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Vincent X. Liu, MD, MS


Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-5933 (phone)
Kaiser Permanente Researcher Profiles


Vincent Liu, MD, MS, is a senior research scientist at the Kaiser Permanente Northern California Division of Research. He also directs the Systems Research Initiative, a multidisciplinary team at the Division of Research supported by The Permanente Medical Group (TPMG). His work focuses on the intersection of sepsis, acute severe illness, informatics, and health care delivery with a goal of building towards a learning hospital system. He is a widely recognized expert in applied informatics.

Dr. Liu is board certified in Internal Medicine, Pulmonary Disease, Critical Care Medicine, and Clinical Informatics. He practices pulmonary and critical care medicine with TPMG. 

Dr. Liu is the Regional Director of Hospital Advanced Analytics in Kaiser Permanente Northern California. He has led and served on committees for the American Thoracic Society, the Society of Critical Care Medicine, the National Quality Forum, and the National Institute for General Medical Services. He has served on multiple NIH grant review committees and the National Commission on Quality Assurance's Utilization Measure Advisory Panel. He is an editorial board member for Critical Care Medicine.

He is also an active mentor and leads the TPMG Informatics Fellowship Program.

Dr. Liu received his undergraduate degree from the University of Pennsylvania and his medical degree from New York University. He completed his residency training at New York University Hospitals (Bellevue) and a chief residency at Memorial Sloan-Kettering Cancer Center. He also completed a pulmonary and critical care medicine fellowship and has master's degrees in Health Services Research and Biomedical Informatics, both from Stanford University.

Current Position(s):

  • Research Scientist III, Division of Research, Kaiser Permanente Northern California
  • Intensivist, Critical Care, Kaiser Permanente Medical Center, Santa Clara, California
  • Clinical Assistant Professor of Medicine (Affiliated), Stanford University, Stanford, California
  • Regional Director, Hospital Advanced Analytics, Kaiser Permanente Northern California

Section Affiliations:

Primary Research Interests:

  • Critical Care and Inpatient Health Services Research
  • Sepsis
  • Data Science
  • Delivery and Implementation Science
  • Electronic Decision Support
  • Health Informatics

    Machine Learning Applied to EHR Data as a Means of Improving Biosurveillance and Diagnostic Excellence: A Pilot Project

    We aim to develop and extend methods of probabilistic modeling of temporal electronic health record (EHR) data, using non-stationary Gaussian processes, hidden Markov models, and composite mixture models, to identify opportunities to conduct clinical biosurveillance and to achieve diagnostic excellence. Building off collaboration between KP DOR and the Lawrence Livermore National Laboratory, this proposal will use population-level EHR data, AI/ML methods and advanced computing to evaluate associations between health system diagnostic testing/treatment and prevalent/incident health conditions and to identify areas of potential diagnostic uncertainty.
    Investigator: Liu, Vincent

    Turning back the clock on sepsis: Defining the epidemiology and opportunities of pre-sepsis

    We intend to determine the epidemiology of pre-sepsis, including ambulatory and prehospital care settings, to identify modifiable care delays, opportunities for primary sepsis prevention, and to improve early sepsis care for vulnerable populations. The objectives include determining the epidemiology of pre-sepsis care across ambulatory and prehospital settings using linked EHR data; measuring delays in pre-sepsis care; and understanding the patient-level variation in pre-sepsis care and delays in vulnerable populations. The project is a collaboration between KPNC and University of Pittsburgh Medical Center.
    Investigator: Liu, Vincent
    Funder: Gordon and Betty Moore Foundation

    Evaluation of Risk-Based Predictive Models to Inform the Efficiency of Perioperative Systems

    We previously developed an automated electronic health record-based risk stratification tool, called the Comorbidity Assessment and Surgical Triage (CAST) score, which we implemented in KP HealthConnect to improve triage of elective surgical patients to perioperative medicine clinic visit types in real-time. This project seeks to improve the efficiency of operative workflows by evaluating the impact of CAST implementation on pre-operative workflows and surgical outcomes; characterizing patients with discordant risk assessments between CAST and the clinician; and evaluating the association between CAST and operative resources, including surgical case duration.
    Investigator: Liu, Vincent
    Funder: TPMG Delivery Science Projects Program

    Effectiveness and safety of treatments for hospitalized patients with COVID-19

    Examine the safety and effectiveness of current treatments for hospitalized patients with COVID-19 and identify patient characteristics and time periods during the disease course that are associated with more favorable treatment response.
    Investigator: Liu, Vincent
    Funder: Garfield Memorial Fund

    Sepsis on FHIR

    Overall goal is to define and refine the current epidemiology, clinical characteristics, and treatment practices in respiratory failure in late and moderately preterm infants. Specific aims are to determine that incidence and epidemiology of respiratory failure in neonates born 32-36 weeks of gestation between 2012 and 2017 in Kaiser Permanente Northern California facilities; describe disease severity and respiratory support by diagnostic category; describe use of surfactant replacement therapy; and assess the impact of surfactant replacement therapy on length of respiratory support, length of hospitalization, and respiratory outcomes in the first year of life.
    Investigator: Liu, Vincent
    Funder: Moore Foundation

    Understanding and Informing Early Hospital Antibiotic Prescribing for Potential Infection

    The goals of this study are to (1) examine temporal trends in early hospital antibiotic prescribing patterns over the past 5 years, to assess for unintended consequences associated with earlier antibiotics in severe sepsis/septic shock; (2) quantify the patient-level harm associated with receipt of unnecessary antibiotics; and (3) identify subsets of patients, discernable in real-time with high certainty, who benefit from immediate antibiotics, versus the subsets of patients for whom it is safe to delay antibiotics by 3 hours (thereby allowing time for rapid diagnostics, such as procalcitonin).
    Investigator: Liu, Vincent
    Funder: Agency for Healthcare Research and Quality

    Targeting Cardiovascular Events to Improve Patient Outcomes After Sepsis

    Sepsis is the most common illness leading to hospitalization in the United States, affecting more than 1 million Americans each year. While short-term mortality has improved over prior decades, sepsis survivors face numerous post-hospital sequelae that negatively impact long-term morbidity and mortality. Cardiovascular complications are among the most common reasons for re-hospitalization and death after sepsis, with approximately 1 in 3 severe sepsis patients experiencing a cardiovascular complication in the year after sepsis hospitalization. This project seeks to identify risk factors for post-sepsis cardiovascular risk based on granular inpatient data collected during hospitalization, and identify potential opportunities to reduce post-sepsis cardiovascular risk.
    Investigator: Liu, Vincent
    Funder: National Heart, Lung, and Blood Institute

    Using EHR Audit Logs to Capture Diagnostic Pathways and Time to Diagnosis

    Rapid expansions in the use of electronic health record (EHR) systems also contribute to large expansions in the availability of metadata. These highly granular metadata may prove particularly useful for understanding how frontline clinicians interact with clinical information when making diagnostic decisions. This project aims to characterize EHR audit log data and advance nascent understanding of the potential to leverage these to provide novel insights into the diagnostic process, with a focus on time to diagnosis, and ultimately inform the achievement of diagnostic excellence.
    Investigator: Liu, Vincent
    Funder: Gordon and Betty Moore Foundation

    Identifying Pre-Sepsis Opportunities for Early, Targeted Intervention

    Early evidence suggests there will be ongoing waves of COVID-19 outbreak that can be mitigated through effective community-level prediction models and intervention. This project will Identify pre-sepsis opportunities for early, targeted intervention to inform community-level mitigation strategies of upcoming COVID19 surges.
    Investigator: Liu, Vincent
    Funder: National Institute of General Medical Sciences

    Benchmarking Hospital Quality - Template Matching

    ​In this study, Kaiser Permanente Northern California researchers will serve as consultants for U.S. Department of Veterans Affairs (VA) researchers to evaluate the utility of template matching techniques, compared with standard regression techniques, for comparing hospital quality.
    Investigator: Liu, Vincent
    Funder: U.S. Department of Veterans Affairs

    Benefits of Intensive Care Unit Admission for Patients with Acute Respiratory Failure or Sepsis

    Ideal and optimally efficient use of intensive care unit (ICU) resources would create benefits across the health care system. Ideal use of ICU resources requires a needs assessment to determine which categories of patients commonly admitted to ICUs derive true net benefit on average from ICU admission versus admission to a regular hospital floor. This project aims to conduct such a needs assessment, which has never before been done.
    Investigator: Liu, Vincent
    Funder: National Heart, Lung, and Blood Institute

    Data-Driven Precision Medicine in Sepsis

    Sepsis is a common and costly disease which contributes to nearly 1 in 2 hospital deaths in our healthcare system. While aggressive early treatment with quantitative resuscitation has demonstrated benefit, many other interventions have not demonstrated efficacy likely resulting from an incomplete understanding of sepsis disease mechanisms. This study seeks to address three questions through innovative approaches to using observational data: (1) what factors can improve our characterization and phenotyping of sepsis patients; (2) what are the potential benefits of using quantitative resuscitation in less severe sepsis subgroups; and (3) how does acute organ dysfunction impact long-term mortality and utilization among sepsis survivors
    Investigator: Liu, Vincent
    Funder: National Institute of General Medical Sciences
    No results found matching criteria

    Use of Sepsis Clinical Prediction Models to Improve Patient Care

    Author(s): Mogri, Murtaza; Grant, Richard W; Liu, Vincent X

    JAMA Intern Med. 2023 Apr 03.

