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Lori Sakoda, PhD


Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3677 (phone)
Kaiser Permanente Researcher Profiles

Lori C. Sakoda, MPH, PhD, is a research scientist of the Kaiser Permanente Northern California Division of Research and an affiliate investigator of the Division of Public Health Sciences at the Fred Hutchinson Cancer Research Center. Her research interests currently encompass identifying genetic and environmental determinants of risk and prognosis for cancer, particularly of the lung. She is also interested in understanding the basis for observed differences in cancer incidence and outcomes by sex and race/ethnicity.

Current Position(s):

  • Research Scientist I, Division of Research, Kaiser Permanente Northern California
  • Affiliate Investigator, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center

Section Affiliations:

Primary Research Interests:

  • Cancer epidemiology and prevention
  • Genetic determinants of cancer risk, progression, and treatment response
  • Racial/ethnic and sex differences in cancer

    Understanding Racial/Ethnic Disparities in Lung Cancer Screening Utilization

    This study proposes to understand patterns and multilevel determinants of racial/ethnic disparities in Lung Cancer Screening utilization from 2017 onward at KPNC.
    Investigator: Sakoda, Lori
    Funder: Northern California Community Benefit Programs

    Assessing Adherence to Follow-Up Care After Low-Dose Computed Tomography Screening for Lung Cancer

    With the recent implementation of lung cancer screening in community-based practice, little is currently known about utilization patterns and outcomes in patients following the initial low-dose computed tomography (CT) screening exam. The primary goals of this study are to 1) examine adherence to recommended follow-up based on initial low-dose CT screening exam results and 2) identify factors associated with adherence (versus non-adherence) to recommended follow-up.
    Investigator: Sakoda, Lori
    Funder: Northern California Community Benefit Programs

    Evaluating a Risk Prediction Model for Lung Cancer

    Screening with low-dose computed tomography (LDCT) presents an opportunity to improve early detection and reduce mortality from lung cancer. However, the potential harms of LDCT screening, including frequent false-positive findings that lead to unnecessary procedures and repeated radiation exposure, have raised concerns. Implementing targeted screening of persons at highest predicted risk for lung cancer may minimize such harms, but empirical evidence to support more personalized risk-based screening remains limited. This study presents a mentored career development plan encompassing training and research activities for establishing independence as a translational cancer epidemiologist, with a primary focus on early detection and management of lung cancer. The goal of the proposed research is to evaluate whether the most predictive and clinically-oriented risk model for lung cancer to date can be validated, extended and applied to aid decision-making about LDCT screening.
    Investigator: Sakoda, Lori
    Funder: National Cancer Institute
    No results found matching criteria

    Early Screening of African Americans (45-50 Years Old) in a Fecal Immunochemical Test-based Colorectal Cancer Screening Program

    Author(s): Levin TR; Jensen CD; Chawla NM; Sakoda LC; Lee JK; Zhao WK; Landau MA; Herm A; Eby E; Quesenberry CP; Corley DA

    Gastroenterology. 2020 Jul 15.

    PubMed abstract

    Telomere maintenance variants and survival after colorectal cancer: Smoking- and sex-specific associations

    Author(s): Yin H; Sakoda LC; Newcomb PA; et al.

    Cancer Epidemiol Biomarkers Prev. 2020 Jun 25.

    PubMed abstract

    Standardized reporting and management of suspicious findings on chest computed tomography is associated with improved lung cancer diagnosis in an observational study

    Author(s): Urbania TH; Dusendang JR; Herrinton LJ; Alexeeff S; Corley DA; Ely S; Patel A; Osinski T; Sakoda LC

    Chest. 2020 Jun 17.

    PubMed abstract

    Association of body mass index with colorectal cancer risk by genome-wide variants

    Author(s): Campbell PT; Sakoda LC; Peters U; et al.

    J Natl Cancer Inst. 2020 Apr 23.

    PubMed abstract

    Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk

    Author(s): Xia Z; Sakoda LC; Peters U; et al.

    Cancer Med. 2020 Mar 24.

    PubMed abstract

    Genetic predictors of circulating 25-hydroxyvitamin D and prognosis after colorectal cancer

    Author(s): Neumeyer S; Sakoda LC; Chang-Claude J; et al.

