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Lori C. Sakoda, PhD

lori.sakoda@kp.org

Kaiser Permanente Researcher Profiles

Lori  Sakoda, PhD

Lori C. Sakoda, MPH, PhD, is a Research Scientist in the Division of Research at Kaiser Permanente Northern California and an Associate Professor of Health Systems Science at the Kaiser Permanente Bernard J. Tyson School of Medicine. Her research interests currently encompass identifying genetic and environmental determinants of risk and prognosis for cancer, particularly of the lung. She is also interested in understanding the basis for observed differences in cancer incidence and outcomes by sex and race/ethnicity.

Current Positions

  • Research Scientist II, Division of Research, Kaiser Permanente Northern California

Section Affiliations

Primary Research Interests

  • Cancer epidemiology and prevention
  • Genetic determinants of cancer risk, progression, and treatment response
  • Racial/ethnic and sex differences in cancer

Studies

Promoting Equity of Cancer Screening and Follow-up for Lung Cancer

This research will elucidate factors that contribute to lung cancer disparities between rural and urban areas and provide contextual information for future interventions and policies. Our specific aims are to: characterize the delivery of evidence-based interventions for lung cancer prevention and early detection, comparing rural to urban areas, by assessing differences in use of smoking cessation interventions and lung cancer screening at multiple levels of influences; identify potentially modifiable care gaps across the lung cancer screening continuum, including risk assessment and timely treatment, by examining patients who died of lung cancer relative to patients who are alive by rural-urban status; and evaluate similarities and differences in the barriers and promoters to delivery of evidence-based intervention across the lung cancer screening continuum (smoking cessation, shared decision-making, screening, and treatment) in the rural and urban contexts.

Investigator: Sakoda, Lori

Funder: National Cancer Institute

Patterns, determinants, and outcomes of guideline-recommended imaging surveillance after surgical resection of early-stage lung cancer

High-quality evidence is limited on the utilization and outcomes of imaging surveillance after definitive surgery for early-stage lung cancer. This study examines patterns and factors associated with guideline-recommended imaging surveillance of lung cancer survivors, in addition to rates of new or recurrent lung cancer and mortality following surgical resection, before and after the implementation of a patient tracking system designed to support imaging surveillance.

Investigator: Sakoda, Lori

Funder: KP National Office of Community Health

Identifying Barriers to Lung Cancer Screening among Asian Americans

This study will identify key barriers to lung cancer screening as well as develop tailored strategies and materials to increase the uptake of lung cancer screening and smoking cessation services among Asian Americans.

Investigator: Sakoda, Lori

Funder: Tobacco-Related Disease Research Program

What Factors Affect Time to Surgery for Lung Cancer and Moderate its Associations with Patient Outcomes

This study will determine factors that influence time to surgery and its associations with outcomes in patients with early-stage non-small cell lung cancer.

Investigator: Sakoda, Lori

Funder: TPMG Delivery Science Projects Program

Utilization and Impact of Extended-Interval Dosing of Immunotherapy on Outcomes in Patients with Locally Advanced NSCLC

This study will evaluate the utilization and dosing of durvalumab and associations with treatment outcomes among patients with unresectable stage III non-small cell lung cancer in an integrated health care system.

Investigator: Sakoda, Lori

Funder: AstraZeneca PLC

Multilevel Determinants of Racial/Ethnic Disparities in Lung Cancer Screening Utilization

Lung cancer screening has been underutilized nationally to date, with growing evidence suggesting that screening rates differ by race. This research aims to identify multilevel factors that influence disparities in utilization of lung cancer screening from eligibility determination to screening initiation.

Investigator: Sakoda, Lori

Funder: National Cancer Institute

Comparative Effectiveness of Pretreatment Lung Cancer Nodal Staging

The proposed project will determine whether a guideline-recommended nodal staging strategy is superior to a guideline-discordant nodal staging strategy, and whether a validated risk-based nodal staging strategy that reduces unnecessary biopsies is an equivalent alternative to a guideline-recommended nodal staging strategy in terms of patient outcomes and costs.

Investigator: Sakoda, Lori

Funder: National Cancer Institute

Leveraging Diversity in Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk Scores

Inadequate representation of diverse racial/ethnic populations in genetic studies is hindering the translational potential of polygenic risk scores (PRS) in cancer risk prediction. To address this shortcoming, we aim to construct and evaluate PRS for cancer and estimate the absolute risk of cancer explained by PRS and non-genetic factors across multiethnic populations.

Investigator: Sakoda, Lori

Funder: National Cancer Institute

Disparities in REsults of Immune Checkpoint Inhibitor Treatment (DiRECT): A Prospective Cohort Study of Cancer Survivors Treated with anti-PD-1/anti-PD-L1 in a Community Oncology Setting

This project will establish a prospective cohort of white and Black cancer patients treated with immune checkpoint inhibitors, leveraging the NCI Community Oncology Research Program network infrastructure, to investigate racial differences in immune-related adverse events and their predictors, treatment delay and discontinuation, and short- and long-term patient outcomes.

Investigator: Sakoda, Lori

Funder: National Cancer Institute

Understanding Racial/Ethnic Disparities in Lung Cancer Screening Utilization

This study proposes to understand patterns and multilevel determinants of racial/ethnic disparities in Lung Cancer Screening utilization from 2017 onward at KPNC.

