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Jeffrey K. Lee, MD, MAS

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Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612


jeffrey.k.lee@kp.org


Jeffrey K. Lee, MD, MAS, is a Research Scientist I at the Kaiser Permanente Northern California Division of Research and an attending gastroenterologist at Kaiser Permanente San Francisco Medical Center. His clinical focus is in general gastroenterology, colorectal cancer prevention, and hereditary gastrointestinal cancer syndromes. His research interests include: colorectal cancer prevention, gastrointenstinal cancer prevention, pharmacoepidemiology, diagnostic testing for gastrointestinal cancers, and improving the quality and safety of endoscopy and colonoscopy. He holds a Bachelor of Arts from the University of California, Berkeley, a Masters in Clinical Research from the University of California, San Diego, and a Doctorate in Medicine, also from UCSD. After medical school, he completed an internal medicine residency at UCSD; and a gastroenterology fellowship at the University of California, San Francisco. Prior to joining Kaiser Permanente, he practiced gastroenterology at UCSF Medical Center for several years.

Current Position(s):

  • Research Scientist I, Division of Research, Kaiser Permanente Northern California
  • Attending Gastroenterologist, Kaiser Permanente, San Francisco Medical Center
  • Assistant Clinical Professor of Medicine, University of California, San Francisco

Section Affiliations:

      Optimizing Long-Term Post-Polypectomy Surveillance for Colorectal Cancer Prevention Using a Prediction Rule Developed from a Large, Community-Based Cohort

      ​Screening has been shown to reduce colorectal cancer incidence and mortality. However, screening has resulted in a growing cohort of patients with adenomatous polyps (adenomas), and little is known about effectively managing their post-polypectomy surveillance. With limited data available in the literature to determine the appropriate timing and frequency of follow-up colonoscopy for patients after adenoma removal, recommendations for post-polypectomy surveillance from our national guidelines have been imprecise at best. To fill this knowledge gap, this project aims to: 1) determine the long- term colorectal cancer risk in patients after colonoscopic polypectomy in a very large “real world” community-based population; 2) identify patient-, polyp-, and exam-related risk factors associated with incident colorectal cancer in these patients; and 3) develop a risk prediction model that will identify post- polypectomy patients at high and low risk for developing subsequent colorectal cancer.


      Investigator: Lee, Jeffrey
      Funder: National Cancer Institute

      Effect of I-scan Electronic Chromoendoscopy on Detection of Adenomas During Colonoscopy.

      Author(s): Kidambi, Trilokesh D TD; Terdiman, Jonathan P JP; El-Nachef, Najwa N; Singh, Aparajita A; Kattah, Michael G MG; Lee, Jeffrey K JK

      Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2018 Jun 20;():. Epub 2018-06-20.

      PubMed abstract

      Accurate Identification of Colonoscopy Quality and Polyp Findings Using Natural Language Processing

      Author(s): Lee JK; Jensen CD; Levin TR; Zauber AG; Doubeni CA; Zhao WK; Corley DA

      J Clin Gastroenterol. 2017 Sep 12.

      PubMed abstract

      Accuracy of fecal immunochemical tests for colorectal cancer: systematic review and meta-analysis

      Author(s): Lee JK; Liles EG; Bent S; Levin TR; Corley DA

      Ann Intern Med. 2014 Feb 4;160(3):171.

      PubMed abstract

      The Utility and Cross-Validation of a Composite Physical Activity Score in Relation to Cardiovascular Health Indicators: Coronary Artery Risk Development in Young Adults

      Author(s): Pettee Gabriel K; Pérez A; Jacobs DR; Lee J; Kohl HW; Sternfeld B

      J Phys Act Health. 2018 Nov 01;15(11):847-856. Epub 2018-10-19.

      PubMed abstract

      Negative withdrawal time: simple and efficient

      Author(s): Kidambi TD; Terdiman JP; Lee JK

      Gastrointest Endosc. 2018 Oct;88(4):781.

      PubMed abstract

      Colorectal Cancer Screening Participation Among Asian Americans Overall and Subgroups in an Integrated Health Care Setting with Organized Screening

      Author(s): Ghai NR; Jensen CD; Corley DA; Doubeni CA; Schottinger JE; Zauber AG; Lee AT; Contreras R; Levin TR; Lee JK; Quinn VP

      Clin Transl Gastroenterol. 2018 Sep 21;9(9):186. Epub 2018-09-21.

