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Vincent Liu, MD, MS

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Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-5933 (phone)
vincent.x.liu@kp.org
Kaiser Permanente Researcher Profiles


Vincent Liu, MD, MS, is a research scientist at the Kaiser Permanente Northern California Division of Research. His work focuses on the intersection of sepsis, acute severe illness, informatics, and health care delivery with a goal of building towards a learning hospital system.

Dr. Liu is board certified in Internal Medicine, Pulmonary Disease, Critical Care Medicine, and Clinical Informatics. He received his undergraduate degree from the University of Pennsylvania and his medical degree from New York University. He completed his residency training at New York University Hospitals (Bellevue) and a chief residency at Memorial Sloan-Kettering Cancer Center. He also completed a pulmonary and critical care medicine fellowship and has master’s degrees in Health Services Research and Biomedical Informatics, both from Stanford University.

In addition to his clinical practice and research, Dr. Liu is also the Regional Director of Hospital Advanced Analytics in Kaiser Permanente Northern California.

Current Position(s):

  • Research Scientist I, Division of Research, Kaiser Permanente Northern California
  • Intensivist, Critical Care, Kaiser Permanente Medical Center, Santa Clara, California
  • Clinical Assistant Professor of Medicine (Affiliated), Stanford University, Stanford, California
  • Regional Director, Hospital Advanced Analytics, Kaiser Permanente Northern California

Section Affiliations:

Primary Research Interests:

  • Critical Care and Inpatient Health Services Research
  • Sepsis
  • Data Science
  • Delivery and Implementation Science
  • Electronic Decision Support
  • Health Informatics

    Benefits of Intensive Care Unit Admission for Patients with Acute Respiratory Failure or Sepsis

    Ideal and optimally efficient use of intensive care unit (ICU) resources would create benefits across the health care system. Ideal use of ICU resources requires a needs assessment to determine which categories of patients commonly admitted to ICUs derive true net benefit on average from ICU admission versus admission to a regular hospital floor. This project aims to conduct such a needs assessment, which has never before been done.
    Investigator: Liu, Vincent
    Funder: National Heart, Lung, and Blood Institute

    Data-Driven Precision Medicine in Sepsis

    Sepsis is a common and costly disease which contributes to nearly 1 in 2 hospital deaths in our healthcare system. While aggressive early treatment with quantitative resuscitation has demonstrated benefit, many other interventions have not demonstrated efficacy likely resulting from an incomplete understanding of sepsis disease mechanisms. This study seeks to address three questions through innovative approaches to using observational data: (1) what factors can improve our characterization and phenotyping of sepsis patients; (2) what are the potential benefits of using quantitative resuscitation in less severe sepsis subgroups; and (3) how does acute organ dysfunction impact long-term mortality and utilization among sepsis survivors
    Investigator: Liu, Vincent
    Funder: National Institute of General Medical Sciences
    No results found matching criteria

    The Impact of Acute Organ Dysfunction on Long-Term Survival in Sepsis

    Author(s): Schuler A; Wulf DA; Lu Y; Iwashyna TJ; Escobar GJ; Shah NH; Liu VX

    Crit Care Med. 2018 Feb 09.

    PubMed abstract

    Healthcare Utilization and Infection in the Week Prior to Sepsis Hospitalization

    Author(s): Liu VX; Escobar GJ; Chaudhary R; Prescott HC

    Crit Care Med. 2018 Jan 05.

    PubMed abstract

    Hospital-Acquired Pressure Injury: Risk-Adjusted Comparisons in an Integrated Healthcare Delivery System

    Author(s): Rondinelli J; Zuniga S; Kipnis P; Kawar LN; Liu V; Escobar GJ

    Nurs Res. 2018 Jan/Feb;67(1):16-25.

    PubMed abstract

    Flexible, Cluster-Based Analysis of the Electronic Medical Record of Sepsis with Composite Mixture Models

    Author(s): Mayhew MB; Petersen BK; Sales AP; Greene JD; Liu VX; Wasson TS

    J Biomed Inform. 2017 Nov 28.

    PubMed abstract

    Machine Learning and Sepsis: On the Road to Revolution

    Author(s): Liu VX; Walkey AJ

    Crit Care Med. 2017 Nov;45(11):1946-1947.

    PubMed abstract

    Comparing Hospital Processes and Outcomes in California Medicare Beneficiaries: Simulation Prompts Reconsideration

    Author(s): Escobar GJ; Baker JM; Turk BJ; Draper D; Liu V; Kipnis P

    Perm J. 2017;21.

