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Jacek Skarbinski, MD

Kaiser Permanente Researcher Profiles

Jacek  Skarbinski, MD

Jacek Skarbinski, MD, is a research scientist at the Kaiser Permanente Division of Research and a practicing infectious diseases and HIV medicine specialist at Kaiser Permanente, Oakland Medical Center. In addition, he serves as the Program Director of the Kaiser Permanente Northern California HIV Fellowship. He is part of The Permanente Medical Group Physician Researcher Program and serves as co-chair of the Kaiser Permanente Northern California COVID-19 Clinical Research Coordinating Team.

Before joining The Permanente Medical Group in 2016, Dr. Skarbinski served with the Centers for Disease Control and Prevention (CDC) in various epidemiology and leadership roles. His CDC research addressed the epidemiology, diagnosis, treatment and prevention of infectious diseases with a focus on malaria, HIV, tuberculosis, and influenza. His current research interests include clinical trials, observational studies, and implementation science in a broad range of infectious diseases including HIV, tuberculosis, and COVID-19.

Dr. Skarbinski earned his MD at Stanford University School of Medicine after completing his BA at Cornell University. He completed his internal medicine residency at the University of California-San Francisco in the San Francisco General Internal Medicine Primary Care Track, served as an Epidemic Intelligence Service Officer at the CDC and completed an infectious diseases fellowship at Emory University School of Medicine.

Current Positions

  • Research Scientist III, Division of Research, Kaiser Permanente Northern California
  • Senior Physician, Department of Infectious Diseases, The Permanente Medical Group, Oakland Medical Center
  • Program Director, Kaiser Permanente Northern California HIV Fellowship

Section Affiliations

Primary Research Interests

  • HIV
  • Tuberculosis
  • COVID-19
  • Chronic fatigue syndrome
  • Clinical trials
  • Infectious diseases epidemiology
  • Delivery and implementation science


CEIP Post COVID Fatiguing Illness

This study aims to identify and characterize persons who are at risk of developing or who have developed post-COVID conditions, including those with medically unexplained illness in certain risk groups, and identify risk factors for post-COVID conditions.

Investigator: Skarbinski, Jacek

Funder: Centers for Disease Control and Prevention

Monitoring shared variation in genomes of SARS-CoV-2 among persons with COVID-19 with and without vaccination in Northern California

We are studying the genomes of SARS-CoV-2 in persons with COVID-19 with and without vaccination to identify and describe variants circulating within our patients, including variants of concern (such as Delta or Omicron. We also are assessing which shared genomic variations are associated with a greater risk for infection (symptomatic and asymptomatic) and severe outcomes (such as hospitalization, intensive care unit use, and death), and whether certain subpopulations, such as those with certain medical comorbidities, might be at a greater risk for infection and severe outcomes from identified variants. Through modeling, we are investigating whether and which mutations result in decreased vaccine effectiveness for prevention of infection and severe outcomes, and which may require a booster or an updated vaccine.

Investigator: Skarbinski, Jacek

Funder: The Rockefeller Foundation

Tuberculosis Epidemiologic Studies Consortium III

This study will identify primary care systems and settings that serve non-U.S.-born persons at risk for latent tuberculosis infection (LTBI) and tuberculosis disease; collect retrospective and prospective electronic medical record data; design and implement clinical care-based interventions to improve performance measures across the LTBI care cascade; and monitor and evaluate intervention performance over time to identify efficient and effective strategies.

Investigator: Skarbinski, Jacek

Funder: Centers for Disease Control and Prevention

Comparing the frequency of SARS-CoV-2 variants of concern among vaccinated and unvaccinated COVID-19 cases

In partnership with the California Emerging Infection Program and the California Department of Public Health, Kaiser Permanente Northern California will contribute to statewide whole genome sequencing efforts for surveillance for SARS-CoV-2 variants of concern by submitting samples from all vaccine breakthrough cases, a subset of hospitalized cases, and a set of matched controls. Sequencing will be done in a central laboratory and sequence data reported to public health authorities.