    Cancer Epidemiol Biomarkers Prev. 2020 Mar 18.

    PubMed abstract

    Alcohol and tobacco use in relation to mammographic density in 23,456 women

    Author(s): McBride RB; Alexeeff SE; Sakoda LC; Achacoso N; Habel LA; Sieh W; et al.

    Cancer Epidemiol Biomarkers Prev. 2020 Feb 17.

    PubMed abstract

    Mendelian randomization of circulating polyunsaturated fatty acids and colorectal cancer risk

    Author(s): Khankari NK; Sakoda LC; Zheng W; et al.

    Cancer Epidemiol Biomarkers Prev. 2020 Feb 12.

    PubMed abstract

    COPD and lung cancer incidence in the Women's Health Initiative Observational Study: A brief report

    Author(s): Nagasaka M; Lehman A; Chlebowski R; Haynes BM; Ho G; Patel M; Sakoda LC; Schwartz AG; Simon MS; Cote ML

    Lung Cancer. 2020 Jan 07;141:78-81. Epub 2020-01-07.

    PubMed abstract

    Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses

    Author(s): Murphy N; Burnett-Hartman A; Sakoda LC; Wang H; Gunter MJ; et al.

    Gastroenterology. 2019 Dec 26.

    PubMed abstract

    Cumulative Burden of Colorectal Cancer-Associated Genetic Variants is More Strongly Associated With Early-onset vs Late-onset Cancer

    Author(s): Archambault AN; Sakoda LC; Burnett-Hartman AN; Corley DA; Hayes RB; et al.

    Gastroenterology. 2019 Dec 19.

    PubMed abstract

    Risk of Mortality between Untreated and Treated Papillary Thyroid Cancer: A Matched Cohort Analysis

    Author(s): Lin JK; Sakoda LC; Darbinian J; Socarras M; Chiao W; Calixto N; Quesenberry C; Gurushanthaiah D; Wang KH; Durr M

    Ann Otol Rhinol Laryngol. 2019 Oct 28:3489419885403.

    PubMed abstract

    Factors associated with employment discontinuation among older and working age survivors of oropharyngeal cancer

    Author(s): Check DK; Hutcheson KA; Poisson LM; Pocobelli G; Sakoda LC; Zaveri J; Chang SS; Chubak J

    Head Neck. 2019 Sep 06.

    PubMed abstract

    An Exploratory Analysis of Real-World End Points for Assessing Outcomes Among Immunotherapy-Treated Patients With Advanced Non-Small-Cell Lung Cancer

    Author(s): Stewart M; Kushi L; Sakoda LC; Valice E; Allen J; et al.

    JCO Clin Cancer Inform. 2019 Jul;3:1-15.

    PubMed abstract

    Effectiveness of a Patient Education Class to Enhance Knowledge about Lung Cancer Screening: a Quality Improvement Evaluation

    Author(s): Sakoda LC; Meyer MA; Chawla N; Sanchez MA; Blatchins MA; Nayak S; San K; Zin GK; Minowada G; Permanente Medical Group Lung Cancer Screening Task Force

    J Cancer Educ. 2019 May 09.

    PubMed abstract

    Discovery of common and rare genetic risk variants for colorectal cancer

    Author(s): Huyghe JR; Burnett-Hartman A; Caan BJ; Sakoda LC; Peters U; et al.

    Nat Genet. 2019 Jan;51(1):76-87. Epub 2018-12-03.

    PubMed abstract

    Examining the role of access to care: Racial/ethnic differences in receipt of resection for early-stage non-small cell lung cancer among integrated system members and non-members

    Author(s): Check DK; Albers KB; Uppal KM; Suga JM; Adams AS; Habel LA; Quesenberry CP; Sakoda LC

    Lung Cancer. 2018 Nov;125:51-56. Epub 2018-09-11.

    PubMed abstract

    The TGFβ-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs

    Author(s): Pellatt AJ; Mullany LE; Herrick JS; Sakoda LC; Wolff RK; Samowitz WS; Slattery ML

    J Transl Med. 2018 Jul 09;16(1):191. Epub 2018-07-09.

