Rachel A. Whitmer, PhD

rawhitmer@ucdavis.edu

Kaiser Permanente Researcher Profiles

Rachel Whitmer, PhD, is an adjunct investigator at the Divison of Research and Professor of Public Health Sciences at the UC Davis School of Medicine, where she is also Chief of the Division of Epidemiology, and Director of Epidemiology Core Alzheimer’s Disease Research Center. Dr. Whitmer received her BS in Psychology/Neuorscience Magna Cum Laude from the University of Massachusetts, Amherst, her PhD in Human Development from the University of California, Davis, and Fellowship in Cardiovascular Epidemiology at the School of Public Health, University of California, Berkeley. Dr. Whitmer was a K12 scholar through the NIH Office of Research in Women’s Health Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) program, administered by the Division of Research at Kaiser Permanente and the University of California, San Francisco, from 2003-2005. She was a Fulbright Faculty Mentor in 2010-11.

Dr. Whitmer leads a laboratory of population-based science in brain aging. Her group focuses on three major themes: 1) Ethnoracial disparities and diversity in cognitive aging and dementia outcomes; 2) Early-life contributions to brain health and dementia risk; and 3) Metabolic and vascular influences on brain aging. Her group utilizes lifecourse methods to address these themes. Dr. Whitmer is Principal Investigator of several studies, among them the SOLID (Study of Longevity in Diabetes), a cohort study of 1200 individuals with diabetes mellitus; KHANDLE  (Kaiser Healthy Aging and Diverse Life Experiences), a multiethnic cohort of 1,800 elderly individuals; and Kaiser STAR (Study of Healthy Aging in African Americans), a cohort of 700 African Americans age 50 and older. The primary objective of her research program is to identify and understand risk and protective factors for cognitive and brain aging in populations at high risk for dementia, including ethnic minority groups and those with chronic disease such as diabetes mellitus.

Dr. Whitmer is also on the faculty at University of California, San Francisco, in the Department of Epidemiology and Biostatistics and is core faculty on the department’sChronic Disease and  Aging Epidemiology T32, and the PhD program inEpidemiology and Translational Sciences. Multiple mentoring opportunities exist through this and other mechanisms. 

Studies

Early Vascular Contributions to Dementia Risk in African-Americans

This is a lifecourse study of vascular risk and brain aging in a well-characterized population of 1,200 elderly African-Americans that will close the gap in knowledge regarding midlife risk and protective factors for cognitive decline. The data collected, in conjunction with extensive electronic medical records spanning decades, will allow for a cost-effective, efficient approach for an observational study of cumulative vascular risk and brain aging. Our overall objective is to understand the magnitude of cognitive decline and long-term contributions of vascular disease on cognitive impairment and brain injury in African-Americans, an understudied and rapidly expanding segment of the elderly population.

Investigator: Whitmer, Rachel

Funder: National Institute on Aging

Lifecourse Health, Cerebral Pathology and Ethnic Disparities in Dementia

Although there are marked ethnic disparities in rates of dementia, almost nothing is known about early life contributors to dementia in ethnic minority groups, nor if the trajectory of cognitive decline or transition to cognitive impairment varies across ethnic groups. This lifecourse study of ethnic disparities in the epidemiology of dementia will use over five decades of data in relation to cognitive decline and brain pathology. The overall objectives are to define ethnic disparities in dementia incidence and to advance our understanding of such disparities by assessing early and midlife risk factors for cognitive impairment and MRI markers of brain injury.

Investigator: Whitmer, Rachel

Funder: National Institute on Aging

Predictors of Late-Life Cognitive Health in Type 1 Diabetes

There is evidence that middle aged-adults with Type 1 diabetes have deficits in cognitive function and are more likely to be diagnosed with depression . Although it is well established that elderly individuals with type 2 diabetes are at double the risk of cognitive impairment and dementia, it remains unknown whether elderly individuals with Type 1 diabetes are also at greater risk for accelerated cognitive aging. The goal of this study is to characterize the extent of cognitive decline in a cohort of elderly individuals with Type 1 diabetes. Aims will focus on examining the role of insulin, depression, and hyper/hypoglycemic events on cognitive decline.

Investigator: Whitmer, Rachel

Funder: National Institute on Aging

Publications

Gender differences in the association between education and late-life cognitive function in the LifeAfter90 Study: A multiethnic cohort of the oldest-old

Authors: Lam, Jennifer O;Whitmer, Rachel A;Corrada, Maria M;Kawas, Claudia H;Vieira, Katherine E;Quesenberry, Charles P;Gilsanz, Paola

Alzheimers Dement. 2024 Sep 10.

