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Dan Li, MD

Dan  Li, MD

Dan Li, MD, a senior physician and gastroenterologist with The Permanente Medical Group, is an Adjunct Investigator with the Division of Research and a physician researcher with the Delivery Science & Applied Research Physician Researcher Program. Dr. Li is also the Regional Quality Lead of Gastroenterology and Medical Director of the Universal Screening Program for Lynch syndrome at Kaiser Permanente Northern California.

Dr. Li’s research focuses on the screening and prevention of gastrointestinal cancers, with a special emphasis on colorectal cancer and gastric cancer. In 2011, Dr. Li co-founded the Universal Screening Program for Lynch syndrome among patients with colorectal cancer. This program has become one of the largest organized screening programs for Lynch syndrome in the United States. Dr. Li also studies colorectal cancer risk in individuals with serrated colon polyps which are the precursors for 20 to 30 percent of all colorectal cancers. In addition, Dr. Li is leading research projects on the risk of gastric (stomach) cancer in individuals with premalignant gastric conditions, such as gastric intestinal metaplasia or dysplasia. Dr. Li currently serves as a member of the American Gastroenterological Association guideline committee for gastric intestinal metaplasia.

Dr. Li completed his undergraduate studies at Peking University and received his MD at the Peking Union Medical College in Beijing, China. He finished his residency training in Internal Medicine at the Brigham and Women’s Hospital of Harvard Medical School, and his fellowship training in Gastroenterology at the University of California, San Francisco. Dr. Li joined Kaiser Permanente in 2009.

Current Position(s)

  • Adjunct Investigator, Division of Research
  • Physician Researcher, Delivery Science & Applied Research Physician Researcher Program, The Permanente Medical Group (TPMG)
  • Gastroenterologist, Kaiser Permanente Northern California
  • Gastroenterology Regional Quality Lead (TPMG)
  • Medical Director, Universal Screening Program for Lynch Syndrome (KPNC)

Section Affiliations

Primary Research Interests

  • Colorectal cancer screening
  • Risk of colorectal cancer associated with serrated colon polyps
  • Lynch syndrome
  • Gastric cancer screening and prevention
  • Health outcomes related to Helicobacter pylori infection


Comparison of Risk factors, Clinical Characteristics, Screening performance, and Survival of Microsatellite Stable vs. Unstable Colorectal Cancers in a Large U.S. Population

Investigator: Li, Dan

Funder: Northern California Community Benefit Programs

Optimization of Diagnosis of Serrated Polyps of the Colorectum among KPNC Gastroenterologists and Pathologists

Investigator: Li, Dan

Funder: TPMG Delivery Science Projects Program

Improving health outcomes and reducing healthcare costs in individuals with Helicobacter pylori infection in a large, community-based population

Optimization of Diagnosis and Surveillance of Colonic Sessile Serrated Adenomas by Pathologists and Gastroenterologists at KPNC.

Investigator: Li, Dan

Funder: The Permanente Medical Group

Optimization of Diagnosis and Surveillance of Colonic Sessile Serrated Adenomas by Pathologists and Gastroenterologists at Kaiser Permanente Northern California

Investigator: Li, Dan

Funder: The Permanente Medical Group


The Stomach Looks Suspicious, But Is It Pernicious?

Authors: Shah, Shailja C;Boeder, Schafer;Piazuelo, M Blanca;Li, Dan

Gastroenterology. 2023 Aug 26.

PubMed abstract

Effect of Helicobacter pylori Eradication Therapy on the Incidence of Noncardia Gastric Adenocarcinoma in a Large Diverse Population in the United States

Authors: Li, Dan;Jiang, Sheng-Fang;Lei, Nan Ye;Shah, Shailja C;Corley, Douglas A

Gastroenterology. 2023 May 02.

PubMed abstract

Risk of Metachronous Advanced Neoplasia After Colonoscopy in Patients Aged 40-49 Years Compared to Patients Aged 50-59 Years

Authors: Ma, Gene; Anderson, Meredith; Liu, Liyan; Li, Dan

Am J Gastroenterol. 2023 Jan 01;118(1):148-156. Epub 2022-08-12.

