Vincent X. Liu , MD, MS

AIM-HI grant management and collaborative hub

This grant funds 5 health-system-based prospective evaluations of the implementation of machine-learning-based diagnostic decision support (ML-DDS) algorithms that will be coordinated through the Kaiser Permanente Augmented Intelligence in Medicine and Healthcare Initiative (AIM-HI). A secondary goal of the grant is to create an International Collaboration Hub for Design and Execution of Clinical AI Evaluation Studies.

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Investigator: Liu, Vincent

Funder: Gordon and Betty Moore Foundation

Machine Learning Applied to EHR Data as a Means of Improving Biosurveillance and Diagnostic Excellence: A Pilot Project

We aim to develop and extend methods of probabilistic modeling of temporal electronic health record (EHR) data, using non-stationary Gaussian processes, hidden Markov models, and composite mixture models, to identify opportunities to conduct clinical biosurveillance and to achieve diagnostic excellence. Building off collaboration between KP DOR and the Lawrence Livermore National Laboratory, this proposal will use population-level EHR data, AI/ML methods and advanced computing to evaluate associations between health system diagnostic testing/treatment and prevalent/incident health conditions and to identify areas of potential diagnostic uncertainty.

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Investigator: Liu, Vincent

Evaluation of Risk-Based Predictive Models to Inform the Efficiency of Perioperative Systems

We previously developed an automated electronic health record-based risk stratification tool, called the Comorbidity Assessment and Surgical Triage (CAST) score, which we implemented in KP HealthConnect to improve triage of elective surgical patients to perioperative medicine clinic visit types in real-time. This project seeks to improve the efficiency of operative workflows by evaluating the impact of CAST implementation on pre-operative workflows and surgical outcomes; characterizing patients with discordant risk assessments between CAST and the clinician; and evaluating the association between CAST and operative resources, including surgical case duration.

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Investigator: Liu, Vincent

Funder: TPMG Delivery Science Projects Program

Turning back the clock on sepsis: Defining the epidemiology and opportunities of pre-sepsis

We intend to determine the epidemiology of pre-sepsis, including ambulatory and prehospital care settings, to identify modifiable care delays, opportunities for primary sepsis prevention, and to improve early sepsis care for vulnerable populations. The objectives include determining the epidemiology of pre-sepsis care across ambulatory and prehospital settings using linked EHR data; measuring delays in pre-sepsis care; and understanding the patient-level variation in pre-sepsis care and delays in vulnerable populations. The project is a collaboration between KPNC and University of Pittsburgh Medical Center.

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Investigator: Liu, Vincent

Funder: Gordon and Betty Moore Foundation

Effectiveness and safety of treatments for hospitalized patients with COVID-19

Examine the safety and effectiveness of current treatments for hospitalized patients with COVID-19 and identify patient characteristics and time periods during the disease course that are associated with more favorable treatment response.

0

Investigator: Liu, Vincent

Funder: Garfield Memorial Fund

Understanding and Informing Early Hospital Antibiotic Prescribing for Potential Infection

The goals of this study are to (1) examine temporal trends in early hospital antibiotic prescribing patterns over the past 5 years, to assess for unintended consequences associated with earlier antibiotics in severe sepsis/septic shock; (2) quantify the patient-level harm associated with receipt of unnecessary antibiotics; and (3) identify subsets of patients, discernable in real-time with high certainty, who benefit from immediate antibiotics, versus the subsets of patients for whom it is safe to delay antibiotics by 3 hours (thereby allowing time for rapid diagnostics, such as procalcitonin).

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Investigator: Liu, Vincent

Funder: Agency for Healthcare Research and Quality

Sepsis on FHIR

Overall goal is to define and refine the current epidemiology, clinical characteristics, and treatment practices in respiratory failure in late and moderately preterm infants. Specific aims are to determine that incidence and epidemiology of respiratory failure in neonates born 32-36 weeks of gestation between 2012 and 2017 in Kaiser Permanente Northern California facilities; describe disease severity and respiratory support by diagnostic category; describe use of surfactant replacement therapy; and assess the impact of surfactant replacement therapy on length of respiratory support, length of hospitalization, and respiratory outcomes in the first year of life.

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Investigator: Liu, Vincent

Funder: Moore Foundation

Using EHR Audit Logs to Capture Diagnostic Pathways and Time to Diagnosis

Rapid expansions in the use of electronic health record (EHR) systems also contribute to large expansions in the availability of metadata. These highly granular metadata may prove particularly useful for understanding how frontline clinicians interact with clinical information when making diagnostic decisions. This project aims to characterize EHR audit log data and advance nascent understanding of the potential to leverage these to provide novel insights into the diagnostic process, with a focus on time to diagnosis, and ultimately inform the achievement of diagnostic excellence.

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Investigator: Liu, Vincent

Funder: Gordon and Betty Moore Foundation

Targeting Cardiovascular Events to Improve Patient Outcomes After Sepsis

Sepsis is the most common illness leading to hospitalization in the United States, affecting more than 1 million Americans each year. While short-term mortality has improved over prior decades, sepsis survivors face numerous post-hospital sequelae that negatively impact long-term morbidity and mortality. Cardiovascular complications are among the most common reasons for re-hospitalization and death after sepsis, with approximately 1 in 3 severe sepsis patients experiencing a cardiovascular complication in the year after sepsis hospitalization. This project seeks to identify risk factors for post-sepsis cardiovascular risk based on granular inpatient data collected during hospitalization, and identify potential opportunities to reduce post-sepsis cardiovascular risk.

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Investigator: Liu, Vincent

Funder: National Heart, Lung, and Blood Institute

Benchmarking Hospital Quality – Template Matching

​In this study, Kaiser Permanente Northern California researchers will serve as consultants for U.S. Department of Veterans Affairs (VA) researchers to evaluate the utility of template matching techniques, compared with standard regression techniques, for comparing hospital quality.

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Investigator: Liu, Vincent

Funder: U.S. Department of Veterans Affairs

Identifying Pre-Sepsis Opportunities for Early, Targeted Intervention

Early evidence suggests there will be ongoing waves of COVID-19 outbreak that can be mitigated through effective community-level prediction models and intervention. This project will Identify pre-sepsis opportunities for early, targeted intervention to inform community-level mitigation strategies of upcoming COVID19 surges.

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Investigator: Liu, Vincent

Funder: National Institute of General Medical Sciences

Benefits of Intensive Care Unit Admission for Patients with Acute Respiratory Failure or Sepsis

Ideal and optimally efficient use of intensive care unit (ICU) resources would create benefits across the health care system. Ideal use of ICU resources requires a needs assessment to determine which categories of patients commonly admitted to ICUs derive true net benefit on average from ICU admission versus admission to a regular hospital floor. This project aims to conduct such a needs assessment, which has never before been done.

0

Investigator: Liu, Vincent

Funder: National Heart, Lung, and Blood Institute

Data-Driven Precision Medicine in Sepsis

Sepsis is a common and costly disease which contributes to nearly 1 in 2 hospital deaths in our healthcare system. While aggressive early treatment with quantitative resuscitation has demonstrated benefit, many other interventions have not demonstrated efficacy likely resulting from an incomplete understanding of sepsis disease mechanisms. This study seeks to address three questions through innovative approaches to using observational data: (1) what factors can improve our characterization and phenotyping of sepsis patients; (2) what are the potential benefits of using quantitative resuscitation in less severe sepsis subgroups; and (3) how does acute organ dysfunction impact long-term mortality and utilization among sepsis survivors

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Investigator: Liu, Vincent

Funder: National Institute of General Medical Sciences

The impact of timing of initiating invasive mechanical ventilation in COVID-19-related respiratory failure

Authors: Myers, Laura C;Kipnis, Patricia;Greene, John D;Chen, Aiyu;Creekmur, Beth;Xu, Stan;Sankar, Viji;Roubinian, Nareg H;Langer-Gould, Annette;Gould, Michael K;Liu, Vincent X

J Crit Care. 2023 Oct;77:154322. Epub 2023-05-08.