    PubMed abstract

    The p53-signaling pathway and colorectal cancer: Interactions between downstream p53 target genes and miRNAs

    Author(s): Slattery ML; Mullany LE; Wolff RK; Sakoda LC; Samowitz WS; Herrick JS

    Genomics. 2018 Jun 01.

    PubMed abstract

    MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer

    Author(s): Mullany LE; Herrick JS; Sakoda LC; Samowitz W; Stevens JR; Wolff RK; Slattery ML

    Genes Cancer. 2018 May;9(5-6):232-246.

    PubMed abstract

    Dysregulated genes and miRNAs in the apoptosis pathway in colorectal cancer patients

    Author(s): Slattery ML; Mullany LE; Sakoda LC; Wolff RK; Samowitz WS; Herrick JS

    Apoptosis. 2018 Apr;23(3-4):237-250.

    PubMed abstract

    The MAPK-Signaling Pathway in Colorectal Cancer: Dysregulated Genes and Their Association With MicroRNAs

    Author(s): Slattery ML; Mullany LE; Sakoda LC; Wolff RK; Samowitz WS; Herrick JS

    Cancer Inform. 2018;17:1176935118766522. Epub 2018-03-26.

    PubMed abstract

    Mutation analysis of adenomas and carcinomas of the colon: early and late drivers

    Author(s): Wolff RK; Hoffman MD; Wolff EC; Herrick JS; Sakoda LC; Samowitz W; Slattery ML

    Genes Chromosomes Cancer. 2018 Mar 25.

    PubMed abstract

    Expression of Wnt-signaling pathway genes and their associations with miRNAs in colorectal cancer

    Author(s): Slattery ML; Mullany LE; Sakoda LC; Samowitz WS; Wolff RK; Stevens JR; Herrick JS

    Oncotarget. 2018 Jan 19;9(5):6075-6085. Epub 2017-12-23.

    PubMed abstract

    The NF-κB signalling pathway in colorectal cancer: associations between dysregulated gene and miRNA expression

    Author(s): Slattery ML; Mullany LE; Sakoda L; Samowitz WS; Wolff RK; Stevens JR; Herrick JS

    J Cancer Res Clin Oncol. 2017 Nov 29.

    PubMed abstract

    The PI3K/AKT Signaling Pathway: associations of miRNAs with dysregulated gene expression in colorectal cancer

    Author(s): Slattery ML; Mullany LE; Sakoda LC; Wolff RK; Stevens JR; Samowitz WS; Herrick JS

    Mol Carcinog. 2017 Oct 25.

    PubMed abstract

    Applying Risk Prediction Models to Optimize Lung Cancer Screening: Current Knowledge, Challenges, and Future Directions

    Author(s): Sakoda LC; Henderson LM; Caverly TJ; Wernli KJ; Katki HA

    Curr Epidemiol Rep. 2017 Dec;4(4):307-320. Epub 2017-10-24.

    PubMed abstract

    Common TDP1 polymorphisms in relation to survival among small cell lung cancer patients: a multicenter study from the International Lung Cancer Consortium

    Author(s): Lohavanichbutr P; Sakoda LC; Amos CI; Arnold SM; Christiani DC; Davies MPA; Field JK; Haura EB; Hung RJ; Kohno T; Landi MT; Liu G; Liu Y; Marcus MW; O'Kane GM; Schabath MB; Shiraishi K; Slone SA; Tardon A; Yang P; Yoshida K; Zhang R; Zong X; Goodman GG; Weiss NS; Chen C

    Clin Cancer Res. 2017 Oct 03.

    PubMed abstract

    Monitoring Lung Cancer Screening Utilization and Outcomes in Four Cancer Research Network Sites

    Author(s): Gould MK; Sakoda LC; Ritzwoller DP; Simoff MJ; Neslund-Dudas CM; Kushi LH; Carter-Harris L; Feigelson HS; Minowada G; Doria-Rose VP

    Ann Am Thorac Soc. 2017 Jul 06.

    PubMed abstract

    The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer

    Author(s): Slattery ML; Herrick JS; Mullany LE; Samowitz WS; Sevens JR; Sakoda L; Wolff RK

    Genes Chromosomes Cancer. 2017 Jul 04.

