Marilyn L. Kwan, PhD

People

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3521 (phone)
marilyn.l.kwan@kp.org
Kaiser Permanente Researcher Profiles

Marilyn L. Kwan, PhD, is a Research Scientist III (equivalent to Professor academic rank) at the Division of Research, Kaiser Permanente Northern California. She graduated from University of California, Berkeley, with her PhD in Epidemiology in May 2004 and completed a one-year postdoctoral fellowship in September 2005, also at UC Berkeley. Dr. Kwan joined the Division of Research in July 2005, where her current research focus is breast and bladder cancer prognosis and survival. Specifically, her interests include lifestyle and molecular factors and their associations with cancer recurrence, survival, and quality of life. She also studies the long-term health effects of cancer treatment specifically lymphedema, fractures, and cardiovascular disease, in breast cancer survivors. Dr. Kwan’s research has been funded by the National Cancer Institute, American Cancer Society, and California Breast Cancer Research Program.

Current Position(s):

Research Scientist III, Division of Research, Kaiser Permanente Northern California

Section Affiliations:

Cancer

Primary Research Interests:

Cancer Epidemiology
Secondary Lymphedema After Breast Cancer
Quality of Cancer Care
Childhood Leukemia
Nutrition
Obesity

Related Website(s):

Studies

Treatment Patterns and Clinical Outcomes in Patients with HR+/HER2- and HR+/HER2+ Metastatic Breast Cancer in an Integrated Health Care System

This is an observational, retrospective cohort study of patients diagnosed with HR+/HER2 - and HR+/HER2+ metastatic breast cancer (mBC) who initiated first-line systemic therapy in the metastatic setting. Study aims are: 1) Among HR+/HER2- mBC patients diagnosed from 2015-2020, describe demographic and clinical characteristics, treatment characteristics, and real-world progression-free survival. 2) Among HR+/HER2+ mBC patients diagnosed from 2012-2020, describe demographic and clinical characteristics, treatment characteristics, and progression-free survival and overall survival. 3) Identify demographic and clinical factors associated with first- and second-line treatment receipt (HR+/HER2-), treatment selection (HR+/HER2+), and their clinical outcomes.
Investigator: Kwan, Marilyn
Funder: Pfizer Inc.

Energy Balance, mTOR Pathway Signaling, and Breast Cancer Prognosis: The Pathways Study

This application will use the Pathways Study resource to investigate genetic and non-genetic factors in the interplay of energy balance, mTOR signaling, and breast cancer prognosis. mTOR expression will be determined in tumor tissue from tissue microarrays that are being created in the Pathways Study, and its role in breast cancer outcomes will be examined.
Investigator: Kwan, Marilyn
Funder: National Cancer Institute

Recurrence, Treatment, and Complication Patterns of Intermediate Risk Non-muscle Invasive Bladder Cancer

This study will comprehensively assess the clinical course of intermediate risk non-muscle invasive bladder cancer (NMIBC) in 291 patients diagnosed at Kaiser Permanente Northern California who are enrolled in the Be-Well Study. Intermediate risk NMIBC is an understudied form of one of the most common urologic cancers in the U.S. We will examine recurrence and progression patterns of intermediate risk NMIBC; determine complications associated with its diagnosis and treatment; and characterize healthcare utilization related to its surveillance.
Investigator: Kwan, Marilyn
Funder: UroGen Pharma, Inc.

Predictors of CVD among Breast Cancer Survivors in an Integrated Health System

This study will comprehensively examine clinical and behavioral predictors of cardiovascular disease (CVD) outcomes among breast cancer survivors, and will maximize unique patient and data resources available at Kaiser Permanente Northern California (KPNC). We will compare CVD events in the Pathways Study, a cohort of female KPNC members age ≥21 years diagnosed with invasive breast cancer (n=4,453, R01CA105274) with CVD events in a new age, race/ethnicity, history of comorbidity, and length of KPNC membership matched cohort of healthy KPNC female members (n=22,265). Results from this study will have important implications for identifying breast cancer subgroups at high risk of CVD and identifying potential targets for intervention, such as medication adherence and control of CVD risk factors.
Investigator: Kwan, Marilyn
Funder: National Cancer Institute

Impact of Low IL-10 Levels at Birth and Leukemia Risk

The objectives of this retrospective cohort study of an established case-control study of childhood leukemia are to understand the relationships among immune status at birth, infectious exposures during childhood, and leukemogenesis, and to use this understanding to decrease the incidence of childhood acute lymphoblastic leukemia (ALL). The aims are to: 1) Assess whether a low interleukin-10 level at birth is associated with an increased incidence of early infections characterized by severe clinical symptoms from medical records and self-report; and 2) Determine whether decreased interleukin-10 can contribute to increased ALL in the setting of immune system activation.
Investigator: Kwan, Marilyn
Funder: National Cancer Institute

Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging

The aims of this multiple PI grant are to: 1) Evaluate patterns of medical imaging (utilization and radiation dose) and estimate cumulative exposure to ionizing radiation from medical imaging in a) children (0-18 years old) and b) pregnant women, from 1996-2016; 2) Determine the risk of childhood leukemia among children and adolescents following exposure to all medical imaging examinations that deliver ionizing radiation from 1996-2016 and followed through 2017. We will also examine effects due to exposure from CT exams alone; 3) Determine the risk of childhood cancers among children and adolescents following fetal, in utero (maternal pregnancy) exposure to medical imaging from 1996-2016 followed through 2017; 4) In the subset of the population with complete information during in utero and child or adolescent exposure to medical imaging, assess the cumulative impact of these exposures on childhood cancers.
Investigator: Kwan, Marilyn
Funder: National Cancer Institute

Diet and Lifestyle in a Prospective Study of Bladder Cancer Survivors

This study involves a new prospective cohort of more than 1,800 non-muscle invasive bladder cancer cases to investigate the role of cruciferous vegetable intake, along with associated individual genetic profiles, on reducing recurrence and progression of disease and improving the efficacy of current treatment modalities.
Investigator: Kwan, Marilyn
Funder: National Cancer Institute

Lifestyle and Molecular Factors of Bone Health in Breast Cancer Survivors

This project will investigate the impact of modifiable lifestyle factors, germline genetic variations, and serum biomarkers, on adverse skeletal outcomes among aromatase inhibitor users, as well as develop a prediction model for risk of fractures for postmenopausal breast cancer patients taking aromatase inhibitors.
Investigator: Kwan, Marilyn
Funder: National Cancer Institute

Urinary Diversion Among Bladder Cancer Survivors: Cost, Complications and QOL

This mixed-method, comparative effectiveness study will compare costs, complications, patient- and family-centered outcomes related to urinary diversion. Study participants will include bladder cancer patients undergoing cystectomy and their family caregivers within three Kaiser Permanente regions with a membership base of over six million enrollees.
Investigator: Kwan, Marilyn
Funder: National Cancer Institute

Highlighted Publications

Race/ethnicity, genetic ancestry, and breast cancer-related lymphedema in the Pathways Study

Author(s): Kwan ML; Yao S; Lee VS; Roh JM; Zhu Q; Ergas IJ; Liu Q; Zhang Y; Kutner SE; Quesenberry CP; Ambrosone CB; Kushi LH

Breast Cancer Res Treat. 2016 Jul 22.

Current Position(s):

Section Affiliations:

Primary Research Interests:

Related Website(s):

Studies

Treatment Patterns and Clinical Outcomes in Patients with HR+/HER2- and HR+/HER2+ Metastatic Breast Cancer in an Integrated Health Care System

Energy Balance, mTOR Pathway Signaling, and Breast Cancer Prognosis: The Pathways Study

Recurrence, Treatment, and Complication Patterns of Intermediate Risk Non-muscle Invasive Bladder Cancer

Predictors of CVD among Breast Cancer Survivors in an Integrated Health System

Impact of Low IL-10 Levels at Birth and Leukemia Risk

Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging

Diet and Lifestyle in a Prospective Study of Bladder Cancer Survivors

Lifestyle and Molecular Factors of Bone Health in Breast Cancer Survivors

Urinary Diversion Among Bladder Cancer Survivors: Cost, Complications and QOL

Highlighted Publications

Race/ethnicity, genetic ancestry, and breast cancer-related lymphedema in the Pathways Study

Breastfeeding, PAM50 Tumor Subtype, and Breast Cancer Prognosis and Survival

Bone health history in breast cancer patients on aromatase inhibitors

Obesity and Mortality After Breast Cancer by Race/Ethnicity; The California Breast Cancer Survivorship Consortium

Publications

Risk of heart failure with preserved versus reduced ejection fraction in women with breast cancer

Risk of Cardiovascular Disease in Women With and Without Breast Cancer: The Pathways Heart Study

UACA locus is associated with breast cancer chemoresistance and survival

Quantifying cancer risk from exposures to medical imaging in the Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging (RIC) Study: research methods and cohort profile

Risk of Cardiometabolic Risk Factors in Women With and Without a History of Breast Cancer: The Pathways Heart Study

Positive predictive value and sensitivity of ICD-9-CM codes for identifying pediatric leukemia

Description of Major Osteoporotic Fractures in Women with Invasive Breast Cancer Who Received Endocrine Therapy

Plant-Based Dietary Patterns and Breast Cancer Recurrence and Survival in the Pathways Study

Long-term medical imaging use in children with central nervous system tumors

Clustering of Social and Physical Pain Variables and Their Association With Mortality in Two Population-Based Cohorts

Leukemia Risk in a Cohort of 3.9 Million Children With and Without Down Syndrome

Diet Quality and Breast Cancer Recurrence and Survival: The Pathways Study

Weight stability masks changes in body composition in colorectal cancer: a retrospective cohort study

"I Had to Make Them Feel at Ease": Narrative Accounts of How Women With Breast Cancer Navigate Social Support

The Adolescent and Young Adult (AYA) Horizon Study: An AYA cancer survivorship cohort

