Stephen Sidney, MD, MPH

People

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3753 (phone)
steve.sidney@kp.org
Kaiser Permanente Researcher Profiles

Stephen Sidney, MD, MPH, is a senior research scientist with the Kaiser Permanente Northern California Division of Research. He earned a Bachelor of Arts in mathematics from Yale University, a medical degree from Stanford University, and a Master's degree in Public Health from the University of California, Berkeley. Dr. Sidney's research interests include cardiovascular epidemiology and surveillance; hypertension, physical activity and fitness; health outcomes associated with cannabis use; and air pollution and cerebrovascular disease.

In 1983, Dr. Sidney helped launch — and has had an ongoing leadership role in — the Coronary Artery Risk Development in Young Adults (CARDIA) study, a landmark NHLBI-funded study of the evolution of cardiovascular risk and of subclinical and clinical cardiovascular disease starting from young adulthood. For more than 3 decades, he has been the Principal Investigator of the KPNC Oakland Field Center. Dr. Sidney also has played significant volunteer roles in local public health efforts, including 6 years as the Chair of the Alameda County Public Health Commission in Northern California. He is a Fellow of the American Heart Association and is the Chief Scientific Advisor to the National Forum for Heart Disease and Stroke Prevention. Dr. Sidney has authored or co-authored approximately 500 peer-reviewed scientific publications while at the Division of Research, primarily in the area of cardiovascular epidemiology.

Current Position(s):

Research Scientist III, Division of Research, Kaiser Permanente Northern California

Section Affiliations:

Cardiovascular and Metabolic Conditions

Primary Research Interests:

Cardiovascular disease
Physical activity and fitness
Obesity
Acute coronary syndrome
Cerebrovascular disease

Studies

Young Adult and Midlife Transitions in Physical Activity and Sedentary Behavior with Heart Failure Risk and Progression: Coronary Artery Risk Development in Young Adults (CARDIA)

This CARDIA ancillary study will examine the longitudinal relations of 35-year changes in reported physical activity from young adulthood to late midlife with indicators of subclinical heart failure collected at late midlife, and evaluate interaction in these relations by race, sex, and stages of adulthood. It will also examine the longitudinal relations of 15-year changes in accelerometer-based physical activity and sedentary behavior during midlife with indicators of subclinical heart failure during late midlife, and evaluate interaction in these relations by race and sex.
Investigator: Sidney, Stephen
Funder: National Heart, Lung, and Blood Institute

Collaborative Cohort of Cohorts for COVID-19 Research

The goal of this study is to obtain COVID-19 surveillance study (questionnaire and serology) in 6 cohort studies funded by NHLBI including the CARDIA study. A surveillance questionnaire will be administered 3 times at approximately 6 month intervals and blood will be collected for COVID-19 serology during the participants' attendance at the Year 35 CARDIA study exam. The data will be used to enhance understanding of the prevalence of COVID-19 and the precursors and sequelae of COVID-19 infection in a multi-ethnic population of participants across the 6 studies.
Investigator: Sidney, Stephen
Funder: National Heart, Lung, and Blood Institute

Cardiovascular Health Associations with Minority Stress: Behavioral Evaluations and Self-Reported Sociopsychological Outcomes by SOGI Status (CHAMBERS)

In CARDIA Year 35 exam: Assess whether sexual minority and gender minority (SGM) individuals in CARDIA have increased odds of objectively-determined traditional cardiovascular disease (CVD) risk factors and poorer CVD outcomes compared to their non-SGM counterparts. Determine whether self and/or perceived SGM stigmas associate with minority stress theory linked psychosocial or behavioral CVD risk and outcomes in cross-section and over time. Determine the role of structural SGM stigma on CVD risk factors and outcomes among SGM CARDIA participants by measuring attitudes toward SGM individuals at the community level.
Investigator: Sidney, Stephen
Funder: National Heart, Lung, and Blood Institute

Determinants and Cardiovascular Consequences of Disparities in Sleep and Circadian Rhythms between Black and White Adults

Determine the independent and joint contributions of behavioral, psychosocial and clinical characteristics over 35 years of CARDIA participation on sleep and circadian characteristics in middle-aged adults. Identify the relationship of sleep and circadian characteristics to the pathophysiologic stress response. Determine the contribution of sleep and circadian characteristics on the management of hypertension and diabetes.
Investigator: Sidney, Stephen
Funder: National Heart, Lung, and Blood Institute

