COVID-19: Antecedents to Hospitalization and Deterioration

This study will characterize and compare antecedents to hospitalization and in-hospital deterioration among patients with COVID-19 and comparator patients with influenza. We will quantify pre-existing comorbidities, medication adherence, and temporal factors prior to hospitalization with COVID-19 or influenza. We will also characterize the antecedents and time course of infections in these 2 groups of patients and quantify the relative contribution of 4 key groups of predictors for non-elective hospitalization and adverse outcomes (critical illness, death): demographics, pre-existing comorbidities, medication adherence, and time to treatment for patients who went to the emergency department.

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