Lori C. Sakoda, PhD

People

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3677 (phone)
lori.sakoda@kp.org
Kaiser Permanente Researcher Profiles

Lori C. Sakoda, MPH, PhD, is a research scientist of the Kaiser Permanente Northern California Division of Research and an affiliate investigator of the Division of Public Health Sciences at the Fred Hutchinson Cancer Research Center. Her research interests currently encompass identifying genetic and environmental determinants of risk and prognosis for cancer, particularly of the lung. She is also interested in understanding the basis for observed differences in cancer incidence and outcomes by sex and race/ethnicity.

Current Position(s):

Research Scientist II, Division of Research, Kaiser Permanente Northern California
Affiliate Investigator, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center

Section Affiliations:

Cancer

Primary Research Interests:

Cancer epidemiology and prevention
Genetic determinants of cancer risk, progression, and treatment response
Racial/ethnic and sex differences in cancer

Studies

Identifying Barriers to Lung Cancer Screening among Asian Americans

This study will identify key barriers to lung cancer screening as well as develop tailored strategies and materials to increase the uptake of lung cancer screening and smoking cessation services among Asian Americans.
Investigator: Sakoda, Lori
Funder: Tobacco-Related Disease Research Program

What Factors Affect Time to Surgery for Lung Cancer and Moderate its Associations with Patient Outcomes

This study will determine factors that influence time to surgery and its associations with outcomes in patients with early-stage non-small cell lung cancer.
Investigator: Sakoda, Lori
Funder: TPMG Delivery Science Projects Program

Utilization and Impact of Extended-Interval Dosing of Immunotherapy on Outcomes in Patients with Locally Advanced NSCLC

This study will evaluate the utilization and dosing of durvalumab and associations with treatment outcomes among patients with unresectable stage III non-small cell lung cancer in an integrated health care system.
Investigator: Sakoda, Lori
Funder: AstraZeneca PLC

Multilevel Determinants of Racial/Ethnic Disparities in Lung Cancer Screening Utilization

Lung cancer screening has been underutilized nationally to date, with growing evidence suggesting that screening rates differ by race. This research aims to identify multilevel factors that influence disparities in utilization of lung cancer screening from eligibility determination to screening initiation.
Investigator: Sakoda, Lori
Funder: National Cancer Institute

Comparative Effectiveness of Pretreatment Lung Cancer Nodal Staging

The proposed project will determine whether a guideline-recommended nodal staging strategy is superior to a guideline-discordant nodal staging strategy, and whether a validated risk-based nodal staging strategy that reduces unnecessary biopsies is an equivalent alternative to a guideline-recommended nodal staging strategy in terms of patient outcomes and costs.
Investigator: Sakoda, Lori
Funder: National Cancer Institute

Disparities in REsults of Immune Checkpoint Inhibitor Treatment (DiRECT): A Prospective Cohort Study of Cancer Survivors Treated with anti-PD-1/anti-PD-L1 in a Community Oncology Setting

This project will establish a prospective cohort of white and Black cancer patients treated with immune checkpoint inhibitors, leveraging the NCI Community Oncology Research Program network infrastructure, to investigate racial differences in immune-related adverse events and their predictors, treatment delay and discontinuation, and short- and long-term patient outcomes.
Investigator: Sakoda, Lori
Funder: National Cancer Institute

Leveraging Diversity in Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk Scores

Inadequate representation of diverse racial/ethnic populations in genetic studies is hindering the translational potential of polygenic risk scores (PRS) in cancer risk prediction. To address this shortcoming, we aim to construct and evaluate PRS for cancer and estimate the absolute risk of cancer explained by PRS and non-genetic factors across multiethnic populations.
Investigator: Sakoda, Lori
Funder: National Cancer Institute

Understanding Racial/Ethnic Disparities in Lung Cancer Screening Utilization

This study proposes to understand patterns and multilevel determinants of racial/ethnic disparities in Lung Cancer Screening utilization from 2017 onward at KPNC.
Investigator: Sakoda, Lori
Funder: Northern California Community Benefit Programs