Investigator: Sakoda, Lori

Funder: Northern California Community Benefit Programs

Assessing Adherence to Follow-Up Care After Low-Dose Computed Tomography Screening for Lung Cancer

With the recent implementation of lung cancer screening in community-based practice, little is currently known about utilization patterns and outcomes in patients following the initial low-dose computed tomography (CT) screening exam. The primary goals of this study are to 1) examine adherence to recommended follow-up based on initial low-dose CT screening exam results and 2) identify factors associated with adherence (versus non-adherence) to recommended follow-up.

Investigator: Sakoda, Lori

Funder: Northern California Community Benefit Programs

Evaluating a Risk Prediction Model for Lung Cancer

Screening with low-dose computed tomography (LDCT) presents an opportunity to improve early detection and reduce mortality from lung cancer. However, the potential harms of LDCT screening, including frequent false-positive findings that lead to unnecessary procedures and repeated radiation exposure, have raised concerns. Implementing targeted screening of persons at highest predicted risk for lung cancer may minimize such harms, but empirical evidence to support more personalized risk-based screening remains limited. This study presents a mentored career development plan encompassing training and research activities for establishing independence as a translational cancer epidemiologist, with a primary focus on early detection and management of lung cancer. The goal of the proposed research is to evaluate whether the most predictive and clinically-oriented risk model for lung cancer to date can be validated, extended and applied to aid decision-making about LDCT screening.

Investigator: Sakoda, Lori

Funder: National Cancer Institute

Publications

Elucidating the Risk of Colorectal Cancer for Variants in Hereditary Colorectal Cancer Genes

Authors: Mahmood, Khalid;Thomas, Minta;Qu, Conghui;Gecco-Ccfr Consortium,;Hsu, Li;Buchanan, Daniel D;Peters, Ulrike

Gastroenterology. 2023 Oct;165(4):1070-1076.e3. Epub 2023-07-14.

PubMed abstract

Genome-wide interaction analysis of folate for colorectal cancer risk

Authors: Bouras, Emmanouil;Ruiz-Narvaez, Edward;Tsilidis, Konstantinos K;et al.

Am J Clin Nutr. 2023 Aug 26.

PubMed abstract

A genetic locus within the FMN1/GREM1 gene region interacts with body mass index in colorectal cancer risk

Authors: Aglago, Elom K;Ruiz-Narvaez, Edward;Campbell, Peter T;et al.

Cancer Res. 2023 Aug 01;83(15):2572-2583.

PubMed abstract

Delays in Follow-up After a Positive Lung Cancer Screening Exam: Is the Benefit of Screening Compromised?

Authors: Rivera, M Patricia;Henderson, Louise M;Sakoda, Lori C

Ann Am Thorac Soc. 2023 Aug;20(8):1102-1104.

PubMed abstract

Current tobacco smoking and risk of SARS-CoV-2 infection and hospitalization: Evaluating the role of socio-demographic factors and comorbidities

Authors: Young-Wolff, Kelly C;Slama, Natalie;Sakoda, Lori C;Prochaska, Judith J;Fogelberg, Renee;Alexeeff, Stacey E

Prev Med. 2023 Jul;172:107523. Epub 2023-04-26.

PubMed abstract

Association of Surgical Timing with Outcomes in Early Stage Lung Cancer

Authors: Banks, Kian C; Dusendang, Jennifer R; Schmittdiel, Julie A; Hsu, Diana S; Ashiku, Simon K; Patel, Ashish R; Sakoda, Lori C; Velotta, Jeffrey B

World J Surg. 2023 May;47(5):1323-1332. Epub 2023-01-25.

PubMed abstract

Molecular Characteristics of Early-onset Colorectal Cancer According to Detailed Anatomical Locations: Comparison to Later-onset Cases: Molecular Characteristics and Early-onset Colorectal Tumor Subsites

Authors: Ugai, Tomotaka; Sakoda, Lori C; Ogino, Shuji; et al.

Am J Gastroenterol. 2023 Apr 01;118(4):712-726. Epub 2022-12-30.

PubMed abstract

Leisure time sedentary behaviour and risks of breast, colorectal, and prostate cancer: A Mendelian randomization analysis

Authors: Papadimitriou, Nikos; Sakoda, Lori C; Murphy, Neil; et al.

medRxiv. 2023 Mar 22.

PubMed abstract

TRENDS IN SMOKING-SPECIFIC LUNG CANCER INCIDENCE RATES WITHIN A U.S. INTEGRATED HEALTH SYSTEM, 2007-2018

Authors: Sakoda, Lori C; Alabaster, Amy; Sumner, Eric T; Gordon, Nancy P; Quesenberry, Charles P; Velotta, Jeffrey B

Chest. 2023 Mar 17.

PubMed abstract

Risk-stratified screening for colorectal cancer using genetic and environmental risk factors: A cost-effectiveness analysis based on real-world data

Authors: van den Puttelaar, Rosita; Lee, Jeffrey K; Sakoda, Lori C; Corley, Douglas A; Lansdorp-Vogelaar, Iris; et al.

Clin Gastroenterol Hepatol. 2023 Mar 09.

PubMed abstract

Validation of a genetic-enhanced risk prediction model for colorectal cancer in a large community-based cohort

Authors: Su, Yu-Ru; Sakoda, Lori C; Lee, Jeffrey K; Corley, Douglas A; Hsu, Li; et al.