PubMed abstract

Predictive Modeling Using Artificial Intelligence and Machine Learning Algorithms on Electronic Health Record Data: Advantages and Challenges

Authors: Patton, Michael J;Liu, Vincent X

Crit Care Clin. 2023 Oct;39(4):647-673. Epub 2023-04-26.

PubMed abstract

Prediction of In-hospital Mortality Among Intensive Care Unit Patients Using Modified Daily Laboratory-based Acute Physiology Score, Version 2

Authors: Kohn, Rachel;Kipnis, Patricia;Kerlin, Meeta Prasad;et al.

Med Care. 2023 Aug 01;61(8):562-569. Epub 2023-06-12.

PubMed abstract

Use of Sepsis Clinical Prediction Models to Improve Patient Care

Authors: Mogri, Murtaza;Grant, Richard W;Liu, Vincent X

JAMA Intern Med. 2023 Jun 01;183(6):612-615.

PubMed abstract

Comparison of Mammography AI Algorithms with a Clinical Risk Model for 5-year Breast Cancer Risk Prediction: An Observational Study

Authors: Arasu, Vignesh A;Kornak, John;Lewis, Donald A;Yoon, Hyo-Chun;Lee, Catherine;et al.

Radiology. 2023 Jun;307(5):e222733.

PubMed abstract

Racial Disparities in Length of Stay Among Severely Ill Patients Presenting With Sepsis and Acute Respiratory Failure

Authors: Chesley, Christopher F;Chowdhury, Marzana;Small, Dylan S;Schaubel, Douglas;Liu, Vincent X;Lane-Fall, Meghan B;Halpern, Scott D;Anesi, George L

JAMA Netw Open. 2023 May 01;6(5):e239739. Epub 2023-05-01.

PubMed abstract

Performance of a Prediction Model of Suicide Attempts Across Race and Ethnicity

Authors: Papini, Santiago; Hsin, Honor; Kipnis, Patricia; Liu, Vincent X; Lu, Yun; Sterling, Stacy A; Iturralde, Esti

JAMA Psychiatry. 2023 Apr 01;80(4):399-400.

PubMed abstract

Practice Patterns and Outcomes Associated With Anticoagulation Use Following Sepsis Hospitalizations With New-Onset Atrial Fibrillation

Authors: Walkey, Allan J; Myers, Laura C; Thai, Khanh K; Kipnis, Patricia; Desai, Manisha; Go, Alan S; Lu, Yun; Clancy, Heather; Devis, Ycar; Neugebauer, Romain; Liu, Vincent X

Circ Cardiovasc Qual Outcomes. 2023 Mar;16(3):e009494. Epub 2023-02-28.

PubMed abstract

Among-Hospital Variation in ICU Admission Practices and Associated Outcomes for Patients with Acute Respiratory Failure

Authors: Anesi, George L; Liu, Vincent X; et al.

Ann Am Thorac Soc. 2023 Mar;20(3):406-413.

PubMed abstract

Development and Validation of an Electronic Health Record-based Score for Triage to Perioperative Medicine

Authors: Le, Sidney T; Corbin, Dalton; Myers, Laura C; Kipnis, Patricia; Cohn, Bradley; Liu, Vincent X

Ann Surg. 2023 Mar 01;277(3):e520-e527. Epub 2021-11-09.

PubMed abstract

Risk of venous thromboembolism in non-respiratory and respiratory presentations of COVID-19 in critically ill patients

Authors: Roubinian, Nareg H; Vinson, David R; Pai, Ashok P; Myers, Laura C; Skarbinski, Jacek; Lee, Catherine; Mark, Dustin G; Liu, Vincent X

Chest. 2023 Feb 12.

PubMed abstract

Hospital Strain and Variation in Sepsis ICU Admission Practices and Associated Outcomes

Authors: Anesi, George L; Dress, Erich; Chowdhury, Marzana; Wang, Wei; Small, Dylan S; Delgado, M Kit; Bayes, Brian; Barreda, Fernando X; Halpern, Scott D; Liu, Vincent X

Crit Care Explor. 2023 Feb;5(2):e0858. Epub 2023-02-02.

PubMed abstract

COVID-19 bacteremic co-infection is a major risk factor for mortality, ICU admission, and mechanical ventilation

Authors: Patton, Michael John; Liu, Vincent X; Gaggar, Amit; et al.

Crit Care. 2023 Jan 23;27(1):34. Epub 2023-01-23.

PubMed abstract

Risk of posthospital venous thromboembolism in patients with COVID-19 varies by SARS-CoV-2 period and vaccination status

Authors: Roubinian, Nareg H;Vinson, David R;Knudson-Fitzpatrick, Tess Wheeler;Mark, Dustin G;Skarbinski, Jacek;Lee, Catherine;Liu, Vincent X;Pai, Ashok P

Blood Adv. 2023 Jan 10;7(1):141-144.

PubMed abstract

Trends in Outpatient Visits and Hospital and Intensive Care Unit Admissions of Adults With COVID-19 in an Integrated US Health Care System, March 2020 to January 2022

Authors: Myers, Laura C; Ng, Kevin; Plimier, Colleen; Daly, Kathleen A; Kipnis, Patricia; Liu, Vincent X

JAMA Netw Open. 2023 Jan 03;6(1):e2253269. Epub 2023-01-03.

PubMed abstract

Risk of hospitalization in a sample of COVID-19 patients with and without chronic obstructive pulmonary disease

Authors: Myers, Laura C; Murray, Richard; Donato, Bonnie; Liu, Vincent X; Kipnis, Patricia; Shaikh, Asif; Franchino-Elder, Jessica

Respir Med. 2023 Jan;206:107064. Epub 2022-11-26.

PubMed abstract

The intensity of anticoagulant dosing in hospitalized patients with COVID-19: An observational, comparative effectiveness study

Authors: Myers, Laura C; Xu, Stanley; Chen, Aiyu; Greene, John D; Creekmur, Beth; Bruxvoort, Katia; Escobar, Gabriel J; Adams, John L; Langer-Gould, Annette; Liu, Vincent X; Gould, Michael K

J Hosp Med. 2023 Jan;18(1):43-54. Epub 2022-11-22.

PubMed abstract

Anakinra or high-dose corticosteroids in COVID-19 pneumonia patients who deteriorate on low-dose dexamethasone: An observational study of comparative effectiveness

Authors: Langer-Gould, Annette; Xu, Stanley; Myers, Laura C; Chen, Aiyu; Greene, John D; Creekmur, Beth; Bruxvoort, Katia; Adams, John L; Liu, Vincent; Gould, Michael K

Int J Infect Dis. 2023 Jan;126:87-93. Epub 2022-11-18.

PubMed abstract

Association between anaemia and hospital readmissions in patients undergoing major surgery requiring postoperative intensive care

Authors: Warner, M A; Hanson, A C; Plimier, C; Lee, C; Liu, V X; Richards, T; Kor, D J; Roubinian, N H

Anaesthesia. 2023 Jan;78(1):45-54. Epub 2022-09-08.

PubMed abstract

Predicting Post-Sepsis Cardiovascular Events with Death as a Competing Risk

Authors: Myers, Laura C; Lee, Catherine; Go, Alan S; Liu, Vincent X; Walkey, Allan J; et al.

Ann Am Thorac Soc. 2023 Jan;20(1):145-148.

PubMed abstract

Team is brain: leveraging EHR audit log data for new insights into acute care processes

Authors: Rose, Christian; Thombley, Robert; Noshad, Morteza; Lu, Yun; Clancy, Heather A; Schlessinger, David; Li, Ron C; Liu, Vincent X; Chen, Jonathan H; Adler-Milstein, Julia

J Am Med Inform Assoc. 2022 Dec 13;30(1):8-15.

PubMed abstract

Persistent Steroid Exposure Before Coronavirus Disease 2019 Diagnosis and Risk of Hospitalization in Patients With Chronic Obstructive Pulmonary Disease

Authors: Myers, Laura C; Murray, Richard K; Donato, Bonnie M K; Liu, Vincent X; Kipnis, Patricia; Kipnis, Patricia; Shaikh, Asif; Franchino-Elder, Jessica

Chronic Obstr Pulm Dis. 2022 Dec 05.

