Lori Sakoda, PhD

People

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3677 (phone)
lori.sakoda@kp.org
Kaiser Permanente Researcher Profiles

Lori C. Sakoda, MPH, PhD, is a research scientist of the Kaiser Permanente Northern California Division of Research and an affiliate investigator of the Division of Public Health Sciences at the Fred Hutchinson Cancer Research Center. Her research interests currently encompass identifying genetic and environmental determinants of risk and prognosis for cancer, particularly of the lung. She is also interested in understanding the basis for observed differences in cancer incidence and outcomes by sex and race/ethnicity.

Current Position(s):

Research Scientist II, Division of Research, Kaiser Permanente Northern California
Affiliate Investigator, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center

Section Affiliations:

Cancer

Primary Research Interests:

Cancer epidemiology and prevention
Genetic determinants of cancer risk, progression, and treatment response
Racial/ethnic and sex differences in cancer

Studies

Comparative Effectiveness of Pretreatment Lung Cancer Nodal Staging

The proposed project will determine whether a guideline-recommended nodal staging strategy is superior to a guideline-discordant nodal staging strategy, and whether a validated risk-based nodal staging strategy that reduces unnecessary biopsies is an equivalent alternative to a guideline-recommended nodal staging strategy in terms of patient outcomes and costs.
Investigator: Sakoda, Lori
Funder: National Cancer Institute

Disparities in REsults of Immune Checkpoint Inhibitor Treatment (DiRECT): A Prospective Cohort Study of Cancer Survivors Treated with anti-PD-1/anti-PD-L1 in a Community Oncology Setting

This project will establish a prospective cohort of white and Black cancer patients treated with immune checkpoint inhibitors, leveraging the NCI Community Oncology Research Program network infrastructure, to investigate racial differences in immune-related adverse events and their predictors, treatment delay and discontinuation, and short- and long-term patient outcomes.
Investigator: Sakoda, Lori
Funder: National Cancer Institute

Leveraging Diversity in Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk Scores

Inadequate representation of diverse racial/ethnic populations in genetic studies is hindering the translational potential of polygenic risk scores (PRS) in cancer risk prediction. To address this shortcoming, we aim to construct and evaluate PRS for cancer and estimate the absolute risk of cancer explained by PRS and non-genetic factors across multiethnic populations.
Investigator: Sakoda, Lori
Funder: National Cancer Institute

Understanding Racial/Ethnic Disparities in Lung Cancer Screening Utilization

This study proposes to understand patterns and multilevel determinants of racial/ethnic disparities in Lung Cancer Screening utilization from 2017 onward at KPNC.
Investigator: Sakoda, Lori
Funder: Northern California Community Benefit Programs

Assessing Adherence to Follow-Up Care After Low-Dose Computed Tomography Screening for Lung Cancer

With the recent implementation of lung cancer screening in community-based practice, little is currently known about utilization patterns and outcomes in patients following the initial low-dose computed tomography (CT) screening exam. The primary goals of this study are to 1) examine adherence to recommended follow-up based on initial low-dose CT screening exam results and 2) identify factors associated with adherence (versus non-adherence) to recommended follow-up.
Investigator: Sakoda, Lori
Funder: Northern California Community Benefit Programs

Evaluating a Risk Prediction Model for Lung Cancer

Screening with low-dose computed tomography (LDCT) presents an opportunity to improve early detection and reduce mortality from lung cancer. However, the potential harms of LDCT screening, including frequent false-positive findings that lead to unnecessary procedures and repeated radiation exposure, have raised concerns. Implementing targeted screening of persons at highest predicted risk for lung cancer may minimize such harms, but empirical evidence to support more personalized risk-based screening remains limited. This study presents a mentored career development plan encompassing training and research activities for establishing independence as a translational cancer epidemiologist, with a primary focus on early detection and management of lung cancer. The goal of the proposed research is to evaluate whether the most predictive and clinically-oriented risk model for lung cancer to date can be validated, extended and applied to aid decision-making about LDCT screening.
Investigator: Sakoda, Lori
Funder: National Cancer Institute

Highlighted Publications

No results found matching criteria

Publications

Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study

Author(s): Nounu A; Sakoda LC; Relton CL; et al.

Nutrients. 2021 Nov 21;13(11). Epub 2021-11-21.

Current Position(s):

Section Affiliations:

Primary Research Interests:

Studies

Comparative Effectiveness of Pretreatment Lung Cancer Nodal Staging

Disparities in REsults of Immune Checkpoint Inhibitor Treatment (DiRECT): A Prospective Cohort Study of Cancer Survivors Treated with anti-PD-1/anti-PD-L1 in a Community Oncology Setting

Leveraging Diversity in Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk Scores

Understanding Racial/Ethnic Disparities in Lung Cancer Screening Utilization

Assessing Adherence to Follow-Up Care After Low-Dose Computed Tomography Screening for Lung Cancer

Evaluating a Risk Prediction Model for Lung Cancer

Highlighted Publications

Publications

Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study

Survival Associated With Consolidated Multidisciplinary Care in Head and Neck Cancer: A Retrospective Cohort Study

The Friends of Cancer Research Real World Data (RWD) Collaboration Pilot 2.0: Methodological Recommendations from Oncology Case Studies

Smoking Behavior and Prognosis After Colorectal Cancer Diagnosis: A Pooled Analysis of 11 Studies

Adherence to Lung Cancer Screening: What Exactly Are We Talking About?