PubMed abstract

Heterogeneity in the effect of type 2 diabetes on dementia incidence in a diverse cohort of Asian American and non-Latino White older adults

Authors: Hayes-Larson, Eleanor;Zhou, Yixuan;Wu, Yingyan;Mobley, Taylor M;Gee, Gilbert C;Brookmeyer, Ron;Whitmer, Rachel A;Gilsanz, Paola;Kanaya, Alka M;Mayeda, Elizabeth Rose

Am J Epidemiol. 2024 Sep 03;193(9):1261-1270.

PubMed abstract

Life course financial mobility and later-life memory function and decline by gender, and race and ethnicity: an intersectional analysis of the US KHANDLE and STAR cohort studies

Authors: Kobayashi, Lindsay C;Peterson, Rachel L;Yu, Xuexin;Avila-Rieger, Justina;Amofa-Ho, Priscilla A;Vila-Castelar, Clara;Meza, Erika;Shaaban, C Elizabeth;Whitmer, Rachel A;Gilsanz, Paola;Mayeda, Elizabeth Rose

Lancet Healthy Longev. 2024 Sep;5(9):100613. Epub 2024-08-30.

PubMed abstract

HbA1c variability associated with dementia risk in people with type 2 diabetes

Authors: Moran, Chris;Whitmer, Rachel A;Dove, Zoe;Lacy, Mary E;Soh, Yenee;Tsai, Ai-Lin;Quesenberry, Charles P;Karter, Andrew J;Adams, Alyce S;Gilsanz, Paola

Alzheimers Dement. 2024 Aug;20(8):5561-5569. Epub 2024-07-03.

PubMed abstract

School-based racial segregation, social support, and late-life cognitive function in the Study of Healthy Aging in African Americans (STAR)

Authors: Gutierrez, Sirena;Gilsanz, Paola;Gilsanz, Paola;et al.

Alzheimers Dement. 2024 Jul 25.

PubMed abstract

Estimating dementia incidence in insured older Asian Americans and Pacific Islanders in California: an application of inverse odds of selection weights

Authors: Hayes-Larson, Eleanor;Zhou, Yixuan;Wu, Yingyan;Rojas-Saunero, Paloma L;Seamans, Marissa J;Gee, Gilbert C;Brookmeyer, Ron;Gilsanz, Paola;Whitmer, Rachel A;Mayeda, Elizabeth Rose

Am J Epidemiol. 2024 Jul 05.

PubMed abstract

School racial composition, effect modification by caring teacher/staff presence, and mid/late-life depressive symptoms: findings from the Study of Healthy Aging among African Americans

Authors: Mobley, Taylor M;Hayes-Larson, Eleanor;Wu, Yingyan;Peterson, Rachel L;George, Kristen M;Gilsanz, Paola;Glymour, M Maria;Thomas, Marilyn D;Barnes, Lisa L;Whitmer, Rachel A;Mayeda, Elizabeth Rose

Am J Epidemiol. 2024 Apr 17.

PubMed abstract

Timing and level of educational attainment and late-life cognition in the KHANDLE study

Authors: Soh, Yenee;Quesenberry, Charles P;Gilsanz, Paola;Gilsanz, Paola;et al.

Alzheimers Dement. 2024 Jan;20(1):593-600. Epub 2023-09-26.

PubMed abstract

Metformin Cessation and Dementia Incidence

Authors: Zimmerman, Scott C;Whitmer, Rachel A;Gilsanz, Paola;Schaefer, Catherine;Ackley, Sarah F;et al.

JAMA Netw Open. 2023 Oct 02;6(10):e2339723. Epub 2023-10-02.

PubMed abstract

Glycemic Control Over Multiple Decades and Dementia Risk in People With Type 2 Diabetes

Authors: Moran, Chris;Lacy, Mary E;Whitmer, Rachel A;Tsai, Ai-Lin;Quesenberry, Charles P;Karter, Andrew J;Adams, Alyce S;Gilsanz, Paola

JAMA Neurol. 2023 Jun 01;80(6):597-604.

PubMed abstract

Association of Early Adulthood Hypertension and Blood Pressure Change With Late-Life Neuroimaging Biomarkers

Authors: George, Kristen M;Maillard, Pauline;DeCarli, Charles;Whitmer, Rachel A;et al.

JAMA Netw Open. 2023 Apr 03;6(4):e236431. Epub 2023-04-03.