    PubMed abstract

    Prediction of Recurrent Clostridium Difficile Infection Using Comprehensive Electronic Medical Records in an Integrated Healthcare Delivery System

    Author(s): Escobar GJ; Baker JM; Kipnis P; Greene JD; Mast TC; Gupta SB; Cossrow N; Mehta V; Liu V; Dubberke ER

    Infect Control Hosp Epidemiol. 2017 Aug 24:1-8.

    PubMed abstract

    Individual and health system variation in rehospitalizations the year after pneumonia

    Author(s): Viglianti EM; Prescott HC; Liu V; Escobar GJ; Iwashyna TJ

    Medicine (Baltimore). 2017 Aug;96(31):e7695.

    PubMed abstract

    Innovation and Technology: Electronic Intensive Care Unit Diaries

    Author(s): Scruth EA; Oveisi N; Liu V

    AACN Adv Crit Care. 2017 Summer;28(2):191-199.

    PubMed abstract

    Identifying Distinct Subgroups of ICU Patients: A Machine Learning Approach

    Author(s): Vranas KC; Jopling JK; Sweeney TE; Ramsey MC; Milstein AS; Slatore CG; Escobar GJ; Liu VX

    Crit Care Med. 2017 Jun 21.

    PubMed abstract

    Enhanced Recovery After Surgery Program Implementation in 2 Surgical Populations in an Integrated Health Care Delivery System

    Author(s): Liu VX; Rosas E; Hwang J; Cain E; Foss-Durant A; Clopp M; Huang M; Lee DC; Mustille A; Kipnis P; Parodi S

    JAMA Surg. 2017 May 10:e171032.

    PubMed abstract

    Reply to the Timing of Early Antibiotics and Hospital Mortality in Sepsis - Playing Devil's Advocate

    Author(s): Liu V; Fielding-Singh V; Iwashyna TJ; Bhattacharya J; Escobar G

    Am J Respir Crit Care Med. 2017 May 09.

    PubMed abstract

    The Timing of Early Antibiotics and Hospital Mortality in Sepsis

    Author(s): Liu VX; Fielding-Singh V; Greene JD; Baker JM; Iwashyna TJ; Bhattacharya J; Escobar GJ

    Am J Respir Crit Care Med. 2017 Mar 27.

    PubMed abstract

    Hospital Readmissions in Sepsis Survivors: Are They Preventable?

    Author(s): Goodwin AJ; Liu V; Ford DW

    Ann Am Thorac Soc. 2017 Feb;14(2):170-171.

    PubMed abstract

    Validation of Administrative Definitions of Invasive Mechanical Ventilation across 30 Intensive Care Units

    Author(s): Kerlin MP; Weissman GE; Wonneberger KA; Kent S; Madden V; Liu VX; Halpern SD

    Am J Respir Crit Care Med. 2016 Dec 15;194(12):1548-1552.

    PubMed abstract

    Evaluation Following Staggered Implementation of the "Rethinking Critical Care" ICU Care Bundle in a Multicenter Community Setting

    Author(s): Liu V; Herbert D; Foss-Durant A; Marelich GP; Patel A; Whippy A; Turk BJ; Ragins AI; Kipnis P; Escobar GJ

    Crit Care Med. 2015 Nov 4.

    PubMed abstract

    Data that drive: Closing the loop in the learning hospital system

    Author(s): Liu VX; Morehouse JW; Baker JM; Greene JD; Kipnis P; Escobar GJ

    J Hosp Med. 2016 Nov;11 Suppl 1:S11-S17.

    PubMed abstract

    Piloting electronic medical record-based early detection of inpatient deterioration in community hospitals

    Author(s): Escobar GJ; Turk BJ; Ragins A; Ha J; Hoberman B; LeVine SM; Ballesca MA; Liu V; Kipnis P

    J Hosp Med. 2016 Nov;11 Suppl 1:S18-S24.

    PubMed abstract

    Variation in the Contents of Sepsis Bundles and Quality Measures: A Systematic Review

    Author(s): Kramer RD; Cooke CR; Liu V; Miller RR; Iwashyna TJ

    Ann Am Thorac Soc. 2015 Sep 23.

    PubMed abstract

    Treatment of Alcohol Withdrawal Syndrome with and without Dexmedetomidine

    Author(s): Beg M; Fisher S; Siu D; Rajan S; Troxell L; Liu VX

    Perm J. 2016 Spring;20(2):49-53.

