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Jacek Skarbinski, MD

People

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

510-418-2196 (phone)
jacek.skarbinski@kp.org


Jacek Skarbinski, MD, is a research scientist at the Kaiser Permanente Division of Research and a practicing infectious diseases and HIV medicine specialist at Kaiser Permanente, Oakland Medical Center. In addition, he serves as the Program Director of the Kaiser Permanente Northern California HIV Fellowship. He is part of The Permanente Medical Group Physician Researcher Program and serves as co-chair of the Kaiser Permanente Northern California COVID-19 Clinical Research Coordinating Team.

Before joining The Permanente Medical Group in 2016, Dr. Skarbinski served with the Centers for Disease Control and Prevention (CDC) in various epidemiology and leadership roles. His CDC research addressed the epidemiology, diagnosis, treatment and prevention of infectious diseases with a focus on malaria, HIV, tuberculosis, and influenza. His current research interests include clinical trials, observational studies, and implementation science in a broad range of infectious diseases including HIV, tuberculosis, and COVID-19.

Dr. Skarbinski earned his MD at Stanford University School of Medicine after completing his BA at Cornell University. He completed his internal medicine residency at the University of California-San Francisco in the San Francisco General Internal Medicine Primary Care Track, served as an Epidemic Intelligence Service Officer at the CDC and completed an infectious diseases fellowship at Emory University School of Medicine.

Current Position(s):

  • Research Scientist III, Division of Research, Kaiser Permanente Northern California
  • Senior Physician, Department of Infectious Diseases, The Permanente Medical Group, Oakland Medical Center
  • Program Director, Kaiser Permanente Northern California HIV Fellowship

Section Affiliations:

Primary Research Interests:

  • HIV
  • Tuberculosis
  • COVID-19
  • Chronic fatigue syndrome
  • Clinical trials
  • Infectious diseases epidemiology
  • Delivery and implementation science

    CEIP Post COVID Fatiguing Illness

    This study aims to identify and characterize persons who are at risk of developing or who have developed post-COVID conditions, including those with medically unexplained illness in certain risk groups, and identify risk factors for post-COVID conditions.
    Investigator: Skarbinski, Jacek
    Funder: Centers for Disease Control and Prevention

    Monitoring shared variation in genomes of SARS-CoV-2 among persons with COVID-19 with and without vaccination in Northern California

    We are studying the genomes of SARS-CoV-2 in persons with COVID-19 with and without vaccination to identify and describe variants circulating within our patients, including variants of concern (such as Delta or Omicron. We also are assessing which shared genomic variations are associated with a greater risk for infection (symptomatic and asymptomatic) and severe outcomes (such as hospitalization, intensive care unit use, and death), and whether certain subpopulations, such as those with certain medical comorbidities, might be at a greater risk for infection and severe outcomes from identified variants. Through modeling, we are investigating whether and which mutations result in decreased vaccine effectiveness for prevention of infection and severe outcomes, and which may require a booster or an updated vaccine.
    Investigator: Skarbinski, Jacek
    Funder: The Rockefeller Foundation

    Tuberculosis Epidemiologic Studies Consortium III

    This study will identify primary care systems and settings that serve non-U.S.-born persons at risk for latent tuberculosis infection (LTBI) and tuberculosis disease; collect retrospective and prospective electronic medical record data; design and implement clinical care-based interventions to improve performance measures across the LTBI care cascade; and monitor and evaluate intervention performance over time to identify efficient and effective strategies.
    Investigator: Skarbinski, Jacek
    Funder: Centers for Disease Control and Prevention

    Comparing the frequency of SARS-CoV-2 variants of concern among vaccinated and unvaccinated COVID-19 cases

    In partnership with the California Emerging Infection Program and the California Department of Public Health, Kaiser Permanente Northern California will contribute to statewide whole genome sequencing efforts for surveillance for SARS-CoV-2 variants of concern by submitting samples from all vaccine breakthrough cases, a subset of hospitalized cases, and a set of matched controls. Sequencing will be done in a central laboratory and sequence data reported to public health authorities.
    Investigator: Skarbinski, Jacek
    Funder: Centers for Disease Control and Prevention

    A Phase 3 Randomized, Double-Blind Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Remdesivir (GS-5734) Treatment of COVID-19 in an Outpatient Setting

    This clinical trial will evaluate treatment with IV administered remdesivir in an outpatient setting in patients with COVID-19 who are at risk for disease progression.
    Investigator: Skarbinski, Jacek
    Funder: Gilead Sciences, Inc.