Assessing Adherence to Follow-Up Care After Low-Dose Computed Tomography Screening for Lung Cancer

With the recent implementation of lung cancer screening in community-based practice, little is currently known about utilization patterns and outcomes in patients following the initial low-dose computed tomography (CT) screening exam. The primary goals of this study are to 1) examine adherence to recommended follow-up based on initial low-dose CT screening exam results and 2) identify factors associated with adherence (versus non-adherence) to recommended follow-up.
Investigator: Sakoda, Lori
Funder: Northern California Community Benefit Programs

Evaluating a Risk Prediction Model for Lung Cancer

Screening with low-dose computed tomography (LDCT) presents an opportunity to improve early detection and reduce mortality from lung cancer. However, the potential harms of LDCT screening, including frequent false-positive findings that lead to unnecessary procedures and repeated radiation exposure, have raised concerns. Implementing targeted screening of persons at highest predicted risk for lung cancer may minimize such harms, but empirical evidence to support more personalized risk-based screening remains limited. This study presents a mentored career development plan encompassing training and research activities for establishing independence as a translational cancer epidemiologist, with a primary focus on early detection and management of lung cancer. The goal of the proposed research is to evaluate whether the most predictive and clinically-oriented risk model for lung cancer to date can be validated, extended and applied to aid decision-making about LDCT screening.
Investigator: Sakoda, Lori
Funder: National Cancer Institute

Highlighted Publications

No results found matching criteria

Publications

Genome-wide interaction study with smoking for colorectal cancer risk identifies novel genetic loci related to tumor suppression, inflammation and immune response

Author(s): Carreras-Torres, Robert; Scacheri, Peter C; Gauderman, W James; et al.

Cancer Epidemiol Biomarkers Prev. 2022 Dec 28.

Current Position(s):

Section Affiliations:

Primary Research Interests:

Studies

Identifying Barriers to Lung Cancer Screening among Asian Americans

What Factors Affect Time to Surgery for Lung Cancer and Moderate its Associations with Patient Outcomes

Utilization and Impact of Extended-Interval Dosing of Immunotherapy on Outcomes in Patients with Locally Advanced NSCLC

Multilevel Determinants of Racial/Ethnic Disparities in Lung Cancer Screening Utilization

Comparative Effectiveness of Pretreatment Lung Cancer Nodal Staging

Disparities in REsults of Immune Checkpoint Inhibitor Treatment (DiRECT): A Prospective Cohort Study of Cancer Survivors Treated with anti-PD-1/anti-PD-L1 in a Community Oncology Setting

Leveraging Diversity in Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk Scores

Understanding Racial/Ethnic Disparities in Lung Cancer Screening Utilization

Assessing Adherence to Follow-Up Care After Low-Dose Computed Tomography Screening for Lung Cancer

Evaluating a Risk Prediction Model for Lung Cancer

Highlighted Publications

Publications

Genome-wide interaction study with smoking for colorectal cancer risk identifies novel genetic loci related to tumor suppression, inflammation and immune response

Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Body Mass Index and Molecular Subtypes of Colorectal Cancer

Interactions between folate intake and genetic predictors of gene expression levels associated with colorectal cancer risk

Assessment of genetic susceptibility to multiple primary cancers through whole-exome sequencing in two large multi-ancestry studies

Sociodemographic and clinical characteristics associated with never-smoking status in patients with lung cancer: findings from a large integrated health system

Fostering a High-Functioning Team in Cancer Care Using the 4R Oncology Model: Assessment in a Large Health System and a Blueprint for Other Institutions

Electronic cigarette use and risk of COVID-19 among young adults without a history of cigarette smoking

Genome-Wide Interaction Analysis of Genetic Variants with Menopausal Hormone Therapy for Colorectal Cancer Risk

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer

Facilitating Adherence to Annual Screening for Lung Cancer: Are Program-Level Interventions Enough?

Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region

Genetic variants associated with circulating C-reactive protein levels and colorectal cancer survival: Sex- and lifestyle factors- specific associations

Genetic associations and architecture of asthma-chronic obstructive pulmonary disease overlap

Risk Stratification for Early-Onset Colorectal Cancer Using a Combination of Genetic and Environmental Risk Scores: An International Multi-Center Study

Cigarette Smoking and Risk of SARS-CoV-2 infection and Disease Severity Among Adults in an Integrated Health Care System in California

Accounting for EGFR mutations in epidemiological analyses of non-small cell lung cancers: Examples based on the International Lung Cancer Consortium data

The Friends of Cancer Research Real World Data (RWD) Collaboration Pilot 2.0: Methodological Recommendations from Oncology Case Studies

Adherence to Lung Cancer Screening: What Exactly Are We Talking About?

Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study

Survival Associated With Consolidated Multidisciplinary Care in Head and Neck Cancer: A Retrospective Cohort Study

Smoking Behavior and Prognosis After Colorectal Cancer Diagnosis: A Pooled Analysis of 11 Studies

Association Between Smoking and Molecular Subtypes of Colorectal Cancer

Genetic architectures of proximal and distal colorectal cancer are partly distinct

Genetically predicted circulating C-reactive protein concentration and colorectal cancer survival: A Mendelian randomization consortium study

Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study

Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer

Two-Sample Mendelian Randomization Analysis of Associations Between Periodontal Disease and Risk of Cancer

An Intervention to Tag Findings Suspicious for Lung Cancer on Chest Computed Tomography Has Good Sensitivity and Number Needed to Diagnose

Ten-year Thyroid Cancer Incidence in an Integrated Healthcare Delivery System

A large-scale association study detects novel rare variants, risk genes, functional elements, and polygenic architecture of prostate cancer susceptibility

Patterns and Factors Associated With Adherence to Lung Cancer Screening in Diverse Practice Settings

Response to Li and Hopper

Identifying novel susceptibility genes for colorectal cancer risk from a transcriptome-wide association study of 125,478 subjects

A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer

Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts

Association of body mass index with colorectal cancer risk by genome-wide variants

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

Genetic Variants in the Regulatory T cell-Related Pathway and Colorectal Cancer Prognosis

Standardized reporting and management of suspicious findings on chest computed tomography is associated with improved lung cancer diagnosis in an observational study

Early Screening of African Americans (45-50 Years Old) in a Fecal Immunochemical Test-based Colorectal Cancer Screening Program

Intake of dietary fruit, vegetables, and fiber and risk of colorectal cancer according to molecular subtypes: A pooled analysis of 9 studies

Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk

Pathway Analysis of Renal Cell Carcinoma Genome-Wide Association Studies Identifies Novel Associations

Addressing Disparities in Lung Cancer Screening Eligibility and Healthcare Access. An Official American Thoracic Society Statement

Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts

Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk

Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses

Telomere maintenance variants and survival after colorectal cancer: Smoking- and sex-specific associations

Postmenopausal Hormone Therapy and Colorectal Cancer Risk by Molecularly Defined Subtypes and Tumor Location

Genetic predictors of circulating 25-hydroxyvitamin D and prognosis after colorectal cancer

Alcohol and tobacco use in relation to mammographic density in 23,456 women

Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk

Cumulative Burden of Colorectal Cancer-Associated Genetic Variants is More Strongly Associated With Early-onset vs Late-onset Cancer

Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses

Mendelian randomization of circulating polyunsaturated fatty acids and colorectal cancer risk

Risk of Mortality between Untreated and Treated Papillary Thyroid Cancer: A Matched Cohort Analysis

COPD and lung cancer incidence in the Women's Health Initiative Observational Study: A brief report

Understanding the natural history of papillary thyroid cancer: Case series

Factors associated with employment discontinuation among older and working age survivors of oropharyngeal cancer

An Exploratory Analysis of Real-World End Points for Assessing Outcomes Among Immunotherapy-Treated Patients With Advanced Non-Small-Cell Lung Cancer

Telomere length and socioeconomic status at neighborhood and individual levels among 80,000 adults in the Genetic Epidemiology Research on Adult Health and Aging cohort

Effectiveness of a Patient Education Class to Enhance Knowledge about Lung Cancer Screening: a Quality Improvement Evaluation

Discovery of common and rare genetic risk variants for colorectal cancer