Romain S. Neugebauer, PhD

People

Feasibility and Performance Assessments of TMLE and hdPS Methodologies to Fit MSM in a Real-World CER Study

This study aims to evaluate the practicability and practical advantages of: 1) Targeted Minimum Loss based Estimation (TMLE), and 2) a high-dimensional propensity score (hdPS) algorithm to fit dynamic Marginal Structural Models (MSM) in a longitudinal comparative effectiveness research (CER) study of adults with type 2 diabetes. 
Investigator: Neugebauer, Romain
Funder: Agency for Healthcare Research and Quality

Software to Automate Implementation of Causal Inference Methods with Time-Varying Interventions

This project aims to develop SAS macros to automate the data structuring required for implementation of Causal Inference methods with electronic health records data in studies with time-varying exposures, confounding and selection bias (e.g., marginal structural modeling with inverse probability weighting). SAS macros are validated with simulated data and their applicability is evaluated using secondary data analyses in cardiovascular, diabetes, and health services research. End-user feedback is used to validate and refine the implementation and documentation of the SAS software.  
Investigator: Neugebauer, Romain
Funder: 

Causal Analyses of Electronic Health Record Data for Assessing the Comparative Effectiveness of Treatment Regimens

This study aims to strengthen causal inferences based on Marginal Structural Modeling (MSM) and large healthcare databases for Comparative Effectiveness Research in Type 2 Diabetes Mellitus (T2DM), specifically, it aims to: 1) Develop a consensus for the types and quantity of MSM parameters relevant to T2DM patients and other stakeholders; 2) Evaluate the feasibility and performance of MSM approaches based on Targeted Learning to estimate these MSM parameters more efficiently and with more robustness to modeling assumptions than the current Inverse Probability Weighting approaches; 3) Explore the biases that may arise from current MSM applications with data where patient monitoring is not fixed but random or where the outcome is not right-censored but interval-censored and evaluate innovative MSM methods that aim to address these biases.
Investigator: Neugebauer, Romain
Funder: Patient-Centered Outcomes Research Institute

A Case Study of the Impact of Data-Adaptive Versus Model-Based Estimation of the Propensity Scores on Causal Inferences from Three Inverse Probability Weighting Estimators

Author(s): Neugebauer R; Schmittdiel JA; van der Laan MJ

Int J Biostat. 2016 May 1;12(1):131-55.

PubMed abstract

High-dimensional propensity score algorithm in comparative effectiveness research with time-varying interventions

Author(s): Neugebauer R; Schmittdiel JA; Zhu Z; Rassen JA; Seeger JD; Schneeweiss S

Stat Med. 2014 Dec 8.

PubMed abstract

Targeted learning in real-world comparative effectiveness research with time-varying interventions

Author(s): Neugebauer R; Schmittdiel JA; van der Laan MJ

Stat Med. 2014 Jun 30;33(14):2480-520. Epub 2014-02-17.

PubMed abstract

Causal inference in longitudinal studies with history-restricted marginal structural models

Author(s): Neugebauer R1; van der Laan MJ; Joffe MM; Tager IB;

​Electron J Stat. 2007 Jan 1;1:119-154.

PubMed abstract

Patients with complex chronic conditions: Health care use and clinical events associated with access to a patient portal

Author(s): Reed ME; Huang J; Brand RJ; Neugebauer R; Graetz I; Hsu J; Ballard DW; Grant R

PLoS ONE. 2019;14(6):e0217636. Epub 2019-06-19.

PubMed abstract

Using Pharmacy Data and Adherence to Define Long-Term Bisphosphonate Exposure in Women

Author(s): Izano MA; Neugebauer R; Ettinger B; Hui R; Chandra M; Adams AL; Niu F; Ott SM; Lo JC

J Manag Care Spec Pharm. 2019 Jun;25(6):719-723.

PubMed abstract

Association of immunosuppression and HIV viremia with anal cancer risk in persons living with HIV in the United States and Canada

Author(s): Hernández-Ramírez RU; Leyden W; Neugebauer RS; Silverberg MJ; North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate AIDS; et al.

Clin Infect Dis. 2019 May 02.

