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Calculator for Length of Use of Bisphosphonates (CLUB)

Despite the wide availability of bisphosphonate drugs that reduce fracture risk, treatment rates have fallen, attributable to concerns for atypical femoral fractures and osteonecrosis of the jaw. While risk/benefit ratios of bisphosphonate treatment for osteoporosis remain highly favorable in the first 3-5 years, fracture-prevention benefit wanes with longer treatment and risks of side effects increases. This study will estimate the risks/benefits of bisphosphonate drug holidays; determine the cost effectiveness of continuing vs discontinuing a bisphosphonate after 3 years; and develop and validate a risk factor calculator to guide decisions about length of bisphosphonate use.

Investigator: Lo, Joan

Funder: National Institute on Aging

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