weyant RJ; Segrè AV; Speliotes EK; Wheeler E; Soranzo N; Park JH; Yang J; Gudbjartsson D; Heard-Costa NL; Randall JC; Qi L; Vernon Smith A; Mägi R; Pastinen T; Liang L; Heid IM; Luan J; Thorleifsson G; Winkler TW; Goddard ME; Sin Lo K; Palmer C; Workalemahu T; Aulchenko YS; Johansson A; Zillikens MC; Feitosa MF; Esko T; Johnson T; Ketkar S; Kraft P; Mangino M; Prokopenko I; Absher D; Albrecht E; Ernst F; Glazer NL; Hayward C; Hottenga JJ; Jacobs KB; Knowles JW; Kutalik Z; Monda KL; Polasek O; Preuss M; Rayner NW; Robertson NR; Steinthorsdottir V; Tyrer JP; Voight BF; Wiklund F; Xu J; Zhao JH; Nyholt DR; Pellikka N; Perola M; Perry JR; Surakka I; Tammesoo ML; Altmaier EL; Amin N; Aspelund T; Bhangale T; Boucher G; Chasman DI; Chen C; Coin L; Cooper MN; Dixon AL; Gibson Q; Grundberg E; Hao K; Juhani Junttila M; Kaplan LM; Kettunen J; König IR; Kwan T; Lawrence RW; Levinson DF; Lorentzon M; McKnight B; Morris AP; Müller M; Suh Ngwa J; Purcell S; Rafelt S; Salem RM; Salvi E; Sanna S; Shi J; Sovio U; Thompson JR; Turchin MC; Vandenput L; Verlaan DJ; Vitart V; White CC; Ziegler A; Almgren P; Balmforth AJ; Campbell H; Citterio L; De Grandi A; Dominiczak A; Duan J; Elliott P; Elosua R; Eriksson JG; Freimer NB; Geus EJ; Glorioso N; Haiqing S; Hartikainen AL; Havulinna AS; Hicks AA; Hui J; Igl W; Illig T; Jula A; Kajantie E; Kilpeläinen TO; Koiranen M; Kolcic I; Koskinen S; Kovacs P; Laitinen J; Liu J; Lokki ML; Marusic A; Maschio A; Meitinger T; Mulas A; Paré G; Parker AN; Peden JF; Petersmann A; Pichler I; Pietiläinen KH; Pouta A; Ridderstråle M; Rotter JI; Sambrook JG; Sanders AR; Schmidt CO; Sinisalo J; Smit JH; Stringham HM; Bragi Walters G; Widen E; Wild SH; Willemsen G; Zagato L; Zgaga L; Zitting P; Alavere H; Farrall M; McArdle WL; Nelis M; Peters MJ; Ripatti S; van Meurs JB; Aben KK; Ardlie KG; Beckmann JS; Beilby JP; Bergman RN; Bergmann S; Collins FS; Cusi D; den Heijer M; Eiriksdottir G; Gejman PV; Hall AS; Hamsten A; Huikuri HV; Iribarren C; Kähönen M; Kaprio J; Kathiresan S; Kiemeney L; Kocher T; Launer LJ; Lehtimäki T; Melander O; Mosley TH Jr; Musk AW; Nieminen MS; O'Donnell CJ; Ohlsson C; Oostra B; Palmer LJ; Raitakari O; Ridker PM; Rioux JD; Rissanen A; Rivolta C; Schunkert H; Shuldiner AR; Siscovick DS; Stumvoll M; Tönjes A; Tuomilehto J; van Ommen GJ; Viikari J; Heath AC; Martin NG; Montgomery GW; Province MA; Kayser M; Arnold AM; Atwood LD; Boerwinkle E; Chanock SJ; Deloukas P; Gieger C; Grönberg H; Hall P; Hattersley AT; Hengstenberg C; Hoffman W; Lathrop GM; Salomaa V; Schreiber S; Uda M; Waterworth D; Wright AF; Assimes TL; Barroso I; Hofman A; Mohlke KL; Boomsma DI; Caulfield MJ; Cupples LA; Erdmann J; Fox CS; Gudnason V; Gyllensten U; Harris TB; Hayes RB; Jarvelin MR; Mooser V; Munroe PB; Ouwehand WH; Penninx BW; Pramstaller PP; Quertermous T; Rudan I; Samani NJ; Spector TD; Völzke H; Watkins H; Wilson JF; Groop LC; Haritunians T; Hu FB; Kaplan RC; Metspalu A; North KE; Schlessinger D; Wareham NJ; Hunter DJ; O'Connell JR; Strachan DP; Wichmann HE; Borecki IB; van Duijn CM; Schadt EE; Thorsteinsdottir U; Peltonen L; Uitterlinden AG; Visscher PM; Chatterjee N; Loos RJ; Boehnke M; McCarthy MI; Ingelsson E; Lindgren CM; Abecasis GR; Stefansson K; Frayling TM; Hirschhorn JN

Nature. 2010 Oct 14;467(7317):832-8. Epub 2010 Sep 29.

