Air Pollutants and Cardiovascular Risk: Investigating Thresholds with Pooled Cohorts and Electronic Health Records

This study will pool data from a set of well-established cohorts in the United States, each with appropriate outcome, residential history, and individual-level covariate detail, to study low-threshold exposures to criteria air pollutants and cardiovascular disease risk. A secondary aim is to study one unusually well-characterized large-scale integrated health delivery system (Kaiser Permanente Northern California) with detailed electronic health records, as well as cohorts within the system, to examine the consistency between a cohort and electronic-health-record approach.

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