PubMed abstract

Association of Education With Dementia Incidence Stratified by Ethnicity and Nativity in a Cohort of Older Asian American Individuals

Authors: Hayes-Larson, Eleanor; Ikesu, Ryo; Fong, Joseph; Mobley, Taylor M; Gee, Gilbert C; Brookmeyer, Ron; Whitmer, Rachel A; Gilsanz, Paola; Mayeda, Elizabeth Rose

JAMA Netw Open. 2023 Mar 01;6(3):e231661. Epub 2023-03-01.

PubMed abstract

The impact of attending historically Black colleges and universities on cognitive decline in Black adults: A longitudinal analysis in the KHANDLE and STAR cohorts

Authors: Thomas, Marilyn D; Calmasini, Camilla; Khela, Harmon; Mobley, Taylor M; Mayeda, Elizabeth Rose; Mangurian, Christina; Barnes, Lisa L; Gilsanz, Paola; Whitmer, Rachel A; Glymour, M Maria

Alzheimers Dement. 2023 Feb 17.

PubMed abstract

Evaluating interpersonal discrimination and depressive symptoms as partial mediators of the effects of education on cognition: Evidence from the Study of Healthy Aging in African Americans (STAR)

Authors: Cintron, Dakota W; Calmasini, Camilla; Barnes, Lisa L; Mungas, Dan M; Whitmer, Rachel A; Eng, Chloe W; Gilsanz, Paola; George, Kristen M; Peterson, Rachel L; Glymour, M Maria

Alzheimers Dement. 2023 Feb 01.

PubMed abstract

Neighborhood disadvantage and dementia incidence in a cohort of Asian American and non-Latino White older adults in Northern California

Authors: Mobley, Taylor M; Shaw, Crystal; Hayes-Larson, Eleanor; Fong, Joseph; Gilsanz, Paola; Gee, Gilbert C; Brookmeyer, Ron; Whitmer, Rachel A; Casey, Joan A; Mayeda, Elizabeth Rose

Alzheimers Dement. 2023 Jan;19(1):296-306. Epub 2022-04-06.

PubMed abstract

Racial and Ethnic Differences in Amyloid PET Positivity in Individuals With Mild Cognitive Impairment or Dementia: A Secondary Analysis of the Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) Cohort Study

Authors: Wilkins, Consuelo H; Whitmer, Rachel A; Rabinovici, Gil D; et al.

JAMA Neurol. 2022 Oct 03.

PubMed abstract

Comparison of cognitive function in older adults with type 1 diabetes, type 2 diabetes, and no diabetes: results from the Study of Longevity in Diabetes (SOLID)

Authors: Lacy, Mary E; Moran, Chris; Gilsanz, Paola; Beeri, Michal S; Karter, Andrew J; Whitmer, Rachel A

BMJ Open Diabetes Res Care. 2022 03;10(2).

PubMed abstract

rPOP: Robust PET-only processing of community acquired heterogeneous amyloid-PET data

Authors: Iaccarino, Leonardo; Carrillo, Maria C; Alzheimer's Disease Neuroimaging Initiative,; et al.

Neuroimage. 2022 02 01;246:118775. Epub 2021-12-07.

PubMed abstract

Identifying Potential Intervention Points for Acute Hypoglycemic Events in Patients With Type 2 Diabetes Using Retrospective Clinical Data

Authors: Lacy, Mary E; Whitmer, Rachel A; Lee, Sei J; Rushakoff, Robert J; Pletcher, Mark J

Clin Diabetes. 2021 Jul;39(3):304-312.

PubMed abstract

Association Between Ambient Air Pollution and Amyloid Positron Emission Tomography Positivity in Older Adults With Cognitive Impairment

Authors: Iaccarino, Leonardo; Carrillo, Maria C; Rabinovici, Gil D; et al.

JAMA Neurol. 2021 02 01;78(2):197-207.

PubMed abstract

Amyloid-PET imaging offers small improvements in predictions of future cognitive trajectories

Authors: Ackley, Sarah F; Hayes-Larson, Eleanor; Brenowitz, Willa D; Swinnerton, Kaitlin; Mungas, Dan; Fletcher, Evan; Singh, Baljeet; Whitmer, Rachel A; DeCarli, Charles; Maria Glymour, M

Neuroimage Clin. 2021;31:102713. Epub 2021-06-08.

PubMed abstract

Association Between Cognitive Test Performance and Subjective Cognitive Decline in a Diverse Cohort of Older Adults: Findings From the KHANDLE Study

Authors: Corlier FW; Shaw C; Hayes-Larson E; Mungas D; Tomaszewski Farias S; Glymour MM; Whitmer RA; Mayeda ER

Alzheimer Dis Assoc Disord. 2020 Jul-Sep;34(3):198-205.