      PubMed abstract

      Influence of Varying Quantitative Fecal Immunochemical Test Positivity Thresholds on Colorectal Cancer Detection: A Community-Based Cohort Study

      Author(s): Selby K; Jensen CD; Lee JK; Doubeni CA; Schottinger JE; Zhao WK; Chubak J; Halm E; Ghai NR; Contreras R; Skinner C; Kamineni A; Levin TR; Corley DA

      Ann Intern Med. 2018 Sep 18.

      PubMed abstract

      Effects of Organized Colorectal Cancer Screening on Cancer Incidence and Mortality in a Large, Community-based Population.

      Author(s): Levin, Theodore R TR; Corley, Douglas A DA; Jensen, Christopher D CD; Schottinger, Joanne E JE; Quinn, Virginia P VP; Zauber, Ann G AG; Lee, Jeffrey K JK; Zhao, Wei K WK; Udaltsova, Natalia N; Ghai, Nirupa R NR; Lee, Alexander T AT; Quesenberry, Charles P CP; Fireman, Bruce H BH; Doubeni, Chyke A CA

      Gastroenterology. 2018 Jul 19;():. Epub 2018-07-19.

      PubMed abstract

      Effect of I-scan Electronic Chromoendoscopy on Detection of Adenomas During Colonoscopy.

      Author(s): Kidambi, Trilokesh D TD; Terdiman, Jonathan P JP; El-Nachef, Najwa N; Singh, Aparajita A; Kattah, Michael G MG; Lee, Jeffrey K JK

      Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2018 Jun 20;():. Epub 2018-06-20.

      PubMed abstract

      Novel variant of unknown significance in MUTYH in a patient with MUTYH-associated polyposis: a case to reclassify.

      Author(s): Kidambi, Trilokesh D TD; Goldberg, Dena D; Nussbaum, Robert R; Blanco, Amie A; Umetsu, Sarah E SE; Terdiman, Jonathan P JP; Lee, Jeffrey K JK

      Clinical journal of gastroenterology. 2018 May 15;():. Epub 2018-05-15.

      PubMed abstract

      Yield of Colonoscopy After a Positive Result From a Fecal Immunochemical Test OC-Light.

      Author(s): Alsayid, Muhammad M; Singh, Maneesh H MH; Issaka, Rachel R; Laleau, Victoria V; Day, Lukejohn L; Lee, Jeffrey J; Allison, James J; Somsouk, Ma M

      Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2018 Oct ;16(10):1593-1597.e1. Epub 2018-04-13.

      PubMed abstract

      Development and validation of the SIMPLE endoscopic classification of diminutive and small colorectal polyps.

      Author(s): Iacucci, Marietta M; Trovato, Cristina C; Daperno, Marco M; Akinola, Oluseyi O; Greenwald, David D; Gross, Seth A SA; Hoffman, Arthur A; Lee, Jeffrey J; Lethebe, Brendan C BC; Lowerison, Mark M; Nayor, Jennifer J; Neumann, Helmut H; Rath, Timo T; Sanduleanu, Silvia S; Sharma, Prateek P; Kiesslich, Ralf R; Ghosh, Subrata S; Saltzman, John R JR;

      Endoscopy. 2018 Aug ;50(8):779-789. Epub 2018-03-23.

      PubMed abstract

      An Unexpected Finding During Colonoscopy: Pinworms.

      Author(s): Kidambi, Trilokesh D TD; Lee, Jeffrey K JK

      Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2018 Jan ;16(1):e4. Epub --.

      PubMed abstract

      Interventions to Improve Follow-up of Positive Results on Fecal Blood Tests: A Systematic Review

      Author(s): Selby K; Baumgartner C; Levin TR; Doubeni CA; Zauber AG; Schottinger J; Jensen CD; Lee JK; Corley DA

      Ann Intern Med. 2017 Oct 17;167(8):565-575. Epub 2017-10-10.

      PubMed abstract

      Accurate Identification of Colonoscopy Quality and Polyp Findings Using Natural Language Processing

      Author(s): Lee JK; Jensen CD; Levin TR; Zauber AG; Doubeni CA; Zhao WK; Corley DA

      J Clin Gastroenterol. 2017 Sep 12.