PubMed abstract

Targeted learning with daily EHR data

Author(s): Sofrygin O; Zhu Z; Schmittdiel JA; Adams AS; Grant RW; van der Laan MJ; Neugebauer R

Stat Med. 2019 Apr 25.

PubMed abstract

Developing a Prognostic Information System for Personalized Care in Real Time

Author(s): Lieu TA; Herrinton LJ; Liu L; Neugebauer R; Ng D; Prausnitz S; Van Den Eeden SK; Baer DM; et al.

EGEMS (Wash DC). 2019 Mar 25;7(1):2. Epub 2019-03-25.

PubMed abstract

Association of immunosuppression and HIV viraemia with non-Hodgkin lymphoma risk overall and by subtype in people living with HIV in Canada and the USA: a multicentre cohort study.

Author(s): Hernández-Ramírez, Raúl U RU; Qin, Li L; Lin, Haiqun H; Leyden, Wendy W; Neugebauer, Romain S RS; Althoff, Keri N KN; Achenbach, Chad J CJ; Hessol, Nancy A NA; D'Souza, Gypsyamber G; Gebo, Kelly A KA; Gill, M John MJ; Grover, Surbhi S; Horberg, Michael A MA; Li, Jun J; Mathews, W Christopher WC; Mayor, Angel M AM; Park, Lesley S LS; Rabkin, Charles S CS; Salters, Kate K; Justice, Amy C AC; Moore, Richard D RD; Engels, Eric A EA; Silverberg, Michael J MJ; Dubrow, Robert R;

The lancet. HIV. 2019 Apr ;6(4):e240-e249. Epub 2019-02-27.

PubMed abstract

Comparative effectiveness of treatment of actinic keratosis with topical fluorouracil and imiquimod in the prevention of keratinocyte carcinoma: a cohort study

Author(s): Neugebauer R; Su KA; Zhu Z; Sokil M; Chren MM; Friedman GD; Asgari MM

J Am Acad Dermatol. 2018 Nov 17.

PubMed abstract

Automated symptom and treatment side effect monitoring for improved quality of life among adults with diabetic peripheral neuropathy in primary care: a pragmatic, cluster, randomized, controlled trial.

Author(s): Adams, A S AS; Schmittdiel, J A JA; Altschuler, A A; Bayliss, E A EA; Neugebauer, R R; Ma, L L; Dyer, W W; Clark, J J; Cook, B B; Willyoung, D D; Jaffe, M M; Young, J D JD; Kim, E E; Boggs, J M JM; Prosser, L A LA; Wittenberg, E E; Callaghan, B B; Shainline, M M; Hippler, R M RM; Grant, R W RW

Diabetic medicine : a journal of the British Diabetic Association. 2018 Oct 21;9(1):4264. Epub 2018-10-21.

PubMed abstract

simcausal R Package: Conducting Transparent and Reproducible Simulation Studies of Causal Effect Estimation with Complex Longitudinal Data

Author(s): Sofrygin O; van der Laan MJ; Neugebauer R

J Stat Softw. 2017;81. Epub 2017-10-16.

PubMed abstract

Cutaneous Melanoma Risk among People with HIV in the United States and Canada

Author(s): Yanik EL; Leyden W; Neugebauer RS; Silverberg MJ; Dubrow R; et al.

J Acquir Immune Defic Syndr. 2018 Apr 27.

PubMed abstract

A real-world, community-based cohort study comparing the effectiveness of topical fluoruracil vs. topical imiquimod for the treatment of actinic keratosis

Author(s): Neugebauer R; Levandoski KA; Zhu Z; Sokil M; Chren MM; Friedman GD; Asgari MM

J Am Acad Dermatol. 2017 Dec 22.

