Assessing Syndemics of Cardiovascular Disease in People with and without HIV

Cardiovascular disease (CVD) is a large and growing public health problem, especially for people with HIV (PWH). Within Kaiser Permanente, we use a syndemic approach to investigate combinations of social and biological conditions that may act synergistically to increase risk for of CVD in PWH, with a focus on the understudied conditions of mental health, substance use, economic factors, social isolation, stigma/discrimination, trauma history, and healthcare access challenges. This study will use Kaiser Permanente’s comprehensive electronic health record data, detailed Research Bank survey data, and stored serum to investigate the association of HIV status on Major Adverse Cardiovascular Events and preclinical biomarkers for cardiovascular disease. Study findings have potential to identify community- and health system-based CVD prevention interventions for vulnerable PWH.

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