PubMed abstract

Current chemoprevention approaches in Lynch syndrome and Familial adenomatous polyposis: a global clinical practice survey

Authors: Mraz, Kathryn A;Kanth, Priyanka;Dominguez-Valentin, Mev;et al.

Front Oncol. 2023;13:1141810. Epub 2023-05-24.

PubMed abstract

Impact of the COVID-19 pandemic on fecal immunochemical testing, colonoscopy services, and colorectal neoplasia detection in a large United States community-based population

Authors: Lee, Jeffrey K; Li, Dan; Corley, Douglas A; Levin, Theodore R; et al.

Gastroenterology. 2022 09;163(3):723-731.e6. Epub 2022-05-14.

PubMed abstract

Understanding the Protective Effect of Helicobacter pylori Eradication on Gastric Cancer after a Quarter Century: New Insights from an Old Trial

Authors: Li, Dan

Gastroenterology. 2022 07;163(1):42-44. Epub 2022-04-29.

PubMed abstract

AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review

Authors: Shah, Shailja C; Piazuelo, M Blanca; Kuipers, Ernst J; Li, Dan

Gastroenterology. 2021 10;161(4):1325-1332.e7. Epub 2021-08-26.

PubMed abstract

Efficacy of paired tumor and germline testing in evaluation of patients with Lynch-like syndrome in a large integrated healthcare setting

Authors: Carwana, Holly; Hoodfar, Elizabeth; Bergoffen, JoAnn; Li, Dan

Fam Cancer. 2021 07;20(3):223-230. Epub 2020-11-20.

PubMed abstract

A Transparent and Adaptable Method to Extract Colonoscopy and Pathology Data Using Natural Language Processing

Authors: Fevrier, Helene B; Liu, Liyan; Herrinton, Lisa J; Li, Dan

J Med Syst. 2020 Jul 31;44(9):151. Epub 2020-07-31.

PubMed abstract

Reply to GASTRO-D-20-0014

Authors: Gupta S; Li D; El Serag H; AGA Gastric Intestinal Metaplasia Guideline Panel

Gastroenterology. 2020 07;159(1):403-404. Epub 2020-04-18.

PubMed abstract

Associations between Genetically Predicted Blood Protein Biomarkers and Pancreatic Cancer Risk

Authors: Zhu J; Van Den Eeden SK; Wu L; et al.

Cancer Epidemiol Biomarkers Prev. 2020 07;29(7):1501-1508. Epub 2020-05-21.

PubMed abstract

Surveillance of Gastric Intestinal Metaplasia

Authors: Shah SC; Gawron AJ; Li D

Am J Gastroenterol. 2020 05;115(5):641-644.

PubMed abstract

Spotlight: Gastric Intestinal Metaplasia

Authors: Shah SC; Gupta S; Li D; Morgan D; Mustafa RA; Gawron AJ

Gastroenterology. 2020 02;158(3):704.

PubMed abstract

Comparison of Universal Versus Age-Restricted Screening of Colorectal Tumors for Lynch Syndrome Using Mismatch Repair Immunohistochemistry: A Cohort Study

Authors: Li D; Levin TR; Corley DA; Bergoffen J; et al.

Ann Intern Med. 2019 07 02;171(1):19-26. Epub 2019-06-11.

PubMed abstract

Effect of Helicobacter pylori Treatment on Unexplained Iron Deficiency Anemia

Authors: Tseng DS; Li D; Cholleti SM; Wei JC; Jodesty Y; Pham HV

Perm J. 2019;23.

PubMed abstract

Recent advances in colorectal cancer screening

Authors: Li D

Chronic Dis Transl Med. 2018 Sep;4(3):139-147. Epub 2018-09-17.

PubMed abstract

Small and diminutive hyperplastic polyps in the proximal colon: Are they innocent or guilty of a crime?

Authors: Li D

Gastrointest Endosc. 2018 06;87(6):1527-1529.

PubMed abstract

Rates and Predictors of Vaccinations Among Inflammatory Bowel Disease Patients Receiving Anti-Tumor Necrosis Factor Agents

Authors: Pham HV; Hasan I; Udaltsova N; Pham K; Abramson O; Armstrong MA; Postlethwaite D; Li D

Dig Dis Sci. 2017 Aug 23.

PubMed abstract

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