    SARS-CoV-2 Serological Antibody Testing for Disease Surveillance and Clinical Use

    This study will assess the sero-prevalence and sero-incidence of SARS-CoV-2 infection in Kaiser Permanente Northern California and assess correlates of exposure and immunity among KPNC members.
    Investigator: Skarbinski, Jacek
    Funder: National Cancer Institute

    Association of Mortality and Years of Potential Life Lost With Active Tuberculosis in the United States

    Author(s): Lee-Rodriguez, Christian; Wada, Paul Y; Hung, Yun-Yi; Skarbinski, Jacek

    JAMA Netw Open. 2020 09 01;3(9):e2014481. Epub 2020-09-01.

    PubMed abstract

    Service Delivery and Patient Outcomes in Ryan White HIV/AIDS Program-Funded and -Nonfunded Health Care Facilities in the United States.

    Author(s): Weiser J; Beer L; Frazier EL; Patel R; Dempsey A; Hauck H; Skarbinski J

    JAMA Intern Med. 2015 Oct;175(10):1650-9. doi: 10.1001/jamainternmed.2015.4095.

    PubMed abstract

    Human immunodeficiency virus transmission at each step of the care continuum in the United States.

    Author(s): Skarbinski J; Rosenberg E; Paz-Bailey G; Hall HI; Rose CE; Viall AH; Fagan JL; Lansky A; Mermin JH

    JAMA Intern Med. 2015 Apr;175(4):588-96. doi: 10.1001/jamainternmed.2014.8180.

    PubMed abstract

    Cigarette smoking prevalence among adults with HIV compared with the general adult population in the United States: cross-sectional surveys.

    Author(s): Mdodo R; Frazier EL; Dube SR; Mattson CL; Sutton MY; Brooks JT; Skarbinski J

    Ann Intern Med. 2015 Mar 3;162(5):335-44. doi: 10.7326/M14-0954.

    PubMed abstract

    Differences in human immunodeficiency virus care and treatment among subpopulations in the United States.

    Author(s): Hall HI; Frazier EL; Rhodes P; Holtgrave DR; Furlow-Parmley C; Tang T; Gray KM; Cohen SM; Mermin J; Skarbinski J

    JAMA Intern Med. 2013 Jul 22;173(14):1337-44. doi: 10.1001/jamainternmed.2013.6841.

    PubMed abstract

    Effect of malaria rapid diagnostic tests on the management of uncomplicated malaria with artemether-lumefantrine in Kenya: a cluster randomized trial.

    Author(s): Skarbinski J; Ouma PO; Causer LM; Kariuki SK; Barnwell JW; Alaii JA; de Oliveira AM; Zurovac D; Larson BA; Snow RW; Rowe AK; Laserson KF; Akhwale WS; Slutsker L; Hamel MJ

    Am J Trop Med Hyg. 2009 Jun;80(6):919-26.

    PubMed abstract

    The burden of out-of-pocket payments for health care in Tbilisi, Republic of Georgia.

    Author(s): Skarbinski J; Walker HK; Baker LC; Kobaladze A; Kirtava Z; Raffin TA

    JAMA. 2002 Feb 27;287(8):1043-9. doi: 10.1001/jama.287.8.1043.

    PubMed abstract

    Human Immunodeficiency Virus Status, Tenofovir Exposure, and the Risk of Poor Coronavirus Disease 19 (COVID-19) Outcomes: Real-World Analysis From 6 United States Cohorts Before Vaccine Rollout

    Author(s): Lea, Alexandra N; Marafino, Ben J; Skarbinski, Jacek; Silverberg, Michael J; et al.

    Clin Infect Dis. 2023 Mar 02.

    PubMed abstract

    Influenza Vaccination Uptake and Associated Factors Among Adults With and Without HIV in a Large, Integrated Health Care System

    Author(s): Imp, Brandon M; Levine, Tory; Satre, Derek D; Skarbinski, Jacek; Luu, Mitchell N; Sterling, Stacy A; Silverberg, Michael J

    Clin Infect Dis. 2023 Mar 01.

    PubMed abstract

    Risk of venous thromboembolism in non-respiratory and respiratory presentations of COVID-19 in critically ill patients

    Author(s): Roubinian, Nareg H; Vinson, David R; Pai, Ashok P; Myers, Laura C; Skarbinski, Jacek; Lee, Catherine; Mark, Dustin G; Liu, Vincent X

    Chest. 2023 Feb 12.

    PubMed abstract

    Risk of posthospital venous thromboembolism in patients with COVID-19 varies by SARS-CoV-2 period and vaccination status

    Author(s): Roubinian, Nareg H; Vinson, David R; Knudson-Fitzpatrick, Tess Wheeler; Mark, Dustin G; Skarbinski, Jacek; Lee, Catherine; Liu, Vincent X; Pai, Ashok P

    Blood Adv. 2023 Jan 10;7(1):141-144.

    PubMed abstract

    Retrospective cohort study to assess the association between treatment with tocilizumab and mortality among mechanically ventilated patients with COVID-19

    Author(s): Skarbinski, Jacek; Fireman, Bruce H; Tartof, Sara Y; et al.

    BMJ Open. 2022 10 31;12(10):e060358. Epub 2022-10-31.

    PubMed abstract

    Analysis of Severe Illness After Postvaccination COVID-19 Breakthrough Among Adults With and Without HIV in the US

    Author(s): Lang, Raynell; Silverberg, Michael J; Skarbinski, Jacek; Corona-Infectious-Virus Epidemiology Team (CIVETs) of the NA-ACORD of IeDEA,; et al.

    JAMA Netw Open. 2022 10 03;5(10):e2236397. Epub 2022-10-03.

    PubMed abstract

    SARS-CoV-2 testing and positivity among persons with and without HIV in 6 United States cohorts

    Author(s): Park, Lesley S; Silverberg, Michael J; Skarbinski, Jacek; Althoff, Keri N; et al.

    J Acquir Immune Defic Syndr. 2022 07 01;90(3):249-255.

    PubMed abstract

    Risk of severe clinical outcomes among persons with SARS-CoV-2 infection with differing levels of vaccination during widespread Omicron (B.1.1.529) and Delta (B.1.617.2) variant circulation in Northern California: A retrospective cohort study

    Author(s): Skarbinski, Jacek; Wood, Mariah S; Chervo, Tyler C; Schapiro, Jeffrey M; Elkin, Eric P; Valice, Emily; Amsden, Laura B; Hsiao, Crystal; Quesenberry, Charles; Corley, Douglas A; Kushi, Lawrence H

    Lancet Reg Health Am. 2022 Jun 16:100297.

    PubMed abstract

    Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort Studies

    Author(s): Figueiredo, Jane C; Kushi, Lawrence H; Corley, Douglas A; Skarbinski, Jacek; et al.

    Open Forum Infect Dis. 2022 Jun;9(6):ofac171. Epub 2022-04-27.

    PubMed abstract

    Analysis of Postvaccination Breakthrough COVID-19 Infections Among Adults With HIV in the United States

    Author(s): Coburn, Sally B; Silverberg, Michael J; Skarbinski, Jacek; Corona-Infectious-Virus Epidemiology Team (CIVETs) of the NA-ACCORD of IeDEA,; et al.

    JAMA Netw Open. 2022 Jun 01;5(6):e2215934. Epub 2022-06-01.

    PubMed abstract

    Population-based assessment of risks for severe COVID-19 disease outcomes

    Author(s): Zerbo, Ousseny; Lewis, Ned; Fireman, Bruce; Goddard, Kristin; Skarbinski, Jacek; Sejvar, James J; Azziz-Baumgartner, Eduardo; Klein, Nicola P

    Influenza Other Respir Viruses. 2022 01;16(1):159-165. Epub 2021-08-25.

    PubMed abstract

    Development and validation of a prediction algorithm to identify birth in countries with high tuberculosis incidence in two large California health systems

    Author(s): Fischer, Heidi; Skarbinski, Jacek; Tartof, Sara Y; et al.

    PLoS One. 2022;17(8):e0273363. Epub 2022-08-25.

    PubMed abstract

    Differences in COVID-19 testing and adverse outcomes by race, ethnicity, sex, and health system setting in a large diverse US cohort

    Author(s): Jefferson, Celeena; Silverberg, Michael J; Skarbinski, Jacek; NA-ACCORD Corona-Infectious-Virus Epidemiology Team (CIVET),; et al.