PubMed abstract

COPD and cognitive impairment: the role of hypoxemia and oxygen therapy

Author(s): Thakur N; Blanc PD; Julian LJ; Yelin EH; Katz PP; Sidney S; Iribarren C; Eisner MD

Int J Chron Obstruct Pulmon Dis. 2010 Sep 7;5:263-9.

PubMed abstract

Prevalence of electrocardiographic abnormalities in a middle-aged, biracial population: Coronary Artery Risk Development in Young Adults study

Author(s): Walsh JA 3rd; Prineas R; Daviglus ML; Ning H; Liu K; Lewis CE; Sidney S; Schreiner PJ; Iribarren C; Lloyd-Jones DM

J Electrocardiol. 2010 Sep-Oct;43(5):385.e1-9. Epub 2010 Apr 5.

PubMed abstract

An 'almost exhaustive' search-based sequential permutation method for detecting epistasis in disease association studies

Author(s): Ma L; Assimes TL; Asadi NB; Iribarren C; Quertermous T; Wong WH

Genet Epidemiol. 2010 Jul;34(5):434-43.

PubMed abstract

Asthma and the prospective risk of anaphylactic shock and other allergy diagnoses in a large integrated health care delivery system

Author(s): Iribarren C; Tolstykh IV; Miller MK; Eisner MD

Ann Allergy Asthma Immunol. 2010 May;104(5):371-7.

PubMed abstract

Measurement of COPD severity using a survey-based score: validation in a clinically and physiologically characterized cohort

Author(s): Eisner MD; Omachi TA; Katz PP; Yelin EH; Iribarren C; Blanc PD

Chest. 2010 Apr;137(4):846-51. Epub 2009 Dec 29.

PubMed abstract

The COPD Helplessness Index: a new tool to measure factors affecting patient self-management

Author(s): Omachi TA; Katz PP; Yelin EH; Iribarren C; Knight SJ; Blanc PD; Eisner MD

Chest. 2010 Apr;137(4):823-30. Epub 2009 Oct 16.

PubMed abstract

Alcohol and lung airways function

Author(s): Siu ST; Udaltsova N; Iribarren C; Klatsky AL

Perm J. 2010 Spring;14(1):11-8.

PubMed abstract

Passive smoke exposure and circulating carotenoids in the CARDIA study

Author(s): Widome R; Jacobs DR Jr; Hozawa A; Sijtsma F; Gross M; Schreiner PJ; Iribarren C

Ann Nutr Metab. 2010;56(2):113-8. Epub 2010 Jan 29.

PubMed abstract

Lipoprotein-associated phospholipase A2 and C-reactive protein for measurement of inflammatory risk: Independent or complementary?

Author(s): Iribarren C

Curr Cardiovasc Risk Rep. 2010;4(1):57-67.

PubMed abstract

Distribution of asymmetric dimethylarginine among 980 healthy, older adults of different ethnicities

Author(s): Sydow K; Fortmann SP; Fair JM; Varady A; Hlatky MA; Go AS; Iribarren C; Tsao PS; ADVANCE Investigators

Clin Chem. 2010 Jan;56(1):111-20. Epub 2009 Nov 5.

PubMed abstract

Validation of the Stanford Brief Activity Survey: examining psychological factors and physical activity levels in older adults

Author(s): Taylor-Piliae RE; Fair JM; Haskell WL; Varady AN; Iribarren C; Hlatky MA; Go AS; Fortmann SP

J Phys Act Health. 2010 Jan;7(1):87-94.

PubMed abstract

Characterizing the admixed African ancestry of African Americans

Author(s): Zakharia F; Basu A; Absher D; Assimes TL; Go AS; Hlatky MA; Iribarren C; Knowles JW; Li J; Narasimhan B; Sidney S; Southwick A; Myers RM; Quertermous T; Risch N; Tang H

Genome Biol. 2009;10(12):R141. Epub 2009 Dec 22.