      PubMed abstract

      Endoscopy is of low yield in the identification of gastrointestinal neoplasia in patients with dermatomyositis: A cross-sectional study.

      Author(s): Kidambi, Trilokesh D TD; Schmajuk, Gabriela G; Gross, Andrew J AJ; Ostroff, James W JW; Terdiman, Jonathan P JP; Lee, Jeffrey K JK

      World journal of gastroenterology. 2017 Jul 14;23(26):4788-4795. Epub --.

      PubMed abstract

      Surveillance for One or Two Small Adenomas: Low Risk Is Really Low Risk.

      Author(s): Lee, Jeffrey K JK; Lieberman, David D

      Gastroenterology. 2017 06 ;152(8):1819-1821. Epub 2017-04-28.

      PubMed abstract

      Association Between Time to Colonoscopy After a Positive Fecal Test Result and Risk of Colorectal Cancer and Cancer Stage at Diagnosis.

      Author(s): Corley, Douglas A DA; Jensen, Christopher D CD; Quinn, Virginia P VP; Doubeni, Chyke A CA; Zauber, Ann G AG; Lee, Jeffrey K JK; Schottinger, Joanne E JE; Marks, Amy R AR; Zhao, Wei K WK; Ghai, Nirupa R NR; Lee, Alexander T AT; Contreras, Richard R; Quesenberry, Charles P CP; Fireman, Bruce H BH; Levin, Theodore R TR

      JAMA. 2017 Apr 25;317(16):1631-1641. Epub --.

      PubMed abstract

      Recommendations on Fecal Immunochemical Testing to Screen for Colorectal Neoplasia: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer.

      Author(s): Robertson, Douglas J DJ; Lee, Jeffrey K JK; Boland, C Richard CR; Dominitz, Jason A JA; Giardiello, Francis M FM; Johnson, David A DA; Kaltenbach, Tonya T; Lieberman, David D; Levin, Theodore R TR; Rex, Douglas K DK

      The American journal of gastroenterology. 2017 01 ;112(1):37-53. Epub 2016-10-18.

      PubMed abstract

      Fecal Immunochemical Test Program Performance Over 4 Rounds of Annual Screening: A Retrospective Cohort Study

      Author(s): Jensen CD; Corley DA; Quinn VP; Doubeni CA; Zauber AG; Lee JK; Zhao WK; Marks AR; Schottinger JE; Ghai NR; Lee AT; Contreras R; Klabunde CN; Quesenberry CP; Levin TR; Mysliwiec PA

      Ann Intern Med. 2016 Apr 5;164(7):456-63. Epub 2016-01-26.

      PubMed abstract

      What makes a "good" colonoscopy quality indicator?

      Author(s): Lee JK; Corley DA

      Gastrointest Endosc. 2016 Jan;83(1):179-81.

      PubMed abstract

      Factors Influencing Variation in Physician Adenoma Detection Rates; a Theory-Based Approach for Performance Improvement

      Author(s): Atkins L; Hunkeler EM; Jensen CD; Michie S; Lee JK; Doubeni CA; Zauber AG; Levin TR; Quinn VP; Corley DA

      Gastrointest Endosc. 2015 Sep 11.

      PubMed abstract

      Development and validation of an algorithm for classifying colonoscopy indication

      Author(s): Lee JK; Jensen CD; Lee A; Doubeni CA; Zauber AG; Levin TR; Zhao WK; Corley DA

      Gastrointest Endosc. 2015 Mar;81(3):575-582.e4. Epub 2015-01-08.

      PubMed abstract

      Importance of determining indication for colonoscopy: implications for practice and policy original

      Author(s): Singal AG; Gupta S; Lee J; Halm EA; Rutter CM; Corley D; Inadomi J

      Clin Gastroenterol Hepatol. 2014 Dec;12(12):1958-63.e1-3.

      PubMed abstract

      Adjusting for Patient Demographics Has Minimal Effects on Rates of Adenoma Detection in a Large, Community-based Setting

      Author(s): Jensen CD; Doubeni CA; Quinn VP; Levin TR; Zauber AG; Schottinger JE; Marks AR; Zhao WK; Lee JK; Ghai NR; Schneider JL; Fireman BH; Quesenberry CP; Corley DA

      Clin Gastroenterol Hepatol. 2015 Apr;13(4):739-46. Epub 2014-10-25.

      PubMed abstract

      Multitarget stool DNA testing for colorectal-cancer screening.

