Optimizing Cancer Chemotherapy Dosing Based on Lean Body Mass

The current chemotherapy dosing based on body surface area leads to high rates and variation of chemotoxicities. Evidence on lean body mass (LBM) and cancer prognosis indicates the potential for this new metric to be incorporated into chemotherapy dosing to minimize toxicity. The proposed project will build an evidence base for exploring the potential of optimizing chemotherapy dosage based on LBM by leveraging advanced statistical modeling techniques.

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