Cancer Epidemiol Biomarkers Prev. 2023 Mar 06;32(3):353-362.

PubMed abstract

Genome-wide interaction study with smoking for colorectal cancer risk identifies novel genetic loci related to tumor suppression, inflammation and immune response

Authors: Carreras-Torres, Robert; Sakoda, Lori C; Gauderman, W James; et al.

Cancer Epidemiol Biomarkers Prev. 2023 Mar 06;32(3):315-328.

PubMed abstract

Prognostic role of detailed colorectal location and tumor molecular features: analyses of 13,101 colorectal cancer patients including 2994 early-onset cases

Authors: Ugai, Tomotaka; Sakoda, Lori C; Ogino, Shuji; et al.

J Gastroenterol. 2023 Mar;58(3):229-245. Epub 2023-01-17.

PubMed abstract

Body Mass Index and Molecular Subtypes of Colorectal Cancer

Authors: Murphy, Neil; Sakoda, Lori C; Campbell, Peter T; et al.

J Natl Cancer Inst. 2023 Feb 08;115(2):165-173.

PubMed abstract

MiXcan: a framework for cell-type-aware transcriptome-wide association studies with an application to breast cancer

Authors: Song, Xiaoyu; Alexeeff, Stacey E; Sakoda, Lori C; Habel, Laurel A; Sieh, Weiva; et al.

Nat Commun. 2023 Jan 23;14(1):377. Epub 2023-01-23.

PubMed abstract

Combining Asian-European Genome-Wide Association Studies of Colorectal Cancer Improves Risk Prediction Across Race and Ethnicity

Authors: Thomas, Minta; Sakoda, Lori C; Lee, Jeffrey K; Corley, Douglas A; Hsu, Li; et al.

medRxiv. 2023 Jan 19.

PubMed abstract

Cigarette Smoking and Risk of SARS-CoV-2 infection and Disease Severity Among Adults in an Integrated Health Care System in California

Authors: Young-Wolff, Kelly C; Slama, Natalie; Alexeeff, Stacey E; Sakoda, Lori C; Fogelberg, Renee; Myers, Laura C; Campbell, Cynthia I; Adams, Alyce S; Prochaska, Judith J

Nicotine Tob Res. 2023 Jan 05;25(2):211-220.

PubMed abstract

Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Authors: Fernandez-Rozadilla, Ceres; Corley, Douglas; Sakoda, Lori; Peters, Ulrike; et al.

Nat Genet. 2023 Jan;55(1):89-99. Epub 2022-12-20.

PubMed abstract

Fostering a High-Functioning Team in Cancer Care Using the 4R Oncology Model: Assessment in a Large Health System and a Blueprint for Other Institutions

Authors: Liu, Raymond; Gordon, Nancy; Sakoda, Lori C; Trosman, Julia R; et al.

JCO Oncol Pract. 2023 Jan;19(1):e125-e137. Epub 2022-09-30.

PubMed abstract

Survival Associated With Consolidated Multidisciplinary Care in Head and Neck Cancer: A Retrospective Cohort Study

Authors: Meltzer, Charles; Nguyen, Nathalie T; Zhang, Jie; Aguilar, Jillian; Blatchins, Maruta A; Quesenberry, Charles P; Wang, Yan; Sakoda, Lori C

Otolaryngol Head Neck Surg. 2023 Jan;168(1):82-90.

PubMed abstract

Interactions between folate intake and genetic predictors of gene expression levels associated with colorectal cancer risk

Authors: Haas, Cameron B; Sakoda, Lori C; Hsu, Li; et al.

Sci Rep. 2022 Nov 07;12(1):18852. Epub 2022-11-07.

PubMed abstract

Assessment of genetic susceptibility to multiple primary cancers through whole-exome sequencing in two large multi-ancestry studies

Authors: Cavazos, Taylor B; Alexeeff, Stacey; Van Den Eeden, Stephen; Corley, Douglas A; Kushi, Lawrence H; Habel, Laurel A; Sakoda, Lori C; Witte, John S; et al.

BMC Med. 2022 10 06;20(1):332. Epub 2022-10-06.

PubMed abstract

Sociodemographic and clinical characteristics associated with never-smoking status in patients with lung cancer: findings from a large integrated health system

Authors: Banks, Kian C; Sumner, Eric T; Alabaster, Amy; Hsu, Diana S; Quesenberry, Charles P; Sakoda, Lori C; Velotta, Jeffrey B

Transl Cancer Res. 2022 Oct;11(10):3522-3534.

PubMed abstract

Electronic cigarette use and risk of COVID-19 among young adults without a history of cigarette smoking

Authors: Young-Wolff, Kelly C; Slama, Natalie E; Alexeeff, Stacey E; Prochaska, Judith J; Fogelberg, Renee; Sakoda, Lori C

Prev Med. 2022 09;162:107151. Epub 2022-07-06.

PubMed abstract

Genome-Wide Interaction Analysis of Genetic Variants with Menopausal Hormone Therapy for Colorectal Cancer Risk

Authors: Tian, Yu; Sakoda, Lori C; Chang-Claude, Jenny; et al.

J Natl Cancer Inst. 2022 08 08;114(8):1135-1148.

PubMed abstract

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer

Authors: Byun, Jinyoung; Spitz, Margaret; Amos, Christopher I; et al.

