Lawrence H. Kushi, ScD

People

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3837 (phone)
larry.kushi@kp.org
Kaiser Permanente Researcher Profiles

Lawrence H. Kushi, ScD, is Director of Scientific Policy at the Kaiser Permanente Northern California Division of Research. Prior to joining the Division of Research, Dr. Kushi was at Columbia University, where he held the Ella McCollum Vahlteich Chair in Human Nutrition in the Department of Health and Behavior Studies, Teachers College; and he was a member of the Herbert Irving Comprehensive Cancer Center at Columbia-Presbyterian Medical Center. Dr. Kushi is internationally recognized for his expertise in nutritional epidemiology, and his research interests focus on the role of diet and nutrition in the etiology of coronary artery disease and breast and other cancers. He serves on a grant review committee for the American Cancer Society and has served on various American Cancer Society committees to develop guidelines for the dietary prevention and management of cancer. Dr. Kushi has also served on review committees for the Epidemiology and Disease Control Study Section of the National Institutes of Health, and the Integration Panel of the Breast Cancer Research Program of the US Army Medical Research and Materiel Command. He was formerly the chair of the Food and Nutrition Section of the American Public Health Association; on the executive committee of the American Society of Preventive Oncology; and has worked at the Fred Hutchinson Cancer Research Center and the University of Minnesota School of Public Health. Dr. Kushi graduated from Amherst College and the Harvard School of Public Health.

Current Position(s):

Research Scientist III, Division of Research, Kaiser Permanente Northern California
Director of Scientific Policy, Division of Research, Kaiser Permanente, Northern California
Adjunct Professor of Nutrition, Teachers College, Columbia University, New York, NY

Section Affiliations:

Cancer

Primary Research Interests:

Nutritional epidemiology
Diet and nutrition in the etiology of coronary artery disease
Diet and nutrition in the etiology and prognosis of breast and other cancers

Related Website(s):

Studies

Breast White Adipose Tissue Inflammation and Breast Cancer Outcomes

We will assess the incidence and severity of breast white adipose tissue (B-WAT) inflammation in mastectomy specimens from approximately 1,900 Pathways Study participants to examine associations of various factors with B-WAT inflammation incidence and severity at the time of breast cancer surgery, and to examine whether B-WAT inflammation impacts breast cancer recurrence, second primary breast cancer, and breast cancer progression-free survival. We will also investigate the associations of inflammatory blood biomarkers, body composition, and lifestyle factors such as diet and physical activity with B-WAT inflammation and severity. This collaborative project includes investigators at the Fred Hutchinson Cancer Research Center, Memorial Sloan Kettering Cancer Center, Roswell Park Comprehensive Cancer Center, and Weill Cornell Medical College, where Dr. Andrew Dannenberg, who co-leads this project, is located.
Investigator: Kushi, Lawrence
Funder: National Cancer Institute

Kaiser Permanente Interregional Cancer Statistics Project

A Kaiser Permanente interregional cancer statistics report will be developed to include incidence and 5-year relative survival rates for breast, colorectal, and lung cancer. The development of new mortality measures will be explored, along with improved routine capture and reporting of these measures. Work will include a landscape review of current procedures and methods used by regional cancer committees to generate region-specific reports; generation of estimates of cancer-specific mortality and all-cause mortality; and assessment of interregional available death and cause of death data. Finally, sustainable reporting processes will be created to enhance the organization's ability to produce this report on an annual basis.
Investigator: Kushi, Lawrence
Funder: Center for Effectiveness and Safety Research

Geospatial, Multilevel, and Contextual Approaches in Cancer Control and Population Sciences

This funding expands on neighborhood resources developed under the U01 grant (geocoded residential histories, linkage to census and area databases, virtual neighborhood audits). Aim 1: Develop methods to use remote sensing data and machine learning techniques to characterize neighborhood attributes (e.g., green space, proximity to blue space, night-time light) and enhance the neighborhood infrastructure of the Pathways Study cohort. Aim 2: Demonstrate their applicability by examining the impact of social and built environment attributes on allostatic load among the Pathways cohort of breast cancer survivors. This work provides an opportunity to apply a comprehensive suite of neighborhood attributes to better understand multilevel factors and outcomes in breast cancer survivors.
Investigator: Kushi, Lawrence
Funder: National Cancer Institute

Comprehensive Translational Science Analytics Tools for the Global Health Agenda

This project builds on a previous Community Benefit grant award to examine changes in cervical and colorectal cancer screening as a result of the implementation of the Patient Protection and Affordable Care Act. It will examine impacts on colorectal cancer incidence and mortality. This will be supported through a collaboration with Dr. Donna Spiegelman of Yale University, through an NIH Pioneer Award to Dr. Spiegelman, DP1 ES025459
Investigator: Kushi, Lawrence
Funder: National Institute of Environmental Health Sciences