PubMed abstract

simcausal R Package: Conducting Transparent and Reproducible Simulation Studies of Causal Effect Estimation with Complex Longitudinal Data

Author(s): Oleg Sofrygin; Mark J. van der Laan; Romain Neugebauer

​Sofrygin O, van der Laan MJ and Neugebauer R (2017). simcausal R Package: Conducting Transparent and Reproducible Simulation Studies of Causal Effect Estimation with Complex Longitudinal Data. Journal of Statistical Software, 81(2), pp. 1–47. doi: 10.18637/jss.v081.i02

PubMed abstract

Adjuvant gemcitabine-docetaxel chemotherapy for stage I uterine leiomyosarcoma: Trends and survival outcomes

Author(s): Littell RD; Tucker LY; Raine-Bennett T; Palen TE; Zaritsky E; Neugebauer R; Embry-Schubert J; Lentz SE

Gynecol Oncol. 2017 Jul 24.

PubMed abstract

Minimally Invasive Hysterectomy and Power Morcellation Trends in a West Coast Integrated Health System

Author(s): Zaritsky E; Tucker LY; Neugebauer R; Chou T; Flanagan T; Walter AJ; Raine-Bennett T

Obstet Gynecol. 2017 Jun;129(6):996-1005.

PubMed abstract

Associations of CD4+ T-cell count, HIV-1 RNA viral load, and antiretroviral therapy with Kaposi sarcoma risk among HIV-infected persons in the United States and Canada

Author(s): Dubrow R; Qin L; Lin H; Hernández-Ramírez RU; Neugebauer RS; Leyden W; Althoff KN; Achenbach CJ; Hessol NA; Modur SP; D'Souza G; Bosch RJ; Grover S; Horberg MA; Kitahata MM; Mayor AM; Novak RM; Rabkin CS; Sterling TR; Goedert JJ; Justice AC; Engels EA; Moore RD; Silverberg MJ; North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate AIDS

J Acquir Immune Defic Syndr. 2017 Apr 07.

PubMed abstract

Community-Based Practice Variations in Topical Treatment of Actinic Keratoses

Author(s): Storer M; Zhu Z; Sokil M; Ford M; Neugebauer R; Asgari MM

JAMA Dermatol. 2017 Apr 05.

PubMed abstract

The impact of telephonic wellness coaching on weight loss: A "Natural Experiments for Translation in Diabetes (NEXT-D)" study

Author(s): Schmittdiel JA; Adams SR; Goler N; Sanna RS; Boccio M; Bellamy DJ; Brown SD; Neugebauer RS; Ferrara A

Obesity (Silver Spring). 2017 Feb;25(2):352-356.

PubMed abstract

Identification of the joint effect of a dynamic treatment intervention and a stochastic monitoring intervention under the no direct effect assumption

Author(s): Neugebauer R; Schmittdiel JA; Adams AS; Grant RW; van der Laan MJ

J Causal Inference. 2017 03;5(1). Epub 2017-01-18.

PubMed abstract

Analysis of Body Mass Index and Mortality in Patients With Colorectal Cancer Using Causal Diagrams

Author(s): Kroenke CH; Neugebauer R; Meyerhardt J; Prado CM; Weltzien E; Kwan ML; Xiao J; Caan BJ

JAMA Oncol. 2016 May 19.

PubMed abstract

A Case Study of the Impact of Data-Adaptive Versus Model-Based Estimation of the Propensity Scores on Causal Inferences from Three Inverse Probability Weighting Estimators

Author(s): Neugebauer R; Schmittdiel JA; van der Laan MJ

Int J Biostat. 2016 May 1;12(1):131-55.

PubMed abstract

The Diabetes Telephone Study; Design and challenges of a pragmatic cluster randomized trial to improve diabetic peripheral neuropathy treatment

Author(s): Adams AS; Bayliss EA; Schmittdiel JA; Altschuler A; Dyer W; Neugebauer R; Jaffe M; Young JD; Kim E; Grant RW; Diabetes Telephone Study Team

Clin Trials. 2016 Mar 31.

PubMed abstract

The association of race/ethnicity and risk of atypical femur fracture among older women receiving oral bisphosphonate therapy

Author(s): Lo JC; Hui RL; Grimsrud CD; Chandra M; Neugebauer RS; Gonzalez JR; Budayr A; Lau G; Ettinger B

Bone. 2016 Jan 6.