Investigator: Skarbinski, Jacek

Funder: Centers for Disease Control and Prevention

SARS-CoV-2 Serological Antibody Testing for Disease Surveillance and Clinical Use

This study will assess the sero-prevalence and sero-incidence of SARS-CoV-2 infection in Kaiser Permanente Northern California and assess correlates of exposure and immunity among KPNC members.

Investigator: Skarbinski, Jacek

Funder: National Cancer Institute

A Phase 3 Randomized, Double-Blind Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Remdesivir (GS-5734) Treatment of COVID-19 in an Outpatient Setting

This clinical trial will evaluate treatment with IV administered remdesivir in an outpatient setting in patients with COVID-19 who are at risk for disease progression.

Investigator: Skarbinski, Jacek

Funder: Gilead Sciences, Inc.


An atypical presentation of mpox transmitted between transgender males through oral sex

Authors: Wick, Jenna M;Pelliccione, Alex;Lee-Rodriguez, Christian;Tran, H Nicole;McCleskey, Patrick E;Nichol, Aran;Skarbinski, Jacek

Sex Transm Dis. 2023 Oct 01;50(10):685-686. Epub 2023-05-12.

PubMed abstract

Real-World Evidence to Supplement Randomized Clinical Trials: Tocilizumab for Severe COVID-19 Pneumonia vs. a Cohort Receiving Standard of Care

Authors: Skarbinski, Jacek;Fischer, Heidi;Hong, Vennis;Liu, Liyan;Yau, Vincent M;Incerti, Devin;Qian, Lei;Ackerson, Bradley K;Amsden, Laura B;Shaw, Sally F;Tartof, Sara Y

Clin Pharmacol Ther. 2023 Aug 11.

PubMed abstract

SARS-CoV-2 Delta variant genomic variation associated with breakthrough infection in Northern California: A retrospective cohort study

Authors: Skarbinski, Jacek;Wyman, Stacia K;et al.

J Infect Dis. 2023 May 17.

PubMed abstract

Latent Tuberculosis Infection Treatment Practices in Two Large Integrated Health Systems in California, 2009-2018

Authors: Bruxvoort, Katia J;Skarbinski, Jacek;Fischer, Heidi;Li, Zhuoxin;Eaton, Abigail;Qian, Lei;Spence, Brigitte;Wei, Rong;Rieg, Gunter;Shaw, Sally;Tartof, Sara Y

Open Forum Infect Dis. 2023 May;10(5):ofad219. Epub 2023-04-21.

PubMed abstract

Human Immunodeficiency Virus Status, Tenofovir Exposure, and the Risk of Poor Coronavirus Disease 19 (COVID-19) Outcomes: Real-World Analysis From 6 United States Cohorts Before Vaccine Rollout

Authors: Lea, Alexandra N; Marafino, Ben J; Skarbinski, Jacek; Silverberg, Michael J; et al.

Clin Infect Dis. 2023 Mar 02.

PubMed abstract

Influenza Vaccination Uptake and Associated Factors Among Adults With and Without HIV in a Large, Integrated Health Care System

Authors: Imp, Brandon M; Levine, Tory; Satre, Derek D; Skarbinski, Jacek; Luu, Mitchell N; Sterling, Stacy A; Silverberg, Michael J

Clin Infect Dis. 2023 Mar 01.

PubMed abstract

Risk of venous thromboembolism in non-respiratory and respiratory presentations of COVID-19 in critically ill patients

Authors: Roubinian, Nareg H; Vinson, David R; Pai, Ashok P; Myers, Laura C; Skarbinski, Jacek; Lee, Catherine; Mark, Dustin G; Liu, Vincent X

Chest. 2023 Feb 12.

PubMed abstract

Risk of posthospital venous thromboembolism in patients with COVID-19 varies by SARS-CoV-2 period and vaccination status

Authors: Roubinian, Nareg H;Vinson, David R;Knudson-Fitzpatrick, Tess Wheeler;Mark, Dustin G;Skarbinski, Jacek;Lee, Catherine;Liu, Vincent X;Pai, Ashok P

Blood Adv. 2023 Jan 10;7(1):141-144.