PubMed abstract

Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis

Authors: Chen HY; Whitmer RA; Thanassoulis G; et al.

JAMA Cardiol. 2020 06 01;5(6):694-702.

PubMed abstract

Severe Hypoglycemia and Cognitive Function in Older Adults With Type 1 Diabetes: The Study of Longevity in Diabetes (SOLID)

Authors: Lacy ME; Gilsanz P; Eng C; Beeri MS; Karter AJ; Whitmer RA

Diabetes Care. 2020 03;43(3):541-548. Epub 2019-12-27.

PubMed abstract

Dyadic Group Exercises for Persons with Memory Deficits and Care Partners: Mixed-Method Findings from the Paired Preventing Loss of Independence through Exercise (PLIÉ) Randomized Trial

Authors: Mehling, Wolf E; Scott, Travis M; Duffy, James; Whitmer, Rachel A; Chesney, Margaret A; Boscardin, W John; Barnes, Deborah E

J Alzheimers Dis. 2020;78(4):1689-1706.

PubMed abstract

Sleep Quality and Cognitive Function in Type 1 Diabetes: Findings From the Study of Longevity in Diabetes (SOLID)

Authors: Gilsanz P; Lacy ME; Beeri MS; Karter AJ; Eng CW; Whitmer RA

Alzheimer Dis Assoc Disord. 2020 Jan-Mar;34(1):18-24.

PubMed abstract

Locus of Control and Cognition in Older Adults With Type I Diabetes: Evidence For Sex Differences From the Study of Longevity in Diabetes (SOLID)

Authors: Eng CW; Gilsanz P; Lacy ME; Beeri M; Whitmer RA

Alzheimer Dis Assoc Disord. 2019 Oct 17.

PubMed abstract

Progress and future challenges in aging and diversity research in the United States

Authors: Brewster P; Whitmer RA; Mungas D; et al.

Alzheimers Dement. 2019 07;15(7):995-1003. Epub 2018-09-19.

PubMed abstract

Association of Amyloid Positron Emission Tomography With Subsequent Change in Clinical Management Among Medicare Beneficiaries With Mild Cognitive Impairment or Dementia

Authors: Rabinovici GD; Whitmer RA; Carrillo MC; et al.

JAMA. 2019 04 02;321(13):1286-1294.

PubMed abstract

Birth in High Infant Mortality States and Dementia Risk in a Cohort of Elderly African American and White Health Care Members

Authors: Gilsanz P; Mayeda ER; Glymour MM; Quesenberry CP; Mungas D; DeCarli CS; Whitmer RA

Alzheimer Dis Assoc Disord. 2019 Jan-Mar;33(1):1-6.

PubMed abstract

Early Midlife Pulmonary Function and Dementia Risk

Authors: Gilsanz P; Mayeda ER; Flatt J; Glymour MM; Quesenberry CP; Whitmer RA

Alzheimer Dis Assoc Disord. 2018 Oct-Dec;32(4):270-275.

PubMed abstract

Traumatic brain injury associated with dementia risk among people with type 1 diabetes

Authors: Gilsanz P; Albers K; Beeri MS; Karter AJ; Quesenberry CP; Whitmer RA

Neurology. 2018 Sep 26.

PubMed abstract

Manuscript title: Can survival bias explain the age attenuation of racial inequalities in stroke incidence? A simulation study

Authors: Mayeda ER; Banack HR; Bibbins-Domingo K; Zeki Al Hazzouri A; Marden JR; Whitmer RA; Glymour MM

Epidemiology. 2018 07;29(4):525-532.

PubMed abstract

Depression in type 1 diabetes and risk of dementia

Authors: Gilsanz P; Schnaider Beeri M; Karter AJ; Quesenberry CP; Adams AS; Whitmer RA

Aging Ment Health. 2018 Apr 10:1-7.

PubMed abstract

Diabetic Retinopathy and Dementia in Type 1 Diabetes

Authors: Rodill LG; Exalto LG; Gilsanz P; Biessels GJ; Quesenberry CP; Whitmer RA

Alzheimer Dis Assoc Disord. 2018 Apr-Jun;32(2):125-130.

PubMed abstract

Statin use and risk of Alzheimer disease: A new view on an old relationship

Authors: Yasar S; Whitmer R

Neurology. 2018 01 16;90(3):103-104. Epub 2017-12-15.