PubMed abstract

Peroxisome proliferator-activated receptor gamma polymorphisms and coronary heart disease

Author(s): Dallongeville J; Iribarren C; Ferrieres J; Lyon L; Evans A; Go AS; Arveiler D; Fortmann SP; Ducimetiere P; Hlatky MA; Amouyel P; Southwick A; Quertermous T; Meirhaeghe A

PPAR Res. 2009;2009:543746. Epub 2009 Dec 1.

PubMed abstract

The dilemma of incidental findings on cardiac computed tomography

Author(s): Hlatky MA; Iribarren C

J Am Coll Cardiol. 2009 Oct 13;54(16):1542-3.

PubMed abstract

Physical fitness and carotid atherosclerosis in men

Author(s): Lee CD; Jae SY; Iribarren C; Pettee KK; Choi YH

Int J Sports Med. 2009 Sep;30(9):672-6. Epub 2009 Jun 30.

PubMed abstract

Depression and health-related quality of life in chronic obstructive pulmonary disease

Author(s): Omachi TA; Katz PP; Yelin EH; Gregorich SE; Iribarren C; Blanc PD; Eisner MD

Am J Med. 2009 Aug;122(8):778.e9-15.

PubMed abstract

The impact of SHS exposure on health status and exacerbations among patients with COPD

Author(s): Eisner MD; Iribarren C; Yelin EH; Sidney S; Katz PP; Sanchez G; Blanc PD

Int J Chron Obstruct Pulmon Dis. 2009;4:169-76. Epub 2009 May 7.

PubMed abstract

Insulin resistance independently predicts the progression of coronary artery calcification

Author(s): Lee KK; Fortmann SP; Fair JM; Iribarren C; Rubin GD; Varady A; Go AS; Quertermous T; Hlatky MA

Am Heart J. 2009 May;157(5):939-45.

PubMed abstract

Birthplace and mortality among insured Latinos: the paradox revisited

Author(s): Iribarren C; Darbinian JA; Fireman BH; Burchard EG

Ethn Dis. 2009 Spring;19(2):185-91.

PubMed abstract

Cardiorespiratory fitness and coronary artery calcification in young adults: The CARDIA Study

Author(s): Lee CD; Jacobs DR Jr; Hankinson A; Iribarren C; Sidney S

Atherosclerosis. 2009 Mar;203(1):263-8. Epub 2008 Jun 22.

PubMed abstract

Reproducibility of breast arterial calcium mass quantification using digital mammography

Author(s): Molloi S; Mehraien T; Iribarren C; Smith C; Ducote JL; Feig SA

Acad Radiol. 2009 Mar;16(3):275-82.

PubMed abstract

Risk factors for end-stage renal disease: 25-year follow-up

Author(s): Hsu CY; Iribarren C; McCulloch CE; Darbinian J; Go AS

Arch Intern Med. 2009 Feb 23;169(4):342-50.

PubMed abstract

Occupational exposures and the risk of COPD: dusty trades revisited

Author(s): Blanc PD; Iribarren C; Trupin L; Earnest G; Katz PP; Balmes J; Sidney S; Eisner MD

Thorax. 2009 Jan;64(1):6-12. Epub 2008 Aug 4.

PubMed abstract

Incidental pulmonary nodules on cardiac computed tomography: prognosis and use

Author(s): Iribarren C; Hlatky MA; Chandra M; Fair JM; Rubin GD; Go AS; Burt JR; Fortmann SP

Am J Med. 2008 Nov;121(11):989-96.

PubMed abstract

COPD as a systemic disease: impact on physical functional limitations

Author(s): Eisner MD; Blanc PD; Yelin EH; Sidney S; Katz PP; Ackerson L; Lathon P; Tolstykh I; Omachi T; Byl N; Iribarren C

Am J Med. 2008 Sep;121(9):789-96.

PubMed abstract

Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study

Author(s): Assimes TL; Knowles JW; Basu A; Iribarren C; Southwick A; Tang H; Absher D; Li J; Fair JM; Rubin GD; Sidney S; Fortmann SP; Go AS; Hlatky MA; Myers RM; Risch N; Quertermous T

Hum Mol Genet. 2008 Aug 1;17(15):2320-8. Epub 2008 Apr 28.