PubMed abstract

High-dose corticosteroids in patients hospitalized for COVID-19 pneumonia: an observational study of comparative effectiveness

Authors: Langer-Gould, Annette; Xu, Stanley; Myers, Laura C; Chen, Aiyu; Greene, John D; Creekmur, Beth; Bruxvoort, Katia; Adams, John L; Liu, Vincent; Gould, Michael K

Int J Infect Dis. 2022 Dec;125:184-191. Epub 2022-10-29.

PubMed abstract

Characterizing Equity of Intensive Care Unit Admissions for Sepsis and Acute Respiratory Failure

Authors: Chesley, Christopher F; Anesi, George L; Chowdhury, Marzana; Schaubel, Doug; Liu, Vincent X; Lane-Fall, Meghan B; Halpern, Scott D

Ann Am Thorac Soc. 2022 Dec;19(12):2044-2052.

PubMed abstract

Association Between Preoperative Hemodialysis Timing and Postoperative Mortality in Patients With End-stage Kidney Disease

Authors: Fielding-Singh, Vikram; Vanneman, Matthew W; Grogan, Tristan; Neelankavil, Jacques P; Winkelmayer, Wolfgang C; Chang, Tara I; Liu, Vincent X; Lin, Eugene

JAMA. 2022 Nov 08;328(18):1837-1848.

PubMed abstract

Trends and Risk Factors for Venous Thromboembolism Among Hospitalized Medical Patients

Authors: Neeman, Elad; Liu, Vincent; Mishra, Pranita; Thai, Khanh K; Xu, James; Clancy, Heather A; Schlessinger, David; Liu, Raymond

JAMA Netw Open. 2022 Nov 01;5(11):e2240373. Epub 2022-11-01.

PubMed abstract

Quantifying Frailty Requires a Conceptual Model Before a Statistical Model-Reply

Authors: Le, Sidney T; Liu, Vincent X; Cespedes Feliciano, Elizabeth M

JAMA Surg. 2022 Nov 01;157(11):1065-1066.

PubMed abstract

Covid-19 Vaccination and the Timing of Surgery Following Covid-19 Infection

Authors: Le, Sidney T; Kipnis, Patricia; Cohn, Bradley; Liu, Vincent X

Ann Surg. 2022 11 01;276(5):e265-e272. Epub 2022-07-15.

PubMed abstract

Quantifying the breadth of antibiotic exposure in sepsis and suspected infection using spectrum scores

Authors: Smith, Joshua T; Manickam, Raj N; Barreda, Fernando; Greene, John D; Bhimarao, Meghana; Pogue, Jason; Jones, Makoto; Myers, Laura; Prescott, Hallie C; Liu, Vincent X

Medicine (Baltimore). 2022 Oct 14;101(41):e30245.

PubMed abstract

Comparing the effectiveness of a brief intervention to reduce unhealthy alcohol use among adult primary care patients with and without depression: A machine learning approach with augmented inverse probability weighting

Authors: Papini, Santiago; Chi, Felicia W; Schuler, Alejandro; Satre, Derek D; Liu, Vincent X; Sterling, Stacy A

Drug Alcohol Depend. 2022 Oct 01;239:109607. Epub 2022-08-27.

PubMed abstract

Unsupervised probabilistic models for sequential Electronic Health Records

Authors: Kaplan, Alan D; Greene, John D; Liu, Vincent X; Ray, Priyadip

J Biomed Inform. 2022 Oct;134:104163. Epub 2022-08-28.

PubMed abstract

Risk of severe COVID-19 infection among adults with prior exposure to children

Authors: Solomon, Matthew D; Escobar, Gabriel J; Lu, Yun; Schlessinger, David; Steinman, Jonathan B; Steinman, Lawrence; Lee, Catherine; Liu, Vincent X

Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2204141119. Epub 2022-07-27.

PubMed abstract

The Kaiser Permanente Northern California Advance Alert Monitor Program: An Automated Early Warning System for Adults at Risk for In-Hospital Clinical Deterioration

Authors: Martinez, Vanessa A; Liu, Vincent X; et al.

Jt Comm J Qual Patient Saf. 2022 Aug;48(8):370-375.

PubMed abstract

Temporal Trends in Antimicrobial Prescribing During Hospitalization for Potential Infection and Sepsis

Authors: Prescott, Hallie C; Liu, Vincent X; et al.

JAMA Intern Med. 2022 08 01;182(8):805-813.

PubMed abstract

Adults hospitalized with breakthrough COVID-19 have lower mortality than matched unvaccinated adults

Authors: Myers, Laura C; Kipnis, Patricia; Greene, John; Lawson, Brian; Escobar, Gabriel J; Fireman, Bruce H; Klein, Nicola P; Liu, Vincent X

J Intern Med. 2022 08;292(2):377-384. Epub 2022-05-17.

PubMed abstract

New complementary perspectives for inpatient physical function assessment: matched clinician-report and patient-report short form measures from the PROMIS adult physical function item bank

Authors: Kallen, Michael A; Brown, Heather E; Hatton, Joeffrey R; Doyle, William A; Murphy, Ryan; Elliott, Ryan; Gutierrez, Mark A; Catherwood, Emma L; Pitman, Heather P; Liu, Vincent X; Gershon, Richard C

Qual Life Res. 2022 Jul;31(7):2201-2212. Epub 2022-03-08.

PubMed abstract

Red Blood Cell Transfusion at a Hemoglobin Threshold of Seven g/dL in Critically Ill Patients: A Regression Discontinuity Study

Authors: Bosch, Nicholas A; Law, Anica C; Bor, Jacob; Myers, Laura C; Roubinian, Nareg H; Liu, Vincent X; Walkey, Allan J

Ann Am Thorac Soc. 2022 07;19(7):1177-1184.

PubMed abstract

Validation of Respiratory Rate-Oxygenation Index in Patients With COVID-19-Related Respiratory Failure

Authors: Myers, Laura C; Mark, Dustin; Ley, Brett; Guarnieri, Michael; Hofmeister, Melinda; Paulson, Shirley; Marelich, Gregory; Liu, Vincent X

Crit Care Med. 2022 07 01;50(7):e638-e642. Epub 2022-02-07.

PubMed abstract

Exploratory analysis of novel electronic health record variables for quantification of healthcare delivery strain, prediction of mortality, and prediction of imminent discharge

Authors: Lee, Catherine; Lawson, Brian L; Mann, Ariana J; Liu, Vincent X; Myers, Laura C; Schuler, Alejandro; Escobar, Gabriel J

J Am Med Inform Assoc. 2022 05 11;29(6):1078-1090.

PubMed abstract

Comparison of Electronic Frailty Metrics for Prediction of Adverse Outcomes of Abdominal Surgery

Authors: Le, Sidney T; Liu, Vincent X; Kipnis, Patricia; Zhang, Jie; Peng, Peter D; Cespedes Feliciano, Elizabeth M

JAMA Surg. 2022 05 01;157(5):e220172. Epub 2022-05-11.

PubMed abstract

Evaluation of Incident 7-Day Infection and Sepsis Hospitalizations in an Integrated Health System

Authors: Liu, Vincent X; Manickam, Raj N; Greene, John D; Schuler, Alejandro; Kipnis, Patricia; Bhimarao, Meghana; Barreda, Fernando; Escobar, Gabriel J

Ann Am Thorac Soc. 2022 05;19(5):781-789.

PubMed abstract

Prospective evaluation of social risks, physical function, and cognitive function in prediction of non-elective rehospitalization and post-discharge mortality

Authors: Clancy, Heather A; Zhu, Zheng; Gordon, Nancy P; Kipnis, Patricia; Liu, Vincent X; Escobar, Gabriel J

BMC Health Serv Res. 2022 Apr 29;22(1):574. Epub 2022-04-29.

PubMed abstract

Developing a shared sepsis data infrastructure: a systematic review and concept map to FHIR

Authors: Brant EB; Kennedy JN; King AJ; Gerstley LD; Mishra P; Schlessinger D; Shalaby J; Escobar GJ; Angus DC; Seymour CW; Liu VX

NPJ Digit Med. 2022 Apr 04;5(1):44. Epub 2022-04-04.

