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Ai Kubo, MPH, PhD

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Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3750 (phone)
ai.kubo@kp.org
Kaiser Permanente Researcher Profiles


Ai Kubo, MPH, PhD, is a research scientist and cancer epidemiologist at the Kaiser Permanente Northern California Division of Research. She received her Master's in Public Health (MPH) degree from University of California, Berkeley, in 2002, and her PhD in Epidemiology from the Columbia University Mailman School of Public Health in 2007. Her current research interest focuses on identification of early life determinants of cancer, modifiable cancer risk factors and prognostic factors, and the development of effective intervention strategies. She is currently the principal investigator of the National Cancer Institute's Career Development Award, investigating early life risk factors of accelerated pubertal onset in girls. Dr. Kubo is also a certified yoga instructor and is the Principal Investigator of a pilot study funded by the American Cancer Society, examining the effect of mobile-application based mindfulness intervention for cancer patients and their family members.

Current Position(s):

  • Research Scientist I, Division of Research, Kaiser Permanente Northern California

Section Affiliations:

Primary Research Interests:

  • Cancer epidemiology
  • Behavioral intervention

    mHealth Mindfulness Intervention for Women with Perinatal Depression: A Feasibility Study

    The primary goal of this project is to assess the feasibility of conducting a mobile-health mindfulness intervention (mHealth) study among pregnant and postpartum women with depressive symptoms. Perinatal depression has numerous adverse health consequences, including preterm delivery, negative maternal-infant interaction, and child behavior problems. We will recruit ~30 women who present symptoms of perinatal depression from the OBGYN clinics at Kaiser Permanente and use a single-arm intervention design to assess the feasibility of conducting a six-week mHealth mindfulness intervention. We will also obtain preliminary efficacy results consisting of patient-reported outcomes on depression, anxiety, perceived stress, health behaviors, mindfulness, and sleep.
    Investigator: Kubo, Ai
    Funder: Northern California Community Benefit Programs

    A Pilot Pragmatic Trial of mHealth Mindfulness Intervention to Improve Quality of Life Among Metastatic Cancer Patients and Their Caregivers

    Screening for psychosocial distress is an accreditation requirement of the Commission on Cancer, underscoring the importance of addressing cancer patients’ psychosocial needs. Mindfulness-based training is one strategy that has been shown to help cancer patients reduce distress and improve quality of life. However, logistical requirements of standard in-person mindfulness classes make it impractical for cancer patients to receive benefit. To address this issue, we have conducted a few studies that demonstrated the feasibility, acceptability, and preliminary efficacy of non-face-to-face mindfulness approaches (e.g., CD, MP3 and mobile app). Building on these studies, this project will pilot test the feasibility of implementing a mobile/online-based mindfulness program for advanced cancer patients and their caregivers in a cluster randomized trial involving six oncology clinics.
    Investigator: Kubo, Ai
    Funder: The Permanente Medical Group

    Being Present: A Feasibility Study of Audio-Based Mindfulness Meditation Intervention for Metastatic Cancer Patients and Caregiver

    Based on our previous pilot study of CD-based mindfulness intervention for cancer patients, we propose to develop a mobile application and pilot test its acceptability among cancer patients and their caregivers in order to reduce stress and to improve quality of life. We will hold a focus group to obtain participants feedback regarding the mobile-based intervention, and conduct an 8-week feasibility study using the application.
    Investigator: Kubo, Ai
    Funder: Kaiser Permanente Institutional Planned Giving

    Mobile App-Based Mindfulness Pilot Study for Cancer Patients and Caregivers

    This pilot randomized trial will test the feasibility of a mobile-app based mindfulness intervention for cancer patients and their caregivers in order to reduce stress, and to improve quality of life and patient-provider communication.
    Investigator: Kubo, Ai
    Funder: American Cancer Society

    Early Life Determinants of Accelerated Pubertal Development in Adolescent Girls

    The goal of this research is to identify early life factors which influence the timing of pubertal development among adolescent girls. The first study utilizes data from the Cohort Study of Young Girls Nutrition, Environment and Transitions (CYGNET), which has been collecting detailed data on pubertal development, behavioral, environmental, and anthropometric information among 444 adolescent girls since 2005. The second study is a prospective cohort study of approximately 10,000 adolescent girls (age 8-9) within the Kaiser Permanente Northern California population. We will use Tanner stage information that has been entered into HealthConnect to identify early life risk factors of early pubertal development as well as racial/ethnic differences in the timing of pubertal development.
    Investigator: Kubo, Ai
    Funder: National Cancer Institute

    Perceived psychosocial stress and gestational weight gain among women with gestational diabetes

    Author(s): Kubo A; Ferrara A; Brown SD; Ehrlich SF; Tsai AL; Quesenberry CP; Crites Y; Hedderson MM

    PLoS ONE. 2017;12(3):e0174290. Epub 2017-03-28.