Germline and Tumor Genomic Analyses of Breast Cancer in Latinas

This project expands a consortium of studies examining germline genetic mutations in breast cancer risk in Latinas. It builds on a study that will include approximately 550 Latina women with breast cancer in the Pathways Study; genetic data from Latina women without breast cancer will be contributed from Kaiser Permanente Northern California’s Research Program on Genes, Environment and Health. Led by Susan Neuhausen, PhD, of City of Hope, and Elad Ziv, MD, of UC San Francisco, this project further incorporates Latina cases and controls from studies led by Dr. Neuhausen. While this project includes investigation of tumor DNA, Pathways Study and Kaiser Permanente Northern California participants will not be included in that aspect.
Investigator: Kushi, Lawrence
Funder: National Cancer Institute

Adolescent and Young Adult Female Cancer Survivors - Cancer Experience Survey

This study aims to: 1) assess reproductive intentions and receipt of fertility counseling or preservation in relation to post-diagnosis birth outcomes among adolescent and young adult cancer survivors in North Carolina and the Kaiser Permanente Northern California and Kaiser Permanente Southern California health systems; 2) examine infertility, pregnancy loss history, and use of infertility services among adolescent and young adult cancer survivors within those health systems compared to the U.S. general population; and 3) examine the frequency of self-reported cancer recurrence among adolescent and young adult female cancer survivors in North Carolina and in those health systems, and examine the impact of cancer recurrence on post-diagnosis birth rates. Current recommendations for when to attempt pregnancy after cancer diagnosis (typically two to five years) are often based on identified periods of highest cancer recurrence risk, rather than optimal timing for achieving pregnancy, but recurrence information is rarely available.
Investigator: Kushi, Lawrence
Funder: University of North Carolina

Obesity, Chemotherapy Dosing, and Breast Cancer Outcomes

Body size is associated with survival in women with breast cancer in complicated ways. Chemotherapy to treat breast cancer is typically dosed based on body size, often as a function of body surface area. Previously, there was concern that obese patients may receive doses of chemotherapy that may be too toxic given their higher body surface area, resulting in dose capping. This has resulted in the suggestion that obese women were receiving less-than-optimal doses for cancer treatment. Indeed, in 2012, the American Society of Clinical Oncology recommended that doses of chemotherapy not be capped. This project, enabled by availability of detailed infusion data, examines the impact of body size on chemotherapy dosing and subsequent outcomes. The project builds upon pilot work conducted in the Pathways Study cohort of 4,505 women with breast cancer, expands to other women with electronic data only, and includes over 4,000 women with breast cancer at Kaiser Permanente Washington. This project is led by Dr. Elizabeth Kantor at Memorial Sloan Kettering Cancer Center.
Investigator: Kushi, Lawrence
Funder: National Cancer Institute

End-of-Life Care for Adolescents and Young Adults with Cancer: An Evaluation of Care and Development of Patient-Centered Quality Measures

This project examines aspects of end-of-life care for people diagnosed with adolescent and young adult cancers (ages 15 to 39 years). Current measures of end-of-life care quality were designed for older adults; a coherent set of measures to characterize high-quality end-of-life care for adolescent and young adult cancer patients does not exist. This study seeks to answer the questions: What is the quality of end-of-life care for adolescents and young adults with cancer, and what is a patient-centered definition of high-quality end-of-life care for adolescents and young adults facing terminal illness? The aims of this project are to examine the quality of end-of-life care in adolescent and young adult cancer patients, identify sources of variation in end-of-life care, and develop a set of indicators of end-of-life care quality suitable for adolescent and young adult cancers. Data from about 1,800 patients diagnosed from 2000 to 2015 with adolescent and young adult cancers in Kaiser Permanente Northern California and Kaiser Permanente Southern California will be included in data-only aspects, with in-depth interviews of patients, family members, and providers from these Kaiser Permanente regions and the Dana-Farber Cancer Institute to better identify factors that may improve end-of-life care quality. This project is led by Dr. Jennifer Mack at the Dana Farber Cancer Institute.
Investigator: Kushi, Lawrence
Funder: National Cancer Institute

Clinical Pregnancy Outcomes in Adolescent and Young Adult Female Cancer Survivors

