Novel Strategies to Identify G x E Contributions to MS Pathogensis

The goal of the study is to examine potential gene X environment interactions in relation to risk and progression of multiple sclerosis (MS) in a 2,400-person case control dataset. The study will examine family and self-history of other autoimmune disorders, as well as a number of potential environmental risk factors, including obesity, history of depression and stressful life events, exposure to tobacco smoke and other factors, in interaction with polymorphisms in potential candidate genes.

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