    PubMed abstract

    Can You Read Me Now? Unlocking Narrative Data with Natural Language Processing

    Author(s): Sjoding MW; Liu VX

    Ann Am Thorac Soc. 2016 Sep;13(9):1443-5.

    PubMed abstract

    Loud and Clear: Sensory Impairment, Delirium, and Functional Recovery in Critical Illness

    Author(s): LaHue SC; Liu VX

    Am J Respir Crit Care Med. 2016 Aug 1;194(3):252-3.

    PubMed abstract

    16 Years and Counting? Time to Implement Noninvasive Screening for ARDS

    Author(s): Rogers AJ; Liu VX

    Chest. 2016 Aug;150(2):266-7.

    PubMed abstract

    Predicting red blood cell transfusion in hospitalized patients: role of hemoglobin level, comorbidities, and illness severity

    Author(s): Roubinian NH; Murphy EL; Swain BE; Gardner MN; Liu V; Escobar GJ; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III); Northern California Kaiser Permanente DOR Systems Research Initiative

    BMC Health Serv Res. 2014;14:213. Epub 2014-05-10.

    PubMed abstract

    In-hospital mortality following treatment with red blood cell transfusion or inotropic therapy during early goal-directed therapy for septic shock: a retrospective propensity-adjusted analysis

    Author(s): Mark DG; Morehouse JW; Hung YY; Kene MV; Elms AR; Liu V; Ballard DW; Vinson DR

    Crit Care. 2014;18(5):496. Epub 2014-09-12.

    PubMed abstract

    Hospital Deaths in Patients With Sepsis From 2 Independent Cohorts

    Author(s): Liu V; Escobar GJ; Greene JD; Soule J; Whippy A; Angus DC; Iwashyna TJ

    JAMA. 2014 Jul 2;312(1):90-2.

    PubMed abstract

    Towards Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and ARDS Clinical Trial Design

    Author(s): Prescott HC; Calfee CS; Thompson BT; Angus DC; Liu VX

    Am J Respir Crit Care Med. 2016 May 31.

    PubMed abstract

    Developing a framework for implementing intensive care unit diaries: a focused review of the literature

    Author(s): Beg M; Scruth E; Liu V

    Aust Crit Care. 2016 May 27.

    PubMed abstract

    Data breaches of protected health information in the United States

    Author(s): Liu V; Musen MA; Chou T

    JAMA. 2015 Apr 14;313(14):1471-3.

    PubMed abstract

    Consensus Statement on Electronic Health Predictive Analytics: A Guiding Framework to Address Challenges

    Author(s): Amarasingham R; Audet AM; Bates DW; Glenn Cohen I; Entwistle M; Escobar GJ; Liu V; Etheredge L; Lo B; Ohno-Machado L; Ram S; Saria S; Schilling LM; Shahi A; Stewart WF; Steyerberg EW; Xie B

    EGEMS (Wash DC). 2016;4(1):1163. Epub 2016-03-07.

    PubMed abstract

    Keeping Score of Severity Scores: Taking the Next Step

    Author(s): Liu V

    Crit Care Med. 2016 Mar;44(3):639-40.

    PubMed abstract

    Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

    Author(s): Shankar-Hari M; Phillips GS; Levy ML; Seymour CW; Liu VX; Deutschman CS; Angus DC; Rubenfeld GD; Singer M; Sepsis Definitions Task Force

    JAMA. 2016 Feb 23;315(8):775-87.

    PubMed abstract

    Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

    Author(s): Seymour CW; Liu VX; Iwashyna TJ; Brunkhorst FM; Rea TD; Scherag A; Rubenfeld G; Kahn JM; Shankar-Hari M; Singer M; Deutschman CS; Escobar GJ; Angus DC

    JAMA. 2016 Feb 23;315(8):762-74.

    PubMed abstract

    Multicenter Implementation of a Treatment Bundle for Sepsis Patients with Intermediate Lactate Values

    Author(s): Liu VX; Morehouse JW; Marelich GP; Soule J; Russell T; Skeath M; Adams C; Escobar GJ; Whippy A

    Am J Respir Crit Care Med. 2015 Dec 22.

    PubMed abstract

    Decreasing sepsis mortality at Kaiser Permanente Northern California

    Author(s): Liu V; Whippy A; Morehouse JW

    Am J Emerg Med. 2015 Sep;33(9):1305-6. Epub 2014-08-02.