PubMed abstract

Association of LPA Variants With Aortic Stenosis: A Large-Scale Study Using Diagnostic and Procedural Codes From Electronic Health Records

Authors: Chen HY; Dufresne L; Burr H; Ambikkumar A; Yasui N; Luk K; Ranatunga DK; Whitmer RA; Lathrop M; Engert JC; Thanassoulis G

JAMA Cardiol. 2018 01 01;3(1):18-23.

PubMed abstract

Post-traumatic stress disorder and risk of dementia among members of a health care delivery system

Authors: Flatt JD; Gilsanz P; Quesenberry CP; Albers KB; Whitmer RA

Alzheimers Dement. 2018 01;14(1):28-34. Epub 2017-06-13.

PubMed abstract

The Bidirectional Association Between Depression and Severe Hypoglycemic and Hyperglycemic Events in Type 1 Diabetes

Authors: Gilsanz P; Karter AJ; Beeri MS; Quesenberry CP; Whitmer RA

Diabetes Care. 2017 Dec 18.

PubMed abstract

Female sex, early-onset hypertension, and risk of dementia

Authors: Gilsanz P; Mayeda ER; Glymour MM; Quesenberry CP; Mungas DM; DeCarli C; Dean A; Whitmer RA

Neurology. 2017 Oct 31;89(18):1886-1893. Epub 2017-10-04.

PubMed abstract

Association Between Birth in a High Stroke Mortality State, Race, and Risk of Dementia

Authors: Gilsanz P; Mayeda ER; Glymour MM; Quesenberry CP; Whitmer RA

JAMA Neurol. 2017 Sep 01;74(9):1056-1062.

PubMed abstract

Survival after dementia diagnosis in five racial/ethnic groups

Authors: Mayeda ER; Glymour MM; Quesenberry CP; Johnson JK; Pérez-Stable EJ; Whitmer RA

Alzheimers Dement. 2017 Jul;13(7):761-769. Epub 2017-02-05.

PubMed abstract

Heterogeneity in 14-year Dementia Incidence Between Asian American Subgroups

Authors: Mayeda ER; Glymour MM; Quesenberry CP; Whitmer RA

Alzheimer Dis Assoc Disord. 2017 Jul-Sep;31(3):181-186.

PubMed abstract

Changes in Medication Use After Dementia Diagnosis in an Observational Cohort of Individuals with Diabetes Mellitus

Authors: Sarkar U; Lyles C; Steinman M; Huang ES; Moffet HH; Whitmer RA; Warton EM; Karter AJ

J Am Geriatr Soc. 2017 Jan;65(1):77-82. Epub 2016-09-19.

PubMed abstract

A call for comparative effectiveness research to learn whether routine clinical care decisions can protect from dementia and cognitive decline

Authors: Dacks PA; Whitmer RA; Fillit HM; et al.

Alzheimers Res Ther. 2016 Aug 20;8:33. Epub 2016-08-20.

PubMed abstract

Modifiable risk factors for nursing home admission among individuals with high and low dementia risk

Authors: Rist PM; Nguyen TT; Whitmer RA; Glymour MM

Arch Gerontol Geriatr. 2016 Jul-Aug;65:140-5. Epub 2016-03-19.

PubMed abstract

Hostile attitudes and effortful coping in young adulthood predict cognition 25 years later

Authors: Albanese E; Matthews KA; Zhang J; Jacobs DR; Whitmer RA; Wadley VG; Yaffe K; Sidney S; Launer LJ

Neurology. 2016 Mar 29;86(13):1227-34. Epub 2016-03-02.

PubMed abstract

Association Between Lifetime Marijuana Use and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Authors: Auer R; Whitmer RA; Pletcher MJ; et al.

JAMA Intern Med. 2016 Mar;176(3):352-61.

PubMed abstract

Inequalities in dementia incidence between six racial and ethnic groups over 14years

Authors: Mayeda ER; Glymour MM; Quesenberry CP; Whitmer RA

Alzheimers Dement. 2016 Mar;12(3):216-24. Epub 2016-02-11.

PubMed abstract

First translational ‘Think Tank’ on cerebrovascular disease, cognitive impairment and dementia

Authors: Barone FC; Whitmer R; Zhang ZG; et al.

J Transl Med. 2016 Feb 13;14:50. Epub 2016-Feb-13.

PubMed abstract

Feasibility study for remote assessment of cognitive function in multiple sclerosis

Authors: George MF; Holingue CB; Briggs FB; Shao X; Bellesis KH; Whitmer RA; Schaefer C; Benedict RH; Barcellos LF

J Neurol Neuromedicine. 2016;1(8):10-18.