Nat Genet. 2022 Aug;54(8):1167-1177. Epub 2022-08-01.

PubMed abstract

Facilitating Adherence to Annual Screening for Lung Cancer: Are Program-Level Interventions Enough?

Authors: Sakoda, Lori C; Gould, Michael K

Chest. 2022 07;162(1):8-10.

PubMed abstract

Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region

Authors: Jordahl, Kristina M; Scacheri, Peter C; Peters, Ulrike; et al.

Cancer Epidemiol Biomarkers Prev. 2022 05 04;31(5):1077-1089.

PubMed abstract

Genetic associations and architecture of asthma-chronic obstructive pulmonary disease overlap

Authors: John, Catherine; Iribarren, Carlos; Tesfaigzi, Yohannes; Tobin, Martin D; et al.

Chest. 2022 05;161(5):1155-1166. Epub 2022-01-31.

PubMed abstract

Genetic variants associated with circulating C-reactive protein levels and colorectal cancer survival: Sex- and lifestyle factors- specific associations

Authors: Huang, Yuhan; Schoen, Robert E; Newcomb, Polly A; et al.

Int J Cancer. 2022 05 01;150(9):1447-1454. Epub 2022-01-13.

PubMed abstract

Risk Stratification for Early-Onset Colorectal Cancer Using a Combination of Genetic and Environmental Risk Scores: An International Multi-Center Study

Authors: Archambault, Alexi N; Sakoda, Lori C; Lee, Jeffrey K; Corley, Douglas A; Hayes, Richard B; et al.

J Natl Cancer Inst. 2022 04 11;114(4):528-539.

PubMed abstract

Accounting for EGFR mutations in epidemiological analyses of non-small cell lung cancers: Examples based on the International Lung Cancer Consortium data

Authors: Schmid, Sabine; Brennan, Paul; Liu, Geoffrey; et al.

Cancer Epidemiol Biomarkers Prev. 2022 Mar 01;31(3):679-687.

PubMed abstract

The Friends of Cancer Research Real World Data (RWD) Collaboration Pilot 2.0: Methodological Recommendations from Oncology Case Studies

Authors: Rivera, Donna R; Kushi, Lawrence; Sakoda, Lori C; Allen, Jeff D; et al.

Clin Pharmacol Ther. 2022 01;111(1):283-292. Epub 2021-11-11.

PubMed abstract

Adherence to Lung Cancer Screening: What Exactly Are We Talking About?

Authors: Sakoda, Lori C; Henderson, Louise M; Rivera, M Patricia

Ann Am Thorac Soc. 2021 12;18(12):1951-1952.

PubMed abstract

Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study

Authors: Nounu, Aayah; Slattery, Martha L; Relton, Caroline L; et al.

Nutrients. 2021 11 21;13(11). Epub 2021-11-21.

PubMed abstract

Smoking Behavior and Prognosis After Colorectal Cancer Diagnosis: A Pooled Analysis of 11 Studies

Authors: Alwers, Elizabeth; Sakoda, Lori C; Brenner, Hermann; et al.

JNCI Cancer Spectr. 2021 10;5(5). Epub 2021-08-31.

PubMed abstract

Association Between Smoking and Molecular Subtypes of Colorectal Cancer

Authors: Wang, Xiaoliang; Sakoda, Lori C; Peters, Ulrike; et al.

JNCI Cancer Spectr. 2021 08;5(4). Epub 2021-06-14.

PubMed abstract

Genetically predicted circulating C-reactive protein concentration and colorectal cancer survival: A Mendelian randomization consortium study

Authors: Hua, Xinwei; Schoen, Robert E; Newcomb, Polly A; et al.

Cancer Epidemiol Biomarkers Prev. 2021 07;30(7):1349-1358. Epub 2021-05-10.

PubMed abstract

Genetic architectures of proximal and distal colorectal cancer are partly distinct

Authors: Huyghe, Jeroen R; Sakoda, Lori C; Caan, Bette J; Peters, Ulrike; et al.

Gut. 2021 07;70(7):1325-1334. Epub 2021-02-25.

PubMed abstract

Two-Sample Mendelian Randomization Analysis of Associations Between Periodontal Disease and Risk of Cancer

Authors: Corlin, Laura; Sakoda, Lori C; Michaud, Dominique S; et al.

JNCI Cancer Spectr. 2021 06;5(3). Epub 2021-04-19.

PubMed abstract

Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer

Authors: Archambault, Alexi N; Sakoda, Lori C; Hayes, Richard B; et al.

JNCI Cancer Spectr. 2021 06;5(3). Epub 2021-05-20.

PubMed abstract

Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study

Authors: Tsilidis, Konstantinos K; Sakoda, Lori C; Gunter, Marc J; et al.

Am J Clin Nutr. 2021 06 01;113(6):1490-1502.

PubMed abstract

An Intervention to Tag Findings Suspicious for Lung Cancer on Chest Computed Tomography Has Good Sensitivity and Number Needed to Diagnose

Authors: Dusendang, Jennifer R; Sakoda, Lori C; Urbania, Thomas H; Ely, Sora; Osinski, Todd; Patel, Ashish; Herrinton, Lisa J

Perm J. 2021 05 12;25. Epub 2021-05-12.