PubMed abstract

Prognostic Accuracy of Presepsis and Intrasepsis Characteristics for Prediction of Cardiovascular Events After a Sepsis Hospitalization

Authors: Walkey AJ; Myers LC; Go AS; Liu VX; et al.

Crit Care Explor. 2022 Apr;4(4):e0674. Epub 2022-04-08.

PubMed abstract

Evaluation of Outcomes Following Hospital-Wide Implementation of a Subcutaneous Insulin Protocol for Diabetic Ketoacidosis

Authors: Rao, Priya; Jiang, Sheng-Fang; Kipnis, Patricia; Patel, Divyesh M; Katsnelson, Svetlana; Madani, Samineh; Liu, Vincent X

JAMA Netw Open. 2022 Apr 01;5(4):e226417. Epub 2022-04-01.

PubMed abstract

The COVID-19 Pandemic Strikes Again and Again and Again

Authors: Myers, Laura C; Liu, Vincent X

JAMA Netw Open. 2022 03 01;5(3):e221760. Epub 2022-03-01.

PubMed abstract

Association of Intensive Care Unit Admission and Outcomes in Sepsis and Acute Respiratory Failure

Authors: Anesi, George L; Liu, Vincent X; Chowdhury, Marzana; Small, Dylan S; Wang, Wei; Delgado, M Kit; Bayes, Brian; Dress, Erich; Escobar, Gabriel J; Halpern, Scott D

Am J Respir Crit Care Med. 2022 03 01;205(5):520-528.

PubMed abstract

Outcomes After Implementation of a Benzodiazepine-Sparing Alcohol Withdrawal Order Set in an Integrated Health Care System

Authors: Smith, Joshua T; Sage, Mary; Szeto, Herb; Myers, Laura C; Lu, Yun; Martinez, Adriana; Kipnis, Patricia; Liu, Vincent X

JAMA Netw Open. 2022 02 01;5(2):e220158. Epub 2022-02-01.

PubMed abstract

Connecting Research and Practice: Implementation of Suicide Prevention Strategies in Learning Health Care Systems

Authors: Rossom, Rebecca C; Sterling, Stacy; Liu, Vincent; Simon, Greg E; et al.

Psychiatr Serv. 2022 02 01;73(2):219-222. Epub 2021-06-30.

PubMed abstract

Performance of Predictive Models for 30-day Hospitalization and Mortality after COVID-19 Infection

Authors: Myers, Laura C; Kipnis, Patricia; O'Suilleabhain, Liam; Escobar, Gabriel; Liu, Vincent X

Ann Am Thorac Soc. 2022 01;19(1):131-134.

PubMed abstract

Hospital-specific Template Matching for Benchmarking Performance in a Diverse Multihospital System

Authors: Vincent, Brenda M; Molling, Daniel; Escobar, Gabriel J; Hofer, Timothy P; Iwashyna, Theodore J; Liu, Vincent X; Rosen, Amy K; Ryan, Andrew M; Seelye, Sarah; Wiitala, Wyndy L; Prescott, Hallie C

Med Care. 2021 12 01;59(12):1090-1098.

PubMed abstract

Assess COVID-19 prognosis … but be aware of your instrument’s accuracy!

Authors: Capuzzo, Maurizia; Amaral, Andre Carlos Kajdacsy-Balla; Liu, Vincent X

Intensive Care Med. 2021 12;47(12):1472-1474. Epub 2021-10-05.

PubMed abstract

Predictive Models for In-Hospital Deterioration in Ward Patients

Authors: Escobar, Gabriel J; Myers, Laura C; Liu, Vincent X

J Hosp Med. 2021 10;16(10):640.

PubMed abstract

Algorithmic prognostication in critical care: a promising but unproven technology for supporting difficult decisions

Authors: Weissman, Gary E; Liu, Vincent X

Curr Opin Crit Care. 2021 10 01;27(5):500-505.

PubMed abstract

Temporal Trends and Hospital Variation in Time-to-Antibiotics Among Veterans Hospitalized With Sepsis

Authors: Wayne, Max T; Seelye, Sarah; Molling, Daniel; Wang, Xiao Qing; Donnelly, John P; Hogan, Cainnear K; Jones, Makoto M; Iwashyna, Theodore J; Liu, Vincent X; Prescott, Hallie C

JAMA Netw Open. 2021 09 01;4(9):e2123950. Epub 2021-09-01.

PubMed abstract

Association Between Troponin I Levels During Sepsis and Post-Sepsis Cardiovascular Complications

Authors: Garcia, Michael A; Go, Alan S; Liu, Vincent X; Walkey, Allan J; et al.

Am J Respir Crit Care Med. 2021 09 01;204(5):557-565.

PubMed abstract

Reducing Readmissions for Chronic Obstructive Pulmonary Disease in Response to the Hospital Readmissions Reduction Program

Authors: Myers, Laura C; Cash, Rebecca; Liu, Vincent X; Camargo, Carlos A

Ann Am Thorac Soc. 2021 09;18(9):1506-1513.

PubMed abstract

Validation of Postpartum Hemorrhage Admission Risk Factor Stratification in a Large Obstetrics Population

Authors: Ruppel H; Liu VX; Gupta NR; Soltesz L; Escobar GJ

Am J Perinatol. 2021 09;38(11):1192-1200. Epub 2020-05-26.

PubMed abstract

Evaluation of an intervention targeted with predictive analytics to prevent readmissions in an integrated health system: observational study

Authors: Marafino, Ben J; Escobar, Gabriel J; Baiocchi, Michael T; Liu, Vincent X; Plimier, Colleen C; Schuler, Alejandro

BMJ. 2021 08 11;374:n1747. Epub 2021-08-11.

PubMed abstract

Evaluation of Vaccination Strategies to Compare Efficient and Equitable Vaccine Allocation by Race and Ethnicity Across Time

Authors: Kipnis, Patricia; Soltesz, Lauren; Escobar, Gabriel J; Myers, Laura; Liu, Vincent X

JAMA Health Forum. 2021 08;2(8):e212095. Epub 2021-08-20.

PubMed abstract

The Coming of Age of Implementation Science and Research in Critical Care Medicine

Authors: Barr, Juliana; Paulson, Shirley S; Kamdar, Biren; Ervin, Jennifer N; Lane-Fall, Meghan; Liu, Vincent; Kleinpell, Ruth

Crit Care Med. 2021 08 01;49(8):1254-1275.

PubMed abstract

Development of a healthcare system COVID Hotspotting Score in California: an observational study with prospective validation

Authors: Liu, Vincent X; Thai, Khanh K; Galin, Jessica; Gerstley, Lawrence David; Myers, Laura C; Parodi, Stephen M; Chen, Yi-Fen Irene; Goler, Nancy; Escobar, Gabriel J; Kipnis, Patricia

BMJ Open. 2021 07 26;11(7):e048211. Epub 2021-07-26.

PubMed abstract

Equitably Allocating Resources During Crises: Racial Differences in Mortality Prediction Models

Authors: Ashana, Deepshikha Charan; Anesi, George L; Liu, Vincent X; Escobar, Gabriel J; Chesley, Christopher; Eneanya, Nwamaka D; Weissman, Gary E; Miller, William Dwight; Harhay, Michael O; Halpern, Scott D

Am J Respir Crit Care Med. 2021 07 15;204(2):178-186.

PubMed abstract

Retrospective Cohort Study Comparing Infliximab-dyyb and Infliximab in Biologic-Naive Patients With Inflammatory Bowel Disease in the United States

Authors: Smith, Joshua T; Velayos, Fernando S; Niu, Fang; Liu, Vincent; Delate, Thomas; Pola, Suresh; Le, Kim; Hui, Rita L

Crohns Colitis 360. 2021 Jul;3(3):otab051. Epub 2021-07-29.

PubMed abstract

Incidence of 30-Day Venous Thromboembolism in Adults Tested for SARS-CoV-2 Infection in an Integrated Health Care System in Northern California

Authors: Roubinian, Nareg H; Dusendang, Jennifer R; Mark, Dustin G; Vinson, David R; Liu, Vincent X; Schmittdiel, Julie A; Pai, Ashok P

JAMA Intern Med. 2021 07 01;181(7):997-1000.