PubMed abstract

Retrospective cohort study to assess the association between treatment with tocilizumab and mortality among mechanically ventilated patients with COVID-19

Authors: Skarbinski, Jacek; Fireman, Bruce H; Tartof, Sara Y; et al.

BMJ Open. 2022 10 31;12(10):e060358. Epub 2022-10-31.

PubMed abstract

Analysis of Severe Illness After Postvaccination COVID-19 Breakthrough Among Adults With and Without HIV in the US

Authors: Lang, Raynell; Silverberg, Michael J; Skarbinski, Jacek; Corona-Infectious-Virus Epidemiology Team (CIVETs) of the NA-ACORD of IeDEA,; et al.

JAMA Netw Open. 2022 10 03;5(10):e2236397. Epub 2022-10-03.

PubMed abstract

SARS-CoV-2 testing and positivity among persons with and without HIV in 6 United States cohorts

Authors: Park, Lesley S; Silverberg, Michael J; Skarbinski, Jacek; Althoff, Keri N; et al.

J Acquir Immune Defic Syndr. 2022 07 01;90(3):249-255.

PubMed abstract

Risk of severe clinical outcomes among persons with SARS-CoV-2 infection with differing levels of vaccination during widespread Omicron (B.1.1.529) and Delta (B.1.617.2) variant circulation in Northern California: A retrospective cohort study

Authors: Skarbinski, Jacek; Wood, Mariah S; Chervo, Tyler C; Schapiro, Jeffrey M; Elkin, Eric P; Valice, Emily; Amsden, Laura B; Hsiao, Crystal; Quesenberry, Charles; Corley, Douglas A; Kushi, Lawrence H

Lancet Reg Health Am. 2022 Jun 16:100297.

PubMed abstract

Analysis of Postvaccination Breakthrough COVID-19 Infections Among Adults With HIV in the United States

Authors: Coburn, Sally B; Silverberg, Michael J; Skarbinski, Jacek; Corona-Infectious-Virus Epidemiology Team (CIVETs) of the NA-ACCORD of IeDEA,; et al.

JAMA Netw Open. 2022 Jun 01;5(6):e2215934. Epub 2022-06-01.

PubMed abstract

Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort Studies

Authors: Figueiredo, Jane C; Kushi, Lawrence H; Corley, Douglas A; Skarbinski, Jacek; et al.

Open Forum Infect Dis. 2022 Jun;9(6):ofac171. Epub 2022-04-27.

PubMed abstract

Population-based assessment of risks for severe COVID-19 disease outcomes

Authors: Zerbo, Ousseny; Lewis, Ned; Fireman, Bruce; Goddard, Kristin; Skarbinski, Jacek; Sejvar, James J; Azziz-Baumgartner, Eduardo; Klein, Nicola P

Influenza Other Respir Viruses. 2022 01;16(1):159-165. Epub 2021-08-25.

PubMed abstract

Differences in COVID-19 testing and adverse outcomes by race, ethnicity, sex, and health system setting in a large diverse US cohort

Authors: Jefferson, Celeena; Silverberg, Michael J; Skarbinski, Jacek; NA-ACCORD Corona-Infectious-Virus Epidemiology Team (CIVET),; et al.

PLoS One. 2022;17(11):e0276742. Epub 2022-11-23.

PubMed abstract

Development and validation of a prediction algorithm to identify birth in countries with high tuberculosis incidence in two large California health systems

Authors: Fischer, Heidi; Skarbinski, Jacek; Tartof, Sara Y; et al.

PLoS One. 2022;17(8):e0273363. Epub 2022-08-25.

PubMed abstract

COVID-19 infections post-vaccination by HIV status in the United States

Authors: Coburn, Sally B; Silverberg, Michael; Skarbinski, Jacek; Corona-Infectious-Virus Epidemiology Team (CIVETs) of the NA-ACCORD of IeDEA,; et al.

medRxiv. 2021 Dec 05.