      Author(s): Lee, Jeffrey K JK; Terdiman, Jonathan P JP; Corley, Douglas A DA

      The New England journal of medicine. 2014 07 10;371(2):186. Epub --.

      PubMed abstract

      Adenoma detection rate and risk of colorectal cancer and death

      Author(s): Corley DA; Jensen CD; Marks AR; Zhao WK; Lee JK; Doubeni CA; Zauber AG; de Boer J; Fireman BH; Schottinger JE; Quinn VP; Ghai NR; Levin TR; Quesenberry CP

      N Engl J Med. 2014 Apr 3;370(14):1298-306.

      PubMed abstract

      Accuracy of fecal immunochemical tests for colorectal cancer: systematic review and meta-analysis

      Author(s): Lee JK; Liles EG; Bent S; Levin TR; Corley DA

      Ann Intern Med. 2014 Feb 4;160(3):171.

      PubMed abstract

      Recurrence of subsquamous dysplasia and carcinoma after successful endoscopic and radiofrequency ablation therapy for dysplastic Barrett's esophagus.

      Author(s): Lee, J K JK; Cameron, R G RG; Binmoeller, K F KF; Shah, J N JN; Shergill, A A; Garcia-Kennedy, R R; Bhat, Y M YM

      Endoscopy. 2013 Jul ;45(7):571-4. Epub 2013-04-16.

      PubMed abstract

      The road ahead: what if gastroenterologists were accountable for preventing colorectal cancer?

      Author(s): Lee, Jeffrey K JK; Levin, Theodore R TR; Corley, Douglas A DA

      Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2013 Mar ;11(3):204-7. Epub --.

      PubMed abstract

      Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study.

      Author(s): Lee, Jeffrey K JK; Bettencourt, Ricki R; Brenner, David D; Le, Thuy-Anh TA; Barrett-Connor, Elizabeth E; Loomba, Rohit R

      PloS one. 2012 ;7(4):e34218. Epub 2012-04-13.

      PubMed abstract

      Cost-effectiveness of a mailed educational reminder to increase colorectal cancer screening.

      Author(s): Lee, Jeffrey K JK; Groessl, Erik J EJ; Ganiats, Theodore G TG; Ho, Samuel B SB

      BMC gastroenterology. 2011 Aug 25;11():93. Epub 2011-08-25.

      PubMed abstract

      Molecular Prognostic and Predictive Markers in Colorectal Cancer: Current Status.

      Author(s): Lee, Jeffrey K JK; Chan, Andrew T AT

      Current colorectal cancer reports. 2011 Jun 01;7(2):136-144. Epub --.

      PubMed abstract

      Evidence for an hMSH3 defect in familial hamartomatous polyps.

      Author(s): Huang, Sherry C SC; Lee, Jeffrey K JK; Smith, E Julieta EJ; Doctolero, Ryan T RT; Tajima, Akihiro A; Beck, Stayce E SE; Weidner, Noel N; Carethers, John M JM

      Cancer. 2011 Feb 01;117(3):492-500. Epub 2010-09-15.

      PubMed abstract

      Achalasia, alcohol-stasis, and acute necrotizing esophagitis: connecting the dots.

      Author(s): Lee, Jeffrey K JK; Bhargava, Valmik V; Mittal, Ravinder K RK; Ghosh, Pradipta P

      Digestive diseases and sciences. 2011 Feb ;56(2):612-4. Epub 2010-06-16.

      PubMed abstract

      Activin signaling in microsatellite stable colon cancers is disrupted by a combination of genetic and epigenetic mechanisms.

      Author(s): Jung, Barbara B; Gomez, Jessica J; Chau, Eddy E; Cabral, Jennifer J; Lee, Jeffrey K JK; Anselm, Aimee A; Slowik, Przemyslaw P; Ream-Robinson, Deena D; Messer, Karen K; Sporn, Judith J; Shin, Sung K SK; Boland, C Richard CR; Goel, Ajay A; Carethers, John M JM

      PloS one. 2009 Dec 14;4(12):e8308. Epub 2009-12-14.

      PubMed abstract

      Improving fecal occult blood testing compliance using a mailed educational reminder.