    PLoS One. 2022;17(11):e0276742. Epub 2022-11-23.

    PubMed abstract

    COVID-19 infections post-vaccination by HIV status in the United States

    Author(s): Coburn, Sally B; Silverberg, Michael; Skarbinski, Jacek; Corona-Infectious-Virus Epidemiology Team (CIVETs) of the NA-ACCORD of IeDEA,; et al.

    medRxiv. 2021 Dec 05.

    PubMed abstract

    Characterization of HIV Preexposure Prophylaxis Use Behaviors and HIV Incidence Among US Adults in an Integrated Health Care System

    Author(s): Hojilla, J Carlo; Hurley, Leo B; Marcus, Julia L; Silverberg, Michael J; Skarbinski, Jacek; Satre, Derek D; Volk, Jonathan E

    JAMA Netw Open. 2021 08 02;4(8):e2122692. Epub 2021-08-02.

    PubMed abstract

    Rationale and Design of the Pragmatic Randomized Trial of Icosapent Ethyl for High Cardiovascular Risk Adults (MITIGATE)

    Author(s): Ambrosy, Andrew P; Solomon, Matthew D; Skarbinski, Jacek; Go, Alan S; et al.

    Am Heart J. 2021 05;235:54-64. Epub 2021-01-28.

    PubMed abstract

    Association of Mortality and Years of Potential Life Lost With Active Tuberculosis in the United States

    Author(s): Lee-Rodriguez, Christian; Wada, Paul Y; Hung, Yun-Yi; Skarbinski, Jacek

    JAMA Netw Open. 2020 09 01;3(9):e2014481. Epub 2020-09-01.

    PubMed abstract

    Obesity and Mortality Among Patients Diagnosed With COVID-19: Results From an Integrated Health Care Organization

    Author(s): Tartof SY; Skarbinski J; Murali SB; et al.

    Ann Intern Med. 2020 Aug 12.

    PubMed abstract

    Burden of Active Tuberculosis in an Integrated Health Care System, 1997-2016: Incidence, Mortality, and Excess Health Care Utilization

    Author(s): Wada PY; Lee-Rodriguez C; Hung YY; Skarbinski J

    Open Forum Infect Dis. 2020 Jan;7(1):ofaa015. Epub 2020-01-12.

    PubMed abstract

    Comparison of msp genotyping and a 24 SNP molecular assay for differentiating Plasmodium falciparum recrudescence from reinfection

    Author(s): Fulakeza J; McNitt S; Vareta J; Saidi A; Mvula G; Taylor T; Mathanga DP; Small DS; Skarbinski J; Gutman JR; Seydel K

    Malar J. 2019 Mar 18;18(1):84. Epub 2019-03-18.

    PubMed abstract

    Epidemiology, detection, and management of tuberculosis among end-stage renal disease patients

    Author(s): Okada RC; Barry PM; Skarbinski J; Chitnis AS

    Infect Control Hosp Epidemiol. 2018 11;39(11):1367-1374. Epub 2018-09-20.

    PubMed abstract

    Latent tuberculous infection testing among HIV-infected persons in clinical care, United States, 2010-2012.

    Author(s): Reaves EJ; Shah NS; France AM; Morris SB; Kammerer S; Skarbinski J; Bradley H

    Int J Tuberc Lung Dis. 2017 Oct 1;21(10):1118-1126. doi: 10.5588/ijtld.17.0041.

    PubMed abstract

    Qualifications, Demographics, Satisfaction, and Future Capacity of the HIV Care Provider Workforce in the United States, 2013-2014.

    Author(s): Weiser J; Beer L; West BT; Duke CC; Gremel GW; Skarbinski J

    Clin Infect Dis. 2016 Oct 1;63(7):966-975. doi: 10.1093/cid/ciw442. Epub 2016 Jun 29.

    PubMed abstract

    Nearly Half Of US Adults Living With HIV Received Federal Disability Benefits In 2009.

    Author(s): Huang YL; Frazier EL; Sansom SL; Farnham PG; Shrestha RK; Hutchinson AB; Fagan JL; Viall AH; Skarbinski J

    Health Aff (Millwood). 2015 Oct;34(10):1657-65. doi: 10.1377/hlthaff.2015.0249.

