Jeffrey K. Lee, MD, MPH

People

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

jeffrey.k.lee@kp.org

Jeffrey K. Lee, MD, MPH, is a Research Scientist I at the Kaiser Permanente Northern California Division of Research and an attending gastroenterologist at Kaiser Permanente San Francisco Medical Center. His clinical focus is in general gastroenterology, colorectal cancer prevention, and hereditary gastrointestinal cancer syndromes. His research interests include: colorectal cancer prevention, gastrointenstinal cancer prevention, pharmacoepidemiology, diagnostic testing for gastrointestinal cancers, and improving the quality and safety of endoscopy and colonoscopy. He holds a Bachelor of Arts from the University of California, Berkeley, a Masters in Clinical Research from the University of California, San Diego, and a Doctorate in Medicine, also from UCSD. After medical school, he completed an internal medicine residency at UCSD; and a gastroenterology fellowship at the University of California, San Francisco. Prior to joining Kaiser Permanente, he practiced gastroenterology at UCSF Medical Center for several years.

Current Position(s):

Research Scientist I, Division of Research, Kaiser Permanente Northern California
Attending Gastroenterologist, Kaiser Permanente, San Francisco Medical Center
Assistant Clinical Professor of Medicine, University of California, San Francisco

Section Affiliations:

Cancer

Studies

Comparison of Survival Rates Across Racial/Ethnic Groups Among Young Adults Diagnosed with Early-Onset Colorectal Cancer in a Large, Community-Based Population.

This study will examine racial differences in overall survival among young adults 50 years of age diagnosed with early-onset colorectal cancer in a large, community- based, fully insured population with access to complete primary and specialty care to identify differences in risk factors, access to care, and treatment effectiveness and adherence.
Investigator: Lee, Jeffrey
Funder: Genentech, Inc.

COmprehensive risk Model for Predicting Advanced neoplasia on Surveillance Study (COMPASS)

The goals of this project are to develop and validate a colorectal neoplasia risk prediction model among average-risk patients who underwent a baseline colonoscopy; estimate the risk of advanced neoplasia among patients with newly diagnosed Lynch Syndrome; and develop and validate a colorectal neoplasia risk prediction model among patients with newly diagnosed Lynch Syndrome.
Investigator: Lee, Jeffrey
Funder: Janssen Pharmaceuticals, Inc.

Rates and Risk Factors of Post-Colonoscopy Colorectal Cancer in a Large, United States Population-based Cohort Study

Colorectal cancer (CRC) is the third leading cause of cancer death in the United States. Colonoscopy can reduce CRC incidence and deaths through removal of precancerous adenomatous polyps (adenomas) and detection of cancer at an earlier, more treatable stage. However, some patients develop CRC after a colonoscopy in which no cancer is diagnosed. The World Endoscopy Organization (WEO) defines post-colonoscopy colorectal cancers (PCCRCs) as CRC diagnosed 6 months after a colonoscopy that did not detect cancer. PCCRC is poorly understood as there is uncertainty about how often these cancers occur, their likely etiologies, the risk factors for these cancers, and whether they are more lethal than detected CRCs. To address these uncertainties, the WEO published a consensus statement to provide comprehensive guidance for the investigation of PCCRC cases. Their recommendations include a standardized definition for PCCRC, a defined method for calculating PCCRC rates, and standardized methods for performing qualitative reviews of cases to determine their likely etiology. The primary goal of the proposed study is to use recently published WEO methods to determine PCCRC rates, the likely etiologies for these cancers, their risk factors, and prognoses for PCCRC in the large integrated healthcare setting of Kaiser Permanente Northern California (KPNC).
Investigator: Lee, Jeffrey
Funder: Northern California Community Benefit Programs

De-Implementation of Outdated Colonoscopy Surveillance Interval Recommendations among Patients with Low-Risk Adenomas (DESIRE)

Recent guidelines have extended surveillance intervals for patients with low-risk adenomas from 5 years to 10. However, it remains unclear how to implement this change. In a pragmatic randomized 2-arm study of 1,000 patients with a history of low-risk adenomas and a standing 5-year surveillance recommendation, we will compare the effectiveness of secure messaging versus mailed outreach for adopting the new 10-year surveillance interval recommendation, continuing with the standing 5-year recommendation, or requesting a provider encounter (e.g., clinic or virtual visit) for shared decision making.
Investigator: Lee, Jeffrey
Funder: TPMG Delivery Science Projects Program

Optimizing Long-Term Post-Polypectomy Surveillance for Colorectal Cancer Prevention Using a Prediction Rule Developed from a Large, Community-Based Cohort

