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Comparative Effectiveness Trial of Non-invasive vs. Invasive Strategies (FIT vs Colonoscopy) for Older Adults with a History of Pre-neoplastic Colon Polyps

This comparative effectiveness trial will evaluate detection of significant neoplasia between the strategies of low threshold annual FIT vs. colonoscopy for older adults with a history of colon polyps. We will investigate whether the FIT strategy is non-inferior to colonoscopy in detecting CRC and advanced colorectal neoplasia over 5 years of follow-up and whether fewer colonoscopies are needed to detect CRC using FIT vs. colonoscopy. We will also compare complication rates and patient experience between the FIT and colonoscopy strategies to see whether those in the FIT strategy will have less complications compared to the colonoscopy strategy and whether the FIT strategy will be more convenient and tolerable compared to the colonoscopy strategy.

Investigator: Levin, Theodore

Funder: Patient-Centered Outcomes Research Institute

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