PubMed abstract

Ten-year Thyroid Cancer Incidence in an Integrated Healthcare Delivery System

Authors: Kim, Stephanie J; Durr, Megan L; Darbinian, Jeanne A; Sakoda, Lori C; Meltzer, Charles J; Arzumanyan, Hasmik; Wang, Kevin H; Lin, Jonathan K; Gurushanthaiah, Deepak; Lo, Joan C

Perm J. 2021 05;25.

PubMed abstract

A large-scale association study detects novel rare variants, risk genes, functional elements, and polygenic architecture of prostate cancer susceptibility

Authors: Emami, Nima C; Presti, Joseph; Habel, Laurel A; Sakoda, Lori C; Schaefer, Catherine; Van Den Eeden, Stephen K; Witte, John S; et al.

Cancer Res. 2021 04 01;81(7):1695-1703. Epub 2020-12-08.

PubMed abstract

Patterns and Factors Associated With Adherence to Lung Cancer Screening in Diverse Practice Settings

Authors: Sakoda, Lori C; Quesenberry, Charles P; Henderson, Louise M; et al.

JAMA Netw Open. 2021 04 01;4(4):e218559. Epub 2021-04-01.

PubMed abstract

Response to Li and Hopper

Authors: Thomas, Minta; Sakoda, Lori C; Lee, Jeffrey K; Corley, Douglas A; Hsu, Li; et al.

Am J Hum Genet. 2021 03 04;108(3):527-529.

PubMed abstract

A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer

Authors: Nounu, Aayah; Sakoda, Lori C; Relton, Caroline L; et al.

Cancer Epidemiol Biomarkers Prev. 2021 03;30(3):564-575. Epub 2020-12-14.

PubMed abstract

Identifying novel susceptibility genes for colorectal cancer risk from a transcriptome-wide association study of 125,478 subjects

Authors: Guo, Xingyi; Sakoda, Lori C; Zheng, Wei; et al.

Gastroenterology. 2021 03;160(4):1164-1178.e6. Epub 2020-10-12.

PubMed abstract

Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts

Authors: Graff, Rebecca E; Alexeeff, Stacey E; Corley, Douglas A; Kushi, Lawrence H; Van Den Eeden, Stephen K; Habel, Laurel A; Sakoda, Lori C; et al.

Nat Commun. 2021 02 12;12(1):970. Epub 2021-02-12.

PubMed abstract

Association of body mass index with colorectal cancer risk by genome-wide variants

Authors: Campbell PT; Slattery ML; Peters U; et al.

J Natl Cancer Inst. 2021 01 04;113(1):38-47.

PubMed abstract

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

Authors: Bull, Caroline J; Sakoda, Lori C; Gunter, Marc J; et al.

BMC Med. 2020 12 17;18(1):396. Epub 2020-12-17.

PubMed abstract

Genetic Variants in the Regulatory T cell-Related Pathway and Colorectal Cancer Prognosis

Authors: Neumeyer, Sonja; Schoen, Robert E; Chang-Claude, Jenny; et al.

Cancer Epidemiol Biomarkers Prev. 2020 12;29(12):2719-2728. Epub 2020-10-02.

PubMed abstract

Early Screening of African Americans (45-50 Years Old) in a Fecal Immunochemical Test-based Colorectal Cancer Screening Program

Authors: Levin TR; Jensen CD; Chawla NM; Sakoda LC; Lee JK; Zhao WK; Landau MA; Herm A; Eby E; Quesenberry CP; Corley DA

Gastroenterology. 2020 11;159(5):1695-1704.e1. Epub 2020-07-20.

PubMed abstract

Standardized reporting and management of suspicious findings on chest computed tomography is associated with improved lung cancer diagnosis in an observational study

Authors: Urbania TH; Dusendang JR; Herrinton LJ; Alexeeff S; Corley DA; Ely S; Patel A; Osinski T; Sakoda LC

Chest. 2020 11;158(5):2211-2220. Epub 2020-06-17.

PubMed abstract

Intake of dietary fruit, vegetables, and fiber and risk of colorectal cancer according to molecular subtypes: A pooled analysis of 9 studies

Authors: Hidaka, Akihisa; Sakoda, Lori C; Peters, Ulrike; et al.

Cancer Res. 2020 10 15;80(20):4578-4590. Epub 2020-08-14.

PubMed abstract

Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk

Authors: Sieh, Weiva; Alexeeff, Stacey E; Sakoda, Lori C; Risch, Neil; Habel, Laurel A; et al.

Nat Commun. 2020 10 09;11(1):5116. Epub 2020-10-09.

PubMed abstract

Addressing Disparities in Lung Cancer Screening Eligibility and Healthcare Access. An Official American Thoracic Society Statement

Authors: Rivera, M Patricia; Sakoda, Lori C; Aldrich, Melinda C; et al.

Am J Respir Crit Care Med. 2020 10 01;202(7):e95-e112.

PubMed abstract

Pathway Analysis of Renal Cell Carcinoma Genome-Wide Association Studies Identifies Novel Associations

Authors: Purdue, Mark P; Sakoda, Lori C; Yu, Kai; et al.

Cancer Epidemiol Biomarkers Prev. 2020 10;29(10):2065-2069. Epub 2020-07-30.

PubMed abstract

Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts

Authors: Rashkin, Sara R; Alexeeff, Stacey E; Corley, Douglas A; Kushi, Lawrence H; Van Den Eeden, Stephen K; Habel, Laurel A; Sakoda, Lori C; Witte, John S; et al.