      Author(s): Lee, Jeffrey K JK; Reis, Veronica V; Liu, Shanglei S; Conn, Lorraine L; Groessl, Erik J EJ; Ganiats, Theodore G TG; Ho, Samuel B SB

      Journal of general internal medicine. 2009 Nov ;24(11):1192-7. Epub 2009-09-23.

      PubMed abstract

      ArterioVenous Malformation within Jejunal Diverticulum: an unusual cause of massive gastrointestinal bleeding.

      Author(s): Lee, Jeffrey K JK; Carethers, John M JM; Ghosh, Pradipta P

      Gastroenterology research and practice. 2009 ;2009():384506. Epub 2009-09-10.

      PubMed abstract

      The inflammatory response in transgastric surgery: gastric content leak leads to localized inflammatory response and higher adhesive disease.

      Author(s): Ramamoorthy, Sonia L SL; Lee, Jeffrey K JK; Luo, Linda L; Mintz, Yoav Y; Cullen, John J; Easter, David W DW; Savu, Michelle K MK; Chock, Alana A; Carethers, John J; Horgan, Santiago S; Talamini, Mark A MA

      Surgical endoscopy. 2010 Mar ;24(3):531-5. Epub 2009-08-18.

      PubMed abstract

      Generalized megaviscera of lupus: refractory intestinal pseudo-obstruction, ureterohydronephrosis and megacholedochus.

      Author(s): Park, Frederick-D FD; Lee, Jeffrey-K JK; Madduri, Ganga-D GD; Ghosh, Pradipta P

      World journal of gastroenterology. 2009 Jul 28;15(28):3555-9. Epub --.

      PubMed abstract

      The impact of proton-pump inhibitors on intraperitoneal sepsis: a word of caution for transgastric NOTES procedures.

      Author(s): Ramamoorthy, Sonia L SL; Lee, Jeffrey K JK; Mintz, Yoav Y; Cullen, John J; Savu, Michelle K MK; Easter, David W DW; Chock, Alana A; Mittal, Ravi R; Horgan, Santiago S; Talamini, Mark A MA

      Surgical endoscopy. 2010 Jan ;24(1):16-20. Epub 2009-06-24.

      PubMed abstract

      Endoscopy is accurate, safe, and effective in the assessment and management of complications following gastric bypass surgery.

      Author(s): Lee, Jeffrey K JK; Van Dam, Jacques J; Morton, John M JM; Curet, Myriam M; Banerjee, Subhas S

      The American journal of gastroenterology. 2009 Mar ;104(3):575-82; quiz 583. Epub 2009-02-03.

      PubMed abstract

      Mutation rates of TGFBR2 and ACVR2 coding microsatellites in human cells with defective DNA mismatch repair.

      Author(s): Chung, Heekyung H; Young, Dennis J DJ; Lopez, Claudia G CG; Le, Thuy-Anh T TA; Lee, Jeffrey K JK; Ream-Robinson, Deena D; Huang, Sherry C SC; Carethers, John M JM

      PloS one. 2008 ;3(10):e3463. Epub 2008-10-21.

      PubMed abstract

      Evidence for colorectal sarcomatoid carcinoma arising from tubulovillous adenoma.

      Author(s): Lee, Jeffrey-K JK; Ghosh, Pradipta P; McWhorter, Valerie V; Payne, Misty M; Olson, Ryan R; Krinsky, Mary-L ML; Ramamoorthy, Sonia S; Carethers, John-M JM

      World journal of gastroenterology. 2008 Jul 21;14(27):4389-94. Epub --.

      PubMed abstract

      Nonmetastatic cancer of the colon associated with pyogenic liver abscess.

      Author(s): Lee, Jeffrey K JK; Kum, Jennifer J; Ghosh, Pradipta P

      The American journal of gastroenterology. 2008 Mar ;103(3):798-9. Epub --.

      PubMed abstract

      Education and imaging. Gastrointestinal: glycogenic acanthosis.

      Author(s): Lee, J K JK; Kum, J J; Ghosh, P P

      Journal of gastroenterology and hepatology. 2007 Sep ;22(9):1550. Epub --.

      PubMed abstract

      Incidental finding of metastatic papillary thyroid carcinoma in a patient with primary hyperparathyroidism.

      Author(s): Lee, Jeffrey K JK; Obrzut, Sebastian L SL; Yi, Eunhee S ES; Deftos, Leonard J LJ; Bouvet, Michael M

      Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. ;13(4):380-3. Epub --.

      PubMed abstract