Joan C. Lo, MD

People

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3492 (phone)
joan.c.lo@kp.org
Kaiser Permanente Researcher Profiles

Joan C. Lo, MD, is a senior physician and research scientist at the Kaiser Permanente Northern California Division of Research; Associate Clinical Professor of Medicine at the University of California, San Francisco (UCSF); and endocrinologist at Kaiser Permanente Oakland Medical Center and San Francisco General Hospital. She is also directs clinical research center activities at the Division of Research in collaboration with UCSF’s Clinical and Translational Science Institute (CTSI). Dr. Lo’s current research interests center on endocrinologic conditions related to women’s health and chronic disease, including reproductive, pregnancy and post-menopausal disorders in women. Her work has also focused on endocrinologic and metabolic perturbations associated with HIV infection and chronic kidney disease.

Current Position(s):

Research Scientist III, Division of Research, Kaiser Permanente Northern California
Associate Clinical Professor, Division of Endocrinology, Department of Medicine, University of California, San Francisco (San Francisco General Hospital)

Section Affiliations:

Cardiovascular and Metabolic Conditions

Primary Research Interests:

Metabolic and reproductive outcomes associated with polycystic ovary syndrome
Bone mineral density, osteoporosis therapies and health-related outcomes
Metabolic and endocrinologic perturbations in HIV infection
Endocrinopathies associated with chronic kidney disease

Studies

Femur Fracture Outcomes Associated with Bisphosphonate Use

In clinical practice, oral bisphosphonate drugs are considered one of the main therapies for osteoporosis, based on strong clinical evidence of significant reduction in risk of hip, vertebral and non-vertebral fractures during the first 3-5 years of therapy. However, data are extremely limited regarding fracture outcomes beyond this initial treatment period and there have been concerns regarding long term adverse outcomes. This joint Kaiser California study proposes to fill an important knowledge gap by examining major osteoporotic fracture and atypical fracture outcomes among postmenopausal women with at least 3 years of bisphosphonate therapy. The aims are to: 1) Examine the association between long-term bisphosphonate use patterns and subsequent risk of osteoporotic fracture; and 2) estimate the association between long-term bisphosphonate use patterns and subsequent risk of atypical fracture.
Investigator: Lo, Joan
Funder: National Institute on Aging

Highlighted Publications

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Publications

The effect of frequent hemodialysis on matrix metalloproteinases, their tissue inhibitors, and FGF23: Implications for blood pressure and left ventricular mass modification in the Frequent Hemodialysis Network trials

Author(s): Chan CT; Kaysen GA; Beck GJ; Li M; Lo JC; Rocco MV; Kliger AS; FHN Trials

Hemodial Int. 2019 Dec 11.

Current Position(s):

Section Affiliations:

Primary Research Interests:

Studies

Femur Fracture Outcomes Associated with Bisphosphonate Use

Highlighted Publications

Publications

The effect of frequent hemodialysis on matrix metalloproteinases, their tissue inhibitors, and FGF23: Implications for blood pressure and left ventricular mass modification in the Frequent Hemodialysis Network trials

Don't Fall for That: A Residency Curricular Innovation about Fall Prevention

Statin Therapy and Risk of Incident Diabetes Mellitus in Adults With Cardiovascular Risk Factors

Longitudinal Evolution of Markers of Mineral Metabolism in Patients With CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study

Atypical femur fracture incidence in women increases with duration of bisphosphonate exposure

Depot Medroxyprogesterone Acetate, Oral Contraceptive, Intrauterine Device Use, and Fracture Risk

Vitamin D Status Among Older Women Initiating Osteoporosis Therapy

Using Pharmacy Data and Adherence to Define Long-Term Bisphosphonate Exposure in Women

Association Between Progression of Retinopathy and Concurrent Progression of Kidney Disease: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study

Secular Trends in Long-Term Oral Bisphosphonate Use

Serum Sex Hormones and the Risk of Fracture across the Menopausal Transition: Study of Women's Health Across the Nation

The Association of Polycystic Ovary Syndrome and Gestational Hypertensive Disorders in a Diverse Community-Based Cohort

Urinary N-Telopeptide as Predictor of Onset of Menopause-Related Bone Loss in Pre- and Perimenopausal Women

Understanding functional and social risk characteristics of frail older adults: a cross-sectional survey study

Recurrence after hospitalization for acute coronary syndrome among HIV-infected and HIV-uninfected individuals

Changes in Biomarker Profile and Left Ventricular Hypertrophy Regression: Results from the Frequent Hemodialysis Network Trials

Risk of Type 2 Diabetes Mellitus following Gestational Diabetes Pregnancy in Women with Polycystic Ovary Syndrome

Changes in bone mineral density in women with breast cancer receiving aromatase inhibitor therapy

Trends in bisphosphonate initiation within an integrated healthcare delivery system

