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A Database Cohort Study to Assess the Risk of Developing non-Melanoma Skin Cancer in Adult Patients with Atopic Dermatitis Exposed to Topical Calcineurin Inhibitor

The primary objective of this study is to assess the long-term risk of developing melanoma in adult subjects aged 40 years with AD exposed to topical calcinuerin inhibitors (TCIs). To accomplish this objective, the long-term risk of developing melanoma will be compared for four groups: a) subjects with AD initiating topical pimecrolimus, b) subjects with AD initiating topical tacrolimus (the only other approved drug in the TCI class), c) subjects who were not prescribed TCIs but were already taking or newly initiating a topical corticosteroid (TCS), and d) subjects with AD treated with neither TCIs nor prescription TCS (emollients only). Analyses will also take into account whether duration, frequency, or extent of exposure affect the risk of melanoma.

Investigator: Quesenberry, Charles

Funder: Valeant Pharmaceuticals International, Inc.

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