Optimizing Prostate Biopsy in Men with Mildly Elevated PSA Levels or Prior Negative Biopsies

This study will examine whether, in biopsy-naive men with mildly elevated PSA levels (less than or equal to 10 ng/ml) or men with a prior negative biopsy, use of the KP Prostate Cancer Risk Calculator improves detection of high-grade cancer while reducing the number of men with negative biopsies or low-grade, indolent cancer compared to current practice. This project will involve KPNC and KPSC. Some additional secondary reflex tests are commonly used in the evaluation of these patients. Our calculator will be incorporated into their workflow to determine the relative merit of these secondary tests.

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