Nat Commun. 2020 09 04;11(1):4423. Epub 2020-09-04.

PubMed abstract

Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses

Authors: Seyed Khoei, Nazlisadat; Schafmayer, Clemens; Freisling, Heinz; et al.

BMC Med. 2020 09 03;18(1):229. Epub 2020-09-03.

PubMed abstract

Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk

Authors: Thomas, Minta; Sakoda, Lori C; Lee, Jeffrey K; Corley, Douglas A; Hsu, Li; et al.

Am J Hum Genet. 2020 09 03;107(3):432-444. Epub 2020-08-05.

PubMed abstract

Telomere maintenance variants and survival after colorectal cancer: Smoking- and sex-specific associations

Authors: Yin H; Sakoda LC; Newcomb PA; et al.

Cancer Epidemiol Biomarkers Prev. 2020 09;29(9):1817-1824. Epub 2020-06-25.

PubMed abstract

Postmenopausal Hormone Therapy and Colorectal Cancer Risk by Molecularly Defined Subtypes and Tumor Location

Authors: Labadie, Julia D; Sakoda, Lori C; Newcomb, Polly A; et al.

2020 Aug;4(5):pkaa042. Epub 2020-05-19.

PubMed abstract

Genetic predictors of circulating 25-hydroxyvitamin D and prognosis after colorectal cancer

Authors: Neumeyer S; Sakoda LC; Chang-Claude J; et al.

Cancer Epidemiol Biomarkers Prev. 2020 06;29(6):1128-1134. Epub 2020-03-18.

PubMed abstract

Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk

Authors: Xia Z; Sakoda LC; Peters U; et al.

Cancer Med. 2020 05;9(10):3563-3573. Epub 2020-03-24.

PubMed abstract

Alcohol and tobacco use in relation to mammographic density in 23,456 women

Authors: McBride RB; Alexeeff SE; Sakoda LC; Habel LA; Sieh W; et al.

Cancer Epidemiol Biomarkers Prev. 2020 05;29(5):1039-1048. Epub 2020-02-17.

PubMed abstract

Mendelian randomization of circulating polyunsaturated fatty acids and colorectal cancer risk

Authors: Khankari NK; Sakoda LC; Zheng W; et al.

Cancer Epidemiol Biomarkers Prev. 2020 04;29(4):860-870. Epub 2020-02-12.

PubMed abstract

Cumulative Burden of Colorectal Cancer-Associated Genetic Variants is More Strongly Associated With Early-onset vs Late-onset Cancer

Authors: Archambault AN; Sakoda LC; Corley DA; Hayes RB; et al.

Gastroenterology. 2020 04;158(5):1274-1286.e12. Epub 2019-12-19.

PubMed abstract

Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses

Authors: Murphy N; Sakoda LC; Gunter MJ; et al.

Gastroenterology. 2020 04;158(5):1300-1312.e20. Epub 2019-12-27.

PubMed abstract

COPD and lung cancer incidence in the Women’s Health Initiative Observational Study: A brief report

Authors: Nagasaka M; Lehman A; Chlebowski R; Haynes BM; Ho G; Patel M; Sakoda LC; Schwartz AG; Simon MS; Cote ML

Lung Cancer. 2020 03;141:78-81. Epub 2020-01-07.

PubMed abstract

Risk of Mortality between Untreated and Treated Papillary Thyroid Cancer: A Matched Cohort Analysis

Authors: Lin JK; Sakoda LC; Darbinian J; Socarras M; Chiao W; Calixto N; Quesenberry C; Gurushanthaiah D; Wang KH; Durr M

Ann Otol Rhinol Laryngol. 2020 Mar;129(3):265-272. Epub 2019-10-28.

PubMed abstract

Understanding the natural history of papillary thyroid cancer: Case series

Authors: Lin JK; Sakoda LC; Darbinian J; Chiao W; Calixto N; Gurushanthaiah D; Wang KH; Durr M

Head Neck. 2019 12;41(12):4164-4170. Epub 2019-10-04.

PubMed abstract

Factors associated with employment discontinuation among older and working age survivors of oropharyngeal cancer

Authors: Check DK; Hutcheson KA; Poisson LM; Pocobelli G; Sakoda LC; Zaveri J; Chang SS; Chubak J

Head Neck. 2019 11;41(11):3948-3959. Epub 2019-09-06.

PubMed abstract

An Exploratory Analysis of Real-World End Points for Assessing Outcomes Among Immunotherapy-Treated Patients With Advanced Non-Small-Cell Lung Cancer

Authors: Stewart M; Kushi L; Sakoda LC; Allen J; et al.

JCO Clin Cancer Inform. 2019 07;3:1-15.

PubMed abstract

Telomere length and socioeconomic status at neighborhood and individual levels among 80,000 adults in the Genetic Epidemiology Research on Adult Health and Aging cohort

Authors: Alexeeff, Stacey E; Schaefer, Catherine A; Risch, Neil; Sakoda, Lori C; Quesenberry, Charles P; Van Den Eeden, Stephen K; et al.

Environ Epidemiol. 2019 Jun;3(3):e049. Epub 2019-05-01.

