Theodore R. Levin, MD

Levin, Theodore

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3460 (phone)
theodore.levin@kp.org
Kaiser Permanente Researcher Profiles

Theodore R. Levin, MD, is a Research Scientist at the Kaiser Permanente Northern California Division of Research and Interim Associate Director for the Cancer section. Dr. Levin is also an Associate Professor of Health System Science at the Kaiser Permanente School of Medicine and a Staff Gastroenterologist at the Kaiser Permanente Walnut Creek Medical Center. He is the Clinical Lead for Colorectal Cancer Screening and Assistant Chair of Gastroenterology for The Permanente Medical Group. Dr. Levin's research interests include health services and outcomes research in gastroenterology and population health. Particular areas of interest are colorectal cancer screening with colonoscopy fecal occult blood tests, and newer DNA-based technologies.

Current Position(s):

Research Scientist III, Division of Research, Kaiser Permanente Northern California
Staff Gastroenterologist, Kaiser Permanente Medical Center, Walnut Creek
Associate Professor of Health System Science, Kaiser Permanente School of Medicine

Section Affiliations:

Cancer

Primary Research Interests:

Health services and outcomes research related to colorectal cancer and endoscopy.
Care delivery research in population health.

Studies

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial of the Efficacy, Safety, and Tolerability of a Single Oral Administration of CP101 for the Prevention of Recurrent Clostridioides difficile Infection (PRISM4)

Phase 3 trial will evaluate the efficacy of CP101 treatment relative to placebo in adults with previously treated recurrent Clostridioides difficile infection (CDI) and evaluate the safety and tolerability of CP101 treatment compared to placebo in adults with previously treated recurrent CDI.
Investigator: Levin, Theodore
Funder: Finch Research and Development, LLC

Comparative Effectiveness Trial of Non-invasive vs. Invasive Strategies (FIT vs Colonoscopy) for Older Adults with a History of Pre-neoplastic Colon Polyps

This comparative effectiveness trial will evaluate detection of significant neoplasia between the strategies of low threshold annual FIT vs. colonoscopy for older adults with a history of colon polyps. We will investigate whether the FIT strategy is non-inferior to colonoscopy in detecting CRC and advanced colorectal neoplasia over 5 years of follow-up and whether fewer colonoscopies are needed to detect CRC using FIT vs. colonoscopy. We will also compare complication rates and patient experience between the FIT and colonoscopy strategies to see whether those in the FIT strategy will have less complications compared to the colonoscopy strategy and whether the FIT strategy will be more convenient and tolerable compared to the colonoscopy strategy.
Investigator: Levin, Theodore
Funder: Patient-Centered Outcomes Research Institute

Evaluating Acceptance and Screening Yield for Early Colorectal Cancer Screening: (EASY Early CRC)

Three national guideline groups now recommend that all adults start colorectal cancer (CRC) screening at age 45. Before 2018, some guideline groups only recommended African Americans begin CRC screening at age 45. There is currently no empirical evidence of the value of screening before age 50. The only evidence comes from modeling studies and observational data collected in cancer registries, such as SEER. This project will evaluate the acceptance, uptake, and yield of mailed FIT screening among KP members in Northern California, Southern California, Washington, and Colorado. The findings will help National Guideline Directors make a recommendation to the Permanente Medical Groups and the Kaiser Foundation Health Plan about starting CRC screening at age 45.
Investigator: Levin, Theodore
Funder: Garfield Memorial Fund

PREEMPT CRC: Prevention of Colorectal Cancer Through Multiomics Blood Testing

The primary objectives of this study are to determine the sensitivity and specificity of Freenome's test for colorectal adenocarcinoma, using screening CS with histopathology as the reference method.
Investigator: Levin, Theodore
Funder: Freenome Holdings, Inc

Non-alcoholic Fatty Liver Disease Prevalence and Associated Mortality (NAFLD PAM)