    PubMed abstract

    Associations Between Maternal Pregravid Obesity and Gestational Diabetes and the Timing of Pubarche in Daughters

    Author(s): Kubo A; Ferrara A; Laurent CA; Windham GC; Greenspan LC; Deardorff J; Hiatt RA; Quesenberry CP; Kushi LH

    Am J Epidemiol. 2016 Jun 7.

    PubMed abstract

    Maternal Hyperglycemia During Pregnancy Predicts Adiposity of the Offspring

    Author(s): Kubo A; Ferrara A; Windham GC; Greenspan LC; Deardorff J; Hiatt RA; Quesenberry CP; Laurent C; Mirabedi AS; Kushi LH

    Diabetes Care. 2014 Nov;37(11):2996-3002. Epub 2014-08-22.

    PubMed abstract

    Yoga for heart failure patients; a feasibility pilot study with a multiethnic population

    Author(s): Kubo A; Hung YY; Ritterman J

    Int J Yoga Therap. 2011;(21):77-83.

    PubMed abstract

    Personal and clinical social support and adherence to adjuvant endocrine therapy among hormone receptor-positive breast cancer patients in an integrated health care system

    Author(s): Kroenke CH; Hershman DL; Gomez SL; Adams SR; Eldridge EH; Kwan ML; Ergas IJ; Kubo A; Kushi LH

    Breast Cancer Res Treat. 2018 Apr 18.

    PubMed abstract

    Genetic Variants in CPA6 and PRPF31 are Associated with Variation in Response to Metformin in Individuals with Type 2 Diabetes

    Author(s): Rotroff DM; Hedderson MM; MetGen Investigators and the ACCORD/ACCORDion Investigators; et al.

    Diabetes. 2018 Apr 12.

    PubMed abstract

    Associations Between Maternal Obesity and Pregnancy Hyperglycemia and Timing of Pubertal Onset in Adolescent Girls: A Population-Based Study

    Author(s): Kubo A; Deardorff J; Laurent CA; Ferrara A; Greenspan LC; Quesenberry CP; Kushi LH

    Am J Epidemiol. 2018 Mar 15.

    PubMed abstract

    Perceived psychosocial stress and gestational weight gain among women with gestational diabetes

    Author(s): Kubo A; Ferrara A; Brown SD; Ehrlich SF; Tsai AL; Quesenberry CP; Crites Y; Hedderson MM

    PLoS ONE. 2017;12(3):e0174290. Epub 2017-03-28.

    PubMed abstract

    Prevention of Vertical Transmission of Hepatitis B: An Observational Study

    Author(s): Kubo A; Shlager L; Marks AR; Lakritz D; Beaumont C; Gabellini K; Corley DA

    Ann Intern Med. 2014 Jun 17;160(12):828-35.

    PubMed abstract

    Associations Between Maternal Pregravid Obesity and Gestational Diabetes and the Timing of Pubarche in Daughters

    Author(s): Kubo A; Ferrara A; Laurent CA; Windham GC; Greenspan LC; Deardorff J; Hiatt RA; Quesenberry CP; Kushi LH

    Am J Epidemiol. 2016 Jun 7.

    PubMed abstract

    Lifestyle behaviors and ethnic identity among diverse women at high risk for type 2 diabetes

    Author(s): Brown SD; Ehrlich SF; Kubo A; Tsai AL; Hedderson MM; Quesenberry CP; Ferrara A

    Soc Sci Med. 2016 May 14;160:87-93. Epub 2016-5-14.

    PubMed abstract

    Maternal Hyperglycemia During Pregnancy Predicts Adiposity of the Offspring

    Author(s): Kubo A; Ferrara A; Windham GC; Greenspan LC; Deardorff J; Hiatt RA; Quesenberry CP; Laurent C; Mirabedi AS; Kushi LH

    Diabetes Care. 2014 Nov;37(11):2996-3002. Epub 2014-08-22.

    PubMed abstract

    Dietary guideline adherence for gastroesophageal reflux disease

    Author(s): Kubo A; Block G; Quesenberry CP; Buffler P; Corley DA

    BMC Gastroenterol. 2014;14:144. Epub 2014-08-14.

    PubMed abstract

    Sex-specific associations between body mass index, waist circumference and the risk of Barrett's oesophagus: a pooled analysis from the international BEACON consortium

    Author(s): Kubo A; Cook MB; Shaheen NJ; Vaughan TL; Whiteman DC; Murray L; Corley DA

    Gut. 2013 Dec;62(12):1684-91.

    PubMed abstract

    Dietary fiber and the risk of precancerous lesions and cancer of the esophagus: a systematic review and meta-analysis

    Author(s): Coleman HG; Murray LJ; Hicks B; Bhat SK; Kubo A; Corley DA; Cardwell CR; Cantwell MM

    Nutr Rev. 2013 Jul;71(7):474-82. Epub 2013 Apr 24.

    PubMed abstract

    Yoga for heart failure patients; a feasibility pilot study with a multiethnic population

    Author(s): Kubo A; Hung YY; Ritterman J

    Int J Yoga Therap. 2011;(21):77-83.

    PubMed abstract

    Dietary factors and the risks of oesophageal adenocarcinoma and Barrett's oesophagus

    Author(s): Kubo A; Corley DA; Jensen CD; Kaur R

    Nutr Res Rev. 2010 Dec;23(2):230-46. Epub 2010 Jul 13.

    PubMed abstract

    Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients

    Author(s): Corley DA; Kubo A; Zhao W; Quesenberry C

    Gastroenterology. 2010 Jul;139(1):93-101. Epub 2010 Mar 27.

    PubMed abstract

    Alcohol types and sociodemographic characteristics as risk factors for Barrett's esophagus

    Author(s): Kubo A; Levin TR; Block G; Rumore GJ; Quesenberry CP Jr; Buffler P; Corley DA

    Gastroenterology. 2009 Mar;136(3):806-15. Epub 2008 Nov 27.

    PubMed abstract

    Race, ethnicity, sex and temporal differences in Barrett's oesophagus diagnosis: a large community-based study, 1994-2006

    Author(s): Corley DA; Kubo A; Levin TR; Block G; Habel L; Rumore G; Quesenberry C; Buffler P

    Gut. 2009 Feb;58(2):182-8. Epub 2008 Oct 31.

    PubMed abstract

    Effects of dietary fiber, fats, and meat intakes on the risk of Barrett's esophagus

    Author(s): Kubo A; Block G; Quesenberry CP Jr; Buffler P; Corley DA

    Nutr Cancer. 2009;61(5):607-16.

    PubMed abstract

    Hemochromatosis gene status as a risk factor for Barrett's esophagus

    Author(s): Corley DA; Kubo A; Levin TR; Block G; Habel L; Rumore GJ; Quesenberry C; Buffler P

    Dig Dis Sci. 2008 Dec;53(12):3095-102. Epub 2008 May 10.

    PubMed abstract

    Helicobacter pylori and gastroesophageal reflux disease: a case-control study

    Author(s): Corley DA; Kubo A; Levin TR; Block G; Habel L; Rumore G; Quesenberry C; Buffler P; Parsonnet J

    Helicobacter. 2008 Oct;13(5):352-60.

    PubMed abstract

    Dietary antioxidants, fruits, and vegetables and the risk of Barrett's esophagus

    Author(s): Kubo A; Levin TR; Block G; Rumore GJ; Quesenberry CP Jr; Buffler P; Corley DA

    Am J Gastroenterol. 2008 Jul;103(7):1614-23; quiz 1624.

    PubMed abstract

    Helicobacter pylori infection and the risk of Barrett's oesophagus: a community-based study

    Author(s): Corley DA; Kubo A; Levin TR; Block G; Habel L; Zhao W; Leighton P; Rumore G; Quesenberry C; Buffler P; Parsonnet J

    Gut. 2008 Jun;57(6):727-33. Epub 2007 Sep 25.

    PubMed abstract

    Abdominal obesity and the risk of esophageal and gastric cardia carcinomas

    Author(s): Corley DA; Kubo A; Zhao W

    Cancer Epidemiol Biomarkers Prev. 2008 Feb;17(2):352-8.

    PubMed abstract

    Meta-analysis of antioxidant intake and the risk of esophageal and gastric cardia adenocarcinoma

    Author(s): Kubo A; Corley DA

    Am J Gastroenterol. 2007 Oct;102(10):2323-30; quiz 2331. Epub 2007 Jun 20.

    PubMed abstract

    Abdominal obesity, ethnicity and gastro-oesophageal reflux symptoms

    Author(s): Corley DA; Kubo A; Zhao W

    Gut. 2007 Jun;56(6):756-62. Epub 2006 Oct 17.

    PubMed abstract

    Body mass index and gastroesophageal reflux disease: a systematic review and meta-analysis

    Author(s): Corley DA; Kubo A

    Am J Gastroenterol. 2006 Nov;101(11):2619-28. Epub 2006 Sep 4.

    PubMed abstract

    Body mass index and adenocarcinomas of the esophagus or gastric cardia: a systematic review and meta-analysis

    Author(s): Kubo A; Corley DA

    Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):872-8.

    PubMed abstract

    Risk of hemorrhagic stroke in Asian American ethnic groups

    Author(s): Klatsky AL; Friedman GD; Sidney S; Kipp H; Kubo A; Armstrong MA

    Neuroepidemiology. 2005;25(1):26-31. Epub 2005 Apr 25.

    PubMed abstract

    Influence of site classification on cancer incidence rates: an analysis of gastric cardia carcinomas

    Author(s): Corley DA; Kubo A

    J Natl Cancer Inst. 2004 Sep 15;96(18):1383-7.

    PubMed abstract

    Marked multi-ethnic variation of esophageal and gastric cardia carcinomas within the United States

    Author(s): Kubo A; Corley DA

    Am J Gastroenterol. 2004 Apr;99(4):582-8.

    PubMed abstract

    Marked regional variation in adenocarcinomas of the esophagus and the gastric cardia in the United States

    Author(s): Kubo A; Corley DA

    Cancer. 2002 Nov 15;95(10):2096-102.

    PubMed abstract