Lifecourse CVD Risk and Midlife Cognitive Trajectories and Brain Aging: Implications for Alzheimer's and Dementia Prevention

Determinants of cognitive aging may begin decades prior to the development of pathological brain changes, but it is unknown whether risk factors such as hypertension and diabetes exert their influence as early as young adulthood. In this CARDIA Year 35 ancillary study, we plan to expand cognitive testing to assess 10-year cognitive change and address: 1) independent associations of 10-year midlife cognitive decline with average level and trend in cardiovascular disease (CVD) risk factors including BMI, blood pressure, and fasting glucose, assessed over 35 years from young adulthood to midlife; 2) association of 10-year midlife cognitive decline with level and trend in subclinical CVD markers derived from carotid ultrasound, coronary CT, and echocardiography; and 3) whether CVD risk factors and subclinical CVD markers are associated with brain aging indices in midlife, derived from brain MRI data obtained on 700 CARDIA participants at Year 30.
Investigator: Sidney, Stephen
Funder: National Institute on Aging

Leveraging Multi-omics Approaches to Examine Metabolic Challenges of Obesity in Relation to Cardiovascular Diseases

This project will generate longitudinal plasma metabolomic profiles in the CARDIA study cohort to better understand underlying molecular mechanisms for cardiovascular disease (CVD). We will identify metabolites and metabolic pathways related to CVD risk factors and CVD incidence; identify specific metabolites that mediate pathways from genomic CVD-susceptibility to CVD risk factors and incidence; identify metabolites and major metabolic pathways to CVD risk factors and incidence that are modified by obesity; and test most-promising metabolic pathways for CVD etiology using targeted metabolic profiling.
Investigator: Sidney, Stephen
Funder: National Heart, Lung, and Blood Institute

10-Year Changes in Objectively-Measured Physical Activity and Sedentary Behavior in the CARDIA Cohort

The goal of this study is to evaluate changes in both self-reported and objectively-measured PA and SB from young adulthood (ages 18-30 years) to late midlife (ages 48-60 years) in relation to disease risk (obesity, hypertension, dyslipidemia, type 2 diabetes, subclinical atherosclerosis and clinical endpoints), and markers of successful aging (physical and cognitive function, and cellular aging, specifically, telomere length and DNA copy number).
Investigator: Sidney, Stephen
Funder: National Heart, Lung, and Blood Institute

Determinants of Midlife and Longitudinal Change in Cognitive Function: CARDIA Study

This is an ancillary study to the ongoing CARDIA study of 5,115 adults who recently completed their seventh (year 25) follow-up, in which cognitive testing was measured, and will be participating in a year 30 exam in 2015-16. The specific aims are: 1) Using repeated measures collected over 30 years, to determine the association between cardiovascular (CV) risk factors in young adulthood on cognitive function (CF) and 5-year change in CF at mid-life. 2) To determine the association between measures of metabolic regulation, oxidative stress and adiposity in young adulthood on CF and 5-year change in CF at mid-life. 3) To use GWAS data in order to identify novel common and rare genetic variants, particularly on pathways of CV disease and metabolic regulation, associated with CF and decline. 4) To determine if there are race/ethnic difference in the association between risk factors and CF and if so, if they are moderated by socio-economic status, education, literacy and other disparities.
Investigator: Sidney, Stephen
Funder: National Heart, Lung, and Blood Institute

Discovering Healthcare Innovations to Address Disparties in Stroke (DIADS)

Blood pressure control rates are known to differ by race and are likely be an important contributor to racial disparities in stroke, particularly for young African American adults in whom a disturbing increase in stroke rates has occurred in recent years. The DIADS program will provide information that is likely to result in better understanding of stroke etiology in the young and a hypertension (HTN) treatment program that can reduce HTN control disparities and be disseminated widely, resulting in reduction of stroke disparities.
Investigator: Sidney, Stephen
Funder: National Institute of Neurological Disorders and Stroke

Coronary Artery Risk Development in Young Adults (CARDiA)