    PubMed abstract

    Performance of a Prediction Model of Suicide Attempts Across Race and Ethnicity

    Author(s): Papini, Santiago; Hsin, Honor; Kipnis, Patricia; Liu, Vincent X; Lu, Yun; Sterling, Stacy A; Iturralde, Esti

    JAMA Psychiatry. 2023 Apr 01;80(4):399-400.

    PubMed abstract

    Development and Validation of an Electronic Health Record-based Score for Triage to Perioperative Medicine

    Author(s): Le, Sidney T; Corbin, Dalton; Myers, Laura C; Kipnis, Patricia; Cohn, Bradley; Liu, Vincent X

    Ann Surg. 2023 Mar 01;277(3):e520-e527. Epub 2021-11-09.

    PubMed abstract

    Among-Hospital Variation in ICU Admission Practices and Associated Outcomes for Patients with Acute Respiratory Failure

    Author(s): Anesi, George L; Liu, Vincent X; et al.

    Ann Am Thorac Soc. 2023 Mar;20(3):406-413.

    PubMed abstract

    Practice Patterns and Outcomes Associated With Anticoagulation Use Following Sepsis Hospitalizations With New-Onset Atrial Fibrillation

    Author(s): Walkey, Allan J; Myers, Laura C; Thai, Khanh K; Kipnis, Patricia; Desai, Manisha; Go, Alan S; Lu, Yun; Clancy, Heather; Devis, Ycar; Neugebauer, Romain; Liu, Vincent X

    Circ Cardiovasc Qual Outcomes. 2023 Mar;16(3):e009494. Epub 2023-02-28.

    PubMed abstract

    Risk of venous thromboembolism in non-respiratory and respiratory presentations of COVID-19 in critically ill patients

    Author(s): Roubinian, Nareg H; Vinson, David R; Pai, Ashok P; Myers, Laura C; Skarbinski, Jacek; Lee, Catherine; Mark, Dustin G; Liu, Vincent X

    Chest. 2023 Feb 12.

    PubMed abstract

    Hospital Strain and Variation in Sepsis ICU Admission Practices and Associated Outcomes

    Author(s): Anesi, George L; Dress, Erich; Chowdhury, Marzana; Wang, Wei; Small, Dylan S; Delgado, M Kit; Bayes, Brian; Barreda, Fernando X; Halpern, Scott D; Liu, Vincent X

    Crit Care Explor. 2023 Feb;5(2):e0858. Epub 2023-02-02.

    PubMed abstract

    COVID-19 bacteremic co-infection is a major risk factor for mortality, ICU admission, and mechanical ventilation

    Author(s): Patton, Michael John; Liu, Vincent X; Gaggar, Amit; et al.

    Crit Care. 2023 Jan 23;27(1):34. Epub 2023-01-23.

    PubMed abstract

    Risk of posthospital venous thromboembolism in patients with COVID-19 varies by SARS-CoV-2 period and vaccination status

    Author(s): Roubinian, Nareg H; Vinson, David R; Knudson-Fitzpatrick, Tess Wheeler; Mark, Dustin G; Skarbinski, Jacek; Lee, Catherine; Liu, Vincent X; Pai, Ashok P

    Blood Adv. 2023 Jan 10;7(1):141-144.

    PubMed abstract

    Trends in Outpatient Visits and Hospital and Intensive Care Unit Admissions of Adults With COVID-19 in an Integrated US Health Care System, March 2020 to January 2022

    Author(s): Myers, Laura C; Ng, Kevin; Plimier, Colleen; Daly, Kathleen A; Kipnis, Patricia; Liu, Vincent X

    JAMA Netw Open. 2023 Jan 03;6(1):e2253269. Epub 2023-01-03.

    PubMed abstract

    Predicting Post-Sepsis Cardiovascular Events with Death as a Competing Risk

    Author(s): Myers, Laura C; Lee, Catherine; Go, Alan S; Liu, Vincent X; Walkey, Allan J; et al.

    Ann Am Thorac Soc. 2023 Jan;20(1):145-148.

    PubMed abstract

    Association between anaemia and hospital readmissions in patients undergoing major surgery requiring postoperative intensive care

    Author(s): Warner, M A; Hanson, A C; Plimier, C; Lee, C; Liu, V X; Richards, T; Kor, D J; Roubinian, N H

    Anaesthesia. 2023 Jan;78(1):45-54. Epub 2022-09-08.

    PubMed abstract

    The intensity of anticoagulant dosing in hospitalized patients with COVID-19: An observational, comparative effectiveness study

    Author(s): Myers, Laura C; Xu, Stanley; Chen, Aiyu; Greene, John D; Creekmur, Beth; Bruxvoort, Katia; Escobar, Gabriel J; Adams, John L; Langer-Gould, Annette; Liu, Vincent X; Gould, Michael K

    J Hosp Med. 2023 Jan;18(1):43-54. Epub 2022-11-22.

    PubMed abstract

    Anakinra or high-dose corticosteroids in COVID-19 pneumonia patients who deteriorate on low-dose dexamethasone: An observational study of comparative effectiveness

    Author(s): Langer-Gould, Annette; Xu, Stanley; Myers, Laura C; Chen, Aiyu; Greene, John D; Creekmur, Beth; Bruxvoort, Katia; Adams, John L; Liu, Vincent; Gould, Michael K

    Int J Infect Dis. 2023 Jan;126:87-93. Epub 2022-11-18.

    PubMed abstract

    Risk of hospitalization in a sample of COVID-19 patients with and without chronic obstructive pulmonary disease

    Author(s): Myers, Laura C; Murray, Richard; Donato, Bonnie; Liu, Vincent X; Kipnis, Patricia; Shaikh, Asif; Franchino-Elder, Jessica

    Respir Med. 2023 Jan;206:107064. Epub 2022-11-26.

    PubMed abstract

    Team is brain: leveraging EHR audit log data for new insights into acute care processes

    Author(s): Rose, Christian; Thombley, Robert; Noshad, Morteza; Lu, Yun; Clancy, Heather A; Schlessinger, David; Li, Ron C; Liu, Vincent X; Chen, Jonathan H; Adler-Milstein, Julia

    J Am Med Inform Assoc. 2022 Dec 13;30(1):8-15.

    PubMed abstract

    Persistent Steroid Exposure Before Coronavirus Disease 2019 Diagnosis and Risk of Hospitalization in Patients With Chronic Obstructive Pulmonary Disease

    Author(s): Myers, Laura C; Murray, Richard K; Donato, Bonnie M K; Liu, Vincent X; Kipnis, Patricia; Kipnis, Patricia; Shaikh, Asif; Franchino-Elder, Jessica

    Chronic Obstr Pulm Dis. 2022 Dec 05.

    PubMed abstract

    Characterizing Equity of Intensive Care Unit Admissions for Sepsis and Acute Respiratory Failure

    Author(s): Chesley, Christopher F; Anesi, George L; Chowdhury, Marzana; Schaubel, Doug; Liu, Vincent X; Lane-Fall, Meghan B; Halpern, Scott D

    Ann Am Thorac Soc. 2022 Dec;19(12):2044-2052.