PubMed abstract

Occult Uterine Sarcoma and Leiomyosarcoma: Incidence of and Survival Associated With Morcellation

Author(s): Raine-Bennett T1; Tucker LY; Zaritsky E; Littell RD; Palen T; Neugebauer R; Axtell A; Schultze PM; Kronbach DW; Embry-Schubert J; Sundang A; Bischoff K; Compton-Phillips AL; Lentz SE;

​​Obstet Gynecol. 2016 Jan;127(1):29-39. doi: 10.1097/AOG.0000000000001187.

PubMed abstract

Wellness Coaching for People With Prediabetes: A Randomized Encouragement Trial to Evaluate Outreach Methods at Kaiser Permanente, Northern California, 2013

Author(s): Xiao H; Adams SR; Goler N; Sanna RS; Boccio M; Bellamy DJ; Brown SD; Neugebauer RS; Ferrara A; Schmittdiel JA

Prev Chronic Dis. 2015;12:E207. Epub 2015-11-25.

PubMed abstract

Telephone-Based Coaching: A Comparison of Tobacco Cessation Programs in an Integrated Health Care System

Author(s): Boccio M; Sanna RS; Adams SR; Goler NC; Brown SD; Neugebauer RS; Ferrara A; Wiley DM; Bellamy DJ; Schmittdiel JA

Am J Health Promot. 2015 Nov 11.

PubMed abstract

Use of abacavir and risk of cardiovascular disease among HIV-infected individuals

Author(s): Marcus JL; Neugebauer RS; Leyden WA; Chao CR; Xu L; Quesenberry CP; Klein DB; Towner WJ; Horberg MA; Silverberg MJ

J Acquir Immune Defic Syndr. 2015 Nov 2.

PubMed abstract

Employer-Based Screening for Diabetes and Prediabetes in an Integrated Health Care Delivery System: A Natural Experiment for Translation in Diabetes (NEXT-D) Study

Author(s): Adams SR; Wiley DM; Fargeix A; George V; Neugebauer RS; Schmittdiel JA

J Occup Environ Med. 2015 Nov;57(11):1147-53.

PubMed abstract

Adherence to Metformin, Statins, and ACE/ARBs Within the Diabetes Health Plan (DHP)

Author(s): Duru OK; Turk N; Ettner SL; Neugebauer R; Moin T; Li J; Kimbro L; Chan C; Luchs RH; Keckhafer AM; Kirvan A; Ho S; Mangione CM

J Gen Intern Med. 2015 May 6.

PubMed abstract

High-dimensional propensity score algorithm in comparative effectiveness research with time-varying interventions

Author(s): Neugebauer R; Schmittdiel JA; Zhu Z; Rassen JA; Seeger JD; Schneeweiss S

Stat Med. 2014 Dec 8.

PubMed abstract

Targeted learning in real-world comparative effectiveness research with time-varying interventions

Author(s): Neugebauer R; Schmittdiel JA; van der Laan MJ

Stat Med. 2014 Jun 30;33(14):2480-520. Epub 2014-02-17.

PubMed abstract

Racial/ethnic differences in hip and diaphyseal femur fractures

Author(s): Lo JC; Zheng P; Grimsrud CD; Chandra M; Ettinger B; Budayr A; Lau G; Baur MM; Hui RL; Neugebauer R

Osteoporos Int. 2014 Jun 26.

PubMed abstract

Exercise as a Vital Sign: A Quasi-Experimental Analysis of a Health System Intervention to Collect Patient-Reported Exercise Levels

Author(s): Grant RW; Schmittdiel JA; Neugebauer RS; Uratsu CS; Sternfeld B

J Gen Intern Med. 2014 Feb;29(2):341-8. Epub 2013-12-06.

PubMed abstract

Accuracy of hemoglobin A1c imputation using fasting plasma glucose in diabetes research using electronic health records data

Author(s): Xu S; Schroeder EB; Shetterly S; Goodrich GK; O'Connor PJ; Steiner JF; Schmittdiel JA; Desai J; Pathak RD; Neugebauer R; Butler MG; Kirchner L; Raebel MA

Stat Optim Inf Comput. 2014;2(2):93-104.