This landmark 30-year study describes the distribution of coronary heart disease risk factors in a biracial cohort of men and women aged 18 to 30 years at entry; and identifies habits, behaviors and lifestyles that are associated with initial levels of risk factors and with the evolution of risk factors.
Investigator: Sidney, Stephen
Funder: National Heart, Lung, and Blood Institute

Highlighted Publications

No results found matching criteria

Publications

Physical activity trajectories, autonomic balance and cognitive function: The Coronary Artery Risk Development in Young Adults (CARDIA) study

Author(s): Gafni, Tal; Gabriel, Kelley Pettee; Shuval, Kerem; Yaffe, Kristine; Sidney, Steve; Weinstein, Galit

Prev Med. 2022 Nov;164:107291. Epub 2022-10-07.

Current Position(s):

Section Affiliations:

Primary Research Interests:

Studies

Young Adult and Midlife Transitions in Physical Activity and Sedentary Behavior with Heart Failure Risk and Progression: Coronary Artery Risk Development in Young Adults (CARDIA)

Collaborative Cohort of Cohorts for COVID-19 Research

Cardiovascular Health Associations with Minority Stress: Behavioral Evaluations and Self-Reported Sociopsychological Outcomes by SOGI Status (CHAMBERS)

Determinants and Cardiovascular Consequences of Disparities in Sleep and Circadian Rhythms between Black and White Adults

Lifecourse CVD Risk and Midlife Cognitive Trajectories and Brain Aging: Implications for Alzheimer's and Dementia Prevention

Leveraging Multi-omics Approaches to Examine Metabolic Challenges of Obesity in Relation to Cardiovascular Diseases

10-Year Changes in Objectively-Measured Physical Activity and Sedentary Behavior in the CARDIA Cohort

Determinants of Midlife and Longitudinal Change in Cognitive Function: CARDIA Study

Discovering Healthcare Innovations to Address Disparties in Stroke (DIADS)

Coronary Artery Risk Development in Young Adults (CARDiA)

Highlighted Publications

Publications

Physical activity trajectories, autonomic balance and cognitive function: The Coronary Artery Risk Development in Young Adults (CARDIA) study

Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Marijuana use and DNA methylation-based biological age in young adults

Association of Obesity With Cognitive Decline in Black and White Americans

A population-based meta-analysis of circulating GFAP for cognition and dementia risk

Prevalence of Atherosclerotic Risk Factors Among Children and Young Adults With Arterial Ischemic Stroke

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Moderate-to-vigorous intensity physical activity from young adulthood to middle age and metabolic disease: a 30-year population-based cohort study

Associations of Clinical and Social Risk Factors With Racial Differences in Premature Cardiovascular Disease

Association of Cardiovascular Health Through Young Adulthood With Genome-Wide DNA Methylation Patterns in Midlife: The CARDIA Study

Association between Current and Cumulative Cannabis use and Heart Rate. The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Oxidative Stress and Menopausal Status: The Coronary Artery Risk Development in Young Adults Cohort Study

Establishing a National Cardiovascular Disease Surveillance System in the United States Using Electronic Health Record Data: Key Strengths and Limitations

Early to Midlife Smoking Trajectories and Cognitive Function in Middle-Aged US Adults: the CARDIA Study

Long-term television viewing patterns and gray matter brain volume in midlife

Joint associations between neighborhood walkability, greenness, and particulate air pollution on cardiovascular mortality among adults with a history of stroke or acute myocardial infarction

Twenty-Five-Year Change in Cardiac Structure and Function and Midlife Cognition: The CARDIA Study

Association of Early Adulthood 25-Year Blood Pressure Trajectories With Cerebral Lesions and Brain Structure in Midlife

Age-Adjusted Mortality Rates and Age and Risk-Associated Contributions to Change in Heart Disease and Stroke Mortality, 2011-2019 and 2019-2020

Mid-life epigenetic age, neuroimaging brain age, and cognitive function: coronary artery risk development in young adults (CARDIA) study

Pulmonary Function in Midlife as a Predictor of Later-Life Cognition: The Coronary Artery Risk Development in Adults (CARDIA) Study

The Metabolic Syndrome Is Associated With Lower Cognitive Performance and Reduced White Matter Integrity in Midlife: The CARDIA Study