    PubMed abstract

    High-dose corticosteroids in patients hospitalized for COVID-19 pneumonia: an observational study of comparative effectiveness

    Author(s): Langer-Gould, Annette; Xu, Stanley; Myers, Laura C; Chen, Aiyu; Greene, John D; Creekmur, Beth; Bruxvoort, Katia; Adams, John L; Liu, Vincent; Gould, Michael K

    Int J Infect Dis. 2022 Dec;125:184-191. Epub 2022-10-29.

    PubMed abstract

    Association Between Preoperative Hemodialysis Timing and Postoperative Mortality in Patients With End-stage Kidney Disease

    Author(s): Fielding-Singh, Vikram; Vanneman, Matthew W; Grogan, Tristan; Neelankavil, Jacques P; Winkelmayer, Wolfgang C; Chang, Tara I; Liu, Vincent X; Lin, Eugene

    JAMA. 2022 Nov 08;328(18):1837-1848.

    PubMed abstract

    Covid-19 Vaccination and the Timing of Surgery Following Covid-19 Infection

    Author(s): Le, Sidney T; Kipnis, Patricia; Cohn, Bradley; Liu, Vincent X

    Ann Surg. 2022 11 01;276(5):e265-e272. Epub 2022-07-15.

    PubMed abstract

    Quantifying Frailty Requires a Conceptual Model Before a Statistical Model-Reply

    Author(s): Le, Sidney T; Liu, Vincent X; Cespedes Feliciano, Elizabeth M

    JAMA Surg. 2022 Nov 01;157(11):1065-1066.

    PubMed abstract

    Trends and Risk Factors for Venous Thromboembolism Among Hospitalized Medical Patients

    Author(s): Neeman, Elad; Liu, Vincent; Mishra, Pranita; Thai, Khanh K; Xu, James; Clancy, Heather A; Schlessinger, David; Liu, Raymond

    JAMA Netw Open. 2022 Nov 01;5(11):e2240373. Epub 2022-11-01.

    PubMed abstract

    Quantifying the breadth of antibiotic exposure in sepsis and suspected infection using spectrum scores

    Author(s): Smith, Joshua T; Manickam, Raj N; Barreda, Fernando; Greene, John D; Bhimarao, Meghana; Pogue, Jason; Jones, Makoto; Myers, Laura; Prescott, Hallie C; Liu, Vincent X

    Medicine (Baltimore). 2022 Oct 14;101(41):e30245.

    PubMed abstract

    Unsupervised probabilistic models for sequential Electronic Health Records

    Author(s): Kaplan, Alan D; Greene, John D; Liu, Vincent X; Ray, Priyadip

    J Biomed Inform. 2022 Oct;134:104163. Epub 2022-08-28.

    PubMed abstract

    Comparing the effectiveness of a brief intervention to reduce unhealthy alcohol use among adult primary care patients with and without depression: A machine learning approach with augmented inverse probability weighting

    Author(s): Papini, Santiago; Chi, Felicia W; Schuler, Alejandro; Satre, Derek D; Liu, Vincent X; Sterling, Stacy A

    Drug Alcohol Depend. 2022 Oct 01;239:109607. Epub 2022-08-27.

    PubMed abstract

    Risk of severe COVID-19 infection among adults with prior exposure to children

    Author(s): Solomon, Matthew D; Escobar, Gabriel J; Lu, Yun; Schlessinger, David; Steinman, Jonathan B; Steinman, Lawrence; Lee, Catherine; Liu, Vincent X

    Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2204141119. Epub 2022-07-27.

    PubMed abstract

    Adults hospitalized with breakthrough COVID-19 have lower mortality than matched unvaccinated adults

    Author(s): Myers, Laura C; Kipnis, Patricia; Greene, John; Lawson, Brian; Escobar, Gabriel J; Fireman, Bruce H; Klein, Nicola P; Liu, Vincent X

    J Intern Med. 2022 08;292(2):377-384. Epub 2022-05-17.

    PubMed abstract

    Temporal Trends in Antimicrobial Prescribing During Hospitalization for Potential Infection and Sepsis

    Author(s): Prescott, Hallie C; Liu, Vincent X; et al.

    JAMA Intern Med. 2022 08 01;182(8):805-813.

    PubMed abstract

    The Kaiser Permanente Northern California Advance Alert Monitor Program: An Automated Early Warning System for Adults at Risk for In-Hospital Clinical Deterioration

    Author(s): Martinez, Vanessa A; Liu, Vincent X; et al.

    Jt Comm J Qual Patient Saf. 2022 Aug;48(8):370-375.

    PubMed abstract

    Validation of Respiratory Rate-Oxygenation Index in Patients With COVID-19-Related Respiratory Failure

    Author(s): Myers, Laura C; Mark, Dustin; Ley, Brett; Guarnieri, Michael; Hofmeister, Melinda; Paulson, Shirley; Marelich, Gregory; Liu, Vincent X

    Crit Care Med. 2022 07 01;50(7):e638-e642. Epub 2022-02-07.

    PubMed abstract

    Red Blood Cell Transfusion at a Hemoglobin Threshold of Seven g/dL in Critically Ill Patients: A Regression Discontinuity Study

    Author(s): Bosch, Nicholas A; Law, Anica C; Bor, Jacob; Myers, Laura C; Roubinian, Nareg H; Liu, Vincent X; Walkey, Allan J

    Ann Am Thorac Soc. 2022 07;19(7):1177-1184.

    PubMed abstract

    New complementary perspectives for inpatient physical function assessment: matched clinician-report and patient-report short form measures from the PROMIS adult physical function item bank

    Author(s): Kallen, Michael A; Brown, Heather E; Hatton, Joeffrey R; Doyle, William A; Murphy, Ryan; Elliott, Ryan; Gutierrez, Mark A; Catherwood, Emma L; Pitman, Heather P; Liu, Vincent X; Gershon, Richard C

    Qual Life Res. 2022 Jul;31(7):2201-2212. Epub 2022-03-08.

    PubMed abstract

    Exploratory analysis of novel electronic health record variables for quantification of healthcare delivery strain, prediction of mortality, and prediction of imminent discharge

    Author(s): Lee, Catherine; Lawson, Brian L; Mann, Ariana J; Liu, Vincent X; Myers, Laura C; Schuler, Alejandro; Escobar, Gabriel J

    J Am Med Inform Assoc. 2022 05 11;29(6):1078-1090.

    PubMed abstract

    Evaluation of Incident 7-Day Infection and Sepsis Hospitalizations in an Integrated Health System

    Author(s): Liu, Vincent X; Manickam, Raj N; Greene, John D; Schuler, Alejandro; Kipnis, Patricia; Bhimarao, Meghana; Barreda, Fernando; Escobar, Gabriel J

    Ann Am Thorac Soc. 2022 05;19(5):781-789.

    PubMed abstract

    Comparison of Electronic Frailty Metrics for Prediction of Adverse Outcomes of Abdominal Surgery

    Author(s): Le, Sidney T; Liu, Vincent X; Kipnis, Patricia; Zhang, Jie; Peng, Peter D; Cespedes Feliciano, Elizabeth M

    JAMA Surg. 2022 05 01;157(5):e220172. Epub 2022-05-11.

    PubMed abstract

    Prospective evaluation of social risks, physical function, and cognitive function in prediction of non-elective rehospitalization and post-discharge mortality

    Author(s): Clancy, Heather A; Zhu, Zheng; Gordon, Nancy P; Kipnis, Patricia; Liu, Vincent X; Escobar, Gabriel J

    BMC Health Serv Res. 2022 Apr 29;22(1):574. Epub 2022-04-29.

    PubMed abstract

    Developing a shared sepsis data infrastructure: a systematic review and concept map to FHIR

    Author(s): Brant EB; Kennedy JN; King AJ; Gerstley LD; Mishra P; Schlessinger D; Shalaby J; Escobar GJ; Angus DC; Seymour CW; Liu VX

    NPJ Digit Med. 2022 Apr 04;5(1):44. Epub 2022-04-04.

    PubMed abstract

    Evaluation of Outcomes Following Hospital-Wide Implementation of a Subcutaneous Insulin Protocol for Diabetic Ketoacidosis

    Author(s): Rao, Priya; Jiang, Sheng-Fang; Kipnis, Patricia; Patel, Divyesh M; Katsnelson, Svetlana; Madani, Samineh; Liu, Vincent X

    JAMA Netw Open. 2022 Apr 01;5(4):e226417. Epub 2022-04-01.