PubMed abstract

Impact of Specific Glucose-Control Strategies on Microvascular and Macrovascular Outcomes in 58,000 Adults With Type 2 Diabetes

Author(s): Neugebauer R; Fireman B; Roy JA; O'Connor PJ

Diabetes Care. 2013 Nov;36(11):3510-6. Epub 2013-07-22.

PubMed abstract

Patient Satisfaction and Perceived Success with a Telephonic Health Coaching Program: The Natural Experiments for Translation in Diabetes (NEXT-D) Study, Northern California, 2011

Author(s): Adams SR; Goler NC; Sanna RS; Boccio M; Bellamy DJ; Brown SD; Neugebauer RS; Ferrara A; Wiley DM; Schmittdiel JA

Prev Chronic Dis. 2013;10:E179. Epub 2013-10-31.

PubMed abstract

Super learning to hedge against incorrect inference from arbitrary parametric assumptions in marginal structural modeling

Author(s): Neugebauer R; Fireman B; Roy JA; Raebel MA; Nichols GA; O'Connor PJ

J Clin Epidemiol. 2013 Aug;66(8 Suppl):S99-109.

PubMed abstract

Health-Plan and Employer-Based Wellness Programs to Reduce Diabetes Risk; The Kaiser Permanente Northern California NEXT-D Study

Author(s): Schmittdiel JA; Brown SD; Neugebauer R; Adams SR; Adams AS; Wiley D; Ferrara A

Prev Chronic Dis. 2013 Jan;10:E15.

PubMed abstract

Causal inference in epidemiological studies with strong confounding

Author(s): Moore KL; Neugebauer R; van der Laan MJ; Tager IB

Stat Med. 2012 Jun 15;31(13):1380-404. Epub 2012 Feb 23.

PubMed abstract

Dynamic marginal structural modeling to evaluate the comparative effectiveness of more or less aggressive treatment intensification strategies in adults with type 2 diabetes

Author(s): Neugebauer R; Fireman B; Roy JA; O'Connor PJ; Selby JV

Pharmacoepidemiol Drug Saf. 2012 May;21 Suppl 2:99-113.

PubMed abstract

Predictors of patient satisfaction with mohs surgery: analysis of preoperative, intraoperative, and postoperative factors in a prospective cohort

Author(s): Asgari MM; Warton EM; Neugebauer R; Chren MM

Arch Dermatol. 2011 Dec;147(12):1387-94.

PubMed abstract

HIV Infection, Immunodeficiency, Viral Replication, and the Risk of Cancer

Author(s): Silverberg MJ; Chao C; Leyden WA; Xu L; Horberg MA; Klein D; Towner WJ; Dubrow R; Quesenberry CP Jr; Neugebauer RS; Abrams DI

Cancer Epidemiol Biomarkers Prev. 2011 Dec;20(12):2551-9. Epub 2011 Nov 22.

PubMed abstract

Robust extraction of covariate information to improve estimation efficiency in randomized trials

Author(s): Moore KL; Neugebauer R; Valappil T; Laan MJ

Stat Med. 2011 Aug 30;30(19):2389-408. Epub 2011 Jul 12.

PubMed abstract

Ambient ozone concentrations and cardiac mortality in Southern California 1983-2000: application of a new marginal structural model approach

Author(s): Moore K; Neugebauer R; Lurmann F; Hall J; Brajer V; Alcorn S; Tager I

Am J Epidemiol. 2010 Jun 1;171(11):1233-43. Epub 2010 May 3.

PubMed abstract

Cohort Profile: The Diabetes Study of Northern California (DISTANCE)--objectives and design of a survey follow-up study of social health disparities in a managed care population

Author(s): Moffet HH; Adler N; Schillinger D; Ahmed AT; Laraia B; Selby JV; Neugebauer R; Liu JY; Parker MM; Warton M; Karter AJ

Int J Epidemiol. 2009 Feb;38(1):38-47. Epub 2008 Mar 7.

PubMed abstract

Causal inference in longitudinal studies with history-restricted marginal structural models

Author(s): Neugebauer R1; van der Laan MJ; Joffe MM; Tager IB;

​Electron J Stat. 2007 Jan 1;1:119-154.

PubMed abstract