Kaiser Healthy Aging and Diverse Life Experiences Study (KHANDLE)

Although there are marked ethnic disparities in rates of dementia, almost nothing is known about early-life contributors to dementia in ethnic minority groups, nor if the trajectory of cognitive decline or transition to cognitive impairment varies across ethnic groups. We propose a lifecourse study of ethnic disparities in the epidemiology of dementia using over 5 decades of data in relation to cognitive decline and brain pathology. The overall objectives are to define ethnic disparities in dementia incidence and to advance our understanding of such disparities by assessing early and midlife risk factors for cognitive impairment and MRI markers of brain injury.

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