    PubMed abstract

    Prognostic Accuracy of Presepsis and Intrasepsis Characteristics for Prediction of Cardiovascular Events After a Sepsis Hospitalization

    Author(s): Walkey AJ; Myers LC; Go AS; Liu VX; et al.

    Crit Care Explor. 2022 Apr;4(4):e0674. Epub 2022-04-08.

    PubMed abstract

    Association of Intensive Care Unit Admission and Outcomes in Sepsis and Acute Respiratory Failure

    Author(s): Anesi, George L; Liu, Vincent X; Chowdhury, Marzana; Small, Dylan S; Wang, Wei; Delgado, M Kit; Bayes, Brian; Dress, Erich; Escobar, Gabriel J; Halpern, Scott D

    Am J Respir Crit Care Med. 2022 03 01;205(5):520-528.

    PubMed abstract

    The COVID-19 Pandemic Strikes Again and Again and Again

    Author(s): Myers, Laura C; Liu, Vincent X

    JAMA Netw Open. 2022 03 01;5(3):e221760. Epub 2022-03-01.

    PubMed abstract

    Connecting Research and Practice: Implementation of Suicide Prevention Strategies in Learning Health Care Systems

    Author(s): Rossom, Rebecca C; Sterling, Stacy; Liu, Vincent; Simon, Greg E; et al.

    Psychiatr Serv. 2022 02 01;73(2):219-222. Epub 2021-06-30.

    PubMed abstract

    Outcomes After Implementation of a Benzodiazepine-Sparing Alcohol Withdrawal Order Set in an Integrated Health Care System

    Author(s): Smith, Joshua T; Sage, Mary; Szeto, Herb; Myers, Laura C; Lu, Yun; Martinez, Adriana; Kipnis, Patricia; Liu, Vincent X

    JAMA Netw Open. 2022 02 01;5(2):e220158. Epub 2022-02-01.

    PubMed abstract

    Performance of Predictive Models for 30-day Hospitalization and Mortality after COVID-19 Infection

    Author(s): Myers, Laura C; Kipnis, Patricia; O'Suilleabhain, Liam; Escobar, Gabriel; Liu, Vincent X

    Ann Am Thorac Soc. 2022 01;19(1):131-134.

    PubMed abstract

    Assess COVID-19 prognosis … but be aware of your instrument's accuracy!

    Author(s): Capuzzo, Maurizia; Amaral, Andre Carlos Kajdacsy-Balla; Liu, Vincent X

    Intensive Care Med. 2021 12;47(12):1472-1474. Epub 2021-10-05.

    PubMed abstract

    Hospital-specific Template Matching for Benchmarking Performance in a Diverse Multihospital System

    Author(s): Vincent, Brenda M; Molling, Daniel; Escobar, Gabriel J; Hofer, Timothy P; Iwashyna, Theodore J; Liu, Vincent X; Rosen, Amy K; Ryan, Andrew M; Seelye, Sarah; Wiitala, Wyndy L; Prescott, Hallie C

    Med Care. 2021 12 01;59(12):1090-1098.

    PubMed abstract

    Algorithmic prognostication in critical care: a promising but unproven technology for supporting difficult decisions

    Author(s): Weissman, Gary E; Liu, Vincent X

    Curr Opin Crit Care. 2021 10 01;27(5):500-505.

    PubMed abstract

    Predictive Models for In-Hospital Deterioration in Ward Patients

    Author(s): Escobar, Gabriel J; Myers, Laura C; Liu, Vincent X

    J Hosp Med. 2021 10;16(10):640.

    PubMed abstract

    Validation of Postpartum Hemorrhage Admission Risk Factor Stratification in a Large Obstetrics Population

    Author(s): Ruppel H; Liu VX; Gupta NR; Soltesz L; Escobar GJ

    Am J Perinatol. 2021 09;38(11):1192-1200. Epub 2020-05-26.

    PubMed abstract

    Reducing Readmissions for Chronic Obstructive Pulmonary Disease in Response to the Hospital Readmissions Reduction Program

    Author(s): Myers, Laura C; Cash, Rebecca; Liu, Vincent X; Camargo, Carlos A

    Ann Am Thorac Soc. 2021 09;18(9):1506-1513.

    PubMed abstract

    Association Between Troponin I Levels During Sepsis and Post-Sepsis Cardiovascular Complications

    Author(s): Garcia, Michael A; Go, Alan S; Liu, Vincent X; Walkey, Allan J; et al.

    Am J Respir Crit Care Med. 2021 09 01;204(5):557-565.

    PubMed abstract

    Temporal Trends and Hospital Variation in Time-to-Antibiotics Among Veterans Hospitalized With Sepsis

    Author(s): Wayne, Max T; Seelye, Sarah; Molling, Daniel; Wang, Xiao Qing; Donnelly, John P; Hogan, Cainnear K; Jones, Makoto M; Iwashyna, Theodore J; Liu, Vincent X; Prescott, Hallie C

    JAMA Netw Open. 2021 09 01;4(9):e2123950. Epub 2021-09-01.

    PubMed abstract

    Evaluation of an intervention targeted with predictive analytics to prevent readmissions in an integrated health system: observational study

    Author(s): Marafino, Ben J; Escobar, Gabriel J; Baiocchi, Michael T; Liu, Vincent X; Plimier, Colleen C; Schuler, Alejandro

    BMJ. 2021 08 11;374:n1747. Epub 2021-08-11.

    PubMed abstract

    The Coming of Age of Implementation Science and Research in Critical Care Medicine

    Author(s): Barr, Juliana; Paulson, Shirley S; Kamdar, Biren; Ervin, Jennifer N; Lane-Fall, Meghan; Liu, Vincent; Kleinpell, Ruth

    Crit Care Med. 2021 08 01;49(8):1254-1275.

    PubMed abstract

    Evaluation of Vaccination Strategies to Compare Efficient and Equitable Vaccine Allocation by Race and Ethnicity Across Time

    Author(s): Kipnis, Patricia; Soltesz, Lauren; Escobar, Gabriel J; Myers, Laura; Liu, Vincent X

    JAMA Health Forum. 2021 08;2(8):e212095. Epub 2021-08-20.

    PubMed abstract

    Development of a healthcare system COVID Hotspotting Score in California: an observational study with prospective validation

    Author(s): Liu, Vincent X; Thai, Khanh K; Galin, Jessica; Gerstley, Lawrence David; Myers, Laura C; Parodi, Stephen M; Chen, Yi-Fen Irene; Goler, Nancy; Escobar, Gabriel J; Kipnis, Patricia

    BMJ Open. 2021 07 26;11(7):e048211. Epub 2021-07-26.

    PubMed abstract

    Equitably Allocating Resources During Crises: Racial Differences in Mortality Prediction Models

    Author(s): Ashana, Deepshikha Charan; Anesi, George L; Liu, Vincent X; Escobar, Gabriel J; Chesley, Christopher; Eneanya, Nwamaka D; Weissman, Gary E; Miller, William Dwight; Harhay, Michael O; Halpern, Scott D

    Am J Respir Crit Care Med. 2021 07 15;204(2):178-186.

    PubMed abstract

    Incidence of 30-Day Venous Thromboembolism in Adults Tested for SARS-CoV-2 Infection in an Integrated Health Care System in Northern California

    Author(s): Roubinian, Nareg H; Dusendang, Jennifer R; Mark, Dustin G; Vinson, David R; Liu, Vincent X; Schmittdiel, Julie A; Pai, Ashok P

    JAMA Intern Med. 2021 07 01;181(7):997-1000.

    PubMed abstract

    Retrospective Cohort Study Comparing Infliximab-dyyb and Infliximab in Biologic-Naive Patients With Inflammatory Bowel Disease in the United States

    Author(s): Smith, Joshua T; Velayos, Fernando S; Niu, Fang; Liu, Vincent; Delate, Thomas; Pola, Suresh; Le, Kim; Hui, Rita L

    Crohns Colitis 360. 2021 Jul;3(3):otab051. Epub 2021-07-29.

    PubMed abstract

    Racial Disparities in COVID-19 Testing and Outcomes : Retrospective Cohort Study in an Integrated Health System

    Author(s): Escobar, Gabriel J; Adams, Alyce S; Liu, Vincent X; Soltesz, Lauren; Chen, Yi-Fen Irene; Parodi, Stephen M; Ray, G Thomas; Myers, Laura C; Ramaprasad, Charulata M; Dlott, Richard; Lee, Catherine

    Ann Intern Med. 2021 06;174(6):786-793. Epub 2021-02-09.