PubMed abstract

Association of Positive Fluid Balance at Discharge After Sepsis Management With 30-Day Readmission

Authors: Yoo, Michael S; Liu, Vincent X; et al.

JAMA Netw Open. 2021 06 01;4(6):e216105. Epub 2021-06-01.

PubMed abstract

Racial Disparities in COVID-19 Testing and Outcomes : Retrospective Cohort Study in an Integrated Health System

Authors: Escobar, Gabriel J; Adams, Alyce S; Liu, Vincent X; Soltesz, Lauren; Chen, Yi-Fen Irene; Parodi, Stephen M; Ray, G Thomas; Myers, Laura C; Ramaprasad, Charulata M; Dlott, Richard; Lee, Catherine

Ann Intern Med. 2021 06;174(6):786-793. Epub 2021-02-09.

PubMed abstract

Regionalization of Acute Myeloid Leukemia Treatment in a Community-Based Population: Implementation and Early Results

Authors: Law, Lisa Y; Uong, Stephen P; Vempaty, Hyma T; Nguyen, Vu H; Baer, David; Liu, Vincent X; Herrinton, Lisa J

Perm J. 2021 05;25.

PubMed abstract

Nonstationary Multivariate Gaussian Processes for Electronic Health Records

Authors: Meng, Rui; Soper, Braden; Lee, Herbert K H; Liu, Vincent X; Greene, John D; Ray, Priyadip

J Biomed Inform. 2021 05;117:103698. Epub 2021-02-19.

PubMed abstract

Sepsis Subclasses: A Framework for Development and Interpretation

Authors: DeMerle, Kimberley M; Liu, Vincent; Seymour, Christopher W; et al.

Crit Care Med. 2021 05 01;49(5):748-759.

PubMed abstract

Measurement of Sepsis in a National Cohort Using Three Different Methods to Define Baseline Organ Function

Authors: Wayne, Max T; Molling, Daniel; Wang, Xiao Qing; Hogan, Cainnear K; Seelye, Sarah; Liu, Vincent X; Prescott, Hallie C

Ann Am Thorac Soc. 2021 04;18(4):648-655.

PubMed abstract

The Presentation, Pace, and Profile of Infection and Sepsis Patients Hospitalized Through the Emergency Department: An Exploratory Analysis

Authors: Liu, Vincent X; Bhimarao, Meghana; Greene, John D; Manickam, Raj N; Martinez, Adriana; Schuler, Alejandro; Barreda, Fernando; Escobar, Gabriel J

Crit Care Explor. 2021 Mar;3(3):e0344. Epub 2021-02-24.

PubMed abstract

Characteristics and Outcomes of Clinic Visits Immediately Preceding Sepsis Hospitalization

Authors: Miller, H Catherine; Liu, Vincent X; Prescott, Hallie C

Am J Crit Care. 2021 03 01;30(2):135-139.

PubMed abstract

Automated Identification of Adults at Risk for In-Hospital Clinical Deterioration. Reply

Authors: Escobar GJ; Liu VX; Kipnis P

N Engl J Med. 2021 02 04;384(5):486.

PubMed abstract

Development and Validation of an Obstetric Comorbidity Risk Score for Clinical Use

Authors: Ruppel, Halley; Liu, Vincent X; Kipnis, Patricia; Hedderson, Monique M; Greenberg, Mara; Forquer, Heather; Lawson, Brian; Escobar, Gabriel J

Womens Health Rep (New Rochelle). 2021;2(1):507-515. Epub 2021-11-02.

PubMed abstract

The future of AI in critical care is augmented, not artificial, intelligence

Authors: Liu, Vincent X

Crit Care. 2020 12 02;24(1):673. Epub 2020-12-02.

PubMed abstract

Predicting preventable hospital readmissions with causal machine learning

Authors: Marafino, Ben J; Schuler, Alejandro; Liu, Vincent X; Escobar, Gabriel J; Baiocchi, Mike

Health Serv Res. 2020 12;55(6):993-1002. Epub 2020-10-30.

PubMed abstract

Automated Identification of Adults at Risk for In-Hospital Clinical Deterioration

Authors: Escobar, Gabriel J; Liu, Vincent X; Schuler, Alejandro; Lawson, Brian; Greene, John D; Kipnis, Patricia

N Engl J Med. 2020 11 12;383(20):1951-1960.

PubMed abstract

Expanding Post-discharge Readmission Metrics in Patients with Chronic Obstructive Pulmonary Disease

Authors: Myers, Laura C; Camargo, Carlos; Escobar, Gabriel; Liu, Vincent X

Chronic Obstr Pulm Dis. 2020 Nov 06.

PubMed abstract

Association of a Novel Index of Hospital Capacity Strain with Admission to Intensive Care Units

Authors: Anesi GL; Chowdhury M; Small DS; Delgado MK; Kohn R; Bayes B; Wang W; Dress E; Escobar GJ; Halpern SD; Liu VX

Ann Am Thorac Soc. 2020 11;17(11):1440-1447.

PubMed abstract

Estimates of Workload Associated With Suicide Risk Alerts After Implementation of Risk-Prediction Model

Authors: Kline-Simon, Andrea H; Sterling, Stacy; Young-Wolff, Kelly; Simon, Gregory; Lu, Yun; Does, Monique; Liu, Vincent

JAMA Netw Open. 2020 10 01;3(10):e2021189. Epub 2020-10-01.

PubMed abstract

Assessment of Value of Neighborhood Socioeconomic Status in Models That Use Electronic Health Record Data to Predict Health Care Use Rates and Mortality

Authors: Schuler, Alejandro; O'Súilleabháin, Liam; Rinetti-Vargas, Gina; Kipnis, Patricia; Barreda, Fernando; Liu, Vincent X; Sofrygin, Oleg; Escobar, Gabriel J

JAMA Netw Open. 2020 10 01;3(10):e2017109. Epub 2020-10-01.

PubMed abstract

Evaluation of automated computed tomography segmentation to assess body composition and mortality associations in cancer patients

Authors: Cespedes Feliciano EM; Liu V; Caan BJ; et al.

J Cachexia Sarcopenia Muscle. 2020 10;11(5):1258-1269. Epub 2020-04-20.

PubMed abstract

Associations of CYP2C9 and CYP2C19 pharmacogenetic variation with phenytoin-induced cutaneous adverse drug reactions

Authors: Fohner AE; Rettie AE; Thai KK; Ranatunga DK; Lawson BL; Liu VX; Schaefer CA

Clin Transl Sci. 2020 09;13(5):1004-1009. Epub 2020-04-18.

PubMed abstract

Developing a template matching algorithm for benchmarking hospital performance in a diverse, integrated healthcare system

Authors: Molling D; Vincent BM; Wiitala WL; Escobar GJ; Hofer TP; Liu VX; Rosen AK; Ryan AM; Seelye S; Prescott HC

Medicine (Baltimore). 2020 Jun 12;99(24):e20385.

PubMed abstract

Characteristics of Hospitalized Adults With COVID-19 in an Integrated Health Care System in California

Authors: Myers LC; Parodi SM; Escobar GJ; Liu VX

JAMA. 2020 Jun 02;323(21):2195-2198.

PubMed abstract

Incidence, clinical outcomes, and transmission dynamics of severe coronavirus disease 2019 in California and Washington: prospective cohort study

Authors: Lewnard JA; Liu VX; Bellows J; et al.

BMJ. 2020 May 22;369:m1923. Epub 2020-05-22.

PubMed abstract

COVID-19: Long-term Planning for Procedure-based Specialties During Extended Mitigation and Suppression Strategies

Authors: Rouillard S; Liu VX; Corley DA

Gastroenterology. 2020 May 18.

PubMed abstract

The Impact of Step-Down Unit Care on Patient Outcomes After ICU Discharge

Authors: Lekwijit S; Chan CW; Green LV; Liu VX; Escobar GJ

Crit Care Explor. 2020 May;2(5):e0114. Epub 2020-05-06.