PubMed abstract

Risk factors for death in adults with severe asthma

Author(s): Omachi TA; Iribarren C; Sarkar U; Tolstykh I; Yelin EH; Katz PP; Blanc PD; Eisner MD

Ann Allergy Asthma Immunol. 2008 Aug;101(2):130-6.

PubMed abstract

Polymorphisms of the IL1-receptor antagonist gene (IL1RN) are associated with multiple markers of systemic inflammation

Author(s): Reiner AP; Wurfel MM; Lange LA; Carlson CS; Nord AS; Carty CL; Rieder MJ; Desmarais C; Jenny NS; Iribarren C; Walston JD; Williams OD; Nickerson DA; Jarvik GP

Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1407-12. Epub 2008 May 1.

PubMed abstract

A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease

Author(s): Assimes TL; Knowles JW; Priest JR; Basu A; Borchert A; Volcik KA; Grove ML; Tabor HK; Southwick A; Tabibiazar R; Sidney S; Boerwinkle E; Go AS; Iribarren C; Hlatky MA; Fortmann SP; Myers RM; Kuhn H; Risch N; Quertermous T

Atherosclerosis. 2008 May;198(1):136-44. Epub 2007 Oct 23.

PubMed abstract

Pulmonary function and the risk of functional limitation in chronic obstructive pulmonary disease

Author(s): Eisner MD; Iribarren C; Yelin EH; Sidney S; Katz PP; Ackerson L; Lathon P; Tolstykh I; Omachi T; Byl N; Blanc PD

Am J Epidemiol. 2008 May 1;167(9):1090-101. Epub 2008 Mar 14.

PubMed abstract

Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease

Author(s): Assimes TL; Knowles JW; Priest JR; Basu A; Volcik KA; Southwick A; Tabor HK; Hartiala J; Allayee H; Grove ML; Tabibiazar R; Sidney S; Fortmann SP; Go A; Hlatky M; Iribarren C; Boerwinkle E; Myers R; Risch N; Quertermous T

Hum Genet. 2008 May;123(4):399-408. Epub 2008 Mar 28.

PubMed abstract

Incidental findings on cardiac multidetector row computed tomography among healthy older adults: prevalence and clinical correlates

Author(s): Burt JR; Iribarren C; Fair JM; Norton LC; Mahbouba M; Rubin GD; Hlatky MA; Go AS; Fortmann SP; Atherosclerotic Disease VFaGEAS

Arch Intern Med. 2008 Apr 14;168(7):756-61.

PubMed abstract

Community-level social capital and recurrence of acute coronary syndrome

Author(s): Scheffler RM; Brown TT; Syme L; Kawachi I; Tolstykh I; Iribarren C

Soc Sci Med. 2008 Apr;66(7):1603-13. Epub 2008 Jan 28.

PubMed abstract

Impaired coronary vasodilation by magnetic resonance angiography is associated with advanced coronary artery calcification

Author(s): Terashima M; Nguyen PK; Rubin GD; Iribarren C; Courtney BK; Go AS; Fortmann SP; McConnell MV

JACC Cardiovasc Imaging. 2008 Mar;1(2):167-73.

PubMed abstract

Longitudinal association of serum carotenoids and tocopherols with hostility: the CARDIA Study

Author(s): Ohira T; Hozawa A; Iribarren C; Daviglus ML; Matthews KA; Gross MD; Jacobs DR Jr

Am J Epidemiol. 2008 Jan 1;167(1):42-50. Epub 2007 Oct 10.

PubMed abstract

Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease

Author(s): Hlatky MA; Quertermous T; Boothroyd DB; Priest JR; Glassford AJ; Myers RM; Fortmann SP; Iribarren C; Tabor HK; Assimes TL; Tibshirani RJ; Go AS

Am Heart J. 2007 Dec;154(6):1035-42. Epub 2007 Sep 18.

PubMed abstract

Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease

Author(s): Hlatky MA; Ashley E; Quertermous T; Boothroyd DB; Ridker P; Southwick A; Myers RM; Iribarren C; Fortmann SP; Go AS; Atherosclerotic Disease VFaGEAS

Am Heart J. 2007 Dec;154(6):1043-51.

PubMed abstract

Do plasma biomarkers of coagulation and fibrinolysis differ between patients who have experienced an acute myocardial infarction versus stable exertional angina?