    PubMed abstract

    Association of Positive Fluid Balance at Discharge After Sepsis Management With 30-Day Readmission

    Author(s): Yoo, Michael S; Liu, Vincent X; et al.

    JAMA Netw Open. 2021 06 01;4(6):e216105. Epub 2021-06-01.

    PubMed abstract

    Sepsis Subclasses: A Framework for Development and Interpretation

    Author(s): DeMerle, Kimberley M; Liu, Vincent; Seymour, Christopher W; et al.

    Crit Care Med. 2021 05 01;49(5):748-759.

    PubMed abstract

    Nonstationary Multivariate Gaussian Processes for Electronic Health Records

    Author(s): Meng, Rui; Soper, Braden; Lee, Herbert K H; Liu, Vincent X; Greene, John D; Ray, Priyadip

    J Biomed Inform. 2021 05;117:103698. Epub 2021-02-19.

    PubMed abstract

    Regionalization of Acute Myeloid Leukemia Treatment in a Community-Based Population: Implementation and Early Results

    Author(s): Law, Lisa Y; Uong, Stephen P; Vempaty, Hyma T; Nguyen, Vu H; Baer, David; Liu, Vincent X; Herrinton, Lisa J

    Perm J. 2021 05;25.

    PubMed abstract

    Measurement of Sepsis in a National Cohort Using Three Different Methods to Define Baseline Organ Function

    Author(s): Wayne, Max T; Molling, Daniel; Wang, Xiao Qing; Hogan, Cainnear K; Seelye, Sarah; Liu, Vincent X; Prescott, Hallie C

    Ann Am Thorac Soc. 2021 04;18(4):648-655.

    PubMed abstract

    Characteristics and Outcomes of Clinic Visits Immediately Preceding Sepsis Hospitalization

    Author(s): Miller, H Catherine; Liu, Vincent X; Prescott, Hallie C

    Am J Crit Care. 2021 03 01;30(2):135-139.

    PubMed abstract

    The Presentation, Pace, and Profile of Infection and Sepsis Patients Hospitalized Through the Emergency Department: An Exploratory Analysis

    Author(s): Liu, Vincent X; Bhimarao, Meghana; Greene, John D; Manickam, Raj N; Martinez, Adriana; Schuler, Alejandro; Barreda, Fernando; Escobar, Gabriel J

    Crit Care Explor. 2021 Mar;3(3):e0344. Epub 2021-02-24.

    PubMed abstract

    Automated Identification of Adults at Risk for In-Hospital Clinical Deterioration. Reply

    Author(s): Escobar GJ; Liu VX; Kipnis P

    N Engl J Med. 2021 02 04;384(5):486.

    PubMed abstract

    Development and Validation of an Obstetric Comorbidity Risk Score for Clinical Use

    Author(s): Ruppel, Halley; Liu, Vincent X; Kipnis, Patricia; Hedderson, Monique M; Greenberg, Mara; Forquer, Heather; Lawson, Brian; Escobar, Gabriel J

    Womens Health Rep (New Rochelle). 2021;2(1):507-515. Epub 2021-11-02.

    PubMed abstract

    The future of AI in critical care is augmented, not artificial, intelligence

    Author(s): Liu, Vincent X

    Crit Care. 2020 12 02;24(1):673. Epub 2020-12-02.

    PubMed abstract

    Predicting preventable hospital readmissions with causal machine learning

    Author(s): Marafino, Ben J; Schuler, Alejandro; Liu, Vincent X; Escobar, Gabriel J; Baiocchi, Mike

    Health Serv Res. 2020 12;55(6):993-1002. Epub 2020-10-30.

    PubMed abstract

    Automated Identification of Adults at Risk for In-Hospital Clinical Deterioration

    Author(s): Escobar, Gabriel J; Liu, Vincent X; Schuler, Alejandro; Lawson, Brian; Greene, John D; Kipnis, Patricia

    N Engl J Med. 2020 11 12;383(20):1951-1960.

    PubMed abstract

    Expanding Post-discharge Readmission Metrics in Patients with Chronic Obstructive Pulmonary Disease

    Author(s): Myers, Laura C; Camargo, Carlos; Escobar, Gabriel; Liu, Vincent X

    Chronic Obstr Pulm Dis. 2020 Nov 06.

    PubMed abstract

    Association of a Novel Index of Hospital Capacity Strain with Admission to Intensive Care Units

    Author(s): Anesi GL; Chowdhury M; Small DS; Delgado MK; Kohn R; Bayes B; Wang W; Dress E; Escobar GJ; Halpern SD; Liu VX

    Ann Am Thorac Soc. 2020 11;17(11):1440-1447.

    PubMed abstract

    Evaluation of automated computed tomography segmentation to assess body composition and mortality associations in cancer patients

    Author(s): Cespedes Feliciano EM; Liu V; Caan BJ; et al.

    J Cachexia Sarcopenia Muscle. 2020 10;11(5):1258-1269. Epub 2020-04-20.

    PubMed abstract

    Assessment of Value of Neighborhood Socioeconomic Status in Models That Use Electronic Health Record Data to Predict Health Care Use Rates and Mortality

    Author(s): Schuler, Alejandro; O'Súilleabháin, Liam; Rinetti-Vargas, Gina; Kipnis, Patricia; Barreda, Fernando; Liu, Vincent X; Sofrygin, Oleg; Escobar, Gabriel J

    JAMA Netw Open. 2020 10 01;3(10):e2017109. Epub 2020-10-01.

    PubMed abstract

    Estimates of Workload Associated With Suicide Risk Alerts After Implementation of Risk-Prediction Model

    Author(s): Kline-Simon, Andrea H; Sterling, Stacy; Young-Wolff, Kelly; Simon, Gregory; Lu, Yun; Does, Monique; Liu, Vincent

    JAMA Netw Open. 2020 10 01;3(10):e2021189. Epub 2020-10-01.

    PubMed abstract

    Associations of CYP2C9 and CYP2C19 pharmacogenetic variation with phenytoin-induced cutaneous adverse drug reactions

    Author(s): Fohner AE; Rettie AE; Thai KK; Ranatunga DK; Lawson BL; Liu VX; Schaefer CA

    Clin Transl Sci. 2020 09;13(5):1004-1009. Epub 2020-04-18.

    PubMed abstract

    Developing a template matching algorithm for benchmarking hospital performance in a diverse, integrated healthcare system

    Author(s): Molling D; Vincent BM; Wiitala WL; Escobar GJ; Hofer TP; Liu VX; Rosen AK; Ryan AM; Seelye S; Prescott HC

    Medicine (Baltimore). 2020 Jun 12;99(24):e20385.

    PubMed abstract

    Characteristics of Hospitalized Adults With COVID-19 in an Integrated Health Care System in California

    Author(s): Myers LC; Parodi SM; Escobar GJ; Liu VX

    JAMA. 2020 Jun 02;323(21):2195-2198.

    PubMed abstract

    Incidence, clinical outcomes, and transmission dynamics of severe coronavirus disease 2019 in California and Washington: prospective cohort study

    Author(s): Lewnard JA; Liu VX; Bellows J; et al.

    BMJ. 2020 May 22;369:m1923. Epub 2020-05-22.

    PubMed abstract

    COVID-19: Long-term Planning for Procedure-based Specialties During Extended Mitigation and Suppression Strategies

    Author(s): Rouillard S; Liu VX; Corley DA

    Gastroenterology. 2020 May 18.

    PubMed abstract

    Comparison of Early Warning Scoring Systems for Hospitalized Patients With and Without Infection at Risk for In-Hospital Mortality and Transfer to the Intensive Care Unit

    Author(s): Liu VX; Escobar GJ; Churpek MM; et al.

    JAMA Netw Open. 2020 May 01;3(5):e205191. Epub 2020-05-01.

    PubMed abstract

    The Impact of Step-Down Unit Care on Patient Outcomes After ICU Discharge

    Author(s): Lekwijit S; Chan CW; Green LV; Liu VX; Escobar GJ

    Crit Care Explor. 2020 May;2(5):e0114. Epub 2020-05-06.

    PubMed abstract

    From Containment to Mitigation of COVID-19 in the US

    Author(s): Parodi SM; Liu VX

    JAMA. 2020 04 21;323(15):1441-1442.