PubMed abstract

Characterization of HIV Preexposure Prophylaxis Use Behaviors and HIV Incidence Among US Adults in an Integrated Health Care System

Authors: Hojilla, J Carlo; Hurley, Leo B; Marcus, Julia L; Silverberg, Michael J; Skarbinski, Jacek; Satre, Derek D; Volk, Jonathan E

JAMA Netw Open. 2021 08 02;4(8):e2122692. Epub 2021-08-02.

PubMed abstract

Rationale and Design of the Pragmatic Randomized Trial of Icosapent Ethyl for High Cardiovascular Risk Adults (MITIGATE)

Authors: Ambrosy, Andrew P; Solomon, Matthew D; Skarbinski, Jacek; Go, Alan S; et al.

Am Heart J. 2021 05;235:54-64. Epub 2021-01-28.

PubMed abstract

Association of Mortality and Years of Potential Life Lost With Active Tuberculosis in the United States

Authors: Lee-Rodriguez, Christian; Wada, Paul Y; Hung, Yun-Yi; Skarbinski, Jacek

JAMA Netw Open. 2020 09 01;3(9):e2014481. Epub 2020-09-01.

PubMed abstract

Obesity and Mortality Among Patients Diagnosed With COVID-19: Results From an Integrated Health Care Organization

Authors: Tartof SY; Skarbinski J; Murali SB; et al.

Ann Intern Med. 2020 Aug 12.

PubMed abstract

Burden of Active Tuberculosis in an Integrated Health Care System, 1997-2016: Incidence, Mortality, and Excess Health Care Utilization

Authors: Wada PY; Lee-Rodriguez C; Hung YY; Skarbinski J

Open Forum Infect Dis. 2020 Jan;7(1):ofaa015. Epub 2020-01-12.

PubMed abstract

Comparison of msp genotyping and a 24 SNP molecular assay for differentiating Plasmodium falciparum recrudescence from reinfection

Authors: Fulakeza J; McNitt S; Vareta J; Saidi A; Mvula G; Taylor T; Mathanga DP; Small DS; Skarbinski J; Gutman JR; Seydel K

Malar J. 2019 Mar 18;18(1):84. Epub 2019-03-18.

PubMed abstract

Epidemiology, detection, and management of tuberculosis among end-stage renal disease patients

Authors: Okada RC; Barry PM; Skarbinski J; Chitnis AS

Infect Control Hosp Epidemiol. 2018 11;39(11):1367-1374. Epub 2018-09-20.

PubMed abstract

Latent tuberculous infection testing among HIV-infected persons in clinical care, United States, 2010-2012.

Authors: Reaves EJ; Shah NS; France AM; Morris SB; Kammerer S; Skarbinski J; Bradley H

Int J Tuberc Lung Dis. 2017 Oct 1;21(10):1118-1126. doi: 10.5588/ijtld.17.0041.

PubMed abstract

Qualifications, Demographics, Satisfaction, and Future Capacity of the HIV Care Provider Workforce in the United States, 2013-2014.

Authors: Weiser J; Beer L; West BT; Duke CC; Gremel GW; Skarbinski J

Clin Infect Dis. 2016 Oct 1;63(7):966-975. doi: 10.1093/cid/ciw442. Epub 2016 Jun 29.

PubMed abstract

Nearly Half Of US Adults Living With HIV Received Federal Disability Benefits In 2009.

Authors: Huang YL; Frazier EL; Sansom SL; Farnham PG; Shrestha RK; Hutchinson AB; Fagan JL; Viall AH; Skarbinski J

Health Aff (Millwood). 2015 Oct;34(10):1657-65. doi: 10.1377/hlthaff.2015.0249.

PubMed abstract

Service Delivery and Patient Outcomes in Ryan White HIV/AIDS Program-Funded and -Nonfunded Health Care Facilities in the United States.