    PubMed abstract

    Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study

    Author(s): Jorgenson, E E; Thai, K K KK; Hoffmann, T J TJ; Sakoda, L C LC; Kvale, M N MN; Banda, Y Y; Schaefer, C C; Risch, N N; Mertens, J J; Weisner, C C; Choquet, H H

    Molecular psychiatry. 2017 Sep ;22(9):1359-1367. Epub 2017-05-09.

    PubMed abstract

    Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.

    Author(s): Hoffmann TJ; Passarelli MN; Graff RE; Emami NC; Sakoda LC; Jorgenson E; Habel LA; Shan J; Ranatunga DK; Quesenberry CP; Chao CR; Ghai NR; Aaronson D; Presti J; Nordström T; Wang Z; Berndt SI; Chanock SJ; Mosley JD; Klein RJ; Middha M; Lilja H; |Melander O; Kvale MN; Kwok PY; Schaefer C; Risch N; Van Den Eeden SK; Witte JS;

    ​Nat Commun. 2017 Jan 31;8:14248. doi: 10.1038/ncomms14248.

    PubMed abstract

    Effect of Angiotensin System Inhibitors on Survival in Patients Receiving Chemotherapy for Advanced Non-Small-Cell Lung Cancer

    Author(s): Menter AR; Carroll NM; Sakoda LC; Delate T; Hornbrook MC; Jain RK; Kushi LH; Quinn VP; Ritzwoller DP

    Clin Lung Cancer. 2016 Aug 20.

    PubMed abstract

    Common coding variants in the HLA-DQB1 region confer susceptibility to age-related macular degeneration

    Author(s): Jorgenson E; Melles RB; Hoffmann TJ; Jia X; Sakoda LC; Kvale MN; Banda Y; Schaefer C; Risch N; Shen L

    Eur J Hum Genet. 2016 Jan 6.

    PubMed abstract

    Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

    Author(s): Kvale MN; Hesselson S; Hoffmann TJ; Cao Y; Chan D; Connell S; Croen LA; Dispensa BP; Eshragh J; Finn A; Gollub J; Iribarren C; Jorgenson E; Kushi LH; Lao R; Lu Y; Ludwig D; Mathauda GK; McGuire WB; Mei G; Miles S; Mittman M; Patil M; Quesenberry CP Jr; Ranatunga D; Rowell S; Sadler M; Sakoda LC; Shapero M; Shen L; Shenoy T; Smethurst D; Somkin CP; Van Den Eeden SK; Walter L; Wan E; Webster T; Whitmer RA; Wong S; Zau C; Zhan Y; Schaefer C; Kwok PY; Risch N;

    ​​Genetics. 2015 Aug;200(4):1051-60. doi: 10.1534/genetics.115.178905. Epub 2015 Jun 19.

    PubMed abstract

    Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

    Author(s): Lapham K; Kvale MN; Lin J; Connell S; Croen LA; Dispensa BP; Fang L; Hesselson S; Hoffmann TJ; Iribarren C; Jorgenson E; Kushi LH; Ludwig D; Matsuguchi T; McGuire WB; Miles S; Quesenberry CP Jr; Rowell S; Sadler M; Sakoda LC; Smethurst D; Somkin CP; Van Den Eeden SK; Walter L; Whitmer RA; Kwok PY; Risch N; Schaefer C; Blackburn EH;

    ​Genetics. 2015 Aug;200(4):1061-72. doi: 10.1534/genetics.115.178624. Epub 2015 Jun 19.

    PubMed abstract

    Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

    Author(s): Banda Y; Kvale MN; Hoffmann TJ; Hesselson SE; Ranatunga D; Tang H; Sabatti C; Croen LA; Dispensa BP; Henderson M; Iribarren C; Jorgenson E; Kushi LH; Ludwig D; Olberg D; Quesenberry CP Jr; Rowell S; Sadler M; Sakoda LC; Sciortino S; Shen L; Smethurst D; Somkin CP; Van Den Eeden SK; Walter L; Whitmer RA; Kwok PY; Schaefer C; Risch N;

    ​Genetics. 2015 Aug;200(4):1285-95. doi: 10.1534/genetics.115.178616. Epub 2015 Jun 19.

    PubMed abstract

    Differences in the Genetic Susceptibility to Age-Related Macular Degeneration Clinical Subtypes

    Author(s): Shen L; Hoffmann TJ; Melles RB; Sakoda LC; Kvale MN; Banda Y; Schaefer C; Risch N; Jorgenson E

    Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4290-9.