Post-diagnosis fertility is a critical issue for adolescent and young adult cancer survivors (diagnosed at age 15 to 39 years), with little information on the impact of cancer diagnosis and treatment on pregnancy outcomes. This study focuses on five leading cancer types among female adolescent and young adult cancer survivors: breast, melanoma, thyroid, and Hodgkins and non-Hodgkins lymphomas. We will analyze North Carolina state-wide cancer registry data linked to claims and offspring birth records from 2003 to 2012, as well as data from Kaiser Permanente Northern California (KPNC) and Kaiser Permanente Southern California (KPSC) for 2000 to 2016. Study aims include assessment of adverse pregnancy outcome risk among 7,200 female adult and young adult cancer survivors at KPNC and KPSC, with 1,300 births, matched five-to-one to 36,000 women without a prior cancer diagnosis on age and enrollment year. Adverse pregnancy outcome risk will also be assessed among 8,000 female adult and young adult cancer survivors in North Carolina, matched five-to-one on maternal age, state, and delivery year. Additionally, the impact of fertility preservation counseling and use on risk of adverse pregnancy and birth outcomes will be evaluated.
Investigator: Kushi, Lawrence
Funder: National Cancer Institute

Infrastructure for Pathways, a Prospective Study of Breast Cancer Survivorship

This grant provides core infrastructure support for the Pathways Study (Kushi, PI), a prospective cohort study of breast cancer survivorship and prognosis. Since 2006, the study enrolled 4,505 women diagnosed with invasive breast cancer in KPNC. Activities (Ambrosone, Christine, Roswell Park Cancer Institute, Co-PI) include ongoing follow-up of participants, active and passive ascertainment of outcomes, collection of tumor specimens, linkage to KPNC electronic records, enhancement of area-level data from contextual databases through virtual neighborhood audits, provision of genotypic data from genome-wide assays, and establishment of a community and participant advisory board. These activities enhance the Pathways Study to make it an unparalleled, outstanding resource for studies of breast cancer prognosis.
Investigator: Kushi, Lawrence
Funder: National Cancer Institute

Highlighted Publications

American Cancer Society guidelines on nutrition and physical activity for cancer prevention; Reducing the risk of cancer with healthy food choices and physical activity

Author(s): Kushi LH; Doyle C; McCullough M; Rock CL; Demark-Wahnefried W; Bandera EV; Gapstur S; Patel AV; Andrews K; Gansler T; The American Cancer Society 2010 Nutrition and Physical Activity Guidelines Advisory Committee

CA Cancer J Clin. 2012 Jan-Feb;62(1):30-67.

Current Position(s):

Section Affiliations:

Primary Research Interests:

Related Website(s):

Studies

Breast White Adipose Tissue Inflammation and Breast Cancer Outcomes

Kaiser Permanente Interregional Cancer Statistics Project

Geospatial, Multilevel, and Contextual Approaches in Cancer Control and Population Sciences

Comprehensive Translational Science Analytics Tools for the Global Health Agenda

Germline and Tumor Genomic Analyses of Breast Cancer in Latinas

Adolescent and Young Adult Female Cancer Survivors - Cancer Experience Survey

Obesity, Chemotherapy Dosing, and Breast Cancer Outcomes

End-of-Life Care for Adolescents and Young Adults with Cancer: An Evaluation of Care and Development of Patient-Centered Quality Measures

Clinical Pregnancy Outcomes in Adolescent and Young Adult Female Cancer Survivors

Infrastructure for Pathways, a Prospective Study of Breast Cancer Survivorship

Highlighted Publications

American Cancer Society guidelines on nutrition and physical activity for cancer prevention; Reducing the risk of cancer with healthy food choices and physical activity

Lifestyle factors and survival in women with breast cancer

Publications

Early life household intactness and timing of pubertal onset in girls: a prospective cohort study

Material and psychological financial hardship related to employment disruption among female adolescent and young adult cancer survivors

Development of a longitudinal two-biomarker algorithm for early detection of ovarian cancer in women with BRCA mutations

Effects of cooking methods on total isothiocyanate yield from cruciferous vegetables

Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts

Streamlining genetic testing for women with ovarian cancer in a Northern California health care system

Urinary polycyclic aromatic hydrocarbons in relation to anthropometric measures and pubertal development in a cohort of Northern California girls

American Cancer Society guideline for diet and physical activity for cancer prevention

Distinct trajectories of moderate to vigorous physical activity and sedentary behavior following a breast cancer diagnosis: the Pathways Study

Feasibility, patient compliance and acceptability of ovarian cancer surveillance using two serum biomarkers and Risk of Ovarian Cancer Algorithm compared to standard ultrasound and CA 125 among women with BRCA mutations

Impact of the Affordable Care Act on Colorectal Cancer Outcomes: A Systematic Review

Adjuvant endocrine therapy for breast cancer patients: impact of a health system outreach program to improve adherence

Serum bone markers and risk of osteoporosis and fragility fractures in women who received endocrine therapy for breast cancer: a prospective study

Validity of state cancer registry treatment information for adolescent and young adult women

Environmental Tobacco Smoke Exposure in Relation to Family Characteristics, Stressors and Chemical Co-Exposures in California Girls