The Association Between Change in Serum Bicarbonate and Change in Thyroid Hormone Levels in Patients Receiving Conventional or More Frequent Maintenance Hemodialysis

Innovative partnerships to advance public health training in community-based academic residency programs

Racial and ethnic differences in hip fracture outcomes in men

Contemporary rates and correlates of statin use and adherence in nondiabetic adults with cardiovascular risk factors: The KP CHAMP study

Teaching Nutrition in Graduate Medical Education: An Interactive Workshop

Predicting Adherence and Persistence with Oral Bisphosphonate Therapy in an Integrated Health Care Delivery System

Thyroid function in end stage renal disease and effects of frequent hemodialysis

Racial-Ethnic Differences in Fall Prevalence among Older Women: A Cross-Sectional Survey Study

Predicting Hypertension Among Children With Incident Elevated Blood Pressure

Changing Patterns in Oral Bisphosphonate Initiation in Women between 2004 and 2012

Mortality following hip fracture in Chinese, Japanese, and Filipina women

Applying ethnic-specific bone mineral density T-scores to Chinese women in the USA

Urinary N-Telopeptide and Rate of Bone Loss Over the Menopause Transition and Early Postmenopause

Accuracy of the Atherosclerotic Cardiovascular Risk Equation in a Large Contemporary, Multiethnic Population

Change in Weight Status and Development of Hypertension

Obesity Severity, Dietary Behaviors, and Lifestyle Risks Vary by Race/Ethnicity and Age in a Northern California Cohort of Children with Obesity

The association of race/ethnicity and risk of atypical femur fracture among older women receiving oral bisphosphonate therapy

Retinopathy and the Risk of Cardiovascular Disease in Patients With Chronic Kidney Disease (from the Chronic Renal Insufficiency Cohort Study)

Serum 25 Hydroxyvitamin D, Bone Mineral Density and Fracture Risk Across the Menopause

The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH): Design of a pharmacogenetic Resource for Type 2 Diabetes

Gestational Thyrotoxicosis, Antithyroid Drug Use and Neonatal Outcomes within an Integrated Healthcare Delivery System

Trends in mortality following hip fracture in older women

Comparing US paediatric and adult weight classification at the transition from late teenage to young adulthood

Bone health history in breast cancer patients on aromatase inhibitors

Lipid Screening in Children and Adolescents in Community Practice: 2007 to 2010

Retinopathy and Progression of CKD: The Chronic Renal Insufficiency Cohort Study

Racial/ethnic differences in hip and diaphyseal femur fractures

Prevalence of obesity and extreme obesity in children aged 3-5 years

Increasing Use of Vitamin D Supplementation in the Chronic Renal Insufficiency Cohort Study

Severe obesity in children: prevalence, persistence and relation to hypertension

Physical performance and frailty in chronic kidney disease

Patterns of care and persistence after incident elevated blood pressure

Prehypertension and Hypertension in Community-Based Pediatric Practice

Clinical characteristics, bone mineral density and non-vertebral osteoporotic fracture outcomes among post-menopausal U.S. South Asian Women

Bone resorption and fracture across the menopausal transition: the Study of Women's Health Across the Nation

Ethnic variability in bone geometry as assessed by hip structure analysis: Findings from the hip strength across the menopausal transition study

Application of new method for evaluating performance of fracture risk tool

Prevalence of cervical insufficiency in polycystic ovarian syndrome

Treatment of vitamin d deficiency within a large integrated health care delivery system

Retinopathy and Chronic Kidney Disease in the Chronic Renal Insufficiency Cohort (CRIC) Study

Atypical Femur Fractures Among Breast Cancer and Multiple Myeloma Patients Receiving Intravenous Bisphosphonate Therapy: A Case Series

Bisphosphonate-Related Osteonecrosis of the Jaw in Patients With Oral Bisphosphonate Exposure: Clinical Course and Outcomes

Association Between Retinopathy and Cardiovascular Disease in Patients With Chronic Kidney Disease (from the Chronic Renal Insufficiency Cohort [CRIC] Study)

Clinical correlates of atypical femoral fracture

The impact of subtrochanteric fracture criteria on hip fracture classification

Risk of preterm delivery in non-diabetic women with polycystic ovarian syndrome

Study of Women, Infant Feeding, and Type 2 diabetes mellitus after GDM pregnancy (SWIFT), a prospective cohort study: methodology and design

Antipsychotic Medication Use Among Children and Risk of Diabetes Mellitus

Methods for Assessing Fracture Risk Prediction Models: Experience With FRAX in a Large Integrated Health Care Delivery System

Bone and the perimenopause

Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease

Oral health considerations in older women receiving oral bisphosphonate therapy

Association of vitamin D insufficiency with carotid intima-media thickness in HIV-infected persons

Fracture risk tool validation in an integrated healthcare delivery system