Blood Pressure and Later-Life Cognition in Hispanic and White Adults (BP-COG): A Pooled Cohort Analysis of ARIC, CARDIA, CHS, FOS, MESA, and NOMAS

Higher literacy is associated with better white matter integrity and cognition in middle age

Association of low-frequency and rare coding variants with information processing speed

Characterizing the Spectrum of Bladder Health and Lower Urinary Tract Symptoms (LUTS) among Women: Results from the CARDIA Study

Long-Term Levels of LDL-C and Cognitive Function: The CARDIA Study

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

Long-term cumulative blood pressure in young adults and incident heart failure, coronary heart disease, stroke, and cardiovascular disease: The CARDIA study

Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health

Cardiovascular Health Trajectories and Elevated C-Reactive Protein: The CARDIA Study

Cardiovascular risk and functional burden at midlife: Prospective associations of isotemporal reallocations of accelerometer-measured physical activity and sedentary time in the CARDIA study

Longitudinal bidirectional associations of physical activity and depressive symptoms: The CARDIA study

Steps per Day and All-Cause Mortality in Middle-aged Adults in the Coronary Artery Risk Development in Young Adults Study

Changes in Mortality in Top 10 Causes of Death from 2011 to 2018

The Coronary Artery Risk Development In Young Adults (CARDIA) Study: JACC Focus Seminar 8/8

Relative-Intensity Physical Activity and Its Association With Cardiometabolic Disease

Particulate Matter and Cardiovascular Risk in Adults with Chronic Obstructive Pulmonary Disease

Associations between menopause, cardiac remodeling, and diastolic function: the CARDIA study

Bidirectional associations of accelerometer-derived physical activity and stationary behavior with self-reported mental and physical health during midlife

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

Cumulative Marijuana Use and Carotid Intima-Media Thickness at Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Bidirectional associations of accelerometer measured sedentary behavior and physical activity with knee pain, stiffness, and physical function: The CARDIA study

Physical Activity and Hypertension From Young Adulthood to Middle Age

Temporal trends in heart failure mortality in an integrated healthcare delivery system, California, and the US, 2001-2017

Particulate Air Pollution and Risk of Cardiovascular Events Among Adults With a History of Stroke or Acute Myocardial Infarction

The Association of Lactation Duration with Visceral and Pericardial Fat Volumes in Parous Women: the CARDIA Study

Blood Pressure Levels in Young Adulthood and Midlife Stroke Incidence in a Diverse Cohort

Longitudinal Associations of Fitness and Obesity in Young Adulthood With Right Ventricular Function and Pulmonary Artery Systolic Pressure in Middle Age: The CARDIA Study

Age-Related Development of Cardiac Remodeling and Dysfunction in Young Black and White Adults: the Coronary Artery Risk Development in Young Adults Study

Gestational Diabetes History and Glucose Tolerance After Pregnancy Associated With Coronary Artery Calcium in Women During Midlife: The CARDIA Study

Non-alcoholic fatty liver disease and cognitive function in middle-aged adults: the CARDIA study

Association between marijuana use and electrocardiographic abnormalities by middle age The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Bending the Curve in Cardiovascular Disease Mortality: Bethesda + 40 and Beyond

Longitudinal Associations of Midlife Accelerometer Determined Sedentary Behavior and Physical Activity With Cognitive Function: The CARDIA Study

Sex Differences in Cognitive Decline Among US Adults

Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits

Long-Term PM2.5 Exposure and Risks of Ischemic Heart Disease and Stroke Events: Review and Meta-Analysis

Relationships of Inflammation Trajectories with White Matter Volume and Integrity in Midlife

The presence of emphysema on chest imaging and mid-life cognition

Pre-Statistical Considerations for Harmonization of Cognitive Instruments: Harmonization of ARIC, CARDIA, CHS, FHS, MESA, and NOMAS

Guidance to Reduce the Cardiovascular Burden of Ambient Air Pollutants: A Policy Statement From the American Heart Association

Cerebral small vessel disease genomics and its implications across the lifespan

Association of negative financial shocks during the Great Recession with depressive symptoms and substance use in the USA: the CARDIA study

Insulin resistance since early adulthood and appendicular lean mass in middle-aged adults without diabetes: 20 years of the CARDIA study