PubMed abstract

Comparison of Early Warning Scoring Systems for Hospitalized Patients With and Without Infection at Risk for In-Hospital Mortality and Transfer to the Intensive Care Unit

Authors: Liu VX; Escobar GJ; Churpek MM; et al.

JAMA Netw Open. 2020 May 01;3(5):e205191. Epub 2020-05-01.

PubMed abstract

From Containment to Mitigation of COVID-19 in the US

Authors: Parodi SM; Liu VX

JAMA. 2020 04 21;323(15):1441-1442.

PubMed abstract

The Role of Professional Organizations in Fostering the Early Career Development of Academic Intensivists

Authors: Vail EA; Nadig NR; Sahetya SK; Vande Vusse LK; Walkey AJ; Liu V; Mathews KS

Ann Am Thorac Soc. 2020 04;17(4):412-418.

PubMed abstract

Assessment of Electronic Health Record Search Patterns and Practices by Practitioners in a Large Integrated Health Care System

Authors: Ruppel H; Bhardwaj A; Manickam RN; Adler-Milstein J; Flagg M; Ballesca M; Liu VX

JAMA Netw Open. 2020 03 02;3(3):e200512. Epub 2020-03-02.

PubMed abstract

Web Exclusive. Annals for Hospitalists Inpatient Notes – The Role of Hospitalists in the Creation of Learning Healthcare Systems

Authors: Gilmartin HM; Liu VX; Burke RE

Ann Intern Med. 2020 01 21;172(2):HO2-HO3.

PubMed abstract

‘No growth to date’? Predicting positive blood cultures in critical illness

Authors: Liu VX; Wiens J

Intensive Care Med. 2020 Jan 21.

PubMed abstract

Goldilocks, the Three Bears and Intensive Care Unit Utilization: Delivering Enough Intensive Care But Not Too Much. A Narrative Review

Authors: Myers LC; Escobar G; Liu VX

Pulm Ther. 2020 Jan 03.

PubMed abstract

Context is Key: Using the Audit Log to Capture Contextual Factors Affecting Stroke Care Processes

Authors: Noshad, Morteza; Rose, Christian C; Thombley, Robert; Chiang, Jonathan; Corbin, Conor K; Nguyen, Minh; Liu, Vincent X; Adler-Milstein, Julia; Chen, Jonathan H

AMIA Annu Symp Proc. 2020;2020:953-962. Epub 2021-01-25.

PubMed abstract

Association Between Peripheral Blood Oxygen Saturation (SpO2)/Fraction of Inspired Oxygen (FiO2) Ratio Time at Risk and Hospital Mortality in Mechanically Ventilated Patients

Authors: Adams JY; Rogers AJ; Schuler A; Marelich GP; Fresco JM; Taylor SL; Riedl AW; Baker JM; Escobar GJ; Liu VX

Perm J. 2020;24. Epub 2020-01-31.

PubMed abstract

Multiyear Rehospitalization Rates and Hospital Outcomes in an Integrated Health Care System

Authors: Escobar GJ; Plimier C; Greene JD; Liu V; Kipnis P

JAMA Netw Open. 2019 12 02;2(12):e1916769. Epub 2019-12-02.

PubMed abstract

Assessing clinical heterogeneity in sepsis through treatment patterns and machine learning

Authors: Fohner AE; Greene JD; Lawson BL; Chen JH; Kipnis P; Escobar GJ; Liu VX

J Am Med Inform Assoc. 2019 12 01;26(12):1466-1477.

PubMed abstract

The number needed to benefit: estimating the value of predictive analytics in healthcare

Authors: Liu VX; Bates DW; Wiens J; Shah NH

J Am Med Inform Assoc. 2019 12 01;26(12):1655-1659.

PubMed abstract

Postoperative Opioid Use Before and After Enhanced Recovery After Surgery Program Implementation

Authors: Liu VX; Eaton A; Lee DC; Reyes VM; Paulson SS; Campbell CI; Avins AL; Parodi SM

Ann Surg. 2019 12;270(6):e69-e71.

PubMed abstract

Assessing the clinical impact of CYP2C9 pharmacogenetic variation on phenytoin prescribing practice and patient response in an integrated health system

Authors: Fohner AE; Ranatunga DK; Thai KK; Lawson BL; Risch N; Oni-Orisan A; Jelalian AT; Rettie AE; Liu VX; Schaefer CA

Pharmacogenet Genomics. 2019 10;29(8):192-199.

PubMed abstract

More Than We Bargained For: The “Dominating” Cost Effectiveness of Sepsis Quality Improvement?

Authors: Peltan ID; Liu VX

Crit Care Med. 2019 10;47(10):1464-1467.

PubMed abstract

Effect of donor, component and recipient characteristics on hemoglobin increments following red blood cell transfusion

Authors: Roubinian NH; Plimier C; Woo JP; Lee C; Bruhn R; Liu VX; Escobar GJ; Kleinman SH; Triulzi DJ; Murphy EL; Busch MP

Blood. 2019 09 26;134(13):1003-1013. Epub 2019-07-26.

PubMed abstract

Enhanced Recovery After Surgery to Change Process Measures and Reduce Opioid Use After Cesarean Delivery: A Quality Improvement Initiative

Authors: Hedderson M; Campbell C; Quesenberry C; Liu V; et al.

Obstet Gynecol. 2019 09;134(3):511-519.

PubMed abstract

Do no harm: a roadmap for responsible machine learning for health care

Authors: Wiens J; Liu VX; Goldenberg A; et al.

Nat Med. 2019 09;25(9):1337-1340. Epub 2019-08-19.

PubMed abstract

Identifying Common Predictors of Multiple Adverse Outcomes Among Elderly Adults With Type-2 Diabetes

Authors: Kabue S; Liu V; Dyer W; Raebel M; Nichols G; Schmittdiel J

Med Care. 2019 09;57(9):702-709.

PubMed abstract

To catch a killer: electronic sepsis alert tools reaching a fever pitch?

Authors: Ruppel H; Liu V

BMJ Qual Saf. 2019 09;28(9):693-696. Epub 2019-04-23.

PubMed abstract

Association between Inpatient Delirium and Hospital Readmission in Patients ≥ 65 Years of Age: A Retrospective Cohort Study

Authors: LaHue SC; Douglas VC; Kuo T; Conell CA; Liu VX; Josephson SA; Angel C; Brooks KB

J Hosp Med. 2019 04;14(4):201-206.

PubMed abstract

The Impact of Pharmacy-specific Predictors on the Performance of 30-Day Readmission Risk Prediction Models

Authors: Kabue S; Greene J; Kipnis P; Lawson B; Rinetti-Vargas G; Liu V; Escobar G

Med Care. 2019 04;57(4):295-299.

PubMed abstract

Statistical Modeling and Aggregate-Weighted Scoring Systems in Prediction of Mortality and ICU Transfer: A Systematic Review

Authors: Linnen DT; Escobar GJ; Hu X; Scruth E; Liu V; Stephens C

J Hosp Med. 2019 Mar;14(3):161-169.

PubMed abstract

Long-Term Outcomes Among Patients Discharged From the Hospital With Moderate Anemia: A Retrospective Cohort Study

Authors: Roubinian NH; Murphy EL; Mark DG; Triulzi DJ; Carson JL; Lee C; Kipnis P; Kleinman S; Liu VX; Escobar GJ

Ann Intern Med. 2019 01 01;170(1):80.

PubMed abstract

Inpatient electronic health record maintenance from 2010 to 2015

Authors: Liu VX; Haq N; Chan IC; Hoberman B

Am J Manag Care. 2019 01;25(1):18-21.

PubMed abstract

Associations of ICU Capacity Strain with Disposition and Outcomes of Patients with Sepsis Presenting to the Emergency Department

Authors: Anesi GL; Liu VX; Gabler NB; Delgado MK; Kohn R; Weissman GE; Bayes B; Escobar GJ; Halpern SD

Ann Am Thorac Soc. 2018 11;15(11):1328-1335.

PubMed abstract

Association between Inhaled Corticosteroid Use and Pulmonary Nontuberculous Mycobacterial Infection

Authors: Liu VX; Winthrop KL; Lu Y; Sharifi H; Nasiri HU; Ruoss SJ

Ann Am Thorac Soc. 2018 10;15(10):1169-1176.