    PubMed abstract

    Service Delivery and Patient Outcomes in Ryan White HIV/AIDS Program-Funded and -Nonfunded Health Care Facilities in the United States.

    Author(s): Weiser J; Beer L; Frazier EL; Patel R; Dempsey A; Hauck H; Skarbinski J

    JAMA Intern Med. 2015 Oct;175(10):1650-9. doi: 10.1001/jamainternmed.2015.4095.

    PubMed abstract

    Ryan White HIV/AIDS Program Assistance and HIV Treatment Outcomes.

    Author(s): Bradley H; Viall AH; Wortley PM; Dempsey A; Hauck H; Skarbinski J

    Clin Infect Dis. 2016 Jan 1;62(1):90-98. doi: 10.1093/cid/civ708. Epub 2015 Aug 30.

    PubMed abstract

    Human immunodeficiency virus transmission at each step of the care continuum in the United States.

    Author(s): Skarbinski J; Rosenberg E; Paz-Bailey G; Hall HI; Rose CE; Viall AH; Fagan JL; Lansky A; Mermin JH

    JAMA Intern Med. 2015 Apr;175(4):588-96. doi: 10.1001/jamainternmed.2014.8180.

    PubMed abstract

    Cigarette smoking prevalence among adults with HIV compared with the general adult population in the United States: cross-sectional surveys.

    Author(s): Mdodo R; Frazier EL; Dube SR; Mattson CL; Sutton MY; Brooks JT; Skarbinski J

    Ann Intern Med. 2015 Mar 3;162(5):335-44. doi: 10.7326/M14-0954.

    PubMed abstract

    Differences in human immunodeficiency virus care and treatment among subpopulations in the United States.

    Author(s): Hall HI; Frazier EL; Rhodes P; Holtgrave DR; Furlow-Parmley C; Tang T; Gray KM; Cohen SM; Mermin J; Skarbinski J

    JAMA Intern Med. 2013 Jul 22;173(14):1337-44. doi: 10.1001/jamainternmed.2013.6841.

    PubMed abstract

    Effectiveness of intermittent preventive treatment with sulfadoxine-pyrimethamine during pregnancy on maternal and birth outcomes in Machinga district, Malawi.

    Author(s): Gutman J; Mwandama D; Wiegand RE; Ali D; Mathanga DP; Skarbinski J

    J Infect Dis. 2013 Sep;208(6):907-16. doi: 10.1093/infdis/jit276. Epub 2013 Jun 24.

    PubMed abstract

    Impact of health facility-based insecticide treated bednet distribution in Malawi: progress and challenges towards achieving universal coverage.

    Author(s): Skarbinski J; Mwandama D; Luka M; Jafali J; Wolkon A; Townes D; Campbell C; Zoya J; Ali D; Mathanga DP

    PLoS One. 2011;6(7):e21995. doi: 10.1371/journal.pone.0021995. Epub 2011 Jul 21.

    PubMed abstract

    Hospitalized patients with 2009 pandemic influenza A (H1N1) virus infection in the United States--September-October 2009.

    Author(s): Skarbinski J; Jain S; Bramley A; Lee EJ; Huang J; Kirschke D; Stone A; Wedlake T; Richards SM; Page S; Ragan P; Bullion L; Neises D; Williams RM; Petruccelli BP; Vandermeer M; Lofy KH; Gindler J; Finelli L

    Clin Infect Dis. 2011 Jan 1;52 Suppl 1:S50-9. doi: 10.1093/cid/ciq021.

    PubMed abstract

    Effect of malaria rapid diagnostic tests on the management of uncomplicated malaria with artemether-lumefantrine in Kenya: a cluster randomized trial.

    Author(s): Skarbinski J; Ouma PO; Causer LM; Kariuki SK; Barnwell JW; Alaii JA; de Oliveira AM; Zurovac D; Larson BA; Snow RW; Rowe AK; Laserson KF; Akhwale WS; Slutsker L; Hamel MJ

    Am J Trop Med Hyg. 2009 Jun;80(6):919-26.

    PubMed abstract

    The burden of out-of-pocket payments for health care in Tbilisi, Republic of Georgia.

    Author(s): Skarbinski J; Walker HK; Baker LC; Kobaladze A; Kirtava Z; Raffin TA

    JAMA. 2002 Feb 27;287(8):1043-9. doi: 10.1001/jama.287.8.1043.

    PubMed abstract