Screening has been shown to reduce colorectal cancer incidence and mortality. However, screening has resulted in a growing cohort of patients with adenomatous polyps (adenomas), and little is known about effectively managing their post-polypectomy surveillance. With limited data available in the literature to determine the appropriate timing and frequency of follow-up colonoscopy for patients after adenoma removal, recommendations for post-polypectomy surveillance from our national guidelines have been imprecise at best. To fill this knowledge gap, this project aims to: 1) determine the long- term colorectal cancer risk in patients after colonoscopic polypectomy in a very large “real world” community-based population; 2) identify patient-, polyp-, and exam-related risk factors associated with incident colorectal cancer in these patients; and 3) develop a risk prediction model that will identify post- polypectomy patients at high and low risk for developing subsequent colorectal cancer.
Investigator: Lee, Jeffrey
Funder: National Cancer Institute

Highlighted Publications

Effects of Electronic Chromoendoscopy on Detection of Adenomas During Colonoscopy

Author(s): Kidambi TD; Terdiman JP; El-Nachef N; Singh A; Kattah MG; Lee JK

Clin Gastroenterol Hepatol. 2019 03;17(4):701-708.e1. Epub 2018-06-20.

Current Position(s):

Section Affiliations:

Studies

Comparison of Survival Rates Across Racial/Ethnic Groups Among Young Adults Diagnosed with Early-Onset Colorectal Cancer in a Large, Community-Based Population.

COmprehensive risk Model for Predicting Advanced neoplasia on Surveillance Study (COMPASS)

Rates and Risk Factors of Post-Colonoscopy Colorectal Cancer in a Large, United States Population-based Cohort Study

De-Implementation of Outdated Colonoscopy Surveillance Interval Recommendations among Patients with Low-Risk Adenomas (DESIRE)

Optimizing Long-Term Post-Polypectomy Surveillance for Colorectal Cancer Prevention Using a Prediction Rule Developed from a Large, Community-Based Cohort

Highlighted Publications

Effects of Electronic Chromoendoscopy on Detection of Adenomas During Colonoscopy

Accurate Identification of Colonoscopy Quality and Polyp Findings Using Natural Language Processing

Accuracy of fecal immunochemical tests for colorectal cancer: systematic review and meta-analysis

Publications

Risk of nonalcoholic fatty liver disease and associations with gastrointestinal cancers

GA White Paper: Challenges and Gaps in Innovation for the Performance of Colonoscopy for Screening and Surveillance of Colorectal Cancer

Impact of the COVID-19 pandemic on fecal immunochemical testing, colonoscopy services, and colorectal neoplasia detection in a large United States community-based population

CMV Colitis Masquerading as MALT Lymphoma in an Immunocompetent Patient

Novel, Emerging Risk Factors for Colorectal Cancer Remain Understudied

Association of Physician Adenoma Detection Rates With Postcolonoscopy Colorectal Cancer

Reduced Implementation and Completion of Average-Risk Annual Fecal Immunochemical Test Colorectal Cancer Screening in Black Patients Aged 45-49 Years

Biopsy of Non-tumor Sites After Biopsy of a Colorectal Cancer is not Associated With Metachronous Cancers: A Case-control Study

The New Kids on the Block: Emerging Complementary Colonoscopy Quality Metrics

American Society for Gastrointestinal Endoscopy guideline on screening for pancreatic cancer in individuals with genetic susceptibility: methodology and review of evidence

Declining Colectomy Rates for Nonmalignant Colorectal Polyps in a Large, Ethnically Diverse, Community-based Population

Risk Stratification for Early-Onset Colorectal Cancer Using a Combination of Genetic and Environmental Risk Scores: An International Multi-Center Study

Trends and Projections in National U.S. Healthcare Spending for Gastrointestinal Malignancies (1996-2030)

Too Good to Be True? Evaluation of Colonoscopy Sensitivity Assumptions Used in Policy Models

Eosinophilic esophagitis: New molecules, better life?

Impact of the Affordable Care Act on Colorectal Cancer Incidence and Mortality

Program components and results from an organized colorectal cancer screening program using annual fecal immunochemical testing

Rising Early-Onset Colorectal Cancer Incidence is Not an Artifact of Increased Screening Colonoscopy Use in a Large, Diverse Healthcare System

Endoscopic Surveillance and Dysplasia Management in IBD: Plus Ça Change, Plus C'est la Même Chose

Systematic review with meta-analysis: the prevalence of post-colonoscopy colorectal cancers using the World Endoscopy Organization nomenclature

Simplifying ADR reporting - a worthy goal, but the devil is in the details

Risk stratification for colorectal cancer in individuals with subtypes of serrated polyps