    PubMed abstract

    A large multi-ethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences

    Author(s): Hoffmann TJ; Van Den Eeden SK; Sakoda LC; Jorgenson E; Habel LA; Graff RE; Passarelli MN; Cario CL; Emami NC; Chao CR; Ghai NR; Shan J; Ranatunga DK; Quesenberry CP; Aaronson D; Presti J; Zhaoming W; Berndt SI; Chanock SJ; McDonnell SK; French AJ; Schaid DJ; Thibodeau SN; Li Q; Freedman ML; Penney KL; Mucci LA; Haiman CA; Henderson BE; Seminara D; Kvale MN; Kwok PY; Schaefer C; Risch N; Witte JS

    Cancer Discov. 2015 Jun 1.

    PubMed abstract

    Metformin use and lung cancer risk in patients with diabetes

    Author(s): Sakoda LC; Ferrara A; Achacoso NS; Peng T; Ehrlich SF; Quesenberry CP; Habel LA

    Cancer Prev Res (Phila). 2015 Feb;8(2):174-9.

    PubMed abstract

    Imputation of the Rare HOXB13 G84E Mutation and Cancer Risk in a Large Population-Based Cohort

    Author(s): Hoffmann TJ; Sakoda LC; Shen L; Jorgenson E; Habel LA; Liu J; Kvale MN; Asgari MM; Banda Y; Corley D; Kushi LH; Quesenberry CP; Schaefer C; Van Den Eeden SK; Risch N; Witte JS

    PLoS Genet. 2015 Jan;11(1):e1004930. Epub 2015-01-28.

    PubMed abstract

    Cross-cancer pleiotropic analysis of endometrial cancer: PAGE and E2C2 consortia

    Author(s): Setiawan VW; Schumacher F; Prescott J; Haessler J; Malinowski J; Wentzensen N; Yang H; Chanock S; Brinton L; Hartge P; Lissowska J; Park SL; Cheng I; Bush WS; Crawford DC; Ursin G; Horn-Ross P; Bernstein L; Lu L; Risch H; Yu H; Sakoda LC; Doherty J; Chen C; Jackson R; Yasmeen S; Cote M; Kocarnik JM; Peters U; Kraft P; De Vivo I; Haiman CA; Kooperberg C; Le Marchand L

    Carcinogenesis. 2014 Sep;35(9):2068-73. Epub 2014-05-15.

    PubMed abstract

    Turning of COGS moves forward findings for hormonally mediated cancers

    Author(s): Sakoda LC; Jorgenson E; Witte JS

    Nat Genet. 2013 Apr;45(4):345-8.

    PubMed abstract

    DNA repair genotype and lung cancer risk in the beta-carotene and retinol efficacy trial

    Author(s): Doherty JA; Sakoda LC; Loomis MM; Barnett MJ; Julianto L; Thornquist MD; Neuhouser ML; Weiss NS; Goodman GE; Chen C

    Int J Mol Epidemiol Genet. 2013;4(1):11-34. Epub 2013 Mar 18.

    PubMed abstract

    HOXB13:IL17BR and molecular grade index and risk of breast cancer death among patients with lymph node-negative invasive disease

    Author(s): Habel LA; Sakoda LC; Achacoso N; Ma XJ; Erlander MG; Sgroi DC; Fehrenbacher L; Greenberg D; Quesenberry CP

    Breast Cancer Res. 2013;15(2):R24. Epub 2013-03-14.

    PubMed abstract

    Screening for colorectal neoplasms with new fecal occult blood tests: update on performance characteristics.

    Author(s): Allison, James E JE; Sakoda, Lori C LC; Levin, Theodore R TR; Tucker, Jo P JP; Tekawa, Irene S IS; Cuff, Thomas T; Pauly, Mary Pat MP; Shlager, Lyle L; Palitz, Albert M AM; Zhao, Wei K WK; Schwartz, J Sanford JS; Ransohoff, David F DF; Selby, Joseph V JV

    Journal of the National Cancer Institute. 2007 Oct 03;99(19):1462-70. Epub 2007-09-25.

    PubMed abstract