PubMed abstract

Risk Adjustment for Hospital Characteristics Reduces Unexplained Hospital Variation in Pressure Injury Risk

Authors: Linnen DT; Kipnis P; Rondinelli J; Greene JD; Liu V; Escobar GJ

Nurs Res. 2018 Jul/Aug;67(4):314-323.

PubMed abstract

Toward the “Plateau of Productivity”: Enhancing the Value of Machine Learning in Critical Care

Authors: Liu VX

Crit Care Med. 2018 07;46(7):1196-1197.

PubMed abstract

The Impact of Acute Organ Dysfunction on Long-Term Survival in Sepsis

Authors: Schuler A; Wulf DA; Lu Y; Iwashyna TJ; Escobar GJ; Shah NH; Liu VX

Crit Care Med. 2018 06;46(6):843-849.

PubMed abstract

Impact of emergency physician-provided patient education about alternative care venues

Authors: Patel PB; Vinson DR; Gardner MN; Wulf DA; Kipnis P; Liu V; Escobar GJ

Am J Manag Care. 2018 05;24(5):225-231.

PubMed abstract

Mortality Measures to Profile Hospital Performance for Patients With Septic Shock

Authors: Walkey AJ; Shieh MS; Liu VX; Lindenauer PK

Crit Care Med. 2018 Apr 30.

PubMed abstract

Healthcare Utilization and Infection in the Week Prior to Sepsis Hospitalization

Authors: Liu VX; Escobar GJ; Chaudhary R; Prescott HC

Crit Care Med. 2018 04;46(4):513-516.

PubMed abstract

Flexible, Cluster-Based Analysis of the Electronic Medical Record of Sepsis with Composite Mixture Models

Authors: Mayhew MB; Petersen BK; Sales AP; Greene JD; Liu VX; Wasson TS

J Biomed Inform. 2018 02;78:33-42. Epub 2017-12-02.

PubMed abstract

Hospital-Acquired Pressure Injury: Risk-Adjusted Comparisons in an Integrated Healthcare Delivery System

Authors: Rondinelli J; Zuniga S; Kipnis P; Kawar LN; Liu V; Escobar GJ

Nurs Res. 2018 Jan/Feb;67(1):16-25.

PubMed abstract

Machine Learning and Sepsis: On the Road to Revolution

Authors: Liu VX; Walkey AJ

Crit Care Med. 2017 11;45(11):1946-1947.

PubMed abstract

Comparing Hospital Processes and Outcomes in California Medicare Beneficiaries: Simulation Prompts Reconsideration

Authors: Escobar GJ; Baker JM; Turk BJ; Draper D; Liu V; Kipnis P

Perm J. 2017;21.

PubMed abstract

Identifying Distinct Subgroups of ICU Patients: A Machine Learning Approach

Authors: Vranas KC; Jopling JK; Sweeney TE; Ramsey MC; Milstein AS; Slatore CG; Escobar GJ; Liu VX

Crit Care Med. 2017 Oct;45(10):1607-1615.

PubMed abstract

Reply to the Timing of Early Antibiotics and Hospital Mortality in Sepsis – Playing Devil’s Advocate

Authors: X Liu V; Fielding-Singh V; Iwashyna TJ; Bhattacharya J; Escobar GJ

Am J Respir Crit Care Med. 2017 10 01;196(7):935-936.

PubMed abstract

The Timing of Early Antibiotics and Hospital Mortality in Sepsis

Authors: Liu VX; Fielding-Singh V; Greene JD; Baker JM; Iwashyna TJ; Bhattacharya J; Escobar GJ

Am J Respir Crit Care Med. 2017 Oct 01;196(7):856-863.

PubMed abstract

Prediction of Recurrent Clostridium Difficile Infection Using Comprehensive Electronic Medical Records in an Integrated Healthcare Delivery System

Authors: Escobar GJ; Baker JM; Kipnis P; Greene JD; Mast TC; Gupta SB; Cossrow N; Mehta V; Liu V; Dubberke ER

Infect Control Hosp Epidemiol. 2017 Aug 24:1-8.

PubMed abstract

Individual and health system variation in rehospitalizations the year after pneumonia

Authors: Viglianti EM; Prescott HC; Liu V; Escobar GJ; Iwashyna TJ

Medicine (Baltimore). 2017 Aug;96(31):e7695.

PubMed abstract

Innovation and Technology: Electronic Intensive Care Unit Diaries

Authors: Scruth EA; Oveisi N; Liu V

AACN Adv Crit Care. 2017 Summer;28(2):191-199.

PubMed abstract

Enhanced Recovery After Surgery Program Implementation in 2 Surgical Populations in an Integrated Health Care Delivery System

Authors: Liu VX; Rosas E; Hwang J; Cain E; Foss-Durant A; Clopp M; Huang M; Lee DC; Mustille A; Kipnis P; Parodi S

JAMA Surg. 2017 Jul 19;152(7):e171032. Epub 2017-07-19.

PubMed abstract

Hospital Readmissions in Sepsis Survivors: Are They Preventable?

Authors: Goodwin AJ; Liu V; Ford DW

Ann Am Thorac Soc. 2017 02;14(2):170-171.

PubMed abstract

Utilization of Health Services Among Adults With Recurrent Clostridium difficile Infection: A 12-Year Population-Based Study

Authors: Kuntz JL; Baker JM; Kipnis P; Li SX; Liu V; Xie Y; Marcella S; Escobar GJ

Infect Control Hosp Epidemiol. 2017 Jan;38(1):45-52. Epub 2016-10-20.

PubMed abstract

The Kaiser Permanente Northern California Enhanced Recovery After Surgery Program: Design, Development, and Implementation

Authors: Liu VX; Parodi S; et al.

Perm J. 2017;21.

PubMed abstract

Validation of Administrative Definitions of Invasive Mechanical Ventilation across 30 Intensive Care Units

Authors: Kerlin MP; Weissman GE; Wonneberger KA; Kent S; Madden V; Liu VX; Halpern SD

Am J Respir Crit Care Med. 2016 12 15;194(12):1548-1552.

PubMed abstract

Incorporating an Early Detection System Into Routine Clinical Practice in Two Community Hospitals

Authors: Dummett BA; Adams C; Scruth E; Liu V; Guo M; Escobar GJ

J Hosp Med. 2016 Nov;11 Suppl 1:S25-S31.

PubMed abstract

Piloting electronic medical record-based early detection of inpatient deterioration in community hospitals

Authors: Escobar GJ; Turk BJ; Ragins A; Ha J; Hoberman B; LeVine SM; Ballesca MA; Liu V; Kipnis P

J Hosp Med. 2016 Nov;11 Suppl 1:S18-S24.

PubMed abstract

Data that drive: Closing the loop in the learning hospital system

Authors: Liu VX; Morehouse JW; Baker JM; Greene JD; Kipnis P; Escobar GJ

J Hosp Med. 2016 Nov;11 Suppl 1:S11-S17.

PubMed abstract

Can You Read Me Now? Unlocking Narrative Data with Natural Language Processing

Authors: Sjoding MW; Liu VX

Ann Am Thorac Soc. 2016 09;13(9):1443-5.

PubMed abstract

16 Years and Counting? Time to Implement Noninvasive Screening for ARDS

Authors: Rogers AJ; Liu VX

Chest. 2016 08;150(2):266-7.

PubMed abstract

Loud and Clear: Sensory Impairment, Delirium, and Functional Recovery in Critical Illness

Authors: LaHue SC; Liu VX

Am J Respir Crit Care Med. 2016 08 01;194(3):252-3.

PubMed abstract

In-hospital mortality following treatment with red blood cell transfusion or inotropic therapy during early goal-directed therapy for septic shock: a retrospective propensity-adjusted analysis

Authors: Mark DG; Morehouse JW; Hung YY; Kene MV; Elms AR; Liu V; Ballard DW; Vinson DR

Crit Care. 2014;18(5):496. Epub 2014-09-12.

PubMed abstract

Towards Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and ARDS Clinical Trial Design

Authors: Prescott HC; Calfee CS; Thompson BT; Angus DC; Liu VX

Am J Respir Crit Care Med. 2016 Jul 15;194(2):147-55.