PubMed abstract

Effect of Early Adult Patterns of Physical Activity and Television Viewing on Midlife Cognitive Function

Authors: Hoang TD; Reis J; Zhu N; Jacobs DR; Launer LJ; Whitmer RA; Sidney S; Yaffe K

JAMA Psychiatry. 2016 Jan;73(1):73-9.

PubMed abstract

Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

Authors: Kvale MN; Croen LA; Iribarren C; Kushi LH; Quesenberry CP; Sakoda LC; Van Den Eeden SK; Whitmer RA; Schaefer C; Risch N; et al.

Genetics. 2015 Aug;200(4):1051-60. Epub 2015-06-19.

PubMed abstract

Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

Authors: Banda Y; Croen LA; Iribarren C; Kushi LH; Quesenberry CP; Sakoda LC; Van Den Eeden SK; Whitmer RA; Schaefer C; Risch N; et al.

Genetics. 2015 Aug;200(4):1285-95. Epub 2015-06-19.

PubMed abstract

Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

Authors: Lapham K; Croen LA; Iribarren C; Kushi LH; Quesenberry CP; Sakoda LC; Van Den Eeden SK; Whitmer RA; Risch N; Schaefer C; Blackburn EH; et al.

Genetics. 2015 Aug;200(4):1061-72. Epub 2015-06-19.

PubMed abstract

Ethnic Differences in Geriatric Conditions and Diabetes Complications Among Older, Insured Adults With Diabetes: The Diabetes and Aging Study

Authors: Karter AJ; Adams AS; Whitmer RA; Huang ES; et al.

J Aging Health. 2015 Aug;27(5):894-918. Epub 2015-02-05.

PubMed abstract

Cardiorespiratory fitness and brain volume and white matter integrity: The CARDIA Study

Authors: Zhu N; Whitmer RA; Bryan RN; et al.

Neurology. 2015 Jun 9;84(23):2347-53. Epub 2015-05-08.

PubMed abstract

Diabetes and Cognition

Authors: Mayeda ER; Whitmer RA; Yaffe K

Clin Geriatr Med. 2015 Feb;31(1):101-15, ix. Epub 2014-11-15.

PubMed abstract

Midlife risk score for the prediction of dementia four decades later

Authors: Exalto LG; Quesenberry CP; Barnes D; Kivipelto M; Biessels GJ; Whitmer RA

Alzheimers Dement. 2014 Sep;10(5):562-70. Epub 2013-09-10.

PubMed abstract

Cognitive impairment in ORIGIN: timing is everything

Authors: Whitmer RA

Lancet Diabetes Endocrinol. 2014 Jul;2(7):531-2. Epub 2014-06-02.

PubMed abstract

Early adult to midlife cardiovascular risk factors and cognitive function

Authors: Yaffe K; Vittinghoff E; Pletcher MJ; Hoang TD; Launer LJ; Whitmer R; Coker LH; Sidney S

Circulation. 2014 Apr 15;129(15):1560-7. Epub 2014-03-31.

PubMed abstract

Cardiorespiratory fitness and cognitive function in middle age: The CARDIA Study

Authors: Zhu N; Whitmer RA; Sternfeld B; et al.

Neurology. 2014 Apr 15;82(15):1339-46. Epub 2014-04-02.

PubMed abstract

Racial/ethnic differences in dementia risk among older type 2 diabetes patients: The Diabetes and Aging Study

Authors: Mayeda ER; Karter AJ; Huang ES; Moffet HH; Haan MN; Whitmer RA

Diabetes Care. 2014 Apr;37(4):1009-15. Epub 2013-11-22.

PubMed abstract

Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions

Authors: Biessels GJ; Strachan MW; Visseren FL; Kappelle LJ; Whitmer RA

Lancet Diabetes Endocrinol. 2014 Mar;2(3):246-55. Epub 2013-10-18.

PubMed abstract

Severe Diabetic Retinal Disease and Dementia Risk in Type 2 Diabetes

Authors: Exalto LG; Biessels GJ; Karter AJ; Huang ES; Quesenberry CP; Whitmer RA

J Alzheimers Dis. 2014;42 Suppl 3:S109-17.

PubMed abstract

Risk score for prediction of 10 year dementia risk in individuals with type 2 diabetes: a cohort study

Authors: Exalto LG; Biessels GJ; Karter AJ; Huang ES; Katon WJ; Minkoff JR; Whitmer RA

Lancet Diabetes Endocrinol. 2013 Nov;1(3):183-90. Epub 2013-08-20.