ASGE guideline on the role of endoscopy in the management of malignant hilar obstruction

ASGE guideline on the management of cholangitis

Sugary truth of early-onset colorectal neoplasia - not so sweet after all

The effect of using fecal testing after a negative sigmoidoscopy on the risk of death from colorectal cancer

Response to Li and Hopper

An update on the epidemiology, molecular characterization, diagnosis, and screening strategies for early-onset colorectal cancer

Validated training tools are needed for assessing competency in colorectal endoscopic mucosal resection

Urban-Rural Disparities and Temporal Trends in Peptic Ulcer Disease Epidemiology, Treatment, and Outcomes in the United States

Influence of Telemedicine-First Intervention on Patient Visit Choice, Post-Visit Care, and Patient Satisfaction in Gastroenterology

ASGE guideline on the role of endoscopy in the management of benign and malignant gastroduodenal obstruction

When Should We Let Colorectal Cancer Screening Get Personal?

Early Screening of African Americans (45-50 Years Old) in a Fecal Immunochemical Test-based Colorectal Cancer Screening Program

Primary Care Provider Beliefs and Recommendations About Colorectal Cancer Screening in Four Healthcare Systems

Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk

Increased Risk of Colorectal Cancer in Individuals With a History of Serrated Polyps

Role of Rare and Low-Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

American Society for Gastrointestinal Endoscopy guideline on the role of endoscopy in familial adenomatous polyposis syndromes

Proton Pump Inhibitor Use and Risk of Gastric, Colorectal, Liver, and Pancreatic Cancers in a Community-Based Population

ASGE guideline on minimum staffing requirements for the performance of GI endoscopy

Long-term Risk of Colorectal Cancer and Related Death After Adenoma Removal in a Large, Community-based Population

Impact of observational training on endoscopic mucosal resection outcomes and competency for large colorectal polyps: single endoscopist experience

Longitudinal Evolution of Markers of Mineral Metabolism in Patients With CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study

ASGE guideline on the management of achalasia

American Society for Gastrointestinal Endoscopy guideline on the role of endoscopy in the management of acute colonic pseudo-obstruction and colonic volvulus

LIFE EXPECTANCY DISPARITIES AMONG ADULTS WITH HIV IN THE UNITED STATES AND CANADA: THE IMPACT OF A REDUCTION IN DRUG- AND ALCOHOL-RELATED DEATHS USING THE LIVES SAVED SIMULATION (LISSO) MODEL

Effect of Sex, Age and Positivity Threshold on Fecal Immunochemical Test Accuracy: a Systematic Review and Meta-Analysis

Immunotherapy-Associated Pseudomembranous Colitis

Morbidity and Mortality After Surgery for Nonmalignant Colorectal Polyps: A 10-Year Nationwide Analysis

ASGE guideline on screening and surveillance of Barrett's esophagus

Colonoscopy Indication Algorithm Performance Across Diverse Health Care Systems in the PROSPR Consortium

A summary of the Fight Colorectal Cancer working meeting: exploring risk factors and etiology of sporadic early-age onset colorectal cancer

Low-Literacy Instructions Enable Successful Completion of Fecal Immunohistochemical Tests

ASGE guideline on the role of endoscopy for bleeding from chronic radiation proctopathy

Systematic review and meta-analysis: efficacy and safety of oral Janus kinase inhibitors for inflammatory bowel disease

ASGE guideline on the role of endoscopy in the evaluation and management of choledocholithiasis

Germline BRCA1 Deletion as Driver Mutation for Metastatic Urachal Adenocarcinoma in Patient Who Achieved Complete Response to Rucaparib

Effects of Electronic Chromoendoscopy on Detection of Adenomas During Colonoscopy

Long-term Risk of Colorectal Cancer and Related Deaths After a Colonoscopy With Normal Findings

Strategies to Improve Follow-up After Positive Fecal Immunochemical Tests in a Community-Based Setting: A Mixed-Methods Study

Accurate Identification of Colonoscopy Quality and Polyp Findings Using Natural Language Processing

Colorectal Cancer Screening Participation Among Asian Americans Overall and Subgroups in an Integrated Health Care Setting with Organized Screening

Novel variant of unknown significance in MUTYH in a patient with MUTYH-associated polyposis: a case to reclassify

Effects of Organized Colorectal Cancer Screening on Cancer Incidence and Mortality in a Large, Community-based Population

Influence of Varying Quantitative Fecal Immunochemical Test Positivity Thresholds on Colorectal Cancer Detection: A Community-Based Cohort Study

The Utility and Cross-Validation of a Composite Physical Activity Score in Relation to Cardiovascular Health Indicators: Coronary Artery Risk Development in Young Adults