    PubMed abstract

    The Role of Professional Organizations in Fostering the Early Career Development of Academic Intensivists

    Author(s): Vail EA; Nadig NR; Sahetya SK; Vande Vusse LK; Walkey AJ; Liu V; Mathews KS

    Ann Am Thorac Soc. 2020 04;17(4):412-418.

    PubMed abstract

    Assessment of Electronic Health Record Search Patterns and Practices by Practitioners in a Large Integrated Health Care System

    Author(s): Ruppel H; Bhardwaj A; Manickam RN; Adler-Milstein J; Flagg M; Ballesca M; Liu VX

    JAMA Netw Open. 2020 03 02;3(3):e200512. Epub 2020-03-02.

    PubMed abstract

    'No growth to date'? Predicting positive blood cultures in critical illness

    Author(s): Liu VX; Wiens J

    Intensive Care Med. 2020 Jan 21.

    PubMed abstract

    Web Exclusive. Annals for Hospitalists Inpatient Notes - The Role of Hospitalists in the Creation of Learning Healthcare Systems

    Author(s): Gilmartin HM; Liu VX; Burke RE

    Ann Intern Med. 2020 01 21;172(2):HO2-HO3.

    PubMed abstract

    Goldilocks, the Three Bears and Intensive Care Unit Utilization: Delivering Enough Intensive Care But Not Too Much. A Narrative Review

    Author(s): Myers LC; Escobar G; Liu VX

    Pulm Ther. 2020 Jan 03.

    PubMed abstract

    Association Between Peripheral Blood Oxygen Saturation (SpO2)/Fraction of Inspired Oxygen (FiO2) Ratio Time at Risk and Hospital Mortality in Mechanically Ventilated Patients

    Author(s): Adams JY; Rogers AJ; Schuler A; Marelich GP; Fresco JM; Taylor SL; Riedl AW; Baker JM; Escobar GJ; Liu VX

    Perm J. 2020;24. Epub 2020-01-31.

    PubMed abstract

    Context is Key: Using the Audit Log to Capture Contextual Factors Affecting Stroke Care Processes

    Author(s): Noshad, Morteza; Rose, Christian C; Thombley, Robert; Chiang, Jonathan; Corbin, Conor K; Nguyen, Minh; Liu, Vincent X; Adler-Milstein, Julia; Chen, Jonathan H

    AMIA Annu Symp Proc. 2020;2020:953-962. Epub 2021-01-25.

    PubMed abstract

    Multiyear Rehospitalization Rates and Hospital Outcomes in an Integrated Health Care System

    Author(s): Escobar GJ; Plimier C; Greene JD; Liu V; Kipnis P

    JAMA Netw Open. 2019 12 02;2(12):e1916769. Epub 2019-12-02.

    PubMed abstract

    Postoperative Opioid Use Before and After Enhanced Recovery After Surgery Program Implementation

    Author(s): Liu VX; Eaton A; Lee DC; Reyes VM; Paulson SS; Campbell CI; Avins AL; Parodi SM

    Ann Surg. 2019 12;270(6):e69-e71.

    PubMed abstract

    The number needed to benefit: estimating the value of predictive analytics in healthcare

    Author(s): Liu VX; Bates DW; Wiens J; Shah NH

    J Am Med Inform Assoc. 2019 12 01;26(12):1655-1659.

    PubMed abstract

    Assessing clinical heterogeneity in sepsis through treatment patterns and machine learning

    Author(s): Fohner AE; Greene JD; Lawson BL; Chen JH; Kipnis P; Escobar GJ; Liu VX

    J Am Med Inform Assoc. 2019 12 01;26(12):1466-1477.

    PubMed abstract

    Assessing the clinical impact of CYP2C9 pharmacogenetic variation on phenytoin prescribing practice and patient response in an integrated health system

    Author(s): Fohner AE; Ranatunga DK; Thai KK; Lawson BL; Risch N; Oni-Orisan A; Jelalian AT; Rettie AE; Liu VX; Schaefer CA

    Pharmacogenet Genomics. 2019 10;29(8):192-199.

    PubMed abstract

    More Than We Bargained For: The "Dominating" Cost Effectiveness of Sepsis Quality Improvement?

    Author(s): Peltan ID; Liu VX

    Crit Care Med. 2019 10;47(10):1464-1467.

    PubMed abstract

    Effect of donor, component and recipient characteristics on hemoglobin increments following red blood cell transfusion

    Author(s): Roubinian NH; Plimier C; Woo JP; Lee C; Bruhn R; Liu VX; Escobar GJ; Kleinman SH; Triulzi DJ; Murphy EL; Busch MP

    Blood. 2019 09 26;134(13):1003-1013. Epub 2019-07-26.

    PubMed abstract

    To catch a killer: electronic sepsis alert tools reaching a fever pitch?

    Author(s): Ruppel H; Liu V

    BMJ Qual Saf. 2019 09;28(9):693-696. Epub 2019-04-23.

    PubMed abstract

    Identifying Common Predictors of Multiple Adverse Outcomes Among Elderly Adults With Type-2 Diabetes

    Author(s): Kabue S; Liu V; Dyer W; Raebel M; Nichols G; Schmittdiel J

    Med Care. 2019 09;57(9):702-709.

    PubMed abstract

    Do no harm: a roadmap for responsible machine learning for health care

    Author(s): Wiens J; Liu VX; Goldenberg A; et al.

    Nat Med. 2019 09;25(9):1337-1340. Epub 2019-08-19.

    PubMed abstract

    Enhanced Recovery After Surgery to Change Process Measures and Reduce Opioid Use After Cesarean Delivery: A Quality Improvement Initiative

    Author(s): Hedderson M; Campbell C; Quesenberry C; Liu V; et al.

    Obstet Gynecol. 2019 09;134(3):511-519.

    PubMed abstract

    The Impact of Pharmacy-specific Predictors on the Performance of 30-Day Readmission Risk Prediction Models

    Author(s): Kabue S; Greene J; Kipnis P; Lawson B; Rinetti-Vargas G; Liu V; Escobar G

    Med Care. 2019 04;57(4):295-299.

    PubMed abstract

    Association between Inpatient Delirium and Hospital Readmission in Patients ≥ 65 Years of Age: A Retrospective Cohort Study

    Author(s): LaHue SC; Douglas VC; Kuo T; Conell CA; Liu VX; Josephson SA; Angel C; Brooks KB

    J Hosp Med. 2019 04;14(4):201-206.

    PubMed abstract

    Statistical Modeling and Aggregate-Weighted Scoring Systems in Prediction of Mortality and ICU Transfer: A Systematic Review

    Author(s): Linnen DT; Escobar GJ; Hu X; Scruth E; Liu V; Stephens C

    J Hosp Med. 2019 Mar;14(3):161-169.

    PubMed abstract

    Long-Term Outcomes Among Patients Discharged From the Hospital With Moderate Anemia: A Retrospective Cohort Study

    Author(s): Roubinian NH; Murphy EL; Mark DG; Triulzi DJ; Carson JL; Lee C; Kipnis P; Kleinman S; Liu VX; Escobar GJ

    Ann Intern Med. 2019 01 01;170(1):80.

    PubMed abstract

    Inpatient electronic health record maintenance from 2010 to 2015

    Author(s): Liu VX; Haq N; Chan IC; Hoberman B

    Am J Manag Care. 2019 01;25(1):18-21.

    PubMed abstract

    Associations of ICU Capacity Strain with Disposition and Outcomes of Patients with Sepsis Presenting to the Emergency Department

    Author(s): Anesi GL; Liu VX; Gabler NB; Delgado MK; Kohn R; Weissman GE; Bayes B; Escobar GJ; Halpern SD

    Ann Am Thorac Soc. 2018 11;15(11):1328-1335.

    PubMed abstract

    Association between Inhaled Corticosteroid Use and Pulmonary Nontuberculous Mycobacterial Infection

    Author(s): Liu VX; Winthrop KL; Lu Y; Sharifi H; Nasiri HU; Ruoss SJ

    Ann Am Thorac Soc. 2018 10;15(10):1169-1176.

    PubMed abstract

    Toward the "Plateau of Productivity": Enhancing the Value of Machine Learning in Critical Care

    Author(s): Liu VX

    Crit Care Med. 2018 07;46(7):1196-1197.