This study will investigate the incremental yield of using radiology imaging report information to diagnose non-alcoholic fatty liver disease (NAFLD) compared to International Classification of Disease, Ninth/Tenth Revision, Clinical Modification diagnoses alone in adult Kaiser Permanente Northern California members between 2009-2018, and whether the use of the Dallas Steatosis Index identifies additional individuals at high risk for NAFLD. The study will also and look at whether patients with NAFLD are at increased risk for all-cause mortality compared to the general population.
Investigator: Levin, Theodore
Funder: Northern California Community Benefit Programs

COVID-19 Pandemic: Impact on Colorectal Cancer Screening and Adenoma Surveillance Outcomes (PICASO)

The goal of this project is to evaluate the impact of the COVID pandemic on colorectal cancer screening and surveillance activities, and the impact on outcomes such as colorectal cancer incidence and stage.
Investigator: Levin, Theodore
Funder: Garfield Memorial Fund

PREDICT PCCC: PREDICTing Post Colonoscopy Colorectal Cancer

We are using post-polypectomy surveillance, an increasingly common indication for colonoscopy in clinical practice at TPMG and across the United States, as a model for how we might risk-stratify patients for care. Patients and physicians desire more precise estimates of risk for cancer after the removal of benign colorectal polyps to guide when they should have repeat surveillance with colonoscopy. We aim to evaluate a traditional risk prediction model compared with a deep learning model to improve the accuracy of risk scoring for post-colonoscopy colorectal cancer and guide personalized care
Investigator: Levin, Theodore
Funder: The Permanente Medical Group

PRISM-EXT: An Open-Label Extension of CP101 Trials Evaluating Oral Full-Spectrum Microbiota (CP101) in Subjects with Recurrence of Clostridium difficile Infection

This study evaluates the safety and efficacy in reducing recurrence of Clostridium difficile infection in adults who had a recurrence within 8 weeks of receiving CP101 or placebo in PRISM3. Subjects who are experiencing recurrent Clostridium difficile infection will undergo screening procedures. Subjects who meet eligibility criteria will be eligible to be enrolled in the extension study and administered CP101.
Investigator: Levin, Theodore
Funder: Finch Research and Development, LLC

A Multicenter Phase 2 Study of the Efficacy, Safety, and Tolerability of Oral Full-Spectrum Microbiota (CP101) in Subjects with Recurrence of Clostridium Difficile Infection

The objectives of this Phase 2 study are to evaluate the safety and tolerability of CP101 treatment compared to placebo in adults with previously treated, recurrent Clostridium difficile infection, and to evaluate the efficacy of CP101 treatment relative to placebo in adults with previously treated, recurrent Clostridium difficile infection.
Investigator: Levin, Theodore
Funder: Finch Research and Development, LLC

Outreach for Colorectal Cancer Screening in African Americans Aged 45 to 49

This study aims to 1) evaluate uptake of fecal immunochemical testing among African Americans aged 45 to 49 who receive outreach for such testing by mail, 2) examine the yield of screening results, including advanced adenomas and colon cancers, and 3) describe adverse events of screening among this population and compare them to those seen in people aged 50 to 55.
Investigator: Levin, Theodore
Funder: The Permanente Medical Group

Highlighted Publications

No results found matching criteria

Publications

Impact of a scalable training program on the quality of colonoscopy performance and risk of post-colonoscopy colorectal cancer

Author(s): Corley, Douglas A; Lee, Jeffrey K; Levin, Theodore R; Fireman, Bruce H; Quesenberry, Charles P; et al.

Gastrointest Endosc. 2023 Apr 22.

