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Study

Genetics at an Extreme: An Efficient Genomic Study of Individuals with Clinically Severe Major Depression Receiving ECT

This study brings together investigators from around the world to carry out a genetics study of severe major depressive disorder (MDD) treated with electroconvulsive therapy (ECT). The National Network of Depression Centers and allied centers in the U.S. will carry out a genetics study that will enroll 25,000 patients receiving ECT for severe MDD. The centers will also carry out a genome-wide association study comparing these 25,000 cases with 50,000 non-depressed and tightly matched previously collected controls. They will also carry out a genome-wide association study of response to ECT in the 10,000 patients with prospective follow-up data.  Analysis will consider changes in measures of depression and cognitive function, test for genetic variances associated with these responses, and examine prediction models.
Investigator: Schaefer, Catherine
Funder: National Institute of Mental Health