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Dan Li, MD

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Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(408) 851-2750  (phone)


Dan Li, MD, a senior physician and gastroenterologist with The Permanente Medical Group, is an Adjunct Investigator with the Division of Research and a physician researcher with the Delivery Science & Applied Research Physician Researcher Program. Dr. Li is also the Regional Quality Lead of Gastroenterology and Medical Director of the Universal Screening Program for Lynch syndrome at Kaiser Permanente Northern California.

Dr. Li's research focuses on the screening and prevention of gastrointestinal cancers, with a special emphasis on colorectal cancer and gastric cancer. In 2011, Dr. Li co-founded the Universal Screening Program for Lynch syndrome among patients with colorectal cancer. This program has become one of the largest organized screening programs for Lynch syndrome in the United States. Dr. Li also studies colorectal cancer risk in individuals with serrated colon polyps which are the precursors for 20 to 30 percent of all colorectal cancers. In addition, Dr. Li is leading research projects on the risk of gastric (stomach) cancer in individuals with premalignant gastric conditions, such as gastric intestinal metaplasia or dysplasia. Dr. Li currently serves as a member of the American Gastroenterological Association guideline committee for gastric intestinal metaplasia.

Dr. Li completed his undergraduate studies at Peking University and received his MD at the Peking Union Medical College in Beijing, China. He finished his residency training in Internal Medicine at the Brigham and Women's Hospital of Harvard Medical School, and his fellowship training in Gastroenterology at the University of California, San Francisco. Dr. Li joined Kaiser Permanente in 2009.

Current Position(s):

Section Affiliations:

Primary Research Interests:

  • Colorectal cancer screening
  • Risk of colorectal cancer associated with serrated colon polyps
  • Lynch syndrome
  • Gastric cancer screening and prevention
  • Health outcomes related to Helicobacter pylori infection

    Comparison of Risk factors, Clinical Characteristics, Screening performance, and Survival of Microsatellite Stable vs. Unstable Colorectal Cancers in a Large U.S. Population

    Investigator: Li, Dan
    Funder: Northern California Community Benefit Programs

    Optimization of Diagnosis of Serrated Polyps of the Colorectum among KPNC Gastroenterologists and Pathologists

    Investigator: Li, Dan
    Funder: TPMG Delivery Science Projects Program

    Improving health outcomes and reducing healthcare costs in individuals with Helicobacter pylori infection in a large, community-based population

    Optimization of Diagnosis and Surveillance of Colonic Sessile Serrated Adenomas by Pathologists and Gastroenterologists at KPNC.
    Investigator: Li, Dan
    Funder: The Permanente Medical Group

    Optimization of Diagnosis and Surveillance of Colonic Sessile Serrated Adenomas by Pathologists and Gastroenterologists at Kaiser Permanente Northern California

    Investigator: Li, Dan
    Funder: The Permanente Medical Group

    AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review

    Author(s): Shah, Shailja C; Piazuelo, M Blanca; Kuipers, Ernst J; Li, Dan

    Gastroenterology. 2021 10;161(4):1325-1332.e7. Epub 2021-08-26.

    PubMed abstract

    Risk stratification for colorectal cancer in individuals with subtypes of serrated polyps

    Author(s): Li, Dan; Doherty, Amanda R; Raju, Menaka; Liu, Liyan; Lei, Nan Ye; Amsden, Laura B; Lee, Jeffrey K; Levin, Theodore R; Corley, Douglas A; Herrinton, Lisa J

    Gut. 2021 Aug 11.

    PubMed abstract

    Efficacy of paired tumor and germline testing in evaluation of patients with Lynch-like syndrome in a large integrated healthcare setting

    Author(s): Carwana, Holly; Hoodfar, Elizabeth; Bergoffen, JoAnn; Li, Dan

    Fam Cancer. 2021 07;20(3):223-230. Epub 2020-11-20.

    PubMed abstract

    Natural language processing for the accurate identification of colorectal cancer mismatch repair status in Lynch syndrome screening

    Author(s): Li D; Udaltsova N; Layefsky E; Doan C; Corley DA

    Clin Gastroenterol Hepatol. 2021 03;19(3):610-612.e1. Epub 2020-02-07.

    PubMed abstract

    Increased Risk of Colorectal Cancer in Individuals With a History of Serrated Polyps

    Author(s): Li D; Liu L; Fevrier HB; Alexeeff SE; Doherty AR; Raju M; Amsden LB; Lee JK; Levin TR; Corley DA; Herrinton LJ

    Gastroenterology. 2020 08;159(2):502-511.e2. Epub 2020-04-08.

    PubMed abstract

    Surveillance of Gastric Intestinal Metaplasia

    Author(s): Shah SC; Gawron AJ; Li D

    Am J Gastroenterol. 2020 05;115(5):641-644.

    PubMed abstract

    AGA Clinical Practice Guidelines on Management of Gastric Intestinal Metaplasia

    Author(s): Gupta S; Li D; El Serag HB; Davitkov P; Altayar O; Sultan S; Falck-Ytter Y; Mustafa RA

    Gastroenterology. 2019 Dec 06.

    PubMed abstract

    Comparison of Universal Versus Age-Restricted Screening of Colorectal Tumors for Lynch Syndrome Using Mismatch Repair Immunohistochemistry: A Cohort Study

    Author(s): Li D; Corley DA; Bergoffen J; Bergoffen J; et al.