PubMed abstract

Effectiveness of a Patient Education Class to Enhance Knowledge about Lung Cancer Screening: a Quality Improvement Evaluation

Authors: Sakoda LC; Meyer MA; Chawla N; Sanchez MA; Blatchins MA; Nayak S; San K; Zin GK; Minowada G; Permanente Medical Group Lung Cancer Screening Task Force

J Cancer Educ. 2019 May 09.

PubMed abstract

Discovery of common and rare genetic risk variants for colorectal cancer

Authors: Huyghe JR; Caan BJ; Sakoda LC; Peters U; et al.

Nat Genet. 2019 01;51(1):76-87. Epub 2018-12-03.

PubMed abstract

Examining the role of access to care: Racial/ethnic differences in receipt of resection for early-stage non-small cell lung cancer among integrated system members and non-members

Authors: Check DK; Albers KB; Uppal KM; Suga JM; Adams AS; Habel LA; Quesenberry CP; Sakoda LC

Lung Cancer. 2018 Nov;125:51-56. Epub 2018-09-11.

PubMed abstract

The TGFβ-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs

Authors: Pellatt AJ; Mullany LE; Herrick JS; Sakoda LC; Wolff RK; Samowitz WS; Slattery ML

J Transl Med. 2018 07 09;16(1):191. Epub 2018-07-09.

PubMed abstract

Mutation analysis of adenomas and carcinomas of the colon: early and late drivers

Authors: Wolff RK; Hoffman MD; Wolff EC; Herrick JS; Sakoda LC; Samowitz WS; Slattery ML

Genes Chromosomes Cancer. 2018 07;57(7):366-376. Epub 2018-04-30.

PubMed abstract

The p53-signaling pathway and colorectal cancer: Interactions between downstream p53 target genes and miRNAs

Authors: Slattery ML; Mullany LE; Wolff RK; Sakoda LC; Samowitz WS; Herrick JS

Genomics. 2018 Jun 01.

PubMed abstract

MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer

Authors: Mullany LE; Herrick JS; Sakoda LC; Samowitz W; Stevens JR; Wolff RK; Slattery ML

Genes Cancer. 2018 May;9(5-6):232-246.

PubMed abstract

Dysregulated genes and miRNAs in the apoptosis pathway in colorectal cancer patients

Authors: Slattery ML; Mullany LE; Sakoda LC; Wolff RK; Samowitz WS; Herrick JS

Apoptosis. 2018 04;23(3-4):237-250.

PubMed abstract

The NF-κB signalling pathway in colorectal cancer: associations between dysregulated gene and miRNA expression

Authors: Slattery ML; Mullany LE; Sakoda L; Samowitz WS; Wolff RK; Stevens JR; Herrick JS

J Cancer Res Clin Oncol. 2018 Feb;144(2):269-283. Epub 2017-11-29.

PubMed abstract

Expression of Wnt-signaling pathway genes and their associations with miRNAs in colorectal cancer

Authors: Slattery ML; Mullany LE; Sakoda LC; Samowitz WS; Wolff RK; Stevens JR; Herrick JS

Oncotarget. 2018 Jan 19;9(5):6075-6085. Epub 2017-12-23.

PubMed abstract

miRNA involvement in cell cycle regulation in colorectal cancer cases

Authors: Mullany LE; Herrick JS; Sakoda LC; Samowitz W; Stevens JR; Wolff RK; Slattery ML

Genes Cancer. 2018 Jan;9(1-2):53-65.

PubMed abstract

The MAPK-Signaling Pathway in Colorectal Cancer: Dysregulated Genes and Their Association With MicroRNAs

Authors: Slattery ML; Mullany LE; Sakoda LC; Wolff RK; Samowitz WS; Herrick JS

Cancer Inform. 2018;17:1176935118766522. Epub 2018-03-26.

PubMed abstract

Common TDP1 polymorphisms in relation to survival among small cell lung cancer patients: a multicenter study from the International Lung Cancer Consortium

Authors: Lohavanichbutr P; Amos CI; Chen C; et al.

Clin Cancer Res. 2017 Dec 15;23(24):7550-7557. Epub 2017-10-03.

PubMed abstract

Applying Risk Prediction Models to Optimize Lung Cancer Screening: Current Knowledge, Challenges, and Future Directions

Authors: Sakoda LC; Henderson LM; Caverly TJ; Wernli KJ; Katki HA

Curr Epidemiol Rep. 2017 Dec;4(4):307-320. Epub 2017-10-24.

PubMed abstract

Monitoring Lung Cancer Screening Utilization and Outcomes in Four Cancer Research Network Sites

Authors: Gould MK; Sakoda LC; Ritzwoller DP; Simoff MJ; Neslund-Dudas CM; Kushi LH; Carter-Harris L; Feigelson HS; Minowada G; Doria-Rose VP

Ann Am Thorac Soc. 2017 Dec;14(12):1827-1835.

PubMed abstract

The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer

Authors: Slattery ML; Herrick JS; Mullany LE; Samowitz WS; Sevens JR; Sakoda L; Wolff RK

Genes Chromosomes Cancer. 2017 11;56(11):769-787. Epub 2017-07-30.

PubMed abstract

The PI3K/AKT Signaling Pathway: associations of miRNAs with dysregulated gene expression in colorectal cancer

Authors: Slattery ML; Mullany LE; Sakoda LC; Wolff RK; Stevens JR; Samowitz WS; Herrick JS

Mol Carcinog. 2017 Oct 25.