A prospective study of lifestyle factors and bone health in breast cancer patients who received aromatase inhibitors in an integrated healthcare setting

Racial/ethnic disparities in survival after breast cancer diagnosis by estrogen and progesterone receptor status: A pooled analysis

Trends in Imaging for Suspected Pulmonary Embolism Across US Health Care Systems, 2004 to 2016

Effects of cooking methods on total isothiocyanate yield from cruciferous vegetables

Association of Low Muscle Mass and Low Muscle Radiodensity With Morbidity and Mortality for Colon Cancer Surgery

Hospital Characteristics and Breast Cancer Survival in the California Breast Cancer Survivorship Consortium

History of Early Childhood Infections and Acute Lymphoblastic Leukemia Risk Among Children in a U.S. Integrated Health Care System

Distinct trajectories of moderate to vigorous physical activity and sedentary behavior following a breast cancer diagnosis: the Pathways Study

Serum bone markers and risk of osteoporosis and fragility fractures in women who received endocrine therapy for breast cancer: a prospective study

The effect of multiple recruitment contacts on response rates and patterns of missing data in a survey of bladder cancer survivors 6 months after cystectomy.

A Scalable Database of Organ Doses for Common Diagnostic Fluoroscopy Procedures of Children: Procedures of Historical Practice for Use in Radiation Epidemiology Studies

Distinct trajectories of fruits and vegetables, dietary fat, and alcohol intake following a breast cancer diagnosis: the Pathways Study

Trends in Use of Medical Imaging in US Health Care Systems and in Ontario, Canada, 2000-2016

Decision Regret Related to Urinary Diversion Choice Among Cystectomy Patients

Trends in Medical Imaging During Pregnancy in the United States and Ontario, Canada, 1996 to 2016

SeqSQC: A Bioconductor Package for Evaluating the Sample Quality of Next-generation Sequencing Data

Early-onset triple-negative breast cancer in multiracial/ethnic populations: Distinct trends of prevalence of truncation mutations

Germline Genetic Variants in GATA3 and Breast Cancer Treatment Outcomes in SWOG S8897 Trial and the Pathways Study

Development of a Goal Elicitation Measure to Support Bladder Cancer Patient Choice about Urinary Diversion.

AUTHOR REPLY

The association of medical and demographic characteristics with sarcopenia and low muscle radiodensity in patients with nonmetastatic colorectal cancer

Recovering from Cystectomy: Patient Perspectives

The Be-Well Study: a prospective cohort study of lifestyle and genetic factors to reduce the risk of recurrence and progression of non-muscle-invasive bladder cancer.

Opportunities to Improve Detection and Treatment of Depression among Patients with Breast Cancer Treated in an Integrated Delivery System

Factors That Influence Selectionof Urinary Diversion Among Bladder Cancer Patients in 3 Community-based Integrated Health Care Systems.

Perioperative Intravesical Chemotherapy for Patients with Non-Muscle Invasive Bladder Cancer: Understanding the Extent of and Sources of Variation in Guideline-Recommended Use

The deterioration of muscle mass and radiodensity is prognostic of poor survival in stage I-III colorectal cancer: a population-based cohort study (C-SCANS)

Lifestyle and nutritional modifiable factors in the prevention and treatment of bladder cancer

Associations of pre-existing co-morbidities with skeletal muscle mass and radiodensity in patients with non-metastatic colorectal cancer

Personal and clinical social support and adherence to adjuvant endocrine therapy among hormone receptor-positive breast cancer patients in an integrated health care system

Understanding racial/ethnic differences in breast cancer-related physical well-being: the role of patient-provider interactions

Changes in bone mineral density in women with breast cancer receiving aromatase inhibitor therapy

Use of iDXA spine scans to evaluate total and visceral abdominal fat

Genetic Ancestry Is not Associated with Breast Cancer Recurrence or Survival in U.S. Latina Women Enrolled in the Kaiser Permanente Pathways Study

Association of Systemic Inflammation and Sarcopenia With Survival in Nonmetastatic Colorectal Cancer: Results From the C SCANS Study

Explaining the Obesity Paradox: The Association between Body Composition and Colorectal Cancer Survival (C-SCANS Study)

Patterns and reasons for switching classes of hormonal therapy among women with early-stage breast cancer

Body mass index, PAM50 subtype, recurrence and survival among patients with nonmetastatic breast cancer

Adiposity, post-diagnosis weight change, and risk of cardiovascular events among early-stage breast cancer survivors

Impact of social and built environment factors on body size among breast cancer survivors; the Pathways Study

BMI, Lifestyle Factors and Taxane-Induced Neuropathy in Breast Cancer Patients; The Pathways Study

Association of Weight Change after Colorectal Cancer Diagnosis and Outcomes in the Kaiser Permanente Northern California Population

Post-diagnosis social networks and breast cancer mortality in the After Breast Cancer Pooling Project

Bone remodeling and regulating biomarkers in women at the time of breast cancer diagnosis

Association of Serum Level of Vitamin D at Diagnosis With Breast Cancer Survival; A Case-Cohort Analysis in the Pathways Study