Current Position(s):

Section Affiliations:

Primary Research Interests:

Studies

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial of the Efficacy, Safety, and Tolerability of a Single Oral Administration of CP101 for the Prevention of Recurrent Clostridioides difficile Infection (PRISM4)

Comparative Effectiveness Trial of Non-invasive vs. Invasive Strategies (FIT vs Colonoscopy) for Older Adults with a History of Pre-neoplastic Colon Polyps

Evaluating Acceptance and Screening Yield for Early Colorectal Cancer Screening: (EASY Early CRC)

PREEMPT CRC: Prevention of Colorectal Cancer Through Multiomics Blood Testing

Non-alcoholic Fatty Liver Disease Prevalence and Associated Mortality (NAFLD PAM)

COVID-19 Pandemic: Impact on Colorectal Cancer Screening and Adenoma Surveillance Outcomes (PICASO)

PREDICT PCCC: PREDICTing Post Colonoscopy Colorectal Cancer

PRISM-EXT: An Open-Label Extension of CP101 Trials Evaluating Oral Full-Spectrum Microbiota (CP101) in Subjects with Recurrence of Clostridium difficile Infection

A Multicenter Phase 2 Study of the Efficacy, Safety, and Tolerability of Oral Full-Spectrum Microbiota (CP101) in Subjects with Recurrence of Clostridium Difficile Infection

Outreach for Colorectal Cancer Screening in African Americans Aged 45 to 49

Highlighted Publications

Publications

Impact of a scalable training program on the quality of colonoscopy performance and risk of post-colonoscopy colorectal cancer

Impact and recovery from COVID-19-related disruptions in colorectal cancer screening and care in the US: A scenario analysis

Risk of colorectal cancer and colorectal cancer mortality beginning ten years after a negative colonoscopy, among screen-eligible adults 76-85 years old

Impact of the COVID-19 pandemic on fecal immunochemical testing, colonoscopy services, and colorectal neoplasia detection in a large United States community-based population

Current and future colorectal cancer screening strategies

Association between Improved Colorectal Screening and Racial Disparities

Program components and results from an organized colorectal cancer screening program using annual fecal immunochemical testing

Simplifying ADR reporting - a worthy goal, but the devil is in the details

Risk stratification for colorectal cancer in individuals with subtypes of serrated polyps

The effect of using fecal testing after a negative sigmoidoscopy on the risk of death from colorectal cancer

Heterogeneity in colorectal cancer incidence among people recommended 3-yearly surveillance post-polypectomy: a validation study

Disparities in Preventable Mortality from Colorectal Cancer: are they the result of structural racism?

Colorectal cancer screening in the COVID-19 era

Early Screening of African Americans (45-50 Years Old) in a Fecal Immunochemical Test-based Colorectal Cancer Screening Program

Increased Risk of Colorectal Cancer in Individuals With a History of Serrated Polyps

Mailed fecal immunochemical test outreach for colorectal cancer screening: Summary of a Centers for Disease Control and Prevention-sponsored summit

Validation of an Algorithm to Identify Patients at Risk for Colorectal Cancer Based on Laboratory Test and Demographic Data in Diverse, Community-Based Population

What Is Organized Screening and What Is Its Value?

Long-term Risk of Colorectal Cancer and Related Death After Adenoma Removal in a Large, Community-based Population

Comparison of Universal Versus Age-Restricted Screening of Colorectal Tumors for Lynch Syndrome Using Mismatch Repair Immunohistochemistry: A Cohort Study

Balancing Adherence and Expense: The Cost-Effectiveness of Two-Sample vs One-Sample Fecal Immunochemical Test

Long-term Risk of Colorectal Cancer and Related Deaths After a Colonoscopy With Normal Findings

Strategies to Improve Follow-up After Positive Fecal Immunochemical Tests in a Community-Based Setting: A Mixed-Methods Study

Accurate Identification of Colonoscopy Quality and Polyp Findings Using Natural Language Processing

Index colonoscopy-related risk factors for postcolonoscopy colorectal cancers

Colorectal Cancer Screening Participation Among Asian Americans Overall and Subgroups in an Integrated Health Care Setting with Organized Screening

Modifiable Failures in the Colorectal Cancer Screening Process and Their Association with Risk of Death

In Screening for Colorectal Cancer, Is the FIT Right for the Right Side of the Colon?