    PubMed abstract

    Risk Adjustment for Hospital Characteristics Reduces Unexplained Hospital Variation in Pressure Injury Risk

    Author(s): Linnen DT; Kipnis P; Rondinelli J; Greene JD; Liu V; Escobar GJ

    Nurs Res. 2018 Jul/Aug;67(4):314-323.

    PubMed abstract

    The Impact of Acute Organ Dysfunction on Long-Term Survival in Sepsis

    Author(s): Schuler A; Wulf DA; Lu Y; Iwashyna TJ; Escobar GJ; Shah NH; Liu VX

    Crit Care Med. 2018 06;46(6):843-849.

    PubMed abstract

    Impact of emergency physician-provided patient education about alternative care venues

    Author(s): Patel PB; Vinson DR; Gardner MN; Wulf DA; Kipnis P; Liu V; Escobar GJ

    Am J Manag Care. 2018 05;24(5):225-231.

    PubMed abstract

    Mortality Measures to Profile Hospital Performance for Patients With Septic Shock

    Author(s): Walkey AJ; Shieh MS; Liu VX; Lindenauer PK

    Crit Care Med. 2018 Apr 30.

    PubMed abstract

    Healthcare Utilization and Infection in the Week Prior to Sepsis Hospitalization

    Author(s): Liu VX; Escobar GJ; Chaudhary R; Prescott HC

    Crit Care Med. 2018 04;46(4):513-516.

    PubMed abstract

    Flexible, Cluster-Based Analysis of the Electronic Medical Record of Sepsis with Composite Mixture Models

    Author(s): Mayhew MB; Petersen BK; Sales AP; Greene JD; Liu VX; Wasson TS

    J Biomed Inform. 2018 02;78:33-42. Epub 2017-12-02.

    PubMed abstract

    Hospital-Acquired Pressure Injury: Risk-Adjusted Comparisons in an Integrated Healthcare Delivery System

    Author(s): Rondinelli J; Zuniga S; Kipnis P; Kawar LN; Liu V; Escobar GJ

    Nurs Res. 2018 Jan/Feb;67(1):16-25.

    PubMed abstract

    Machine Learning and Sepsis: On the Road to Revolution

    Author(s): Liu VX; Walkey AJ

    Crit Care Med. 2017 11;45(11):1946-1947.

    PubMed abstract

    Comparing Hospital Processes and Outcomes in California Medicare Beneficiaries: Simulation Prompts Reconsideration

    Author(s): Escobar GJ; Baker JM; Turk BJ; Draper D; Liu V; Kipnis P

    Perm J. 2017;21.

    PubMed abstract

    The Timing of Early Antibiotics and Hospital Mortality in Sepsis

    Author(s): Liu VX; Fielding-Singh V; Greene JD; Baker JM; Iwashyna TJ; Bhattacharya J; Escobar GJ

    Am J Respir Crit Care Med. 2017 Oct 01;196(7):856-863.

    PubMed abstract

    Reply to the Timing of Early Antibiotics and Hospital Mortality in Sepsis - Playing Devil's Advocate

    Author(s): X Liu V; Fielding-Singh V; Iwashyna TJ; Bhattacharya J; Escobar GJ

    Am J Respir Crit Care Med. 2017 10 01;196(7):935-936.

    PubMed abstract

    Identifying Distinct Subgroups of ICU Patients: A Machine Learning Approach

    Author(s): Vranas KC; Jopling JK; Sweeney TE; Ramsey MC; Milstein AS; Slatore CG; Escobar GJ; Liu VX

    Crit Care Med. 2017 Oct;45(10):1607-1615.

    PubMed abstract

    Prediction of Recurrent Clostridium Difficile Infection Using Comprehensive Electronic Medical Records in an Integrated Healthcare Delivery System

    Author(s): Escobar GJ; Baker JM; Kipnis P; Greene JD; Mast TC; Gupta SB; Cossrow N; Mehta V; Liu V; Dubberke ER

    Infect Control Hosp Epidemiol. 2017 Aug 24:1-8.

    PubMed abstract

    Individual and health system variation in rehospitalizations the year after pneumonia

    Author(s): Viglianti EM; Prescott HC; Liu V; Escobar GJ; Iwashyna TJ

    Medicine (Baltimore). 2017 Aug;96(31):e7695.

    PubMed abstract

    Innovation and Technology: Electronic Intensive Care Unit Diaries

    Author(s): Scruth EA; Oveisi N; Liu V

    AACN Adv Crit Care. 2017 Summer;28(2):191-199.

    PubMed abstract

    Enhanced Recovery After Surgery Program Implementation in 2 Surgical Populations in an Integrated Health Care Delivery System

    Author(s): Liu VX; Rosas E; Hwang J; Cain E; Foss-Durant A; Clopp M; Huang M; Lee DC; Mustille A; Kipnis P; Parodi S

    JAMA Surg. 2017 Jul 19;152(7):e171032. Epub 2017-07-19.

    PubMed abstract

    Hospital Readmissions in Sepsis Survivors: Are They Preventable?

    Author(s): Goodwin AJ; Liu V; Ford DW

    Ann Am Thorac Soc. 2017 02;14(2):170-171.

    PubMed abstract

    The Kaiser Permanente Northern California Enhanced Recovery After Surgery Program: Design, Development, and Implementation

    Author(s): Liu VX; Parodi S; et al.

    Perm J. 2017;21.

    PubMed abstract

    Utilization of Health Services Among Adults With Recurrent Clostridium difficile Infection: A 12-Year Population-Based Study

    Author(s): Kuntz JL; Baker JM; Kipnis P; Li SX; Liu V; Xie Y; Marcella S; Escobar GJ

    Infect Control Hosp Epidemiol. 2017 Jan;38(1):45-52. Epub 2016-10-20.

    PubMed abstract

    Validation of Administrative Definitions of Invasive Mechanical Ventilation across 30 Intensive Care Units

    Author(s): Kerlin MP; Weissman GE; Wonneberger KA; Kent S; Madden V; Liu VX; Halpern SD

    Am J Respir Crit Care Med. 2016 12 15;194(12):1548-1552.

    PubMed abstract

    Data that drive: Closing the loop in the learning hospital system

    Author(s): Liu VX; Morehouse JW; Baker JM; Greene JD; Kipnis P; Escobar GJ

    J Hosp Med. 2016 Nov;11 Suppl 1:S11-S17.

    PubMed abstract

    Piloting electronic medical record-based early detection of inpatient deterioration in community hospitals

    Author(s): Escobar GJ; Turk BJ; Ragins A; Ha J; Hoberman B; LeVine SM; Ballesca MA; Liu V; Kipnis P

    J Hosp Med. 2016 Nov;11 Suppl 1:S18-S24.

    PubMed abstract

    Incorporating an Early Detection System Into Routine Clinical Practice in Two Community Hospitals

    Author(s): Dummett BA; Adams C; Scruth E; Liu V; Guo M; Escobar GJ

    J Hosp Med. 2016 Nov;11 Suppl 1:S25-S31.

    PubMed abstract

    Can You Read Me Now? Unlocking Narrative Data with Natural Language Processing

    Author(s): Sjoding MW; Liu VX

    Ann Am Thorac Soc. 2016 09;13(9):1443-5.

    PubMed abstract

    Loud and Clear: Sensory Impairment, Delirium, and Functional Recovery in Critical Illness

    Author(s): LaHue SC; Liu VX

    Am J Respir Crit Care Med. 2016 08 01;194(3):252-3.

    PubMed abstract

    16 Years and Counting? Time to Implement Noninvasive Screening for ARDS

    Author(s): Rogers AJ; Liu VX

    Chest. 2016 08;150(2):266-7.

    PubMed abstract

    In-hospital mortality following treatment with red blood cell transfusion or inotropic therapy during early goal-directed therapy for septic shock: a retrospective propensity-adjusted analysis

    Author(s): Mark DG; Morehouse JW; Hung YY; Kene MV; Elms AR; Liu V; Ballard DW; Vinson DR

    Crit Care. 2014;18(5):496. Epub 2014-09-12.

    PubMed abstract

    Towards Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and ARDS Clinical Trial Design

    Author(s): Prescott HC; Calfee CS; Thompson BT; Angus DC; Liu VX

    Am J Respir Crit Care Med. 2016 Jul 15;194(2):147-55.