PubMed abstract

Multicenter Implementation of a Treatment Bundle for Sepsis Patients with Intermediate Lactate Values

Authors: Liu VX; Morehouse JW; Marelich GP; Soule J; Russell T; Skeath M; Adams C; Escobar GJ; Whippy A

Am J Respir Crit Care Med. 2016 Jun 01;193(11):1264-70.

PubMed abstract

Developing a framework for implementing intensive care unit diaries: a focused review of the literature

Authors: Beg M; Scruth E; Liu V

Aust Crit Care. 2016 May 27.

PubMed abstract

The Natural History of Changes in Preferences for Life-Sustaining Treatments and Implications for Inpatient Mortality in Younger and Older Hospitalized Adults

Authors: Kim YS; Escobar GJ; Halpern SD; Greene JD; Kipnis P; Liu V

J Am Geriatr Soc. 2016 May;64(5):981-9. Epub 2016-04-27.

PubMed abstract

Keeping Score of Severity Scores: Taking the Next Step

Authors: Liu V

Crit Care Med. 2016 Mar;44(3):639-40.

PubMed abstract

Evaluation Following Staggered Implementation of the “Rethinking Critical Care” ICU Care Bundle in a Multicenter Community Setting

Authors: Liu V; Herbert D; Foss-Durant A; Marelich GP; Patel A; Whippy A; Turk BJ; Ragins AI; Kipnis P; Escobar GJ

Crit Care Med. 2016 Mar;44(3):460-7.

PubMed abstract

Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Authors: Shankar-Hari M; Phillips GS; Levy ML; Seymour CW; Liu VX; Deutschman CS; Angus DC; Rubenfeld GD; Singer M; Sepsis Definitions Task Force

JAMA. 2016 Feb 23;315(8):775-87.

PubMed abstract

Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Authors: Seymour CW; Liu VX; Angus DC; et al.

JAMA. 2016 Feb 23;315(8):762-74.

PubMed abstract

Treatment of Alcohol Withdrawal Syndrome with and without Dexmedetomidine

Authors: Beg M; Fisher S; Siu D; Rajan S; Troxell L; Liu VX

Perm J. 2016 spring;20(2):49-53.

PubMed abstract

Consensus Statement on Electronic Health Predictive Analytics: A Guiding Framework to Address Challenges

Authors: Amarasingham R; Liu V; Xie B; et al.

EGEMS (Wash DC). 2016;4(1):1163. Epub 2016-03-07.

PubMed abstract

Variation in the Contents of Sepsis Bundles and Quality Measures: A Systematic Review

Authors: Kramer RD; Cooke CR; Liu V; Miller RR; Iwashyna TJ

Ann Am Thorac Soc. 2015 Nov;12(11):1676-84.

PubMed abstract

Decreasing sepsis mortality at Kaiser Permanente Northern California

Authors: Liu V; Whippy A; Morehouse JW

Am J Emerg Med. 2015 Sep;33(9):1305-6. Epub 2014-08-02.

PubMed abstract

Impact of Relative Contraindications to Home Management in Emergency Department Patients with Low-Risk Pulmonary Embolism

Authors: Vinson DR; Drenten CE; Huang J; Morley JE; Anderson ML; Reed ME; Nishijima DK; Liu V; Kaiser Permanente Clinical Research on Emergency Services and Treatment (CREST) Network

Ann Am Thorac Soc. 2015 May;12(5):666-73.

PubMed abstract

Data breaches of protected health information in the United States

Authors: Liu V; Musen MA; Chou T

JAMA. 2015 Apr 14;313(14):1471-3.

PubMed abstract

The Accuracy of an Electronic Pulmonary Embolism Severity Index Auto-Populated from the Electronic Health Record: Setting the stage for computerized clinical decision support

Authors: Vinson DR; Morley JE; Huang J; Liu V; Anderson ML; Drenten CE; Radecki RP; Nishijima DK; Reed ME; Kaisers Permanente CREST Network

Appl Clin Inform. 2015;6(2):318-33. Epub 2015-05-13.

PubMed abstract

Trends in red blood cell transfusion and 30-day mortality among hospitalized patients

Authors: Roubinian NH; Liu V; NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III); et al.

Transfusion. 2014 Oct;54(10 Pt 2):2678-86. Epub 2014-08-18.

PubMed abstract

Hospital readmission and healthcare utilization following sepsis in community settings

Authors: Liu V; Lei X; Prescott HC; Kipnis P; Iwashyna TJ; Escobar GJ

J Hosp Med. 2014 Aug;9(8):502-7. Epub 2014-04-04.

PubMed abstract

Decreased Red Blood Cell Use and Mortality in Hospitalized Patients

Authors: Roubinian NH; Escobar GJ; Liu V; Gardner MN; Carson JL; Kleinman SH; Murphy EL; NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III)

JAMA Intern Med. 2014 Aug;174(8):1405-7.

PubMed abstract

Hospital Deaths in Patients With Sepsis From 2 Independent Cohorts

Authors: Liu V; Escobar GJ; Greene JD; Soule J; Whippy A; Angus DC; Iwashyna TJ

JAMA. 2014 Jul 2;312(1):90-2.

PubMed abstract

Increased one-year health care utilization in survivors of severe sepsis

Authors: Prescott HC; Langa KM; Liu V; Escobar GJ; Iwashyna TJ

Am J Respir Crit Care Med. 2014 Jul 1;190(1):62-9.

PubMed abstract

Only Time Will Tell. Data-driven Approaches to Phenotyping Critical Illness

Authors: Liu V

Ann Am Thorac Soc. 2014 Jun;11(5):795-6.

PubMed abstract

Accuracy of hospital standardized mortality rates: effects of model calibration

Authors: Kipnis P; Liu V; Escobar GJ

Med Care. 2014 Apr;52(4):378-84.

PubMed abstract

Predicting red blood cell transfusion in hospitalized patients: role of hemoglobin level, comorbidities, and illness severity

Authors: Roubinian NH; Murphy EL; Swain BE; Gardner MN; Liu V; Escobar GJ; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III); Northern California Kaiser Permanente DOR Systems Research Initiative

BMC Health Serv Res. 2014;14:213. Epub 2014-05-10.

PubMed abstract

Fluid Volume, Lactate Values, and Mortality in Sepsis Patients with Intermediate Lactate Values

Authors: Liu V; Morehouse JW; Soule J; Whippy A; Escobar GJ

Ann Am Thorac Soc. 2013 Oct;10(5):466-73.

PubMed abstract

Automated identification of pneumonia in chest radiograph reports in critically ill patients

Authors: Liu V; Clark MP; Mendoza M; Saket R; Gardner MN; Turk BJ; Escobar GJ

BMC Med Inform Decis Mak. 2013;13:90. Epub 2013-08-15.

PubMed abstract

Visitation policies and practices in United States intensive care units

Authors: Liu V; Read JL; Scruth E; Cheng E

Crit Care. 2013;17(2):R71. Epub 2013-04-16.

PubMed abstract

An electronic simplified acute physiology score-based risk adjustment score for critical illness in an integrated healthcare system*

Authors: Liu V; Turk BJ; Ragins AI; Kipnis P; Escobar GJ

Crit Care Med. 2013 Jan;41(1):41-8.

PubMed abstract

Risk factors for unplanned transfer to intensive care within 24 hours of admission from the emergency department in an integrated healthcare system

Authors: Delgado MK; Liu V; Pines JM; Kipnis P; Gardner MN; Escobar GJ

J Hosp Med. 2013 Jan;8(1):13-9. Epub 2012 Sep 28.

PubMed abstract

The association between sepsis and potential medical injury among hospitalized patients

Authors: Liu V; Turk BJ; Rizk NW; Kipnis P; Escobar GJ

Chest. 2012 Sep;142(3):606-13.

PubMed abstract

Potential for overuse of corticosteroids and vasopressin in septic shock

Authors: Hsu JL; Liu V; Patterson AJ; Martin GS; Nicolls MR; Russell JA

Crit Care. 2012;16(5):447. Epub 2012-09-06.

PubMed abstract