Authors: Weiser J; Beer L; Frazier EL; Patel R; Dempsey A; Hauck H; Skarbinski J

JAMA Intern Med. 2015 Oct;175(10):1650-9. doi: 10.1001/jamainternmed.2015.4095.

PubMed abstract

Ryan White HIV/AIDS Program Assistance and HIV Treatment Outcomes.

Authors: Bradley H; Viall AH; Wortley PM; Dempsey A; Hauck H; Skarbinski J

Clin Infect Dis. 2016 Jan 1;62(1):90-98. doi: 10.1093/cid/civ708. Epub 2015 Aug 30.

PubMed abstract

Human immunodeficiency virus transmission at each step of the care continuum in the United States.

Authors: Skarbinski J; Rosenberg E; Paz-Bailey G; Hall HI; Rose CE; Viall AH; Fagan JL; Lansky A; Mermin JH

JAMA Intern Med. 2015 Apr;175(4):588-96. doi: 10.1001/jamainternmed.2014.8180.

PubMed abstract

Cigarette smoking prevalence among adults with HIV compared with the general adult population in the United States: cross-sectional surveys.

Authors: Mdodo R; Frazier EL; Dube SR; Mattson CL; Sutton MY; Brooks JT; Skarbinski J

Ann Intern Med. 2015 Mar 3;162(5):335-44. doi: 10.7326/M14-0954.

PubMed abstract

Differences in human immunodeficiency virus care and treatment among subpopulations in the United States.

Authors: Hall HI; Frazier EL; Rhodes P; Holtgrave DR; Furlow-Parmley C; Tang T; Gray KM; Cohen SM; Mermin J; Skarbinski J

JAMA Intern Med. 2013 Jul 22;173(14):1337-44. doi: 10.1001/jamainternmed.2013.6841.

PubMed abstract

Effectiveness of intermittent preventive treatment with sulfadoxine-pyrimethamine during pregnancy on maternal and birth outcomes in Machinga district, Malawi.

Authors: Gutman J; Mwandama D; Wiegand RE; Ali D; Mathanga DP; Skarbinski J

J Infect Dis. 2013 Sep;208(6):907-16. doi: 10.1093/infdis/jit276. Epub 2013 Jun 24.

PubMed abstract

Impact of health facility-based insecticide treated bednet distribution in Malawi: progress and challenges towards achieving universal coverage.

Authors: Skarbinski J; Mwandama D; Luka M; Jafali J; Wolkon A; Townes D; Campbell C; Zoya J; Ali D; Mathanga DP

PLoS One. 2011;6(7):e21995. doi: 10.1371/journal.pone.0021995. Epub 2011 Jul 21.

PubMed abstract

Hospitalized patients with 2009 pandemic influenza A (H1N1) virus infection in the United States–September-October 2009.

Authors: Skarbinski J; Jain S; Bramley A; Lee EJ; Huang J; Kirschke D; Stone A; Wedlake T; Richards SM; Page S; Ragan P; Bullion L; Neises D; Williams RM; Petruccelli BP; Vandermeer M; Lofy KH; Gindler J; Finelli L

Clin Infect Dis. 2011 Jan 1;52 Suppl 1:S50-9. doi: 10.1093/cid/ciq021.

PubMed abstract

Effect of malaria rapid diagnostic tests on the management of uncomplicated malaria with artemether-lumefantrine in Kenya: a cluster randomized trial.

Authors: Skarbinski J; Ouma PO; Causer LM; Kariuki SK; Barnwell JW; Alaii JA; de Oliveira AM; Zurovac D; Larson BA; Snow RW; Rowe AK; Laserson KF; Akhwale WS; Slutsker L; Hamel MJ

Am J Trop Med Hyg. 2009 Jun;80(6):919-26.

PubMed abstract

The burden of out-of-pocket payments for health care in Tbilisi, Republic of Georgia.

Authors: Skarbinski J; Walker HK; Baker LC; Kobaladze A; Kirtava Z; Raffin TA

JAMA. 2002 Feb 27;287(8):1043-9. doi: 10.1001/jama.287.8.1043.

PubMed abstract

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