Effects of Organized Colorectal Cancer Screening on Cancer Incidence and Mortality in a Large, Community-based Population

Influence of Varying Quantitative Fecal Immunochemical Test Positivity Thresholds on Colorectal Cancer Detection: A Community-Based Cohort Study

Diagnosis of sessile serrated adenoma after educational training in a large, community-based, integrated healthcare setting

Effectiveness of screening colonoscopy in reducing the risk of death from right and left colon cancer: a large community-based study

Colorectal Cancer Screening: Money Isn't Everything...But it Helps!

A Comparison of Fecal Immunochemical and High-Sensitivity Guaiac Tests for Colorectal Cancer Screening

Interventions to Improve Follow-up of Positive Results on Fecal Blood Tests: A Systematic Review

Colorectal Cancer Screening Initiation After Age 50 Years in an Organized Program

Time to Diagnostic Testing After a Positive Colorectal Cancer Screening Test

Colorectal Cancer Screening: Recommendations for Physicians and Patients from the U.S. Multi-Society Task Force on Colorectal Cancer

Colorectal Cancer Screening: Recommendations for Physicians and Patients From the U.S. Multi-Society Task Force on Colorectal Cancer

Colorectal cancer screening: Recommendations for physicians and patients from the U.S. Multi-Society Task Force on Colorectal Cancer

Recommendations on Surveillance and Management of Biallelic Mismatch Repair Deficiency (BMMRD) Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer

Recommendations on Surveillance and Management of Biallelic Mismatch Repair Deficiency Syndrome: A Consensus Statement by the US Multi-society Task Force on Colorectal Cancer

Recommendations on Surveillance and Management of Biallelic Mismatch Repair Deficiency (BMMRD) Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer

Recommendations on surveillance and management of biallelic mismatch repair deficiency (BMMRD) syndrome: a consensus statement by the US Multi-Society Task Force on Colorectal Cancer

Association Between Time to Colonoscopy After a Positive Fecal Test Result and Risk of Colorectal Cancer and Cancer Stage at Diagnosis

In simulation modelling, there are multiple ways to effectively screen for colorectal cancer

Recommendations on Fecal Immunochemical Testing to Screen for Colorectal Neoplasia: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer

Genetic Biomarker Prevalence Is Similar in Fecal Immunochemical Test Positive and Negative Colorectal Cancer Tissue

The Best Laid Plans: Adaptation is an Essential Part of Going From Efficacy Research to Program Implementation

Endoscopist Fatigue Estimates and Colonoscopic Adenoma Detection in a Large Community-Based Setting

Fecal Immunochemical Test (FIT) for Colon Cancer Screening: Variable Performance with Ambient Temperature

Beyond Colonoscopy: The Role of Alternative Screening Tests for Colorectal Cancer in Your Practice

Recommendations on Fecal Immunochemical Testing to Screen for Colorectal Neoplasia: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer

Recommendations on fecal immunochemical testing to screen for colorectal neoplasia: a consensus statement by the US Multi-Society Task Force on colorectal cancer

Shifts in the fecal microbiota associated with adenomatous polyps

Race/Ethnicity and Adoption of a Population Health Management Approach to Colorectal Cancer Screening in a Community-Based Healthcare System

Consequences of Increasing Time to Colonoscopy Examination Following Positive Result From Fecal Colorectal Cancer Screening Test

Fecal Immunochemical Test Program Performance Over 4 Rounds of Annual Screening: A Retrospective Cohort Study

Factors Influencing Variation in Physician Adenoma Detection Rates: a Theory-Based Approach for Performance Improvement

Colonoscopy Surveillance after Colorectal Cancer Resection: Recommendations of the US Multi-Society Task Force on Colorectal Cancer

Colonoscopy surveillance after colorectal cancer resection: recommendations of the US multi-society task force on colorectal cancer

Colonoscopy Surveillance After Colorectal Cancer Resection: Recommendations of the US Multi-Society Task Force on Colorectal Cancer

Colorectal cancer screening: 80% by 2018. Colonoscopists simply cannot do it alone

Ten-year incidence of colorectal cancer following a negative screening sigmoidoscopy: an update from the Colorectal Cancer Prevention (CoCaP) programme