Author(s): Itakura H; Sobel BE; Boothroyd D; Leung LL; Iribarren C; Go AS; Fortmann SP; Quertermous T; Hlatky MA; Atherosclerotic Disease VFaGEAAS

Am Heart J. 2007 Dec;154(6):1059-64.

PubMed abstract

Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction

Author(s): Knowles JW; Wang H; Itakura H; Southwick A; Myers RM; Iribarren C; Fortmann SP; Go AS; Quertermous T; Hlatky MA

Am Heart J. 2007 Dec;154(6):1052-8.

PubMed abstract

Circulating chemokines accurately identify individuals with clinically significant atherosclerotic heart disease

Author(s): Ardigo D; Assimes TL; Fortmann SP; Go AS; Hlatky M; Hytopoulos E; Iribarren C; Tsao PS; Tabibiazar R; Quertermous T; ADVANCE Investigators

Physiol Genomics. 2007 Nov 14;31(3):402-9. Epub 2007 Aug 14.

PubMed abstract

Effect of race on asthma management and outcomes in a large, integrated managed care organization

Author(s): Erickson SE; Iribarren C; Tolstykh IV; Blanc PD; Eisner MD

Arch Intern Med. 2007 Sep 24;167(17):1846-52.

PubMed abstract

Ethnic differences in coronary artery calcium in a healthy cohort aged 60 to 69 years

Author(s): Fair JM; Kiazand A; Varady A; Mahbouba M; Norton L; Rubin GD; Iribarren C; Go AS; Hlatky MA; Fortmann SP

Am J Cardiol. 2007 Sep 15;100(6):981-5. Epub 2007 Jul 2.

PubMed abstract

Traditional and novel risk factors for clinically diagnosed abdominal aortic aneurysm: the Kaiser multiphasic health checkup cohort study

Author(s): Iribarren C; Darbinian JA; Go AS; Fireman BH; Lee CD; Grey DP

Ann Epidemiol. 2007 Sep;17(9):669-78. Epub 2007 May 18.

PubMed abstract

The metabolic syndrome is no better than its components

Author(s): Iribarren C

Minerva Cardioangiol. 2007 Aug;55(4):487-9.

PubMed abstract

Abdominal obesity and coronary artery calcification in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study

Author(s): Lee CD; Jacobs DR Jr; Schreiner PJ; Iribarren C; Hankinson A

Am J Clin Nutr. 2007 Jul;86(1):48-54.

PubMed abstract

Clinical utility of the Stanford brief activity survey in men and women with early-onset coronary artery disease

Author(s): Taylor-Piliae RE; Haskell WL; Iribarren C; Norton LC; Mahbouba MH; Fair JM; Hlatky MA; Go AS; Fortmann SP

J Cardiopulm Rehabil Prev. 2007 Jul-Aug;27(4):227-32.

PubMed abstract

Genetic ancestry, population sub-structure, and cardiovascular disease-related traits among African-American participants in the CARDIA Study

Author(s): Reiner AP; Carlson CS; Ziv E; Iribarren C; Jaquish CE; Nickerson DA

Hum Genet. 2007 Jun;121(5):565-75. Epub 2007 Mar 14.

PubMed abstract

Passive smoke exposure trends and workplace policy in the Coronary Artery Risk Development in Young Adults (CARDIA) study (1985-2001)

Author(s): Widome R; Jacobs DR Jr; Schreiner PJ; Iribarren C

Prev Med. 2007 Jun;44(6):490-5. Epub 2007 Feb 23.

PubMed abstract

Asymmetric dimethyl-arginine and coronary artery calcification in young adults entering middle age: the CARDIA Study

Author(s): Iribarren C; Husson G; Sydow K; Wang BY; Sidney S; Cooke JP

Eur J Cardiovasc Prev Rehabil. 2007 Apr;14(2):222-9.

PubMed abstract

Patients with vascular calcifications are at increased risk of cardiovascular events: implications for risk factor management and further research

Author(s): Iribarren C

J Intern Med. 2007 Mar;261(3):235-7.

PubMed abstract

Plasma leptin levels and coronary artery calcification in older adults

Author(s): Iribarren C; Husson G; Go AS; Lo JC; Fair JM; Rubin GD; Hlatky MA; Fortmann SP

J Clin Endocrinol Metab. 2007 Feb;92(2):729-32. Epub 2006 Dec 5.