    PubMed abstract

    Multicenter Implementation of a Treatment Bundle for Sepsis Patients with Intermediate Lactate Values

    Author(s): Liu VX; Morehouse JW; Marelich GP; Soule J; Russell T; Skeath M; Adams C; Escobar GJ; Whippy A

    Am J Respir Crit Care Med. 2016 Jun 01;193(11):1264-70.

    PubMed abstract

    Developing a framework for implementing intensive care unit diaries: a focused review of the literature

    Author(s): Beg M; Scruth E; Liu V

    Aust Crit Care. 2016 May 27.

    PubMed abstract

    The Natural History of Changes in Preferences for Life-Sustaining Treatments and Implications for Inpatient Mortality in Younger and Older Hospitalized Adults

    Author(s): Kim YS; Escobar GJ; Halpern SD; Greene JD; Kipnis P; Liu V

    J Am Geriatr Soc. 2016 May;64(5):981-9. Epub 2016-04-27.

    PubMed abstract

    Evaluation Following Staggered Implementation of the "Rethinking Critical Care" ICU Care Bundle in a Multicenter Community Setting

    Author(s): Liu V; Herbert D; Foss-Durant A; Marelich GP; Patel A; Whippy A; Turk BJ; Ragins AI; Kipnis P; Escobar GJ

    Crit Care Med. 2016 Mar;44(3):460-7.

    PubMed abstract

    Keeping Score of Severity Scores: Taking the Next Step

    Author(s): Liu V

    Crit Care Med. 2016 Mar;44(3):639-40.

    PubMed abstract

    Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

    Author(s): Shankar-Hari M; Phillips GS; Levy ML; Seymour CW; Liu VX; Deutschman CS; Angus DC; Rubenfeld GD; Singer M; Sepsis Definitions Task Force

    JAMA. 2016 Feb 23;315(8):775-87.

    PubMed abstract

    Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

    Author(s): Seymour CW; Liu VX; Angus DC; et al.

    JAMA. 2016 Feb 23;315(8):762-74.

    PubMed abstract

    Consensus Statement on Electronic Health Predictive Analytics: A Guiding Framework to Address Challenges

    Author(s): Amarasingham R; Liu V; Xie B; et al.

    EGEMS (Wash DC). 2016;4(1):1163. Epub 2016-03-07.

    PubMed abstract

    Treatment of Alcohol Withdrawal Syndrome with and without Dexmedetomidine

    Author(s): Beg M; Fisher S; Siu D; Rajan S; Troxell L; Liu VX

    Perm J. 2016 spring;20(2):49-53.

    PubMed abstract

    Variation in the Contents of Sepsis Bundles and Quality Measures: A Systematic Review

    Author(s): Kramer RD; Cooke CR; Liu V; Miller RR; Iwashyna TJ

    Ann Am Thorac Soc. 2015 Nov;12(11):1676-84.

    PubMed abstract

    Decreasing sepsis mortality at Kaiser Permanente Northern California

    Author(s): Liu V; Whippy A; Morehouse JW

    Am J Emerg Med. 2015 Sep;33(9):1305-6. Epub 2014-08-02.

    PubMed abstract

    Impact of Relative Contraindications to Home Management in Emergency Department Patients with Low-Risk Pulmonary Embolism

    Author(s): Vinson DR; Drenten CE; Huang J; Morley JE; Anderson ML; Reed ME; Nishijima DK; Liu V; Kaiser Permanente Clinical Research on Emergency Services and Treatment (CREST) Network

    Ann Am Thorac Soc. 2015 May;12(5):666-73.

    PubMed abstract

    Data breaches of protected health information in the United States

    Author(s): Liu V; Musen MA; Chou T

    JAMA. 2015 Apr 14;313(14):1471-3.

    PubMed abstract

    The Accuracy of an Electronic Pulmonary Embolism Severity Index Auto-Populated from the Electronic Health Record: Setting the stage for computerized clinical decision support

    Author(s): Vinson DR; Morley JE; Huang J; Liu V; Anderson ML; Drenten CE; Radecki RP; Nishijima DK; Reed ME; Kaisers Permanente CREST Network

    Appl Clin Inform. 2015;6(2):318-33. Epub 2015-05-13.

    PubMed abstract

    Trends in red blood cell transfusion and 30-day mortality among hospitalized patients

    Author(s): Roubinian NH; Liu V; NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III); et al.

    Transfusion. 2014 Oct;54(10 Pt 2):2678-86. Epub 2014-08-18.

    PubMed abstract

    Decreased Red Blood Cell Use and Mortality in Hospitalized Patients

    Author(s): Roubinian NH; Escobar GJ; Liu V; Gardner MN; Carson JL; Kleinman SH; Murphy EL; NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III)

    JAMA Intern Med. 2014 Aug;174(8):1405-7.

    PubMed abstract

    Hospital readmission and healthcare utilization following sepsis in community settings

    Author(s): Liu V; Lei X; Prescott HC; Kipnis P; Iwashyna TJ; Escobar GJ

    J Hosp Med. 2014 Aug;9(8):502-7. Epub 2014-04-04.

    PubMed abstract

    Hospital Deaths in Patients With Sepsis From 2 Independent Cohorts

    Author(s): Liu V; Escobar GJ; Greene JD; Soule J; Whippy A; Angus DC; Iwashyna TJ

    JAMA. 2014 Jul 2;312(1):90-2.

    PubMed abstract

    Increased one-year health care utilization in survivors of severe sepsis

    Author(s): Prescott HC; Langa KM; Liu V; Escobar GJ; Iwashyna TJ

    Am J Respir Crit Care Med. 2014 Jul 1;190(1):62-9.

    PubMed abstract

    Only Time Will Tell. Data-driven Approaches to Phenotyping Critical Illness

    Author(s): Liu V

    Ann Am Thorac Soc. 2014 Jun;11(5):795-6.

    PubMed abstract

    Accuracy of hospital standardized mortality rates: effects of model calibration

    Author(s): Kipnis P; Liu V; Escobar GJ

    Med Care. 2014 Apr;52(4):378-84.

    PubMed abstract

    Predicting red blood cell transfusion in hospitalized patients: role of hemoglobin level, comorbidities, and illness severity

    Author(s): Roubinian NH; Murphy EL; Swain BE; Gardner MN; Liu V; Escobar GJ; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III); Northern California Kaiser Permanente DOR Systems Research Initiative

    BMC Health Serv Res. 2014;14:213. Epub 2014-05-10.

    PubMed abstract

    Fluid Volume, Lactate Values, and Mortality in Sepsis Patients with Intermediate Lactate Values

    Author(s): Liu V; Morehouse JW; Soule J; Whippy A; Escobar GJ

    Ann Am Thorac Soc. 2013 Oct;10(5):466-73.

    PubMed abstract

    Automated identification of pneumonia in chest radiograph reports in critically ill patients

    Author(s): Liu V; Clark MP; Mendoza M; Saket R; Gardner MN; Turk BJ; Escobar GJ

    BMC Med Inform Decis Mak. 2013;13:90. Epub 2013-08-15.

    PubMed abstract

    Visitation policies and practices in United States intensive care units

    Author(s): Liu V; Read JL; Scruth E; Cheng E

    Crit Care. 2013;17(2):R71. Epub 2013-04-16.

    PubMed abstract

    Risk factors for unplanned transfer to intensive care within 24 hours of admission from the emergency department in an integrated healthcare system

    Author(s): Delgado MK; Liu V; Pines JM; Kipnis P; Gardner MN; Escobar GJ

    J Hosp Med. 2013 Jan;8(1):13-9. Epub 2012 Sep 28.

    PubMed abstract

    An electronic simplified acute physiology score-based risk adjustment score for critical illness in an integrated healthcare system*

    Author(s): Liu V; Turk BJ; Ragins AI; Kipnis P; Escobar GJ

    Crit Care Med. 2013 Jan;41(1):41-8.

    PubMed abstract

    The association between sepsis and potential medical injury among hospitalized patients

    Author(s): Liu V; Turk BJ; Rizk NW; Kipnis P; Escobar GJ

    Chest. 2012 Sep;142(3):606-13.

    PubMed abstract

    Potential for overuse of corticosteroids and vasopressin in septic shock

    Author(s): Hsu JL; Liu V; Patterson AJ; Martin GS; Nicolls MR; Russell JA

    Crit Care. 2012;16(5):447. Epub 2012-09-06.

    PubMed abstract