    Ann Intern Med. 2019 07 02;171(1):19-26. Epub 2019-06-11.

    PubMed abstract

    Diagnosis of sessile serrated adenoma after educational training in a large, community-based, integrated healthcare setting

    Author(s): Li D; Postlethwaite D; Levin TR; Levin TR; et al.

    Gastrointest Endosc. 2018 Mar;87(3):755-765.e1. Epub 2017-08-24.

    PubMed abstract

    Risks and Predictors of Gastric Adenocarcinoma in Patients with Gastric Intestinal Metaplasia and Dysplasia: A Population-Based Study

    Author(s): Li D; Bautista MC; Jiang SF; Daryani P; Brackett M; Armstrong MA; Hung YY; Postlethwaite D; Ladabaum U

    Am J Gastroenterol. 2016 Aug;111(8):1104-13. Epub 2016-05-17.

    PubMed abstract

    Impact of the COVID-19 pandemic on fecal immunochemical testing, colonoscopy services, and colorectal neoplasia detection in a large United States community-based population

    Author(s): Lee, Jeffrey K; Corley, Douglas A; Levin, Theodore R; Levin, Theodore R; et al.

    Gastroenterology. 2022 09;163(3):723-731.e6. Epub 2022-05-14.

    PubMed abstract

    Risk of Metachronous Advanced Neoplasia After Colonoscopy in Patients Aged 40-49 Years Compared to Patients Aged 50-59 Years

    Author(s): Ma, Gene; Anderson, Meredith; Liu, Liyan; Li, Dan

    Am J Gastroenterol. 2022 Aug 12.

    PubMed abstract

    Understanding the Protective Effect of Helicobacter pylori Eradication on Gastric Cancer after a Quarter Century: New Insights from an Old Trial

    Author(s): Li, Dan

    Gastroenterology. 2022 07;163(1):42-44. Epub 2022-04-29.

    PubMed abstract

    AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review

    Author(s): Shah, Shailja C; Piazuelo, M Blanca; Kuipers, Ernst J; Li, Dan

    Gastroenterology. 2021 10;161(4):1325-1332.e7. Epub 2021-08-26.

    PubMed abstract

    Efficacy of paired tumor and germline testing in evaluation of patients with Lynch-like syndrome in a large integrated healthcare setting

    Author(s): Carwana, Holly; Hoodfar, Elizabeth; Bergoffen, JoAnn; Li, Dan

    Fam Cancer. 2021 07;20(3):223-230. Epub 2020-11-20.

    PubMed abstract

    A Transparent and Adaptable Method to Extract Colonoscopy and Pathology Data Using Natural Language Processing

    Author(s): Fevrier, Helene B; Liu, Liyan; Herrinton, Lisa J; Li, Dan

    J Med Syst. 2020 Jul 31;44(9):151. Epub 2020-07-31.

    PubMed abstract

    Associations between Genetically Predicted Blood Protein Biomarkers and Pancreatic Cancer Risk

    Author(s): Zhu J; Arslan AA; Wu L; et al.

    Cancer Epidemiol Biomarkers Prev. 2020 07;29(7):1501-1508. Epub 2020-05-21.

    PubMed abstract

    Reply to GASTRO-D-20-0014

    Author(s): Gupta S; Li D; El Serag H; AGA Gastric Intestinal Metaplasia Guideline Panel

    Gastroenterology. 2020 07;159(1):403-404. Epub 2020-04-18.

    PubMed abstract

    Surveillance of Gastric Intestinal Metaplasia

    Author(s): Shah SC; Gawron AJ; Li D

    Am J Gastroenterol. 2020 05;115(5):641-644.

    PubMed abstract

    Spotlight: Gastric Intestinal Metaplasia

    Author(s): Shah SC; Gupta S; Li D; Morgan D; Mustafa RA; Gawron AJ

    Gastroenterology. 2020 02;158(3):704.

    PubMed abstract

    Comparison of Universal Versus Age-Restricted Screening of Colorectal Tumors for Lynch Syndrome Using Mismatch Repair Immunohistochemistry: A Cohort Study

    Author(s): Li D; Corley DA; Bergoffen J; Bergoffen J; et al.

    Ann Intern Med. 2019 07 02;171(1):19-26. Epub 2019-06-11.

    PubMed abstract

    Effect of Helicobacter pylori Treatment on Unexplained Iron Deficiency Anemia

    Author(s): Tseng DS; Li D; Cholleti SM; Wei JC; Jodesty Y; Pham HV

    Perm J. 2019;23.

    PubMed abstract

    Recent advances in colorectal cancer screening

    Author(s): Li D

    Chronic Dis Transl Med. 2018 Sep;4(3):139-147. Epub 2018-09-17.

    PubMed abstract

    Small and diminutive hyperplastic polyps in the proximal colon: Are they innocent or guilty of a crime?

    Author(s): Li D

    Gastrointest Endosc. 2018 06;87(6):1527-1529.

    PubMed abstract

    Rates and Predictors of Vaccinations Among Inflammatory Bowel Disease Patients Receiving Anti-Tumor Necrosis Factor Agents

    Author(s): Pham HV; Hasan I; Udaltsova N; Pham K; Abramson O; Armstrong MA; Postlethwaite D; Li D

    Dig Dis Sci. 2017 Aug 23.

    PubMed abstract