PubMed abstract

Body composition and functional limitation in COPD

Author(s): Eisner MD; Blanc PD; Sidney S; Yelin EH; Lathon PV; Katz PP; Tolstykh I; Ackerson L; Iribarren C

Respir Res. 2007 Jan 29;8:7.

PubMed abstract

Exploring secular trends in the likelihood of receiving treatment for end-stage renal disease

Author(s): Hsu CY; Go AS; McCulloch CE; Darbinian J; Iribarren C

Clin J Am Soc Nephrol. 2007 Jan;2(1):81-8. Epub 2006 Nov 29.

PubMed abstract

The influence of cigarette smoking on adult asthma outcomes

Author(s): Eisner MD; Iribarren C

Nicotine Tob Res. 2007 Jan;9(1):53-6.

PubMed abstract

Value of the sagittal abdominal diameter in coronary heart disease risk assessment: cohort study in a large, multiethnic population

Author(s): Iribarren C; Darbinian JA; Lo JC; Fireman BH; Go AS

Am J Epidemiol. 2006 Dec 15;164(12):1150-9. Epub 2006 Oct 13.

PubMed abstract

Metabolic syndrome and early-onset coronary artery disease: is the whole greater than its parts?

Author(s): Iribarren C; Go AS; Husson G; Sidney S; Fair JM; Quertermous T; Hlatky MA; Fortmann SP

J Am Coll Cardiol. 2006 Nov 7;48(9):1800-7. Epub 2006 Oct 17.

PubMed abstract

The influence of perceived control of asthma on health outcomes

Author(s): Calfee CS; Katz PP; Yelin EH; Iribarren C; Eisner MD

Chest. 2006 Nov;130(5):1312-8.

PubMed abstract

Smoking status and common carotid artery intima-medial thickness among middle-aged men and women based on ultrasound measurement: a cohort study

Author(s): Fan AZ; Paul-Labrador M; Merz CN; Iribarren C; Dwyer JH

BMC Cardiovasc Disord. 2006 Oct 26;6:42.

PubMed abstract

Risk factors for work disability in severe adult asthma

Author(s): Eisner MD; Yelin EH; Katz PP; Lactao G; Iribarren C; Blanc PD

Am J Med. 2006 Oct;119(10):884-91.

PubMed abstract

Validation of a new brief physical activity survey among men and women aged 60-69 years

Author(s): Taylor-Piliae RE; Norton LC; Haskell WL; Mahbouda MH; Fair JM; Iribarren C; Hlatky MA; Go AS; Fortmann SP

Am J Epidemiol. 2006 Sep 15;164(6):598-606. Epub 2006 Jul 13.

PubMed abstract

Active and passive smoking and development of glucose intolerance among young adults in a prospective cohort: CARDIA study

Author(s): Houston TK; Person SD; Pletcher MJ; Liu K; Iribarren C; Kiefe CI

BMJ. 2006 May 6;332(7549):1064-9. Epub 2006 Apr 7.

PubMed abstract

The association of cigarette smoking with self-reported disease before middle age: the Coronary Artery Risk Development in Young Adults (CARDIA) study

Author(s): Hozawa A; Houston T; Steffes MW; Widome R; Williams OD; Iribarren C; Pletcher MJ; Daviglus ML; Carr JJ; Jacobs DR Jr

Prev Med. 2006 Mar;42(3):193-9. Epub 2006 Feb 15.

PubMed abstract

Does the association between serum endostatin, an endogenous anti-angiogenic protein, and acute myocardial infarction differ by race?

Author(s): Iribarren C; Herrinton LJ; Darbinian JA; Tamarkin L; Malinowski D; Vogelman JH; Orentreich N; Baer D

Vasc Med. 2006 Feb;11(1):13-20.

PubMed abstract

Body mass index and risk for end-stage renal disease

Author(s): Hsu CY; McCulloch CE; Iribarren C; Darbinian J; Go AS

Ann Intern Med. 2006 Jan 3;144(1):21-8.

PubMed abstract

Lipoprotein-associated phospholipase A2 and cardiovascular risk: state of the evidence and future directions

Author(s): Iribarren C

Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):5-6.

PubMed abstract

History of depression, race, and cardiovascular risk in CARDIA

Author(s): Knox S; Barnes A; Kiefe C; Lewis CE; Iribarren C; Matthews KA; Wong ND; Whooley M

Int J Behav Med. 2006;13(1):44-50.