Distinct trajectories of fruits and vegetables, dietary fat, and alcohol intake following a breast cancer diagnosis: the Pathways Study

A polygenic risk score for breast cancer in U.S. Latinas and Latin-American women

Trends in Use of Medical Imaging in US Health Care Systems and in Ontario, Canada, 2000-2016

Clinical Molecular Marker Testing Data Capture to Promote Precision Medicine Research Within the Cancer Research Network

Perfluorooctanoate and changes in anthropometric parameters with age in young girls in the Greater Cincinnati and San Francisco Bay Area

Trends in Medical Imaging During Pregnancy in the United States and Ontario, Canada, 1996 to 2016

An Exploratory Analysis of Real-World End Points for Assessing Outcomes Among Immunotherapy-Treated Patients With Advanced Non-Small-Cell Lung Cancer

Longitudinal study of age of menarche in association with childhood concentrations of persistent organic pollutants

Is breast cancer in Asian and Asian American women a different disease?

Predictors of Long-Term Survival among High-Grade Serous Ovarian Cancer Patients

SeqSQC: A Bioconductor Package for Evaluating the Sample Quality of Next-generation Sequencing Data

Collaborating on Data, Science, and Infrastructure: The 20-Year Journey of the Cancer Research Network

Maternal Gestational Weight Gain, Obesity, and the Timing of Pubertal Onset in Daughters

Early-onset triple-negative breast cancer in multiracial/ethnic populations: Distinct trends of prevalence of truncation mutations

Germline Genetic Variants in GATA3 and Breast Cancer Treatment Outcomes in SWOG S8897 Trial and the Pathways Study

The Be-Well Study: a prospective cohort study of lifestyle and genetic factors to reduce the risk of recurrence and progression of non-muscle-invasive bladder cancer.

Identification of novel common breast cancer risk variants at the 6q25 locus among Latinas

Opportunities to Improve Detection and Treatment of Depression among Patients with Breast Cancer Treated in an Integrated Delivery System

Lead exposure during childhood and subsequent anthropometry through adolescence in girls

Perioperative Intravesical Chemotherapy for Patients with Non-Muscle Invasive Bladder Cancer: Understanding the Extent of and Sources of Variation in Guideline-Recommended Use

Differences in molecular features of triple-negative breast cancers based on the age at diagnosis

Conflicts of Interest in Nutrition Research

Comparing Reported Dietary Supplement Intakes between Two 24-Hour Recall Methods: The Automated Self-Administered 24-Hour Dietary Assessment Tool and the Interview-Administered Automated Multiple Pass Method

Personal and clinical social support and adherence to adjuvant endocrine therapy among hormone receptor-positive breast cancer patients in an integrated health care system

Reparameterization of PAM50 expression identifies novel breast tumor dimensions and leads to discovery of a genomewide significant breast cancer locus at 12q15

Understanding racial/ethnic differences in breast cancer-related physical well-being: the role of patient-provider interactions

Associations Between Maternal Obesity and Pregnancy Hyperglycemia and Timing of Pubertal Onset in Adolescent Girls: A Population-Based Study

Development, Validation, and Dissemination of a Breast Cancer Recurrence Detection and Timing Informatics Algorithm

Cardiovascular disease incidence in adolescent and young adult cancer survivors: a retrospective cohort study

Girls' Sleep Trajectories Across the Pubertal Transition: Emerging Racial/Ethnic Differences

Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention

Changes in bone mineral density in women with breast cancer receiving aromatase inhibitor therapy

Breast Cancer Chemoprevention in an Integrated Health Care Setting

Childhood Socioeconomic Position and Pubertal Onset in a Cohort of Multiethnic Girls: Implications for Breast Cancer

Genetic Ancestry Is not Associated with Breast Cancer Recurrence or Survival in U.S. Latina Women Enrolled in the Kaiser Permanente Pathways Study

Monitoring Lung Cancer Screening Utilization and Outcomes in Four Cancer Research Network Sites

Age at Pubertal Onset in Girls and Tobacco Smoke Exposure during Pre- and Post-natal Susceptibility Windows

Primary care visit use after positive fecal immunochemical test for colorectal cancer screening

Vitamin D and Breast Cancer Survival-In Reply

Impact of body mass index on ovarian cancer survival varies by stage

Invited Commentary: The Contribution to the Field of Nutritional Epidemiology of the Landmark 1985 Publication by Willett et al

Phenol concentrations during childhood and subsequent measures of adiposity among young girls

Comparison of recruitment and retention among demographic subgroups in a large diverse population study of diet

Patterns and reasons for switching classes of hormonal therapy among women with early-stage breast cancer

Body mass index, PAM50 subtype, recurrence and survival among patients with nonmetastatic breast cancer

Adiposity, post-diagnosis weight change, and risk of cardiovascular events among early-stage breast cancer survivors