Comparing the effects of pharmacological treatment for gestational diabetes on long-term maternal and child health outcomes

Comparing the effects of pharmacological treatment for gestational diabetes on long-term maternal and child health outcomes
This study will use real-world clinical data on pregnancies with gestational diabetes requiring pharmacological treatment to compare the risk of long-term maternal and child health outcomes associated with oral hypoglycemic agents (metformin and glyburide) in comparison to insulin. It will compare the risk of long-term effects of metformin and glyburide versus insulin on child neurodevelopmental and growth trajectory and obesity; compare the risk of long-term effects of metformin and glyburide versus insulin alone on mothers long-term cardiometabolic health (diabetes, diabetes severity and hypertension); and explore whether the risks vary by maternal race/ethnicity or obesity status.
Funder: National Institute of Diabetes and Digestive and Kidney Diseases

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