PubMed abstract

Commentary: mediterranean diet and cognitive function: are we approaching clarity in this area?

Authors: Whitmer RA; Kushi LH

Epidemiology. 2013 Jul;24(4):500-2.

PubMed abstract

Symptom Burden of Adults with Type 2 Diabetes Across the Disease Course: Diabetes & Aging Study

Authors: Sudore RL; Karter AJ; Adams A; Whitmer RA; Schillinger D; et al.

J Gen Intern Med. 2012 Dec;27(12):1674-81. Epub 2012 Aug 2.

PubMed abstract

An update on type 2 diabetes, vascular dementia and Alzheimer’s disease

Authors: Exalto LG; Whitmer RA; Kappele LJ; Biessels GJ

Exp Gerontol. 2012 Nov;47(11):858-64. Epub 2012 Aug 3.

PubMed abstract

Hormone therapy and Alzheimer disease dementia: New findings from the Cache County Study

Authors: Shao H; Whitmer RA; Cache County Investigators; et al.

Neurology. 2012 Oct 30;79(18):1846-52. Epub 2012 Oct 24.

PubMed abstract

Midlife vs Late-Life Depressive Symptoms and Risk of Dementia: Differential Effects for Alzheimer Disease and Vascular Dementia

Authors: Barnes DE; Yaffe K; Byers AL; McCormick M; Schaefer C; Whitmer RA

Arch Gen Psychiatry. 2012 May;69(5):493-8.

PubMed abstract

Association of Depression With Increased Risk of Dementia in Patients With Type 2 Diabetes: The Diabetes and Aging Study

Authors: Katon W; Lyles CR; Parker MM; Karter AJ; Huang ES; Whitmer RA

Arch Gen Psychiatry. 2012 Apr;69(4):410-7. Epub 2011 Dec 5.

PubMed abstract

Central Obesity, Leptin and Cognitive Decline: The Sacramento Area Latino Study on Aging

Authors: Zeki Al Hazzouri A; Haan MN; Whitmer RA; Yaffe K; Neuhaus J

Dement Geriatr Cogn Disord. 2012;33(6):400-9. Epub 2012 Jul 17.

PubMed abstract

Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm

Authors: Hoffmann TJ; Iribarren C; Quesenberry C; Van den Eeden SK; Whitmer RA; Schaefer C; Risch N; et al.

Genomics. 2011 Dec;98(6):422-30. Epub 2011 Aug 28.

PubMed abstract

Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array

Authors: Hoffmann TJ; Iribarren C; Quesenberry C; Van den Eeden SK; Whitmer RA; Schaefer C; Risch N; et al.

Genomics. 2011 Aug;98(2):79-89. Epub 2011 Apr 30.

PubMed abstract

Heavy smoking in midlife and long-term risk of Alzheimer disease and vascular dementia

Authors: Rusanen M; Kivipelto M; Zhou J; Whitmer RA; Quesenberry CP Jr

Arch Intern Med. 2011 Feb 28;171(4):333-9. Epub 2010 Oct 25.

PubMed abstract

Timing of hormone therapy and dementia: the critical window theory revisited

Authors: Whitmer RA; Quesenberry CP; Zhou J; Yaffe K

Ann Neurol. 2011 Jan;69(1):163-9. Epub 2010 Nov 12.

PubMed abstract

Commentary on ‘Developing a national strategy to prevent dementia: Leon Thal Symposium 2009.’ Dementia risk indices: A framework for identifying individuals with a high dementia risk

Authors: Barnes DE; Covinsky KE; Whitmer RA; Kuller LH; Lopez OL; Yaffe K

Alzheimers Dement. 2010 Mar;6(2):138-41.

PubMed abstract

Psychiatric disorders and cognitive dysfunction among older, postmenopausal women: results from the Women’s Health Initiative Memory Study

Authors: Colenda CC; Legault C; Rapp SR; DeBon MW; Hogan P; Wallace R; Hershey L; Ockene J; Whitmer R; Phillips LS; Sarto GE

Am J Geriatr Psychiatry. 2010 Feb;18(2):177-86.

PubMed abstract

Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis

Authors: Li NC; Lee A; Whitmer RA; Kivipelto M; Lawler E; Kazis LE; Wolozin B

BMJ. 2010 Jan 12;340:b5465.

PubMed abstract

Predicting risk of dementia in older adults: The late-life dementia risk index

Authors: Barnes DE; Covinsky KE; Whitmer RA; Kuller LH; Lopez OL; Yaffe K

Neurology. 2009 Jul 21;73(3):173-9. Epub 2009 May 13.