PubMed abstract

The conundrum of increased burden of end-stage renal disease in Asians

Author(s): Hall YN; Hsu CY; Iribarren C; Darbinian J; McCulloch CE; Go AS

Kidney Int. 2005 Nov;68(5):2310-6.

PubMed abstract

Sex and racial/ethnic disparities in outcomes after acute myocardial infarction: a cohort study among members of a large integrated health care delivery system in northern California

Author(s): Iribarren C; Tolstykh I; Somkin CP; Ackerson LM; Brown TT; Scheffler R; Syme L; Kawachi I

Arch Intern Med. 2005 Oct 10;165(18):2105-13.

PubMed abstract

The impact of allergy and pulmonary specialist care on emergency asthma utilization in a large managed care organization

Author(s): Erickson S; Tolstykh I; Selby JV; Mendoza G; Iribarren C; Eisner MD

Health Serv Res. 2005 Oct;40(5 Pt 1):1443-65.

PubMed abstract

Directly measured second hand smoke exposure and asthma health outcomes

Author(s): Eisner MD; Klein J; Hammond SK; Koren G; Lactao G; Iribarren C

Thorax. 2005 Oct;60(10):814-21.

PubMed abstract

Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels

Author(s): Carlson CS; Aldred SF; Lee PK; Tracy RP; Schwartz SM; Rieder M; Liu K; Williams OD; Iribarren C; Lewis EC; Fornage M; Boerwinkle E; Gross M; Jaquish C; Nickerson DA; Myers RM; Siscovick DS; Reiner AP

Am J Hum Genet. 2005 Jul;77(1):64-77. Epub 2005 May 16.

PubMed abstract

Intensive care unit admission for asthma: a marker for severe disease

Author(s): Eisner MD; Boland M; Tolstykh I; Mendoza G; Iribarren C

J Asthma. 2005 Jun;42(5):315-23.

PubMed abstract

Impact of depressive symptoms on adult asthma outcomes

Author(s): Eisner MD; Katz PP; Lactao G; Iribarren C

Ann Allergy Asthma Immunol. 2005 May;94(5):566-74.

PubMed abstract

Elevated blood pressure and risk of end-stage renal disease in subjects without baseline kidney disease

Author(s): Hsu CY; McCulloch CE; Darbinian J; Go AS; Iribarren C

Arch Intern Med. 2005 Apr 25;165(8):923-8.

PubMed abstract

Relation of echocardiographic left ventricular mass, geometry and wall stress, and left atrial dimension to coronary calcium in young adults (the CARDIA study)

Author(s): Gardin JM; Iribarren C; Detrano RC; Liu K; Schreiner PJ; Loria CM; Wong ND

Am J Cardiol. 2005 Mar 1;95(5):626-9.

PubMed abstract

Causes and demographic, medical, lifestyle and psychosocial predictors of premature mortality: the CARDIA study

Author(s): Iribarren C; Jacobs DR; Kiefe CI; Lewis CE; Matthews KA; Roseman JM; Hulley SB

Soc Sci Med. 2005 Feb;60(3):471-82.

PubMed abstract

Association of lipoprotein-associated phospholipase A2 mass and activity with calcified coronary plaque in young adults: the CARDIA study

Author(s): Iribarren C; Gross MD; Darbinian JA; Jacobs DR Jr; Sidney S; Loria CM

Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):216-21. Epub 2004 Oct 21.

PubMed abstract

Analysis of late risk of systemic blood pressures 120/80 mm Hg

Author(s): Ananthakrishnan S; Klatsky AL; Udaltsova N; Iribarren C; Guidry U

Am J Cardiol. 2004 Dec 15;94(12):1575-6.

PubMed abstract

Are patients with asthma at increased risk of coronary heart disease?

Author(s): Iribarren C; Tolstykh IV; Eisner MD

Int J Epidemiol. 2004 Aug;33(4):743-8. Epub 2004 May 6.

PubMed abstract

Breast vascular calcification and risk of coronary heart disease, stroke, and heart failure

Author(s): Iribarren C; Go AS; Tolstykh I; Sidney S; Johnston SC; Spring DB

J Womens Health (Larchmt). 2004 May;13(4):381-9; discussion 390-2.

PubMed abstract

Dietary intake of n-3, n-6 fatty acids and fish: relationship with hostility in young adults--the CARDIA study

Author(s): Iribarren C; Markovitz JH; Jacobs DR Jr; Schreiner PJ; Daviglus M; Hibbeln JR

Eur J Clin Nutr. 2004 Jan;58(1):24-31.

