Genomics of Blood Pressure-induced Target Organ Damage

The study’s aims are to: 1) ascertain the genomic contribution of common genetic variants to blood pressure (BP) variation within and between multiple ethnic groups; 2) conduct Mendelian randomization experiments using all new and known BP-associated variants to investigate the interplay of genetic BP risk with hypertensive target organ damage including left ventricular hypertrophy, renal dysfunction, and clinical cardiovascular disease across ethnic groups; and 3) perform deep whole-genome sequencing in very extreme individuals for systolic blood pressure to uncover the entire spectrum of allele frequencies.

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