    PubMed abstract

    The Accuracy of an Electronic Pulmonary Embolism Severity Index Auto-Populated from the Electronic Health Record: Setting the stage for computerized clinical decision support

    Author(s): Vinson DR; Morley JE; Huang J; Liu V; Anderson ML; Drenten CE; Radecki RP; Nishijima DK; Reed ME

    Appl Clin Inform. 2015;6(2):318-33. Epub 2015-05-13.

    PubMed abstract

    Impact of Relative Contraindications to Home Management in Emergency Department Patients with Low-Risk Pulmonary Embolism

    Author(s): Vinson DR; Drenten CE; Huang J; Morley JE; Anderson ML; Reed ME; Nishijima DK; Liu V; Kaiser Permanente Clinical Research on Emergency Services and Treatment (CREST) Network

    Ann Am Thorac Soc. 2015 May;12(5):666-73.

    PubMed abstract

    Trends in red blood cell transfusion and 30-day mortality among hospitalized patients

    Author(s): Roubinian NH; Escobar GJ; Liu V; Swain BE; Gardner MN; Kipnis P; Triulzi DJ; Gottschall JL; Wu Y; Carson JL; Kleinman SH; Murphy EL; NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III)

    Transfusion. 2014 Oct;54(10 Pt 2):2678-86. Epub 2014-08-18.

    PubMed abstract

    Decreased Red Blood Cell Use and Mortality in Hospitalized Patients

    Author(s): Roubinian NH; Escobar GJ; Liu V; Gardner MN; Carson JL; Kleinman SH; Murphy EL; NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III)

    JAMA Intern Med. 2014 Aug;174(8):1405-7.

    PubMed abstract

    Hospital readmission and healthcare utilization following sepsis in community settings

    Author(s): Liu V; Lei X; Prescott HC; Kipnis P; Iwashyna TJ; Escobar GJ

    J Hosp Med. 2014 Aug;9(8):502-7. Epub 2014-04-04.

    PubMed abstract

    Increased one-year health care utilization in survivors of severe sepsis

    Author(s): Prescott HC; Langa KM; Liu V; Escobar GJ; Iwashyna TJ

    Am J Respir Crit Care Med. 2014 Jul 1;190(1):62-9.

    PubMed abstract

    Only Time Will Tell. Data-driven Approaches to Phenotyping Critical Illness

    Author(s): Liu V

    Ann Am Thorac Soc. 2014 Jun;11(5):795-6.

    PubMed abstract

    Accuracy of hospital standardized mortality rates: effects of model calibration

    Author(s): Kipnis P; Liu V; Escobar GJ

    Med Care. 2014 Apr;52(4):378-84.

    PubMed abstract

    Fluid Volume, Lactate Values, and Mortality in Sepsis Patients with Intermediate Lactate Values

    Author(s): Liu V; Morehouse JW; Soule J; Whippy A; Escobar GJ

    Ann Am Thorac Soc. 2013 Oct;10(5):466-73.

    PubMed abstract

    Automated identification of pneumonia in chest radiograph reports in critically ill patients

    Author(s): Liu V; Clark MP; Mendoza M; Saket R; Gardner MN; Turk BJ; Escobar GJ

    BMC Med Inform Decis Mak. 2013;13:90. Epub 2013-08-15.

    PubMed abstract

    Visitation policies and practices in United States intensive care units

    Author(s): Liu V; Read JL; Scruth E; Cheng E

    Crit Care. 2013;17(2):R71. Epub 2013-04-16.

    PubMed abstract

    An electronic simplified acute physiology score-based risk adjustment score for critical illness in an integrated healthcare system*

    Author(s): Liu V; Turk BJ; Ragins AI; Kipnis P; Escobar GJ

    Crit Care Med. 2013 Jan;41(1):41-8.

    PubMed abstract

    Risk factors for unplanned transfer to intensive care within 24 hours of admission from the emergency department in an integrated healthcare system

    Author(s): Delgado MK; Liu V; Pines JM; Kipnis P; Gardner MN; Escobar GJ

    J Hosp Med. 2013 Jan;8(1):13-9. Epub 2012 Sep 28.

    PubMed abstract

    The association between sepsis and potential medical injury among hospitalized patients

    Author(s): Liu V; Turk BJ; Rizk NW; Kipnis P; Escobar GJ

    Chest. 2012 Sep;142(3):606-13.

    PubMed abstract

    Potential for overuse of corticosteroids and vasopressin in septic shock

    Author(s): Hsu JL; Liu V; Patterson AJ; Martin GS; Nicolls MR; Russell JA

    Crit Care. 2012;16(5):447. Epub 2012-09-06.

    PubMed abstract