PubMed abstract

Cohort study of exposure to environmental tobacco smoke and risk of first ischemic stroke and transient ischemic attack

Author(s): Iribarren C; Darbinian J; Klatsky AL; Friedman GD

Neuroepidemiology. 2004 Jan-Apr;23(1-2):38-44.

PubMed abstract

Asthma is associated with weight gain in females but not males, independent of physical activity

Author(s): Beckett WS; Jacobs DR Jr; Yu X; Iribarren C; Williams OD

Am J Respir Crit Care Med. 2001 Dec 1;164(11):2045-50.

PubMed abstract

Exposure to environmental tobacco smoke: association with personal characteristics and self reported health conditions

Author(s): Iribarren C; Friedman GD; Klatsky AL; Eisner MD

J Epidemiol Community Health. 2001 Oct;55(10):721-8.

PubMed abstract

Cohort study of thyroid cancer in a San Francisco Bay area population

Author(s): Iribarren C; Haselkorn T; Tekawa IS; Friedman GD

Int J Cancer. 2001 Sep 1;93(5):745-50.

PubMed abstract

Glycemic control and heart failure among adult patients with diabetes

Author(s): Iribarren C; Karter AJ; Go AS; Ferrara A; Liu JY; Sidney S; Selby JV

Circulation. 2001 Jun 5;103(22):2668-73.

PubMed abstract

The association between asthma, asthma, therapeutic classes and hepatic enzyme elevation among adult HMO members

Author(s): Iribarren C; Sidney S; Lydick E; Sorel ME; Eisner MD

Compr Ther. 2001 Summer;27(2):133-9.

PubMed abstract

Hospitalization for suicide attempt and completed suicide: epidemiological features in a managed care population

Author(s): Iribarren C; Sidney S; Jacobs DR Jr; Weisner C

Soc Psychiatry Psychiatr Epidemiol. 2000 Jul;35(7):288-96.

PubMed abstract

Calcification of the aortic arch: risk factors and association with coronary heart disease, stroke, and peripheral vascular disease

Author(s): Iribarren C; Sidney S; Sternfeld B; Browner WS

JAMA. 2000 Jun 7;283(21):2810-5.

PubMed abstract

Association of hostility with coronary artery calcification in young adults: the CARDIA study. Coronary Artery Risk Development in Young Adults

Author(s): Iribarren C; Sidney S; Bild DE; Liu K; Markovitz JH; Roseman JM; Matthews K

JAMA. 2000 May 17;283(19):2546-51.

PubMed abstract

Invited commentary: low cholesterol and nonartherosclerotic disease risk: a persistently perplexing question

Author(s): Jacobs DR Jr; Iribarren C

Am J Epidemiol. 2000 Apr 15;151(8):748-51.

PubMed abstract

Serum uric acid and risk of coronary heart disease: Atherosclerosis Risk in Communities (ARIC) Study

Author(s): Moriarity JT; Folsom AR; Iribarren C; Nieto FJ; Rosamond WD

Ann Epidemiol. 2000 Apr;10(3):136-43.

PubMed abstract

Reexamining health effects of cigar smoking: fashionable, but may increase the risk of coronary heart disease

Author(s): Iribarren C

Eur Heart J. 2000 Apr;21(7):505-6.

PubMed abstract

Uric acid and serum antioxidant capacity: a reaction to atherosclerosis?

Author(s): Nieto FJ; Iribarren C; Gross MD; Comstock GW; Cutler RG

Atherosclerosis. 2000 Jan;148(1):131-9.

PubMed abstract

Cigarette smoking, alcohol consumption, and risk of ARDS: a 15-year cohort study in a managed care setting

Author(s): Iribarren C; Jacobs DR Jr; Sidney S; Gross MD; Eisner MD

Chest. 2000 Jan;117(1):163-8.

PubMed abstract

Effect of cigar smoking on the risk of cardiovascular disease, chronic obstructive pulmonary disease, and cancer in men

Author(s): Iribarren C; Tekawa IS; Sidney S; Friedman GD

N Engl J Med. 1999 Jun 10;340(23):1773-80.

PubMed abstract

Cohort study of serum total cholesterol and in-hospital incidence of infectious diseases

Author(s): Iribarren C; Jacobs DR Jr; Sidney S; Claxton AJ; Feingold KR

Epidemiol Infect. 1998 Oct;121(2):335-47.

PubMed abstract