This proposal uses a novel holistic framework that leverages both targeted and untargeted metabolomics approach, electronic health records data, and bioinformatics analytics to investigate the mechanisms by which the in-utero environment may infer risk of fetal growth extremes and altered infant growth trajectories and excess adiposity. It will also explore metabolomic signatures for maternal dietary factors during pregnancy, as a means to objectively capture dietary exposures in utero.
Fetal Programming of Growth and Obesity: A Metabolomics Approach
Investigator: Zhu, Yeyi
Funder: National Institute of Diabetes and Digestive and Kidney Diseases