PubMed abstract

Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study

Authors: Jorgenson E; Thai KK; Hoffmann TJ; Sakoda LC; Kvale MN; Banda Y; Schaefer C; Risch N; Mertens J; Weisner C; Choquet H

Mol Psychiatry. 2017 Sep;22(9):1359-1367. Epub 2017-05-09.

PubMed abstract

Effect of Angiotensin System Inhibitors on Survival in Patients Receiving Chemotherapy for Advanced Non-Small-Cell Lung Cancer

Authors: Menter AR; Carroll NM; Sakoda LC; Delate T; Hornbrook MC; Jain RK; Kushi LH; Quinn VP; Ritzwoller DP

Clin Lung Cancer. 2017 Mar;18(2):189-197.e3. Epub 2016-08-20.

PubMed abstract

Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer

Authors: Hoffmann TJ; Sakoda LC; Habel LA; Quesenberry CP; Schaefer C; Risch N; Van Den Eeden SK; Witte JS; et al.

Nat Commun. 2017 Jan 31;8:14248. Epub 2017-01-31.

PubMed abstract

Common coding variants in the HLA-DQB1 region confer susceptibility to age-related macular degeneration

Authors: Jorgenson E; Melles RB; Hoffmann TJ; Jia X; Sakoda LC; Kvale MN; Banda Y; Schaefer C; Risch N; Shen L

Eur J Hum Genet. 2016 Jul;24(7):1049-55. Epub 2016-01-06.

PubMed abstract

Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

Authors: Banda Y; Croen LA; Iribarren C; Kushi LH; Quesenberry CP; Sakoda LC; Van Den Eeden SK; Whitmer RA; Schaefer C; Risch N; et al.

Genetics. 2015 Aug;200(4):1285-95. Epub 2015-06-19.

PubMed abstract

Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

Authors: Lapham K; Croen LA; Iribarren C; Kushi LH; Quesenberry CP; Sakoda LC; Van Den Eeden SK; Whitmer RA; Risch N; Schaefer C; Blackburn EH; et al.

Genetics. 2015 Aug;200(4):1061-72. Epub 2015-06-19.

PubMed abstract

Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

Authors: Kvale MN; Croen LA; Iribarren C; Kushi LH; Quesenberry CP; Sakoda LC; Van Den Eeden SK; Whitmer RA; Schaefer C; Risch N; et al.

Genetics. 2015 Aug;200(4):1051-60. Epub 2015-06-19.

PubMed abstract

A large multi-ethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences

Authors: Hoffmann TJ; Van Den Eeden SK; Sakoda LC; Habel LA; Quesenberry CP; Schaefer C; Witte JS; et al.

Cancer Discov. 2015 Aug;5(8):878-91. Epub 2015-06-01.

PubMed abstract

Differences in the Genetic Susceptibility to Age-Related Macular Degeneration Clinical Subtypes

Authors: Shen L; Hoffmann TJ; Melles RB; Sakoda LC; Kvale MN; Banda Y; Schaefer C; Risch N; Jorgenson E

Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4290-9.

PubMed abstract

Metformin use and lung cancer risk in patients with diabetes

Authors: Sakoda LC; Ferrara A; Achacoso NS; Peng T; Ehrlich SF; Quesenberry CP; Habel LA

Cancer Prev Res (Phila). 2015 Feb;8(2):174-9.

PubMed abstract

Imputation of the Rare HOXB13 G84E Mutation and Cancer Risk in a Large Population-Based Cohort

Authors: Hoffmann TJ; Sakoda LC; Habel LA; Asgari MM; Corley D; Kushi LH; Quesenberry CP; Schaefer C; Van Den Eeden SK; Risch N; Witte JS; et al.

PLoS Genet. 2015 Jan;11(1):e1004930. Epub 2015-01-28.

PubMed abstract

Cross-cancer pleiotropic analysis of endometrial cancer: PAGE and E2C2 consortia

Authors: Setiawan VW; Sakoda LC; Le Marchand L; et al.

Carcinogenesis. 2014 Sep;35(9):2068-73. Epub 2014-05-15.

PubMed abstract

Turning of COGS moves forward findings for hormonally mediated cancers

Authors: Sakoda LC; Jorgenson E; Witte JS

Nat Genet. 2013 Apr;45(4):345-8.

PubMed abstract

DNA repair genotype and lung cancer risk in the beta-carotene and retinol efficacy trial

Authors: Doherty JA; Sakoda LC; Loomis MM; Barnett MJ; Julianto L; Thornquist MD; Neuhouser ML; Weiss NS; Goodman GE; Chen C

Int J Mol Epidemiol Genet. 2013;4(1):11-34. Epub 2013 Mar 18.

PubMed abstract

HOXB13:IL17BR and molecular grade index and risk of breast cancer death among patients with lymph node-negative invasive disease

Authors: Habel LA; Sakoda LC; Achacoso N; Ma XJ; Erlander MG; Sgroi DC; Fehrenbacher L; Greenberg D; Quesenberry CP

Breast Cancer Res. 2013;15(2):R24. Epub 2013-03-14.

PubMed abstract

Screening for colorectal neoplasms with new fecal occult blood tests: update on performance characteristics

Authors: Allison JE; Levin TR; Selby JV; et al.

J Natl Cancer Inst. 2007 Oct 3;99(19):1462-70. Epub 2007 Sep 25.

PubMed abstract

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