Association Between Smoking and Molecular Subtypes of Colorectal Cancer

Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer

Genetically predicted circulating C-reactive protein concentration and colorectal cancer survival: A Mendelian randomization consortium study

Ten-year Thyroid Cancer Incidence in an Integrated Healthcare Delivery System

Two-Sample Mendelian Randomization Analysis of Associations Between Periodontal Disease and Risk of Cancer

Patterns and Factors Associated With Adherence to Lung Cancer Screening in Diverse Practice Settings

Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study

Response to Li and Hopper

Genetic architectures of proximal and distal colorectal cancer are partly distinct

Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer

A large-scale association study detects novel rare variants, risk genes, functional elements, and polygenic architecture of prostate cancer susceptibility

Identifying novel susceptibility genes for colorectal cancer risk from a transcriptome-wide association study of 125,478 subjects

Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk

Genetic Variants in the Regulatory T cell-Related Pathway and Colorectal Cancer Prognosis

Addressing Disparities in Lung Cancer Screening Eligibility and Healthcare Access. An Official American Thoracic Society Statement

Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts

Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses

Intake of dietary fruit, vegetables, and fiber and risk of colorectal cancer according to molecular subtypes: A pooled analysis of 9 studies

Pathway Analysis of Renal Cell Carcinoma Genome-Wide Association Studies Identifies Novel Associations

Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk

Early Screening of African Americans (45-50 Years Old) in a Fecal Immunochemical Test-based Colorectal Cancer Screening Program

Telomere maintenance variants and survival after colorectal cancer: Smoking- and sex-specific associations

Standardized reporting and management of suspicious findings on chest computed tomography is associated with improved lung cancer diagnosis in an observational study

Postmenopausal Hormone Therapy and Colorectal Cancer Risk by Molecularly Defined Subtypes and Tumor Location

Association of body mass index with colorectal cancer risk by genome-wide variants

Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk

Genetic predictors of circulating 25-hydroxyvitamin D and prognosis after colorectal cancer

Alcohol and tobacco use in relation to mammographic density in 23,456 women

Mendelian randomization of circulating polyunsaturated fatty acids and colorectal cancer risk

COPD and lung cancer incidence in the Women's Health Initiative Observational Study: A brief report

Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses

Cumulative Burden of Colorectal Cancer-Associated Genetic Variants is More Strongly Associated With Early-onset vs Late-onset Cancer

Risk of Mortality between Untreated and Treated Papillary Thyroid Cancer: A Matched Cohort Analysis

Factors associated with employment discontinuation among older and working age survivors of oropharyngeal cancer

An Exploratory Analysis of Real-World End Points for Assessing Outcomes Among Immunotherapy-Treated Patients With Advanced Non-Small-Cell Lung Cancer

Effectiveness of a Patient Education Class to Enhance Knowledge about Lung Cancer Screening: a Quality Improvement Evaluation

Telomere length and socioeconomic status at neighborhood and individual levels among 80,000 adults in the Genetic Epidemiology Research on Adult Health and Aging cohort

Discovery of common and rare genetic risk variants for colorectal cancer

Examining the role of access to care: Racial/ethnic differences in receipt of resection for early-stage non-small cell lung cancer among integrated system members and non-members

The TGFβ-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs

The p53-signaling pathway and colorectal cancer: Interactions between downstream p53 target genes and miRNAs

MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer

Dysregulated genes and miRNAs in the apoptosis pathway in colorectal cancer patients

The MAPK-Signaling Pathway in Colorectal Cancer: Dysregulated Genes and Their Association With MicroRNAs

Mutation analysis of adenomas and carcinomas of the colon: early and late drivers

Expression of Wnt-signaling pathway genes and their associations with miRNAs in colorectal cancer

The NF-κB signalling pathway in colorectal cancer: associations between dysregulated gene and miRNA expression

The PI3K/AKT Signaling Pathway: associations of miRNAs with dysregulated gene expression in colorectal cancer

Applying Risk Prediction Models to Optimize Lung Cancer Screening: Current Knowledge, Challenges, and Future Directions

Common TDP1 polymorphisms in relation to survival among small cell lung cancer patients: a multicenter study from the International Lung Cancer Consortium

Monitoring Lung Cancer Screening Utilization and Outcomes in Four Cancer Research Network Sites

The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer

Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study

Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.

Effect of Angiotensin System Inhibitors on Survival in Patients Receiving Chemotherapy for Advanced Non-Small-Cell Lung Cancer

Common coding variants in the HLA-DQB1 region confer susceptibility to age-related macular degeneration

Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

Differences in the Genetic Susceptibility to Age-Related Macular Degeneration Clinical Subtypes

A large multi-ethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences