A Pragmatic Randomized Controlled Trial of a Bundled, Pharmacist-Led Hyperpolypharmacy Deprescribing Intervention

This randomized controlled trial study is testing an intervention to reduce unsafe medication use in patients aged 75 years and older. The intervention uses collaborative drug therapy management between physicians and pharmacists, standard-of-care treatment protocols, shared decision-making, and the CEASE deprescribing protocol. Following physician authorization, it is administered by ambulatory care pharmacists working over multiple deprescribing cycles to reduce doses, switch to safer drugs, and discontinue medications while monitoring for adverse drug withdrawal effects. Outcomes include the number of medications used and the diagnosis of conditions related to medication overuse. The safety of the intervention is also being evaluated.

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