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Dan Li, MD

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Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(408) 851-2750  (phone)


Dan Li, MD, a senior physician and gastroenterologist with The Permanente Medical Group, is an Adjunct Investigator with the Division of Research and a physician researcher with the Delivery Science & Applied Research Physician Researcher Program. Dr. Li is also the Regional Quality Lead of Gastroenterology and Medical Director of the Universal Screening Program for Lynch syndrome at Kaiser Permanente Northern California.

Dr. Li's research focuses on the screening and prevention of gastrointestinal cancers, with a special emphasis on colorectal cancer and gastric cancer. In 2011, Dr. Li co-founded the Universal Screening Program for Lynch syndrome among patients with colorectal cancer. This program has become one of the largest organized screening programs for Lynch syndrome in the United States. Dr. Li also studies colorectal cancer risk in individuals with serrated colon polyps which are the precursors for 20 to 30 percent of all colorectal cancers. In addition, Dr. Li is leading research projects on the risk of gastric (stomach) cancer in individuals with premalignant gastric conditions, such as gastric intestinal metaplasia or dysplasia. Dr. Li currently serves as a member of the American Gastroenterological Association guideline committee for gastric intestinal metaplasia.

Dr. Li completed his undergraduate studies at Peking University and received his MD at the Peking Union Medical College in Beijing, China. He finished his residency training in Internal Medicine at the Brigham and Women's Hospital of Harvard Medical School, and his fellowship training in Gastroenterology at the University of California, San Francisco. Dr. Li joined Kaiser Permanente in 2009.

Current Position(s):

Section Affiliations:

Primary Research Interests:

  • Colorectal cancer screening
  • Risk of colorectal cancer associated with serrated colon polyps
  • Lynch syndrome
  • Gastric cancer screening and prevention
  • Health outcomes related to Helicobacter pylori infection

    Comparison of Risk factors, Clinical Characteristics, Screening performance, and Survival of Microsatellite Stable vs. Unstable Colorectal Cancers in a Large U.S. Population

    Investigator: Li, Dan
    Funder: Northern California Community Benefit Programs

    Optimization of Diagnosis of Serrated Polyps of the Colorectum among KPNC Gastroenterologists and Pathologists

    Investigator: Li, Dan
    Funder: TPMG Delivery Science Projects Program

    Improving health outcomes and reducing healthcare costs in individuals with Helicobacter pylori infection in a large, community-based population

    Optimization of Diagnosis and Surveillance of Colonic Sessile Serrated Adenomas by Pathologists and Gastroenterologists at KPNC.
    Investigator: Li, Dan
    Funder: The Permanente Medical Group

    Optimization of Diagnosis and Surveillance of Colonic Sessile Serrated Adenomas by Pathologists and Gastroenterologists at Kaiser Permanente Northern California

    Investigator: Li, Dan
    Funder: The Permanente Medical Group

    Efficacy of paired tumor and germline testing in evaluation of patients with Lynch-like syndrome in a large integrated healthcare setting

    Author(s): Carwana H; Hoodfar E; Bergoffen J; Li D

    Fam Cancer. 2020 Nov 20.

    PubMed abstract

    Increased Risk of Colorectal Cancer in Individuals With a History of Serrated Polyps

    Author(s): Li D; Liu L; Fevrier HB; Alexeeff SE; Doherty AR; Menaka LR; Amsden LB; Lee JK; Levin TR; Corley DA; Herrinton LJ

    Gastroenterology. 2020 Apr 08.

    PubMed abstract

    Surveillance of Gastric Intestinal Metaplasia

    Author(s): Shah SC; Gawron AJ; Li D

    Am J Gastroenterol. 2020 Feb 14.

    PubMed abstract

    Natural language processing for the accurate identification of colorectal cancer mismatch repair status in Lynch syndrome screening

    Author(s): Li D; Udaltsova N; Layefsky E; Doan C; Corley DA

    Clin Gastroenterol Hepatol. 2020 Feb 06.

    PubMed abstract

    AGA Clinical Practice Guidelines on Management of Gastric Intestinal Metaplasia

    Author(s): Gupta S; Li D; El Serag HB; Davitkov P; Altayar O; Sultan S; Falck-Ytter Y; Mustafa RA

    Gastroenterology. 2019 Dec 06.

    PubMed abstract

    Comparison of Universal Versus Age-Restricted Screening of Colorectal Tumors for Lynch Syndrome Using Mismatch Repair Immunohistochemistry: A Cohort Study.

    Author(s): Li, Dan D; Hoodfar, Elizabeth E; Jiang, Sheng-Fang SF; Udaltsova, Natalia N; Pham, Nhung P NP; Jodesty, Yves Y; Armstrong, Mary Anne MA; Hung, Yun-Yi YY; Baker, Robin J RJ; Postlethwaite, Debbie D; Ladabaum, Uri U; Levin, Theodore R TR; Corley, Douglas A DA; Bergoffen, JoAnn J

    Annals of internal medicine. 2019 Jun 11;():. Epub 2019-06-11.

    PubMed abstract

    Diagnosis of sessile serrated adenoma after educational training in a large, community-based, integrated healthcare setting

    Author(s): Li D; Jensen CD; Armstrong MA; Postlethwaite D; Corley DA; Levin TR; et al.

    Gastrointest Endosc. 2018 Mar;87(3):755-765.e1. Epub 2017-08-24.

    PubMed abstract

    Risks and Predictors of Gastric Adenocarcinoma in Patients with Gastric Intestinal Metaplasia and Dysplasia: A Population-Based Study

    Author(s): Li D; Bautista MC; Jiang SF; Daryani P; Brackett M; Armstrong MA; Hung YY; Postlethwaite D; Ladabaum U

    Am J Gastroenterol. 2016 Aug;111(8):1104-13. Epub 2016-05-17.

    PubMed abstract

    A Transparent and Adaptable Method to Extract Colonoscopy and Pathology Data Using Natural Language Processing

    Author(s): Fevrier HB; Liu L; Herrinton LJ; Li D

    J Med Syst. 2020 Jul 31;44(9):151. Epub 2020-07-31.

    PubMed abstract

    Associations between Genetically Predicted Blood Protein Biomarkers and Pancreatic Cancer Risk

    Author(s): Zhu J; Li D; Van Den Eeden SK; Wu L; et al.

    Cancer Epidemiol Biomarkers Prev. 2020 May 21.

    PubMed abstract

    Comparison of Universal Versus Age-Restricted Screening of Colorectal Tumors for Lynch Syndrome Using Mismatch Repair Immunohistochemistry: A Cohort Study.

    Author(s): Li, Dan D; Hoodfar, Elizabeth E; Jiang, Sheng-Fang SF; Udaltsova, Natalia N; Pham, Nhung P NP; Jodesty, Yves Y; Armstrong, Mary Anne MA; Hung, Yun-Yi YY; Baker, Robin J RJ; Postlethwaite, Debbie D; Ladabaum, Uri U; Levin, Theodore R TR; Corley, Douglas A DA; Bergoffen, JoAnn J

    Annals of internal medicine. 2019 Jun 11;():. Epub 2019-06-11.

    PubMed abstract

    Rates and Predictors of Vaccinations Among Inflammatory Bowel Disease Patients Receiving Anti-Tumor Necrosis Factor Agents

    Author(s): Pham HV; Hasan I; Udaltsova N; Pham K; Abramson O; Armstrong MA; Postlethwaite D; Li D

    Dig Dis Sci. 2017 Aug 23.

    PubMed abstract