PubMed abstract

NSAID exposure and risk of Alzheimer disease: is timing everything?

Authors: Bennett DA; Whitmer RA

Neurology. 2009 Jun 2;72(22):1884-5. Epub 2009 Apr 22.

PubMed abstract

Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus

Authors: Whitmer RA; Karter AJ; Yaffe K; Quesenberry CP Jr; Selby JV

JAMA. 2009 Apr 15;301(15):1565-72.

PubMed abstract

Midlife serum cholesterol and increased risk of Alzheimer’s and vascular dementia three decades later

Authors: Solomon A; Kivipelto M; Wolozin B; Zhou J; Whitmer RA

Dement Geriatr Cogn Disord. 2009;28(1):75-80. Epub 2009 Aug 4.

PubMed abstract

Central obesity and increased risk of dementia more than three decades later

Authors: Whitmer RA; Gustafson DR; Barrett-Connor E; Haan MN; Gunderson EP; Yaffe K

Neurology. 2008 Sep 30;71(14):1057-64. Epub 2008 Mar 26.

PubMed abstract

Childbearing may increase visceral adipose tissue independent of overall increase in body fat

Authors: Gunderson EP; Sternfeld B; Wellons MF; Whitmer RA; Chiang V; Quesenberry CP Jr; Lewis CE; Sidney S

Obesity (Silver Spring). 2008 May;16(5):1078-84. Epub 2008 Mar 6.

PubMed abstract

Statin use and risk of prostate cancer in the California Men’s Health Study cohort

Authors: Flick ED; Habel LA; Van Den Eeden SK; Quesenberry CP Jr; Sternfeld B; Whitmer RA; Caan BJ; et al.

Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2218-25. Epub 2007 Oct 30.

PubMed abstract

Type 2 diabetes and risk of cognitive impairment and dementia

Authors: Whitmer RA

Curr Neurol Neurosci Rep. 2007 Sep;7(5):373-80.

PubMed abstract

Metabolic syndrome and cognitive decline in elderly Latinos: findings from the Sacramento Area Latino Study of Aging study

Authors: Yaffe K; Haan M; Blackwell T; Cherkasova E; Whitmer RA; West N

J Am Geriatr Soc. 2007 May;55(5):758-62.

PubMed abstract

The epidemiology of adiposity and dementia

Authors: Whitmer RA

Curr Alzheimer Res. 2007 Apr;4(2):117-22.

PubMed abstract

Body mass index in midlife and risk of Alzheimer disease and vascular dementia

Authors: Whitmer RA; Gunderson EP; Quesenberry CP Jr; Zhou J; Yaffe K

Curr Alzheimer Res. 2007 Apr;4(2):103-9.

PubMed abstract

Lactation and changes in maternal metabolic risk factors

Authors: Gunderson EP; Lewis CE; Wei GS; Whitmer RA; Quesenberry CP; Sidney S

Obstet Gynecol. 2007 Mar;109(3):729-38.

PubMed abstract

Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: results from the Sacramento Area Latino Study on Aging

Authors: Haan MN; Miller JW; Aiello AE; Whitmer RA; Jagust WJ; Mungas DM; Allen LH; Green R

Am J Clin Nutr. 2007 Feb;85(2):511-7.

PubMed abstract

Physical activity and dementia: The need for prevention trials

Authors: Barnes DE; Whitmer RA; Yaffe K

Exerc Sport Sci Rev. 2007 Jan;35(1):24-9.

PubMed abstract

Midlife obesity and long-term risk of nursing home admission

Authors: Elkins JS; Whitmer RA; Sidney S; Sorel M; Yaffe K; Johnston SC

Obesity (Silver Spring). 2006 Aug;14(8):1472-8.

PubMed abstract

Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study

Authors: Whitmer RA; Gunderson EP; Barrett-Connor E; Quesenberry CP Jr; Yaffe K

BMJ. 2005 Jun 11;330(7504):1360. Epub 2005 Apr 29.

PubMed abstract

Midlife cardiovascular risk factors and risk of dementia in late life

Authors: Whitmer RA; Sidney S; Selby J; Johnston SC; Yaffe K

Neurology. 2005 Jan 25;64(2):277-81.

PubMed abstract

Hormone replacement therapy and cognitive performance: the role of homocysteine

Authors: Whitmer RA; Haan MN; Miller JW; Yaffe K

J Gerontol A Biol Sci Med Sci. 2003 Apr;58(4):324-30.

PubMed abstract

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