Ms. LILAC: Muscle Mass in the Life and Longevity After Cancer (LILAC) Study

In WHI, we use the LILAC study and the Long Life Study 2 to collect D-3 creatine to measure muscle mass in older women who are cancer survivors and a matched control group of older women who have not had cancer. Specifically, we will develop age-standardized percentile curves to characterize the distribution of D-3 muscle mass in the cancer survivor and control groups; examine whether the relationship between muscle mass, physical function, and functional decline differs in cancer survivors and controls by assessing the cross-sectional relationship between muscle mass and physical function; the longitudinal relationship between muscle mass and functional decline; and use machine learning methods to create multivariate risk-prediction algorithms to detect low muscle mass in the cancer survivor and control groups.

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