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Particulate Air Pollution, Cardiovascular Events, and Susceptibility Factors (PACES)

This is a retrospective cohort study of 5 million adult members of Kaiser Permanente Northern California during 2000 to 2012, linked to state-of-the-art estimates of exposure to PM2.5 (particulate matter less than 2.5 micrometers in diameter) generated at 1km x 1km resolution using a novel hybrid model that incorporates meteorologic, land-use, and satellite measures. This project will quantify the associations between ambient PM2.5 exposure and risk of cardiovascular disease events, and determine whether demographic characteristics (age, sex, race/ethnicity, and socioeconomic status) and clinical comorbidities (obesity, diabetes, hypertension, and hyperlipidemia) are susceptibility factors that confer elevated risk to the effects of PM2.5.

Investigator: Alexeeff, Stacey

Funder: National Institute of Environmental Health Sciences

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